{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:13:58Z","timestamp":1787865238192,"version":"build-2784847793"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs - Real World Outcomes"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s40801-021-00281-4","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T08:17:48Z","timestamp":1633594668000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adverse Drug Reactions in Japanese Patients with End-Stage Heart Failure Receiving Continuous Morphine Infusion: A Single-Center Retrospective Cohort Study"],"prefix":"10.1007","volume":"9","author":[{"given":"Masayuki","family":"Gotou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-7196","authenticated-orcid":false,"given":"Tsuyoshi","family":"Shiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayui","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"281_CR1","doi-asserted-by":"publisher","unstructured":"Fang JC, Ewald GA, Allen LA, Butler J, Westlake Canary CA, Colvin-Adams M, Dickinson MG, Levy P, Stough WG, Sweitzer NK, Teerlink JR, Whellan DJ, Albert NM, Krishnamani R, Rich MW, Walsh MN, Bonnell MR, Carson PE, Chan MC, Dries DL, Hernandez AF, Hershberger RE, Katz SD, Moore S, Rodgers JE, Rogers JG, Vest AR, Givertz MM, Heart Failure Society of America Guidelines Committee. Advanced (stage D) heart failure: a statement from the Heart Failure Society of America Guidelines Committee. J Card Fail. 2015; 21:519\u201334. https:\/\/doi.org\/10.1016\/j.cardfail.2015.04.013.","DOI":"10.1016\/j.cardfail.2015.04.013"},{"key":"281_CR2","doi-asserted-by":"publisher","unstructured":"Tsutsui H, Isobe M, Ito H, Ito H, Okumura K, Ono M, Kitakaze M, Kinugawa K, Kihara Y, Goto Y, Komuro I, Saiki Y, Saito Y, Sakata Y, Sato N, Sawa Y, Shiose A, Shimizu W, Shimokawa H, Seino Y, Node K, Higo T, Hirayama A, Makaya M, Masuyama T, Murohara T, Momomura SI, Yano M, Yamazaki K, Yamamoto K, Yoshikawa T, Yoshimura M, Akiyama M, Anzai T, Ishihara S, Inomata T, Imamura T, Iwasaki YK, Ohtani T, Onishi K, Kasai T, Kato M, Kawai M, Kinugasa Y, Kinugawa S, Kuratani T, Kobayashi S, Sakata Y, Tanaka A, Toda K, Noda T, Nochioka K, Hatano M, Hidaka T, Fujino T, Makita S, Yamaguchi O, Ikeda U, Kimura T, Kohsaka S, Kosuge M, Yamagishi M, Yamashina A, Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. JCS 2017\/JHFS 2017 Guideline on diagnosis and treatment of acute and chronic heart failure-digest version. Circ J. 2019; 83:2084\u2013184. https:\/\/doi.org\/10.1253\/circj.CJ-19-0342.","DOI":"10.1253\/circj.CJ-19-0342"},{"key":"281_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1191\/026921601678320269","volume":"15","author":"H Anderson","year":"2001","unstructured":"Anderson H, Ward C, Eardley A, Gomm SA, Connolly M, Coppinger T, Corgie D, Williams JL, Makin WP. The concerns of patients under palliative care and a heart failure clinic are not being met. Palliat Med. 2001;15:279\u201386. https:\/\/doi.org\/10.1191\/026921601678320269.","journal-title":"Palliat Med"},{"key":"281_CR4","doi-asserted-by":"publisher","first-page":"e391","DOI":"10.1161\/CIRCULATIONAHA.109.192065","volume":"119","author":"SA Hunt","year":"2009","unstructured":"Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW. 2009 focused update incorporated into the ACC\/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:e391-479. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192065.","journal-title":"Circulation"},{"key":"281_CR5","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/s1388-9842(02)00158-7","volume":"4","author":"MJ Johnson","year":"2002","unstructured":"Johnson MJ, McDonagh TA, Harkness A, McKay SE, Dargie HJ. Morphine for the relief of breathlessness in patients with chronic heart failure\u2013a pilot study. Eur J Heart Fail. 2002;4:753\u20136. https:\/\/doi.org\/10.1016\/s1388-9842(02)00158-7.","journal-title":"Eur J Heart Fail"},{"key":"281_CR6","doi-asserted-by":"publisher","unstructured":"Anzai T, Sato T, Fukumoto Y, Izumi C, Kizawa Y, Koga M, Nishimura K, Ohishi M, Sakashita A, Sakata Y, Shiga T, Takeishi Y, Yasuda S, Yamamoto K, Abe T, Akaho R, Hamatani Y, Hosoda H, Ishimori N, Kato M, Kinugasa Y, Kubozono T, Nagai T, Oishi S, Okada K, Shibata T, Suzuki A, Suzuki T, Takagi M, Takada Y, Tsuruga K, Yoshihisa A, Yumino D, Fukuda K, Kihara Y, Saito Y, Sawa Y, Tsutsui H, Kimura T, Japanese Circulation Society Joint Working Group. JCS\/JHFS 2021 Statement on Palliative Care in Cardiovascular Diseases. Circ J. 2021; 85:695\u2013757. https:\/\/doi.org\/10.1253\/circj.CJ-20-1127.","DOI":"10.1253\/circj.CJ-20-1127"},{"key":"281_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/1049909106289068","volume":"23","author":"P Glare","year":"2006","unstructured":"Glare P, Walsh D, Sheehan D. The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain. Am J Hosp Palliat Care. 2006;23:229\u201335. https:\/\/doi.org\/10.1177\/1049909106289068.","journal-title":"Am J Hosp Palliat Care"},{"key":"281_CR8","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jpainsymman.2004.02.021","volume":"28","author":"M Dean","year":"2004","unstructured":"Dean M. Opioids in renal failure and dialysis patients. J Pain Symptom Manage. 