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Thomas Carroll, Peter Dicpinigaitis and Peter Kardos declare consultancy fees from GSK. Peter Kardos also declares consultancy fees from MSD. Bonnie Pobiner, Dasha Shamarina and Aarti Tarkar are employed by, and hold financial equities in, GSK. Thomas Carroll has stock options in GSK and is on the scientific advisory board for N-Zyme Biomedical. Bonnie Pobiner was an employee of GSK at the time of the advice-seeking meetings and development of the manuscript.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article is based on the output from discussions held at two advice-seeking meetings. It does not contain any new interventional studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}