{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:48:14Z","timestamp":1791244094498,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81560274"],"award-info":[{"award-number":["81560274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Science and Technology Plan of Guilin","award":["20190218-5-3"],"award-info":[{"award-number":["20190218-5-3"]}]},{"name":"Guangxi medical and health appropriate technology development and application project","award":["S2022128"],"award-info":[{"award-number":["S2022128"]}]},{"name":"Innovation Project of Guangxi Graduate Education","award":["JGY2021153"],"award-info":[{"award-number":["JGY2021153"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Ther"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s40744-024-00640-x","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T09:02:41Z","timestamp":1707123761000},"page":"349-362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Emerging Role of Interleukin-38 (IL-38) in the Development of Rheumatoid Arthritis"],"prefix":"10.1007","volume":"11","author":[{"given":"Shengxiang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-1278","authenticated-orcid":false,"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"issue":"9","key":"640_CR1","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69(9):1580\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"10055","key":"640_CR2","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023\u201338.","journal-title":"Lancet"},{"issue":"03","key":"640_CR3","first-page":"300","volume":"13","author":"S-F Zeng","year":"2013","unstructured":"Zeng S-F, Zhu S-L, Tan A-C, et al. Systematic evaluation of rheumatoid arthritis disease burden and quality of survival studies in China. Chin J Evid Based Med. 2013;13(03):300\u20137.","journal-title":"Chin J Evid Based Med"},{"key":"640_CR4","first-page":"1873","volume":"27","author":"Li Zanguo","year":"2009","unstructured":"Zanguo Li. The low awareness and high disability rate of rheumatoid arthritis in China should not be ignored. Chin Med J. 2009;27:1873\u20135.","journal-title":"Chin Med J"},{"issue":"6","key":"640_CR5","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","volume":"13","author":"M Noack","year":"2014","unstructured":"Noack M, Miossec P. Th17 and regulatory T\u00a0cell balance in autoimmune and inflammatory diseases. Autoimmun Rev. 2014;13(6):668\u201377.","journal-title":"Autoimmun Rev"},{"issue":"4","key":"640_CR6","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/cells9040880","volume":"9","author":"YJ Lin","year":"2020","unstructured":"Lin YJ, Anzaghe M, Sch\u00fclke S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells. 2020;9(4):880.","journal-title":"Cells"},{"issue":"2","key":"640_CR7","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3390\/ijms23020905","volume":"23","author":"S Jang","year":"2022","unstructured":"Jang S, Kwon EJ, Lee JJ. Rheumatoid arthritis: pathogenic roles of diverse immune cells. Int J Mol Sci. 2022;23(2):905.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"640_CR8","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1002\/art.23951","volume":"58","author":"G Schett","year":"2008","unstructured":"Schett G, Stach C, Zwerina J, Voll R, Manger B. How antirheumatic drugs protect joints from damage in rheumatoid arthritis. Arthritis Rheum. 2008;58(10):2936\u201348.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"640_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11914-013-0183-y","volume":"12","author":"R Baum","year":"2014","unstructured":"Baum R, Gravallese EM. Impact of inflammation on the osteoblast in rheumatic diseases. Curr Osteoporos Rep. 2014;12(1):9\u201316.","journal-title":"Curr Osteoporos Rep"},{"issue":"11","key":"640_CR10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1089\/107999001753289505","volume":"21","author":"JT Bensen","year":"2001","unstructured":"Bensen JT, Dawson PA, Mychaleckyj JC, et al. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J Interferon Cytokine Res. 2001;21(11):899\u2013904.","journal-title":"J Interferon Cytokine Res"},{"issue":"8","key":"640_CR11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3390\/biom9080345","volume":"9","author":"L Xie","year":"2019","unstructured":"Xie L, Huang Z, Li H, Liu X, Zheng S, Su W. IL-38: a new player in inflammatory autoimmune disorders. Biomolecules. 2019;9(8):345.","journal-title":"Biomolecules"},{"key":"640_CR12","unstructured":"Wang M, Wang B, Ma Z, et al. Detection of the novel IL-1 family cytokines by QAH-IL1F-1 assay in rheumatoid arthritis. Cell Mol Biol (Noisy-le-grand). 