2004;28:497\u2013504. https:\/\/doi.org\/10.1016\/j.jpainsymman.2004.02.021.","journal-title":"J Pain Symptom Manage"},{"key":"281_CR9","doi-asserted-by":"publisher","unstructured":"Shiga T, Suzuki A, Haruta S, Mori F, Ota Y, Yagi M, Oka T, Tanaka H, Murasaki S, Yamauchi T, Katoh J, Hattori H, Kikuchi N, Watanabe E, Yamada Y, Haruki S, Kogure T, Suzuki T, Uetsuka Y, Hagiwara N; HIJ-HF II Investigators. Clinical characteristics of hospitalized heart failure patients with preserved, mid-range, and reduced ejection fractions in Japan. ESC Heart Fail. 2019; 6:475\u201386. https:\/\/doi.org\/10.1002\/ehf2.12418.","DOI":"10.1002\/ehf2.12418"},{"key":"281_CR10","doi-asserted-by":"publisher","unstructured":"Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009; 53:982\u201392. https:\/\/doi.org\/10.1053\/j.ajkd.2008.12.034.","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"281_CR11","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) v5.0-JCOG. [CTCAE v5.0\/MedDRA v20.1 (Japanese notation: MedDRA\/J v24.0) compatible \u2013 March 5, 2021]. 2021. https:\/\/www.jcog.jp\/doctor\/tool\/CTCAEv5J_20210305_v24.0.pdf. Accessed 17 Apr 2021."},{"key":"281_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0002-9343(84)90691-0","volume":"77","author":"ML Citron","year":"1984","unstructured":"Citron ML, Johnston-Early A, Fossieck BE Jr, Krasnow SH, Franklin R, Spagnolo SV, Cohen MH. Safety and efficacy of continuous intravenous morphine for severe cancer pain. Am J Med. 1984;77:199\u2013204. https:\/\/doi.org\/10.1016\/0002-9343(84)90691-0.","journal-title":"Am J Med"},{"key":"281_CR13","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1177\/106002808602001211","volume":"20","author":"GJ Stuart","year":"1986","unstructured":"Stuart GJ, Davey EB, Wight SE. Continuous intravenous morphine infusions for terminal pain control: a retrospective review. Drug Intell Clin Pharm. 1986;20:968\u201372. https:\/\/doi.org\/10.1177\/106002808602001211.","journal-title":"Drug Intell Clin Pharm"},{"key":"281_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1191\/0269216303pm695oa","volume":"17","author":"JT Harris","year":"2003","unstructured":"Harris JT, Suresh Kumar K, Rajagopal MR. Intravenous morphine for rapid control of severe cancer pain. Palliat Med. 2003;17:248\u201356. https:\/\/doi.org\/10.1191\/0269216303pm695oa.","journal-title":"Palliat Med"},{"key":"281_CR15","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1345\/aph.1E642","volume":"39","author":"RS Evans","year":"2005","unstructured":"Evans RS, Lloyd JF, Stoddard GJ, Nebeker JR, Samore MH. Risk factors for adverse drug events: a 10-year analysis. Ann Pharmacother. 2005;39:1161\u20138. https:\/\/doi.org\/10.1345\/aph.1E642.","journal-title":"Ann Pharmacother"},{"key":"281_CR16","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/bcp.12596","volume":"80","author":"EA Davies","year":"2015","unstructured":"Davies EA, O\u2019Mahony MS. Adverse drug reactions in special populations\u2014the elderly. Br J Clin Pharmacol. 2015;80:796\u2013807. https:\/\/doi.org\/10.1111\/bcp.12596.","journal-title":"Br J Clin Pharmacol"},{"key":"281_CR17","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1002\/ehf2.12498","volume":"6","author":"MJ Johnson","year":"2019","unstructured":"Johnson MJ, Cockayne S, Currow DC, Bell K, Hicks K, Fairhurst C, Gabe R, Torgerson D, Jefferson L, Oxberry S, Ghosh J, Hogg KJ, Murphy J, Allgar V, Cleland JGF, Clark AL. Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial. ESC Heart Fail. 2019;6:1149\u201360. https:\/\/doi.org\/10.1002\/ehf2.12498.","journal-title":"ESC Heart Fail."},{"key":"281_CR18","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1177\/1049909119832816","volume":"36","author":"M Murakami","year":"2019","unstructured":"Murakami M. Opioids for relief of dyspnea immediately before death in patients with noncancer disease: a case series study. Am J Hosp Palliat Care. 2019;36:734\u20139. https:\/\/doi.org\/10.1177\/1049909119832816.","journal-title":"Am J Hosp Palliat Care"},{"key":"281_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.jjcc.2019.12.015","volume":"75","author":"J Kawaguchi","year":"2020","unstructured":"Kawaguchi J, Hamatani Y, Hirayama A, Nishimura K, Nakai E, Nakamura E, Miyata M, Kawano Y, Takada Y, Anchi Y, Funabashi S, Kuroda K, Azechi M, Takahama H, Anzai T, Yasuda S, Kitaoka H, Izumi C. Experience of morphine therapy for refractory dyspnea as palliative care in advanced heart failure patients. J Cardiol. 