{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:42:57Z","timestamp":1763116977167,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"National Key Technology R&D Program, Ministry of Science and Technology","award":["National Key Technology R&D Program","Ministry of Science","Technology"],"award-info":[{"award-number":["National Key Technology R&D Program","Ministry of Science","Technology"]}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z201100005520022","23","25-27"],"award-info":[{"award-number":["Z201100005520022","23","25-27"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021-I2M-1-005"],"award-info":[{"award-number":["2021-I2M-1-005"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Ther"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s40744-023-00538-0","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T16:48:05Z","timestamp":1677170885000},"page":"649-658","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immune Thrombocytopenia Could be an Independent Clinical Phenotype of Antiphospholipid Syndrome: A Prospective Cohort Study"],"prefix":"10.1007","volume":"10","author":[{"given":"Yu","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-1806","authenticated-orcid":false,"given":"Jiuliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"issue":"2","key":"538_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, de Groot PG, Koike T, Meroni PL, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295\u2013306.","journal-title":"J Thromb Haemost"},{"issue":"2","key":"538_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1182\/blood-2009-06-225565","volume":"115","author":"D Provan","year":"2010","unstructured":"Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010;115(2):168\u201386.","journal-title":"Blood"},{"issue":"2","key":"538_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1365-2141.1985.tb02989.x","volume":"59","author":"EN Harris","year":"1985","unstructured":"Harris EN, Gharavi AE, Hegde U, Derue G, Morgan SH, Englert H, Chan JK, Asherson RA, Hughes GR. Anticardiolipin antibodies in autoimmune thrombocytopenic purpura. Br J Haematol. 1985;59(2):231\u20134.","journal-title":"Br J Haematol"},{"issue":"8","key":"538_CR4","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1111\/jth.12636","volume":"12","author":"M Ruggeri","year":"2014","unstructured":"Ruggeri M, Tosetto A, Palandri F, Polverelli N, Mazzucconi MG, Santoro C, Gaidano G, Lunghi M, Zaja F, De Stefano V, et al. Thrombotic risk in patients with primary immune thrombocytopenia is only mildly increased and explained by personal and treatment-related risk factors. J Thromb Haemost. 2014;12(8):1266\u201373.","journal-title":"J Thromb Haemost"},{"issue":"12","key":"538_CR5","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.revmed.2011.07.014","volume":"32","author":"G Moulis","year":"2011","unstructured":"Moulis G, Delavigne K, Huguet F, Fortenfant F, Beyne-Rauzy O, Adoue D. Antiphospholipid antibodies and the risk of thrombosis: a comparative survey between chronic immune thrombocytopenia and primary antiphospholipid syndrome. Rev Med Interne. 2011;32(12):724\u20139.","journal-title":"Rev Med Interne"},{"key":"538_CR6","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1016\/j.ejim.2019.08.013","volume":"69","author":"ACL Cruz","year":"2019","unstructured":"Cruz ACL, Colella MP, De Paula EV, Annichinno-Bizzachi J, Orsi FA. Clinical course of primary immune thrombocytopenia with positive antiphospholipid antibodies. Eur J Intern Med. 2019;69:e6\u20137.","journal-title":"Eur J Intern Med"},{"issue":"4","key":"538_CR7","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3904\/kjim.2011.26.4.449","volume":"26","author":"YJ Yang","year":"2011","unstructured":"Yang YJ, Yun GW, Song IC, Baek SW, Lee KS, Ryu HW, Lee MW, Lee HJ, Yun HJ, Kim S, et al. Clinical implications of elevated antiphospholipid antibodies in adult patients with primary immune thrombocytopenia. Korean J Intern Med. 2011;26(4):449\u201354.","journal-title":"Korean J Intern Med"},{"issue":"5","key":"538_CR8","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/bjh.12318","volume":"161","author":"KJ Kim","year":"2013","unstructured":"Kim KJ, Baek IW, Yoon CH, Kim WU, Cho CS. Thrombotic risk in patients with immune thrombocytopenia and its association with antiphospholipid antibodies. Br J Haematol. 2013;161(5):706\u201314.","journal-title":"Br J Haematol"},{"issue":"9","key":"538_CR9","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/nrrheum.2017.124","volume":"13","author":"S Sciascia","year":"2017","unstructured":"Sciascia S, Amigo MC, Roccatello D, Khamashta M. Diagnosing antiphospholipid syndrome: \u201cextra-criteria\u201d manifestations and technical advances. Nat Rev Rheumatol. 