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However, maintaining the integrity of active sites during functionalization while preserving catalytic performance in biological environments remains a critical challenge. Here, we present a low-temperature-photochemical synthesis strategy for constructing platinum single-atoms within liposomes (PtSANs@Lipo), achieving atomic-level regulation of SANs active sites through axial chlorine (Cl) coordination engineering. The PtN\n                    <jats:sub>3<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    coordination structure, validated by synchrotron X-ray absorption spectroscopy, induces optimal\n                    <jats:italic>d<\/jats:italic>\n                    -band center modulation giving a remarkably low determining step energy barrier compared to conventional PtN\n                    <jats:sub>3<\/jats:sub>\n                    configurations. This architecture further enables non-contact functionalization via liposomal encapsulation, fully preserving catalytic activity while preventing catalytic sites occupation by antibody, thereby reducing the Michaelis constant (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>m<\/jats:italic>\n                    <\/jats:sub>\n                    ) value by 50-fold compared to direct modification onto Pt single-atoms. The constructed immunosensor based on PtSANs@Lipo demonstrates highly sensitive detection of viral pathogens, including influenza A virus H1N1, SARS-CoV-2, and influenza B virus antigens with limits of detection as low as 0.42, 2.23, and 0.36\u00a0fg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. This work establishes a paradigm for bio-adaptive nanozyme design through synergistic coordination engineering and liposomal functionalization architectures, and may thus provide a universal approach for signal amplification in point-of-care diagnostics.\n                  <\/jats:p>","DOI":"10.1007\/s40820-026-02136-5","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:58:10Z","timestamp":1773889090000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Confined Synthesis of Axial Chlorine Coordinated Single-Atom Nanozyme Within Liposomes for Sensitive Immunoassay"],"prefix":"10.1007","volume":"18","author":[{"given":"Chenchen","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolei","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Feng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyong","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"issue":"10","key":"2136_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209633","volume":"36","author":"S Ding","year":"2024","unstructured":"S. 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