2020;75:682\u20138. https:\/\/doi.org\/10.1016\/j.jjcc.2019.12.015.","journal-title":"J Cardiol"},{"key":"281_CR20","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.jpain.2015.05.006","volume":"16","author":"AW Oosten","year":"2015","unstructured":"Oosten AW, Oldenmenger WH, Mathijssen RH, van der Rijt CC. A systematic review of prospective studies reporting adverse events of commonly used opioids for cancer-related pain: a call for the use of standardized outcome measures. J Pain. 2015;16:935\u201346. https:\/\/doi.org\/10.1016\/j.jpain.2015.05.006.","journal-title":"J Pain"},{"key":"281_CR21","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.2215\/CJN.01030120","volume":"15","author":"SM Laville","year":"2020","unstructured":"Laville SM, Gras-Champel V, Moragny J, Metzger M, Jacquelinet C, Combe C, Fouque D, Laville M, Frimat L, Robinson BM, Stengel B, Massy ZA, Liabeuf S. Chronic kidney disease-renal epidemiology and information network (CKD-REIN) Study Group. Adverse Drug Reactions in Patients with CKD. Clin J Am Soc Nephrol. 2020;15:1090\u2013102. https:\/\/doi.org\/10.2215\/CJN.01030120.","journal-title":"Clin J Am Soc Nephrol"},{"key":"281_CR22","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1089\/jpm.2019.0127","volume":"22","author":"T Ohmori","year":"2019","unstructured":"Ohmori T, Mizuno A, Kawai F, Oya K, Okamura T, Oishi S, Shibata T, Sakashita A, Kishi T, Kashiwagi H. Morphine use for heart failure patients with renal insufficiency. J Palliat Med. 2019;22:617\u20138. https:\/\/doi.org\/10.1089\/jpm.2019.0127.","journal-title":"J Palliat Med"},{"key":"281_CR23","doi-asserted-by":"publisher","first-page":"135504","DOI":"10.1016\/j.neulet.2020.135504","volume":"741","author":"AS Taskiran","year":"2021","unstructured":"Taskiran AS, Avci O. Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect. Neurosci Lett. 2021;741:135504. https:\/\/doi.org\/10.1016\/j.neulet.2020.135504.","journal-title":"Neurosci Lett"},{"key":"281_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1873","author":"A Ofoegbu","year":"2021","unstructured":"Ofoegbu A, Ettienne BE. Pharmacogenomics and morphine. J Clin Pharmacol. 2021. https:\/\/doi.org\/10.1002\/jcph.1873.","journal-title":"J Clin Pharmacol"},{"key":"281_CR25","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1097\/00000542-200210000-00011","volume":"97","author":"J L\u00f6tsch","year":"2002","unstructured":"L\u00f6tsch J, Zimmermann M, Darimont J, Marx C, Dudziak R, Skarke C, Geisslinger G. Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity? Anesthesiology. 2002;97:814\u20139. https:\/\/doi.org\/10.1097\/00000542-200210000-00011.","journal-title":"Anesthesiology"}],"container-title":["Drugs - Real World Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40801-021-00281-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40801-021-00281-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40801-021-00281-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T17:46:12Z","timestamp":1644860772000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40801-021-00281-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["281"],"URL":"https:\/\/doi.org\/10.1007\/s40801-021-00281-4","relation":{},"ISSN":["2199-1154","2198-9788"],"issn-type":[{"value":"2199-1154","type":"print"},{"value":"2198-9788","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]},"assertion":[{"value":"9 September 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research received no grants from any funding agency in the public, commercial, or not-for-profit sectors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Masayuki Gotou, Atsushi Suzuki, Tsuyoshi Shiga, Rumi Wakabayashi, Mayui Nakazawa, Noriko Kikuchi, and Nobuhisa Hagiwara have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The protocol was approved by the Institutional Review Board of Tokyo Women\u2019s Medical University (5402) because of the retrospective nature of the study, and all the procedures being performed were part of routine care.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The requirement for written informed consent was waived because of the retrospective design.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The data that support the findings of this study are available from the corresponding author upon reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Materials"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"AS and TS conceived of and designed the study. MG collected and organized the patient data from the patient files. MG and AS analyzed the data. RW, MN, and NK contributed to the interpretation of the data. TS was a major contributor in writing the manuscript. NH supervised the work. All authors read and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}