2016;62(4):31\u201334."},{"key":"640_CR13","doi-asserted-by":"crossref","unstructured":"Pei B, Chen K, Zhou S, et al. IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1\/HIF-1\u03b1 signaling pathway. Biosci Rep. 2020;40(5):BSR20182431.","DOI":"10.1042\/BSR20182431"},{"key":"640_CR14","doi-asserted-by":"crossref","unstructured":"Boutet MA, Bart G, Penhoat M, et al. Distinct expression of interleukin (IL)-36\u03b1, \u03b2 and \u03b3, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease. Clin Exp Immunol. 2016;184:159\u2013173.","DOI":"10.1111\/cei.12761"},{"key":"640_CR15","doi-asserted-by":"crossref","unstructured":"Boutet MA, Najm A, Bart G, et al. IL-38 overexpression induces antiinflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis. 2017;76:1304\u20131312.","DOI":"10.1136\/annrheumdis-2016-210630"},{"key":"640_CR16","first-page":"386","volume":"4","author":"SI Takenaka","year":"2015","unstructured":"Takenaka SI, Kaieda S, Kawayama T, et al. IL-38: a new factor in rheumatoid arthritis. Biochem Biophys Rep. 2015;4:386\u201391.","journal-title":"Biochem Biophys Rep"},{"key":"640_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2018.09.028","volume":"65","author":"WD Xu","year":"2018","unstructured":"Xu WD, Su LC, He CS, et al. Plasma interleukin-38 in patients with rheumatoid arthritis. Int Immunopharmacol. 2018;65:1\u20137.","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"640_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31(3):315\u201324.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"640_CR19","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/acr.21641","volume":"64","author":"JA Singh","year":"2012","unstructured":"Singh JA, Furst DE, Bharat A, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012;64(5):625\u201339.","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"12","key":"640_CR20","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1136\/annrheumdis-2017-211585","volume":"76","author":"I M\u00f6ller","year":"2017","unstructured":"M\u00f6ller I, Janta I, Backhaus M, et al. The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology. Ann Rheum Dis. 2017;76(12):1974\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"640_CR21","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/art.10877","volume":"48","author":"M Szkudlarek","year":"2003","unstructured":"Szkudlarek M, Court-Payen M, Jacobsen S, et al. Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum. 2003;48(4):955\u201362.","journal-title":"Arthritis Rheum"},{"key":"640_CR22","doi-asserted-by":"publisher","first-page":"1051787","DOI":"10.3389\/fimmu.2022.1051787","volume":"13","author":"W Qiang","year":"2022","unstructured":"Qiang W, Linna Ma, Caiping An, et al. The role of IL-38 in intestinal diseases - its potential as a therapeutic target. Front Immunol. 2022;13:1051787.","journal-title":"Front Immunol"},{"key":"640_CR23","first-page":"386","volume":"4","author":"SI Takenaka","year":"2015","unstructured":"Takenaka SI, Kaieda S, Kawayama T, et al. IL-38: a new factor in rheumatoid arthritis. Biochem Biophys Rep. 2015;4:386\u201391.","journal-title":"Biochem Biophys Rep"}],"container-title":["Rheumatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-024-00640-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40744-024-00640-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40744-024-00640-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T13:34:35Z","timestamp":1709818475000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40744-024-00640-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["640"],"URL":"https:\/\/doi.org\/10.1007\/s40744-024-00640-x","relation":{},"ISSN":["2198-6576","2198-6584"],"issn-type":[{"value":"2198-6576","type":"print"},{"value":"2198-6584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]},"assertion":[{"value":"31 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Shengxiang Liang, Liting Chen, Ruilan Liang, Jiayi Ling, Minghui Hou, Song Gao, Minglin Ou and Min Yang have nothing to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study was approved by the ethics committee of the Affiliated Hospital of Guilin Medical University (approval number YJSLL202151) and performed in accordance with the Helsinki Declaration of 1964 and its later amendments. Each participant signed an informed consent form. No identifying information of participants was included in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}