{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:00:44Z","timestamp":1791270044782,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"National Science & Technology Pillar Program during the Twelfth Five-year Plan Period","award":["2014BAI07B05"],"award-info":[{"award-number":["2014BAI07B05"]}]},{"name":"National Key Basic Research Program of China","award":["2014CB541806"],"award-info":[{"award-number":["2014CB541806"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Ther"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s40744-021-00293-0","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T17:03:20Z","timestamp":1615482200000},"page":"555-571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characteristics Associated with the Occurrence and Development of Acute Anterior Uveitis, Inflammatory Bowel Disease, and Psoriasis in Patients with Ankylosing Spondylitis: Data from the Chinese Ankylosing Spondylitis Prospective Imaging Cohort"],"prefix":"10.1007","volume":"8","author":[{"given":"Siliang","family":"Man","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-873X","authenticated-orcid":false,"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"293_CR1","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","volume":"369","author":"J Braun","year":"2007","unstructured":"Braun J, Sieper J. Ankylosing spondylitis. Lancet. 2007;369:1379\u201390. https:\/\/doi.org\/10.1016\/S0140-6736(07)60635-7.","journal-title":"Lancet"},{"key":"293_CR2","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1136\/ard.2009.124206","volume":"69","author":"P Machado","year":"2010","unstructured":"Machado P, Landew\u00e9 R, Braun J, et al. Both structural damage and inflammation of the spine contribute to impairment of spinal mobility in patients with ankylosing spondylitis. Ann Rheum Dis. 2010;69:1465\u201370. https:\/\/doi.org\/10.1136\/ard.2009.124206.","journal-title":"Ann Rheum Dis"},{"key":"293_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1136\/annrheumdis-2013-203582","volume":"74","author":"C Stolwijk","year":"2015","unstructured":"Stolwijk C, van Tubergen A, Castillo-Ortiz JD, et al. Prevalence of extra-articular manifestations in patients with ankylosing spondylitis: a systematic review and meta-analysis. Ann Rheum Dis. 2015;74:65\u201373. https:\/\/doi.org\/10.1136\/annrheumdis-2013-203582.","journal-title":"Ann Rheum Dis"},{"key":"293_CR4","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/rheumatology\/ket387","volume":"53","author":"LE Dean","year":"2014","unstructured":"Dean LE, Jones GT, MacDonald AG, et al. Global prevalence of ankylosing spondylitis. Rheumatol (Oxf). 2014;53:650\u20137. https:\/\/doi.org\/10.1093\/rheumatology\/ket387.","journal-title":"Rheumatol (Oxf)"},{"key":"293_CR5","first-page":"333","volume":"28","author":"AJ Geirsson","year":"2010","unstructured":"Geirsson AJ, Eyjolfsdottir H, Bjornsdottir G, et al. Prevalence and clinical characteristics of ankylosing spondylitis in Iceland\u2014a nationwide study. Clin Exp Rheumatol. 2010;28:333.","journal-title":"Clin Exp Rheumatol"},{"key":"293_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/03009740903544212","volume":"39","author":"P Hanova","year":"2010","unstructured":"Hanova P, Pavelka K, Holcatova I, et al. Incidence and prevalence of psoriatic arthritis, ankylosing spondylitis, and reactive arthritis in the first descriptive population-based study in the Czech Republic. Scand J Rheumatol. 2010;39:310\u20137. https:\/\/doi.org\/10.3109\/03009740903544212.","journal-title":"Scand J Rheumatol"},{"key":"293_CR7","first-page":"496","volume":"24","author":"O Kaipiainen-Seppanen","year":"1997","unstructured":"Kaipiainen-Seppanen O, Aho K, Heliovaara M. Incidence and prevalence of ankylosing spondylitis in Finland. J Rheumatol. 1997;24:496\u20139.","journal-title":"J Rheumatol"},{"key":"293_CR8","first-page":"832","volume":"49","author":"J-y Jin","year":"2010","unstructured":"Jin J-y, Han S-l, Li K-p, et al. Epidemiological investigation of back pain and spondyloarthritis in Shougang resident communities. Zhonghua Nei Ke Za Zhi. 2010;49:832\u20135.