{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:34:53Z","timestamp":1790750093513,"version":"4.1.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Stem Cell Rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose of Review<\/jats:title>\n                <jats:p>How stem cells balance proliferation with differentiation, giving rise to specific daughter cells during development to build an embryo or tissue, remains an open question. Here, we discuss recent evidence that cytokinetic abscission regulation in stem cells, particularly neural stem cells (NSCs), is part of the answer. Abscission is a multi-step process mediated by the midbody, a microtubule-based structure formed in the intercellular bridge between daughter cells after mitosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Recent Findings<\/jats:title>\n                <jats:p>Human mutations and mouse knockouts in abscission genes reveal that subtle disruptions of NSC abscission can cause brain malformations. Experiments in several epithelial systems have shown that midbodies serve as scaffolds for apical junction proteins and are positioned near apical membrane fate determinants. Abscission timing is tightly controlled and developmentally regulated in stem cells, with delayed abscission in early embryos and faster abscission later. Midbody remnants (MBRs) contain over 400 proteins and may influence polarity, fate, and ciliogenesis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Summary<\/jats:title>\n                <jats:p>As NSCs and other stem cells build tissues, they tightly regulate three aspects of abscission: midbody positioning, duration, and MBR handling. Midbody positioning and remnants establish or maintain cell polarity. MBRs are deposited on the apical membranes of epithelia, can be released or internalized by surrounding cells, and may sequester fate determinants or transfer information between cells. Work in cell lines and simpler systems has shown multiple roles for abscission regulation influencing stem cell polarity, potency, and daughter fates during development. Elucidating how the abscission process influences cell fate and tissue growth is important for our continued understanding of brain development and stem cell biology.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40778-021-00193-7","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T12:02:55Z","timestamp":1628683375000},"page":"161-173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cytokinetic Abscission Regulation in Neural Stem Cells and Tissue Development"],"prefix":"10.1007","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-8161","authenticated-orcid":false,"given":"Katrina C.","family":"McNeely","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-7203","authenticated-orcid":false,"given":"Noelle D.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"193_CR1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.conb.2020.10.017","volume":"66","author":"Y Lin","year":"2021","unstructured":"Lin Y, Yang J, Shen Z, Ma J, Simons BD, Shi SH. Behavior and lineage progression of neural progenitors in the mammalian cortex. Curr Opin Neurobiol. 2021;66:144\u201357. https:\/\/doi.org\/10.1016\/j.conb.2020.10.017.","journal-title":"Curr Opin Neurobiol"},{"issue":"21","key":"193_CR2","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.4161\/15384101.2014.956486","volume":"13","author":"O Gershony","year":"2014","unstructured":"Gershony O, Pe'er T, Noach-Hirsh M, Elia N, Tzur A. Cytokinetic abscission is an acute G1 event. Cell Cycle. 2014;13(21):3436\u201341. https:\/\/doi.org\/10.4161\/15384101.2014.956486.","journal-title":"Cell Cycle"},{"issue":"1","key":"193_CR3","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1038\/s41467-020-15205-z","volume":"11","author":"C Addi","year":"2020","unstructured":"\u2022\u2022 Addi C, Presle A, Fremont S, Cuvelier F, Rocancourt M, Milin F, et al. The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX\/syntenin\/syndecan-4 required for completion of cytokinesis. Nat Commun. 2020;11(1):1941. https:\/\/doi.org\/10.1038\/s41467-020-15205-zDeveloped an efficient method to purify intact post-abscission midbody remnants (Flemming bodies) from HeLa cells to obtain a proteome and identify 489 enriched proteins.","journal-title":"Nat Commun"},{"issue":"5680","key":"193_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1126\/science.1097931","volume":"305","author":"AR Skop","year":"2004","unstructured":"Skop AR, Liu H, Yates J 3rd, Meyer BJ, Heald R. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science. 2004;305(5680):61\u20136. https:\/\/doi.org\/10.1126\/science.1097931.","journal-title":"Science."},{"key":"193_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev-cellbio-101011-155718","volume":"28","author":"RA Green","year":"2012","unstructured":"Green RA, Paluch E, Oegema K. Cytokinesis in animal cells. 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