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In this study, an injectable self-healing multifunctional hydrogel (CMCGel) was developed based on dynamic cross\u2011linking between manganese ions (Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ) and carboxymethyl chitosan loaded with chlorella extract (CE). This platform implements an integrated \u201cRemove\n                    <jats:bold>\u2013<\/jats:bold>\n                    Remodel\n                    <jats:bold>\u2013<\/jats:bold>\n                    Repair\u201d (3R) strategy for comprehensive perioperative management. CMCGel exhibits distinctive pH\/laser dual-responsive behavior: In the acidic tumor microenvironment, the accelerated release of CE and Mn\n                    <jats:sup>2+<\/jats:sup>\n                    enhances photodynamic therapy and chemodynamic therapy (CDT). This combination, activated by laser and gated by endogenous pH, achieves remarkable tumor suppression rates of 85.81% in vitro and 96.01% in vivo. As pH normalizes, Mn\n                    <jats:sup>2+<\/jats:sup>\n                    shifts from CDT to activate the cyclic GMP-AMP synthase stimulator of interferon genes (cGAS-STING) pathway, remodeling the immune microenvironment. Crucially, CMCGel\u2019s adhesion strength in artificial pancreatic fluid at 48\u00a0h was 4703.80\u2009\u00b1\u200950.36\u00a0Pa, only 8.17% lower than that at 10\u00a0min. This enzyme-resistant property enables durable mechanical sealing at the fistula site, reducing amylase leakage by 55.71% and creating favorable conditions for tissue repair. By integrating pH\/laser-triggered combination therapy, immunomodulation, and enzyme-resistant barrier functionality into a single platform, CMCGel presents a clinically promising strategy for perioperative management of pancreatic cancer.\n                  <\/jats:p>","DOI":"10.1007\/s40820-026-02344-z","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:02:03Z","timestamp":1788912123000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Manganese-Chlorella Hydrogel for an Integrated \u201cRemove\u2013Remodel\u2013Repair\u201d Strategy in Pancreatic Cancer Therapy"],"prefix":"10.1007","volume":"19","author":[{"given":"Tinglin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"10485","key":"2344_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","volume":"405","author":"TF Stoop","year":"2025","unstructured":"T.F. 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