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"293_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.semarthrit.2007.01.003","volume":"37","author":"SC Ng","year":"2007","unstructured":"Ng SC, Liao Z, Yu DTT, et al. Epidemiology of spondyloarthritis in the People\u2019s Republic of China: review of the literature and commentary. Semin Arthritis Rheum. 2007;37:39\u201347. https:\/\/doi.org\/10.1016\/j.semarthrit.2007.01.003.","journal-title":"Semin Arthritis Rheum"},{"key":"293_CR10","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1136\/ard.2003.011247","volume":"63","author":"M Rudwaleit","year":"2004","unstructured":"Rudwaleit M, van der Heijde D, Khan MA, et al. How to diagnose axial spondyloarthritis early. Ann Rheum Dis. 2004;63:535\u201343. https:\/\/doi.org\/10.1136\/ard.2003.011247.","journal-title":"Ann Rheum Dis"},{"issue":"68","key":"293_CR11","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1136\/ard.2009.108233","volume":"2009","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, van der Heijde D, Landew\u00e9 R, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;2009(68):777\u201383. https:\/\/doi.org\/10.1136\/ard.2009.108233.","journal-title":"Ann Rheum Dis"},{"key":"293_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/ard.2010.133645","volume":"70","author":"M Rudwaleit","year":"2011","unstructured":"Rudwaleit M, van der Heijde D, Landew\u00e9 R, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis. 2011;70:25\u201331. https:\/\/doi.org\/10.1136\/ard.2010.133645.","journal-title":"Ann Rheum Dis"},{"key":"293_CR13","doi-asserted-by":"publisher","first-page":"2171475","DOI":"10.1155\/2019\/2171475","volume":"2019","author":"X Ji","year":"2019","unstructured":"Ji X, Wang Y, Ma Y, et al. Improvement of disease management and cost effectiveness in Chinese patients with ankylosing spondylitis using a smart-phone management system: a prospective cohort study. Biomed Res Int. 2019;2019:2171475. https:\/\/doi.org\/10.1155\/2019\/2171475.","journal-title":"Biomed Res Int"},{"key":"293_CR14","doi-asserted-by":"publisher","unstructured":"van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984; 27:361\u20138. https:\/\/doi.org\/10.1002\/art.1780270401.","DOI":"10.1002\/art.1780270401"},{"key":"293_CR15","doi-asserted-by":"publisher","unstructured":"Lukas C, Landew\u00e9 R, Sieper J, et al. Assessment of SpondyloArthritis international S. Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Ann Rheum Dis 2009; 68:18\u201324. https:\/\/doi.org\/10.1136\/ard.2008.094870","DOI":"10.1136\/ard.2008.094870"},{"key":"293_CR16","doi-asserted-by":"publisher","unstructured":"van der Heijde D, Lie E, Kvien TK, Sieper J, et al. Assessment of SpondyloArthritis international S. ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis. Ann Rheum Dis 2009; 68:1811\u20138. https:\/\/doi.org\/10.1136\/ard.2008.100826.","DOI":"10.1136\/ard.2008.100826"},{"key":"293_CR17","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/art.38921","volume":"67","author":"P Machado","year":"2015","unstructured":"Machado P, Navarro-Comp\u00e1n V, Landew\u00e9 R, et al. Calculating the ankylosing spondylitis disease activity score if the conventional c-reactive protein level is below the limit of detection or if high-sensitivity c-reactive protein is used: an analysis in the DESIR cohort. Arthritis Rheumatol. 2015;67:408\u201313. https:\/\/doi.org\/10.1002\/art.38921.","journal-title":"Arthritis Rheumatol"},{"key":"293_CR18","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/BOR.0b013e3283470f23","volume":"23","author":"P Machado","year":"2011","unstructured":"Machado P, van der Heijde D. How to measure disease activity in axial spondyloarthritis? Curr Opin Rheumatol. 2011;23:339\u201345. https:\/\/doi.org\/10.1097\/BOR.0b013e3283470f23.","journal-title":"Curr Opin Rheumatol"},{"key":"293_CR19","first-page":"2286","volume":"21","author":"S Garrett","year":"1994","unstructured":"Garrett S, Jenkinson T, Kennedy LG, et al. