{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T22:22:33Z","timestamp":1767046953760,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Ther"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s40744-021-00422-9","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T08:02:59Z","timestamp":1642579379000},"page":"753-762","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Similar Clinical Outcomes in Patients with Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still\u2019s Disease Treated with Canakinumab: Bayesian and Population Model-Based Analyses"],"prefix":"10.1007","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5917-7052","authenticated-orcid":false,"given":"Cornelia","family":"Dunger-Baldauf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila","family":"Nakasato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Noviello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Bieth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"422_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12969-015-0047-3","volume":"13","author":"N Nirmala","year":"2015","unstructured":"Nirmala N, Brachat A, Feist E, et al. Gene-expression analysis of adult-onset Still\u2019s disease and systemic juvenile idiopathic arthritis is consistent with a continuum of a single disease entity. Pediatr Rheumatol Online J. 2015;13:50.","journal-title":"Pediatr Rheumatol Online J"},{"key":"422_CR2","first-page":"668","volume":"36","author":"E Feist","year":"2018","unstructured":"Feist E, Quartier P, Fautrel B, et al. Efficacy and safety of canakinumab in patients with Still\u2019s disease: exposure-response analysis of pooled systemic juvenile idiopathic arthritis data by age groups. Clin Exp Rheumatol. 2018;36:668\u201375.","journal-title":"Clin Exp Rheumatol"},{"key":"422_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s12026-014-8561-9","volume":"61","author":"Y Jamilloux","year":"2015","unstructured":"Jamilloux Y, Gerfaud-Valentin M, Martinon F, Belot A, Henry T, Seve P. Pathogenesis of adult-onset Still\u2019s disease: new insights from the juvenile counterpart. Immunol Res. 2015;61:53\u201362.","journal-title":"Immunol Res"},{"key":"422_CR4","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1136\/annrheumdis-2020-217155","volume":"79","author":"C Kedor","year":"2020","unstructured":"Kedor C, Listing J, Zernicke J, et al. Canakinumab for Treatment of Adult-Onset Still\u2019s Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial. Ann Rheum Dis. 2020;79:1090\u20137.","journal-title":"Ann Rheum Dis"},{"key":"422_CR5","doi-asserted-by":"publisher","first-page":"vi9","DOI":"10.1093\/rheumatology\/kez350","volume":"58","author":"SJ Vastert","year":"2019","unstructured":"Vastert SJ, Jamilloux Y, Quartier P, et al. Anakinra in children and adults with Still\u2019s disease. Rheumatology (Oxford). 2019;58:vi9\u201322.","journal-title":"Rheumatology (Oxford)"},{"key":"422_CR6","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1056\/NEJMoa1205099","volume":"367","author":"N Ruperto","year":"2012","unstructured":"Ruperto N, Brunner HI, Quartier P, et al. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. N Engl J Med. 2012;367:2396\u2013406.","journal-title":"N Engl J Med"},{"key":"422_CR7","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1136\/annrheumdis-2018-213150","volume":"77","author":"N Ruperto","year":"2018","unstructured":"Ruperto N, Brunner HI, Quartier P, et al. Canakinumab in patients with systemic juvenile idiopathic arthritis and active systemic features: results from the 5-year long-term extension of the phase III pivotal trials. Ann Rheum Dis. 2018;77:1710\u20139.","journal-title":"Ann Rheum Dis"},{"key":"422_CR8","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/14397595.2020.1783163","volume":"31","author":"K Nishimura","year":"2021","unstructured":"Nishimura K, Hara R, Umebayashi H, et al. Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis: 48-week results from an open-label phase III study in Japanese patients. Mod Rheumatol. 2021;31:226\u201334.","journal-title":"Mod Rheumatol"},{"key":"422_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/art.41488","volume":"73","author":"P Quartier","year":"2021","unstructured":"Quartier P, Alexeeva E, Constantin T, et al. Tapering canakinumab monotherapy in patients with systemic juvenile idiopathic arthritis in clinical remission: results from a phase IIIb\/IV open-label, randomized study. Arthritis Rheumatol. 2021;73:336\u201346.","journal-title":"Arthritis Rheumatol"},{"key":"422_CR10","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/cpt.1723","volume":"107","author":"H Schmidli","year":"2020","unstructured":"Schmidli H, H\u00e4ring D, Thomas M, Cassidy A, Weber S, Bretz F. Beyond randomized clinical trials: use of external controls. Clin Pharmacol Ther. 2020;107:806\u201316.","journal-title":"Clin Pharmacol Ther"},{"key":"422_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/00031305.2019.1566091","volume":"73","author":"S Ruberg","year":"2019","unstructured":"Ruberg S, Harrell F, Gamalo-Siebers M, et al. Inference and decision making for 21st-century drug development and approval. Am Stat. 2019;73:319\u201327.","journal-title":"Am Stat"},{"key":"422_CR12","unstructured":"Food And Drug Administration (FDA). Population Pharmacokinetics Draft Guidance for Industry 2019. https:\/\/www.fda.gov\/media\/128793\/download. Accessed June 2021."},{"key":"422_CR13","unstructured":"European Medicines Agency (EMA). ILARIS (canakinumab): European Public Assessment Report (EPAR). https:\/\/www.ema.europa.eu\/en\/documents\/variation-report\/ilaris-h-c-1109-ii-0026-epar-assessment-report-variation_en.pdf. Accessed June 2021."},{"key":"422_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/biom.12242","volume":"70","author":"H Schmidli","year":"2014","unstructured":"Schmidli H, Gsteiger S, Roychoudhry S, O\u2019Hagan A, Spiegelhalter D, Neuenschwander B. Robust meta-analytic-predictive priors in clinical trials with historical control information. Biometrics. 2014;70:1023\u201332.","journal-title":"Biometrics"},{"key":"422_CR15","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.2165\/11599820-000000000-00000","volume":"51","author":"A Chakraborty","year":"2012","unstructured":"Chakraborty A, Tannenbaum S, Rordorf C, et al. Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1beta monoclonal antibody. Clin Pharmacokinet. 2012;51:e1-18.","journal-title":"Clin Pharmacokinet"},{"key":"422_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.2307\/2982063","volume":"143","author":"E Box","year":"1980","unstructured":"Box E. Sampling and Bayes inference in scientific modeling and robustness. J R Stat Soc Ser A. 1980;143:383\u2013430.","journal-title":"J R Stat Soc Ser A"}],"container-title":["Rheumatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-021-00422-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40744-021-00422-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-021-00422-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:09:46Z","timestamp":1648555786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40744-021-00422-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,19]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["422"],"URL":"https:\/\/doi.org\/10.1007\/s40744-021-00422-9","relation":{},"ISSN":["2198-6576","2198-6584"],"issn-type":[{"type":"print","value":"2198-6576"},{"type":"electronic","value":"2198-6584"}],"subject":[],"published":{"date-parts":[[2022,1,19]]},"assertion":[{"value":"8 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}