2017;13(9):548\u201360.","journal-title":"Nat Rev Rheumatol"},{"issue":"16","key":"538_CR10","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1182\/blood-2010-08-302984","volume":"117","author":"C Neunert","year":"2011","unstructured":"Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011;117(16):4190\u2013207.","journal-title":"Blood"},{"issue":"10","key":"538_CR11","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1177\/0961203307081847","volume":"16","author":"AW de Souza","year":"2007","unstructured":"de Souza AW, Silva NP, de Carvalho JF, D\u2019Almeida V, Noguti MA, Sato EI. Impact of hypertension and hyperhomocysteinemia on arterial thrombosis in primary antiphospholipid syndrome. Lupus. 2007;16(10):782\u20137.","journal-title":"Lupus"},{"issue":"8","key":"538_CR12","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1093\/rheumatology\/41.8.924","volume":"41","author":"D Erkan","year":"2002","unstructured":"Erkan D, Yazici Y, Peterson MG, Sammaritano L, Lockshin MD. A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology (Oxford). 2002;41(8):924\u20139.","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"538_CR13","first-page":"788","volume":"44","author":"R Li","year":"2012","unstructured":"Li R, Zhou YS, Jia Y, Li ZG. Analysis of risk factors in development of thrombosis in patients with antiphospholipid syndrome. Beijing Da Xue Xue Bao Yi Xue Ban. 2012;44(5):788\u201391.","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"8","key":"538_CR14","first-page":"1560","volume":"31","author":"JA Gir\u00f3n-Gonz\u00e1lez","year":"2004","unstructured":"Gir\u00f3n-Gonz\u00e1lez JA, Garc\u00eda del R\u00edo E, Rodr\u00edguez C, Rodr\u00edguez-Martorell J, Serrano A. Antiphospholipid syndrome and asymptomatic carriers of antiphospholipid antibody: prospective analysis of 404 individuals. J Rheumatol. 2004;31(8):1560\u20137.","journal-title":"J Rheumatol"},{"issue":"5","key":"538_CR15","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1160\/TH09-06-0393","volume":"103","author":"MN Di Minno","year":"2010","unstructured":"Di Minno MN, Tremoli E, Coppola A, Lupoli R, Di Minno G. Homocysteine and arterial thrombosis: Challenge and opportunity. Thromb Haemost. 2010;103(5):942\u201361.","journal-title":"Thromb Haemost"},{"issue":"6","key":"538_CR16","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1160\/TH04-03-0138","volume":"92","author":"J Kassis","year":"2004","unstructured":"Kassis J, Neville C, Rauch J, Busque L, Chang ER, Joseph L, Le Comte M, Subang R, Fortin PR. Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis. Thromb Haemost. 2004;92(6):1312\u20139.","journal-title":"Thromb Haemost"},{"issue":"5","key":"538_CR17","doi-asserted-by":"publisher","first-page":"E40","DOI":"10.1016\/S0272-6386(05)90004-8","volume":"37","author":"MB Lande","year":"2001","unstructured":"Lande MB, Thomas GA, Houghton DC. Membranous nephropathy associated with chronic immune thrombocytopenic purpura in childhood. Am J Kidney Dis. 2001;37(5):E40.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"538_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s13730-021-00630-w","volume":"11","author":"K Nishizawa","year":"2022","unstructured":"Nishizawa K, Yamashita T, Ogawa Y, Kobayashi H. Membranous nephropathy complicated by immune thrombocytopenia treated with low-density lipoprotein apheresis: a case report and literature review. CEN Case Rep. 2022;11(1):43\u20139.","journal-title":"CEN Case Rep"},{"issue":"6","key":"538_CR19","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1182\/blood.V98.6.1760","volume":"98","author":"R Diz-K\u00fc\u00e7\u00fckkaya","year":"2001","unstructured":"Diz-K\u00fc\u00e7\u00fckkaya R, Hacihanefio\u011flu A, Yenerel M, Turgut M, Keskin H, Nal\u00e7aci M, Inan\u00e7 M. Antiphospholipid antibodies and antiphospholipid syndrome in patients presenting with immune thrombocytopenic purpura: a prospective cohort study. Blood. 2001;98(6):1760\u20134.","journal-title":"Blood"},{"issue":"1","key":"538_CR20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1080\/10245332.2018.1532649","volume":"24","author":"L Frison","year":"2019","unstructured":"Frison L, Lombardi A, Caputo I, Semenzato G, Fabris F, Vianello F. Relevance of antiphospholipid antibody profile in the clinical outcome of ITP: a single-centre study. Hematology. 