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994;21:2286\u201391.","journal-title":"J Rheumatol"},{"key":"293_CR20","unstructured":"Jenkinson TR, Mallorie PA, Whitelock HC, et al. Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index. J Rheumatol. 1994; 21:1694\u20131698."},{"key":"293_CR21","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/rheumatology\/keu388","volume":"54","author":"I Essers","year":"2015","unstructured":"Essers I, Ramiro S, Stolwijk C, et al. Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS. Rheumatol (Oxf). 2015;54:633\u201340. https:\/\/doi.org\/10.1093\/rheumatology\/keu388.","journal-title":"Rheumatol (Oxf)"},{"key":"293_CR22","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/art.40551","volume":"70","author":"G Varkas","year":"2018","unstructured":"Varkas G, Vastesaeger N, Cypers H, et al. Association of inflammatory bowel disease and acute anterior uveitis, but not psoriasis, with disease duration in patients with axial spondyloarthritis: results from two Belgian nationwide axial spondyloarthritis cohorts. Arthritis Rheumatol. 2018;70:1588\u201396. https:\/\/doi.org\/10.1002\/art.40551.","journal-title":"Arthritis Rheumatol"},{"key":"293_CR23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12348-020-00202-6","volume":"10","author":"F Nicolela Susanna","year":"2020","unstructured":"Nicolela Susanna F, Pavesio C. A review of ocular adverse events of biological anti-TNF drugs. J Ophthalmic Inflamm Infect. 2020;10:11.","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"293_CR24","doi-asserted-by":"publisher","first-page":"e000250","DOI":"10.1136\/bmjophth-2018-000250","volume":"4","author":"C Iwahashi","year":"2019","unstructured":"Iwahashi C, Ono H, Haruta M, et al. New onset or exacerbation of uveitis with infliximab: paradoxical effects? BMJ Open Ophthalmol. 2019;4:e000250. https:\/\/doi.org\/10.1136\/bmjophth-2018-000250.","journal-title":"BMJ Open Ophthalmol"},{"key":"293_CR25","first-page":"1132","volume":"38","author":"EY Choi","year":"2020","unstructured":"Choi EY, Lee M, Lee CS, et al. Uveitis occurrence in AS patients according to the type of anti-TNF-a cohort study of 175 patients. Clin Exp Rheumatol. 2020;38:1132\u20137.","journal-title":"Clin Exp Rheumatol"},{"key":"293_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1440-0960.1998.tb01478.x","volume":"39","author":"A Plunkett","year":"1998","unstructured":"Plunkett A, Marks R. A review of the epidemiology of psoriasis vulgaris in the community. Australas J Dermatol. 1998;39:225\u201332. https:\/\/doi.org\/10.1111\/j.1440-0960.1998.tb01478.x.","journal-title":"Australas J Dermatol"},{"key":"293_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","volume":"142","author":"NA Molodecky","year":"2012","unstructured":"Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142:46-e30. https:\/\/doi.org\/10.1053\/j.gastro.2011.10.001.","journal-title":"Gastroenterology"},{"key":"293_CR28","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/art.24483","volume":"60","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Haibel H, Baraliakos X, et al. The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum. 2009;60:717\u201327. https:\/\/doi.org\/10.1002\/art.24483.","journal-title":"Arthritis Rheum"},{"key":"293_CR29","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.jbspin.2011.01.013","volume":"78","author":"M Dougados","year":"2011","unstructured":"Dougados M, d\u2019Agostino M-A, Benessiano J, et al. The DESIR cohort: a 10-year follow-up of early inflammatory back pain in France: study design and baseline characteristics of the 708 recruited patients. Joint Bone Spine. 2011;78:598\u2013603. https:\/\/doi.org\/10.1016\/j.jbspin.2011.01.013.","journal-title":"Joint Bone Spine"},{"key":"293_CR30","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/acr.21648","volume":"64","author":"D Wendling","year":"2012","unstructured":"Wendling D, Prati C, Demattei C, et al. Impact of uveitis on the phenotype of patients with recent inflammatory back pain: data from a prospective multicenter French cohort. Arthritis Care Res (Hoboken). 