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JMDC Inc. did not intervene in data implementation according to the analyzed results of this study. KM received honorarium fees for presentations from JMDC Inc. and Abbvie. TS received an honorarium for presentations at Daiichi Sankyo, NIPRO, Nichi-Iko, Pfizer, Sandoz, Mylan, and Meiji Seika Pharma. BL has been employed by Baxter Healthcare Corporation. However, this funder was not involved in any aspect of this article. The Department of Hospital Pharmaceutics, School of Pharmacy, Showa University received a budget from Ono with a contract research project according to the collaborative research agreement. HK owns shares of Meiji Holdings, Alfresa, Shionogi, Chugai, Eisai, Ono, Rohto, Towa, Daiichi Sankyo, Sawai, FUJIFILM, and Nipro. As a potential conflict of interest, in addition, Hospital Pharmaceutics received a research grant from Daiichi Sankyo, Mochida, Shionogi, Ono, Taiho, and Nippon-kayaku. AM has second-degree relatives who are employed and own shares in Terumo Corp. The other authors declare no conflict of interest associated with this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"The commercially available JMDC database used in this study contains anonymized processed information based on Japan\u2019s Personal Information Protection Law, and individual informed consent is not required for provision and use. According to the ethical guidelines for clinical research in Japan, research using anonymized processed information is not required to be reviewed by an ethical review committee. 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All authors read and approved the final version.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}