2019;24(1):134\u20138.","journal-title":"Hematology"},{"issue":"3","key":"538_CR21","first-page":"382","volume":"31","author":"G Hern\u00e1ndez-Molina","year":"2013","unstructured":"Hern\u00e1ndez-Molina G, Espericueta-Arriola G, Cabral AR. The role of lupus anticoagulant and triple marker positivity as risk factors for rethrombosis in patients with primary antiphospholipid syndrome. Clin Exp Rheumatol. 2013;31(3):382\u20138.","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"538_CR22","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1365-2141.2008.07228.x","volume":"142","author":"C Pierrot-DeseillignyDespujol","year":"2008","unstructured":"Pierrot-DeseillignyDespujol C, Michel M, Khellaf M, Gouault M, Intrator L, Bierling P, Godeau B. Antiphospholipid antibodies in adults with immune thrombocytopenic purpura. Br J Haematol. 2008;142(4):638\u201343.","journal-title":"Br J Haematol"},{"issue":"5","key":"538_CR23","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1177\/0961203315617538","volume":"25","author":"M Bazzan","year":"2016","unstructured":"Bazzan M, Vaccarino A, Stella S, Sciascia S, Montaruli B, Bertero MT, Carignola R, Roccatello D. Patients with antiphospholipid syndrome and thrombotic recurrences: a real-world observation (the Piedmont cohort study). Lupus. 2016;25(5):479\u201385.","journal-title":"Lupus"},{"issue":"9","key":"538_CR24","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1136\/ard.2008.093179","volume":"68","author":"R Cervera","year":"2009","unstructured":"Cervera R, Khamashta MA, Shoenfeld Y, Camps MT, Jacobsen S, Kiss E, Zeher MM, Tincani A, Kontopoulou-Griva I, Galeazzi M, et al. Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients. Ann Rheum Dis. 2009;68(9):1428\u201332.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"538_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/ard.2005.045443","volume":"65","author":"Y Shoenfeld","year":"2006","unstructured":"Shoenfeld Y, Blank M, Cervera R, Font J, Raschi E, Meroni PL. Infectious origin of the antiphospholipid syndrome. Ann Rheum Dis. 2006;65(1):2\u20136.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"538_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jaut.2008.11.002","volume":"32","author":"V De Angelis","year":"2009","unstructured":"De Angelis V, Scurati S, Raschi E, Liutkus A, Belot A, Borghi MO, Meroni PL, Cimaz R. Pro-inflammatory genotype as a risk factor for aPL-associated thrombosis: report of a family with multiple anti-phospholipid positive members. J Autoimmun. 2009;32(1):60\u20133.","journal-title":"J Autoimmun"},{"issue":"4","key":"538_CR27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1182\/blood.2019003863","volume":"135","author":"S Chaturvedi","year":"2020","unstructured":"Chaturvedi S, Braunstein EM, Yuan X, Yu J, Alexander A, Chen H, Gavriilaki E, Alluri R, Streiff MB, Petri M, et al. Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS. Blood. 2020;135(4):239\u201351.","journal-title":"Blood"},{"issue":"2","key":"538_CR28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/107602960401000201","volume":"10","author":"MA Ozt\u00fcrk","year":"2004","unstructured":"Ozt\u00fcrk MA, Haznedaro\u011flu IC, Turgut M, G\u00f6ker H. Current debates in antiphospholipid syndrome: the acquired antibody-mediated thrombophilia. Clin Appl Thromb Hemost. 2004;10(2):89\u2013126.","journal-title":"Clin Appl Thromb Hemost"},{"key":"538_CR29","unstructured":"Barbhaiya MZS, Ahmadzadeh Y, Costenbader K, Naden R, Erkan D. Development of new international classification criteria for antiphospholipid syndrome: phase III case collection results [abstract]. Arthritis Rheumatol. 2020;72 (suppl 10). https:\/\/acrabstracts.org\/abstract\/development-of-new-international-classification-criteria-for-antiphospholipidsyndrome-phase-iii-case-collection-results\/"}],"container-title":["Rheumatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-023-00538-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40744-023-00538-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-023-00538-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T18:08:27Z","timestamp":1682618907000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40744-023-00538-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["538"],"URL":"https:\/\/doi.org\/10.1007\/s40744-023-00538-0","relation":{},"ISSN":["2198-6576","2198-6584"],"issn-type":[{"type":"print","value":"2198-6576"},{"type":"electronic","value":"2198-6584"}],"subject":[],"published":{"date-parts":[[2023,2,20]]},"assertion":[{"value":"23 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}