2012;64:1089\u201393. https:\/\/doi.org\/10.1002\/acr.21648.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"293_CR31","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1136\/ard.2007.075754","volume":"67","author":"N Zeboulon","year":"2008","unstructured":"Zeboulon N, Dougados M, Gossec L. Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review. Ann Rheum Dis. 2008;67:955\u20139. https:\/\/doi.org\/10.1136\/ard.2007.075754.","journal-title":"Ann Rheum Dis"},{"key":"293_CR32","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/ard.2009.108217","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Landew\u00e9 R, van der Heijde D, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis. 2009;68:770\u20136. https:\/\/doi.org\/10.1136\/ard.2009.108217.","journal-title":"Ann Rheum Dis"},{"key":"293_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/ard.2010.133645","volume":"70","author":"M Rudwaleit","year":"2011","unstructured":"Rudwaleit M, van der Heijde D, Landew\u00e9 R, Akkoc N, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis. 2011;70:25\u201331. https:\/\/doi.org\/10.1136\/ard.2010.133645.","journal-title":"Ann Rheum Dis"},{"key":"293_CR34","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/242121a0","volume":"242","author":"MF Caffrey","year":"1973","unstructured":"Caffrey MF, James DC. Human lymphocyte antigen association in ankylosing spondylitis. Nature. 1973;242:121. https:\/\/doi.org\/10.1038\/242121a0.","journal-title":"Nature"},{"key":"293_CR35","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s13075-018-1672-2","volume":"20","author":"M van Lunteren","year":"2018","unstructured":"van Lunteren M, Sepriano A, Landew\u00e9 R, et al. Do ethnicity, degree of family relationship, and the spondyloarthritis subtype in affected relatives influence the association between a positive family history for spondyloarthritis and HLA-B27 carriership? Results from the worldwide ASAS cohort. Arthritis Res Ther. 2018;20:166.","journal-title":"Arthritis Res Ther"},{"key":"293_CR36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11926-017-0654-8","volume":"19","author":"N Akko\u00e7","year":"2017","unstructured":"Akko\u00e7 N, Yarkan H, Kenar G, et al. Ankylosing spondylitis: HLA-B*27-positive versus HLA-B*27-negative disease. Curr Rheumatol Rep. 2017;19:26. https:\/\/doi.org\/10.1007\/s11926-017-0654-8.","journal-title":"Curr Rheumatol Rep"},{"key":"293_CR37","doi-asserted-by":"publisher","unstructured":"Feldtkeller E, Khan MA, van der Heijde D, et al. Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 2003; 23:61\u20136. https:\/\/doi.org\/10.1007\/s00296-002-0237-4.","DOI":"10.1007\/s00296-002-0237-4"},{"key":"293_CR38","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3760\/cma.j.issn.0578-1426.2018.03.006","volume":"57","author":"XJ Ji","year":"2018","unstructured":"Ji XJ, Sun K, Hu ZY, et al. Comparison of clinical manifestations according to HLA-B(27) genotype in ankylosing spondylitis patients: real-world evidence from smart management system for spondyloarthritis. Zhonghua Nei Ke Za Zhi. 2018;57:179\u201384. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1426.2018.03.006.","journal-title":"Zhonghua Nei Ke Za Zhi"}],"container-title":["Rheumatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-021-00293-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40744-021-00293-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-021-00293-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T02:10:52Z","timestamp":1616638252000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40744-021-00293-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["293"],"URL":"https:\/\/doi.org\/10.1007\/s40744-021-00293-0","relation":{},"ISSN":["2198-6576","2198-6584"],"issn-type":[{"value":"2198-6576","type":"print"},{"value":"2198-6584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"12 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}