{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:14:55Z","timestamp":1791648895835,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"MHLW Research on Regulatory Science of Pharmaceuticals and Medical Devices Program","award":["23KC1004"],"award-info":[{"award-number":["23KC1004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs - Real World Outcomes"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s40801-025-00517-7","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:44:18Z","timestamp":1758300258000},"page":"607-614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of Dysphagia-Inducing Drugs and Risk of Aspiration Pneumonia: A Cross-Sectional Analysis Using a Japanese Claims Database"],"prefix":"10.1007","volume":"12","author":[{"given":"Naoko","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Maida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-5346","authenticated-orcid":false,"given":"Katsunori","family":"Yamaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"517_CR1","volume-title":"International classification of functioning, disability, and health","author":"World Health Organization","year":"2001","unstructured":"World Health Organization. International classification of functioning, disability, and health. Geneva: WHO; 2001."},{"key":"517_CR2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/B978-0-12-801772-2.00039-4","volume":"139","author":"A Baumann","year":"2016","unstructured":"Baumann A, Katz PO. Functional disorders of swallowing. Handb Clin Neurol. 2016;139:483\u20138.","journal-title":"Handb Clin Neurol"},{"key":"517_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03380-0","volume":"20","author":"F Rajati","year":"2022","unstructured":"Rajati F, Ahmadi N, Naghibzadeh ZA, Kazeminia M. The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis. J Transl Med. 2022;20:175. https:\/\/doi.org\/10.1186\/s12967-022-03380-0.","journal-title":"J Transl Med"},{"key":"517_CR4","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.parkreldis.2011.11.006","volume":"18","author":"JG Kalf","year":"2012","unstructured":"Kalf JG, de Swart BJ, Bloem BR, Munneke M. Prevalence of oropharyngeal dysphagia in Parkinson\u2019s disease: a meta-analysis. Parkinsonism Relat Disord. 2012;18:311\u20135.","journal-title":"Parkinsonism Relat Disord"},{"key":"517_CR5","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/s00455-016-9695-9","volume":"31","author":"C Takizawa","year":"2016","unstructured":"Takizawa C, Gemmell E, Kenworthy J, Speyer R. A systematic review of the prevalence of oropharyngeal dysphagia in stroke, Parkinson\u2019s disease, Alzheimer\u2019s disease, head injury, and pneumonia. Dysphagia. 2016;31:434\u201341.","journal-title":"Dysphagia"},{"key":"517_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1007\/s12603-016-0712-3","volume":"20","author":"A Madhavan","year":"2016","unstructured":"Madhavan A, LaGorio LA, Crary MA, Dahl WJ, Carnaby GD. Prevalence of and risk factors for dysphagia in the community dwelling elderly: a systematic review. J Nutr Health Aging. 2016;20:806\u201315.","journal-title":"J Nutr Health Aging"},{"key":"517_CR7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.9740\/mhc.2017.03.056","volume":"7","author":"EL Crouse","year":"2017","unstructured":"Crouse EL, Alastanos JN, Bozymski KM, Toscano RA. Dysphagia with second-generation antipsychotics: a case report and review of the literature. Ment Health Clin. 2017;7:56\u201364.","journal-title":"Ment Health Clin"},{"key":"517_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23407","volume":"10","author":"M Hirano","year":"2024","unstructured":"Hirano M, Samukawa M, Isono C, Kusunoki S, Nagai Y. The effect of rasagiline on swallowing function in Parkinson\u2019s disease. Heliyon. 2024;10:e23407. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e23407.","journal-title":"Heliyon"},{"key":"517_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286066","volume":"18","author":"M Hirano","year":"2023","unstructured":"Hirano M, Samukawa M, Isono C, Nagai Y. The effects of safinamide on dysphagia in Parkinson\u2019s disease. PLoS\u00a0One. 2023;18:e0286066. https:\/\/doi.org\/10.1371\/journal.pone.0286066.","journal-title":"PLoS\u00a0One"},{"key":"517_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000339989","volume":"72","author":"J Almirall","year":"2012","unstructured":"Almirall J, Cabr\u00e9 M, Clav\u00e9 P. Complications of oropharyngeal dysphagia: aspiration pneumonia. Nestle Nutr Inst Workshop Ser. 2012;72:67\u201376.","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"517_CR11","doi-asserted-by":"publisher","first-page":"e57077","DOI":"10.7759\/cureus.57077","volume":"16","author":"M Ahmad","year":"2024","unstructured":"Ahmad M, et al. Risk factors for the development of pneumonia in stroke patients: a systematic review and meta-analysis. Cureus. 2024;16:e57077. https:\/\/doi.org\/10.7759\/cureus.57077.","journal-title":"Cureus"},{"key":"517_CR12","unstructured":"Ministry of Health, Labour and Welfare. Year 2022. Summary of vital statistics (fixed number) (Ministry of Health, Labour and Welfare, 2023)."},{"key":"517_CR13","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s00455-022-10412-w","volume":"37","author":"T Gupte","year":"2022","unstructured":"Gupte T, Knack A, Cramer JD. Mortality from aspiration pneumonia: incidence, trends, and risk factors. Dysphagia. 2022;37:1493\u2013500.","journal-title":"Dysphagia"},{"key":"517_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jamda.2010.12.099","volume":"12","author":"CD van der Maarel-Wierink","year":"2011","unstructured":"van der Maarel-Wierink CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Risk factors for aspiration pneumonia in frail older people: a systematic literature review. J Am Med Dir Assoc. 2011;12:344\u201354.","journal-title":"J Am Med Dir Assoc"},{"key":"517_CR15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/s0140-6736(05)75550-1","volume":"354","author":"T Yoneyama","year":"1999","unstructured":"Yoneyama T, Yoshida M, Matsui T, Sasaki H, Oral Care Working Group. Oral care and pneumonia. Lancet. 1999;354:515. https:\/\/doi.org\/10.1016\/s0140-6736(05)75550-1.","journal-title":"Lancet"},{"key":"517_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jcrc.2014.07.011","volume":"30","author":"DM DiBardino","year":"2015","unstructured":"DiBardino DM, Wunderink RG. Aspiration pneumonia: a review of modern trends. J Crit Care. 2015;30:40\u20138.","journal-title":"J Crit Care"},{"key":"517_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2198259","volume":"2023","author":"T Zhao","year":"2023","unstructured":"Zhao T, et al. Identifying risk factors for aspiration in patients hospitalized with community-acquired pneumonia. Int J Clin Pract. 2023;2023:2198259. https:\/\/doi.org\/10.1155\/2023\/2198259.","journal-title":"Int J Clin Pract"},{"key":"517_CR18","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.neuroscience.2008.10.049","volume":"158","author":"N Zhang","year":"2009","unstructured":"Zhang N, et al. Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model. Neuroscience. 2009;158:665\u201372.","journal-title":"Neuroscience"},{"key":"517_CR19","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1532-5415.2008.01703.x","volume":"56","author":"S Teramoto","year":"2008","unstructured":"Teramoto S, et al. Antiplatelet cilostazol, an inhibitor of type III phosphodiesterase, improves swallowing function in patients with a history of stroke. J Am Geriatr Soc. 2008;56:1153\u20134.","journal-title":"J Am Geriatr Soc"},{"key":"517_CR20","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/jch.14695","volume":"25","author":"Y Hu","year":"2023","unstructured":"Hu Y, Liang L, Liu S, Kung JY, Banh HL. Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: a systematic review, and network meta-analysis. J Clin Hypertens (Greenwich). 2023;25:661\u201388.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"517_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4260","volume":"345","author":"D Caldeira","year":"2012","unstructured":"Caldeira D, Alarc\u00e3o J, Vaz-Carneiro A, Costa J. Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis. BMJ. 2012;345:e4260. https:\/\/doi.org\/10.1136\/bmj.e4260.","journal-title":"BMJ"},{"key":"517_CR22","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S0895-7061(99)00035-7","volume":"12","author":"K Okaishi","year":"1999","unstructured":"Okaishi K, et al. Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients. Am J Hypertens. 1999;12:778\u201383.","journal-title":"Am J Hypertens"},{"key":"517_CR23","doi-asserted-by":"publisher","first-page":"396","DOI":"10.5582\/ddt.2023.01093","volume":"17","author":"N Maida","year":"2024","unstructured":"Maida N, et al. Lack of information on sex differences in the package inserts of prescription drugs in Japan. Drug Discov Ther. 2024;17:396\u2013403.","journal-title":"Drug Discov Ther"},{"key":"517_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2024.105363","volume":"122","author":"H Suzuki","year":"2024","unstructured":"Suzuki H, et al. Is polypharmacy a risk factor for aspiration pneumonia in older adults? A case\u2013control study. Arch Gerontol Geriatr. 2024;122:105363. https:\/\/doi.org\/10.1016\/j.archger.2024.105363.","journal-title":"Arch Gerontol Geriatr"},{"key":"517_CR25","first-page":"60","volume":"17","author":"H Ayumu","year":"2013","unstructured":"Ayumu H, et al. A study of selection of drugs to treat basal diseases with considerating of influence on the swallowing function in the patients undergoing swallowing rehabilitation. Jpn Soc Dysphagia Rehab. 2013;17:60\u20137.","journal-title":"Jpn Soc Dysphagia Rehab"}],"container-title":["Drugs - Real World Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40801-025-00517-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40801-025-00517-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40801-025-00517-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T01:17:06Z","timestamp":1763687826000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40801-025-00517-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1007\/s40801-025-00517-7","relation":{},"ISSN":["2199-1154","2198-9788"],"issn-type":[{"value":"2199-1154","type":"print"},{"value":"2198-9788","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"assertion":[{"value":"31 August 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The data that support the findings of this article are available from the corresponding author (K.Y.) upon reasonable request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Faculty of Pharmacy, Keio University (14 October 2022, approval no. 221014-1).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"N.H. and K.Y. wrote the main manuscript text and contributed to study design. M.Y. prepared the figure and performed the statistical analysis. N.M. and M.O. collected data. S.K., H.I., and N.K. wrote the manuscript and provided comments. All authors read and approved the final version.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}