{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:44:06Z","timestamp":1784630646648,"version":"3.55.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Top Curr Chem (Z)"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s41061-019-0234-7","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T04:16:49Z","timestamp":1551759409000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Role of Trifluoromethyl Substitution in Design of Antimalarial Quinolones: a Comprehensive Review"],"prefix":"10.1007","volume":"377","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-5153","authenticated-orcid":false,"given":"Angel H.","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"234_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/415673a","volume":"415","author":"LH Miller","year":"2002","unstructured":"Miller LH, Baruch DL, Marsk K, Doumbo OK (2002) Nature 415:673\u2013679","journal-title":"Nature"},{"key":"234_CR2","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrd1416","volume":"3","author":"DA Fidock","year":"2004","unstructured":"Fidock DA, Rosenthal PJ, Croft SL, Brunn R, Nwaka S (2004) Nat Rev Drug Discov 3:509","journal-title":"Nat Rev Drug Discov"},{"key":"234_CR3","unstructured":"World Malaria Report (2017). (\n                    http:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2017\/en\/\n                    \n                  ). Accessed 29 Nov 2017"},{"key":"234_CR4","unstructured":"http:\/\/www.who.int\/malaria\/media\/world-malaria-day-2018\/en\/\n                    \n                  . Accessed Apr 2018"},{"key":"234_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0163-7258(97)00084-3","volume":"77","author":"PM O\u2019Neill","year":"1998","unstructured":"O\u2019Neill PM, Bray PG, Hawley SR, Ward SA, Park BK (1998) Pharmacol Ther 77:29","journal-title":"Pharmacol Ther"},{"key":"234_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0163-7258(98)00012-6","volume":"79","author":"M Foley","year":"1998","unstructured":"Foley M, Tilley L (1998) Pharmacol Ther 79:55","journal-title":"Pharmacol Ther"},{"key":"234_CR7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1126\/science.1074045","volume":"298","author":"AB Singh-Sidhu","year":"2002","unstructured":"Singh-Sidhu AB, Verdier-Pinard D, Fidock DA (2002) Science 298:210\u2013213","journal-title":"Science"},{"key":"234_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4269\/ajtmh.15-0007","volume":"93","author":"L Cui","year":"2015","unstructured":"Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ (2015) Am J Trop Med Hyg 93:57\u201368","journal-title":"Am J Trop Med Hyg"},{"key":"234_CR9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nrd2972","volume":"8","author":"TNC Wells","year":"2009","unstructured":"Wells TNC, Alonso PL, Gutteridge WE (2009) Nat Rev Drug Discov 8:879\u2013891","journal-title":"Nat Rev Drug Discov"},{"key":"234_CR10","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/415686a","volume":"415","author":"RG Ridley","year":"2002","unstructured":"Ridley RG (2002) Nature 415:686\u2013693","journal-title":"Nature"},{"key":"234_CR11","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1021\/jm00156a009","volume":"29","author":"LM Werbel","year":"1986","unstructured":"Werbel LM, Cook PD, Elslager EF, Hung JH, Johnson JL, Kesten SJ, McNamara DJ, Ortwinw DF, Worth DF (1986) J Med Chem 29:924","journal-title":"J Med Chem"},{"key":"234_CR12","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.1021\/jm030796n","volume":"46","author":"PM O\u2019Neill","year":"2003","unstructured":"O\u2019Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O\u2019Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK (2003) J Med Chem 46:4933\u20134945","journal-title":"J Med Chem"},{"key":"234_CR13","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1021\/jm8012757","volume":"52","author":"PM O\u2019Neill","year":"2009","unstructured":"O\u2019Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-las-Heras FM, Gargallo OV, Parapini OS, Vivas L, Lander H, Taramelli D, Ward SA (2009) J Med Chem 52:1828\u20131844","journal-title":"J Med Chem"},{"key":"234_CR14","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1021\/jm00388a027","volume":"30","author":"SJ Kesten","year":"1987","unstructured":"Kesten SJ, Johnson J, Werbel LM (1987) J Med Chem 30:907","journal-title":"J Med Chem"},{"key":"234_CR15","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1021\/jm960370r","volume":"40","author":"PM O\u2019Neill","year":"1997","unstructured":"O\u2019Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK (1997) J Med Chem 40:437\u2013448","journal-title":"J Med Chem"},{"key":"234_CR16","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1021\/jm00035a017","volume":"37","author":"PM O\u2019Neill","year":"1994","unstructured":"O\u2019Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK (1994) J Med Chem 37:1362\u20131370","journal-title":"J Med Chem"},{"key":"234_CR17","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1021\/jm9901374","volume":"42","author":"KJ Raynes","year":"1999","unstructured":"Raynes KJ, Stocks PA, O\u2019Neill PM, Park BK, Ward SA (1999) J Med Chem 42:2747\u20132751","journal-title":"J Med Chem"},{"key":"234_CR18","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1021\/jm061232x","volume":"50","author":"OV Miroshnikova","year":"2007","unstructured":"Miroshnikova OV, Hudson TH, Gerena L, Kyle DE, Lin AJ (2007) J Med Chem 50:889\u2013896","journal-title":"J Med Chem"},{"key":"234_CR19","doi-asserted-by":"publisher","first-page":"6813","DOI":"10.1016\/j.bmc.2008.05.068","volume":"16","author":"M Casagrande","year":"2008","unstructured":"Casagrande M, Basilico N, Parapini S, Romeo S, Taramelli D, Sparatore A (2008) Bioorg Med Chem 16:6813\u20136823","journal-title":"Bioorg Med Chem"},{"key":"234_CR20","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.1016\/j.bmc.2015.05.040","volume":"23","author":"AH Romero","year":"2015","unstructured":"Romero AH, Acosta ME, Gamboa N, Charris J, Salazar J, L\u00f3pez SE (2015) Bioorg Med Chem 23:4755\u20134762","journal-title":"Bioorg Med Chem"},{"key":"234_CR21","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.ejmech.2017.10.051","volume":"148","author":"EA Valverde","year":"2018","unstructured":"Valverde EA, Romero AH, Acosta ME, Gamboa N, Henriques G, Rodrigues JR, L\u00f3pez SE (2018) Eur J Med Chem 148:498\u2013506","journal-title":"Eur J Med Chem"},{"key":"234_CR22","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1054-3589(08)60952-7","volume":"37","author":"JN Cumming","year":"1997","unstructured":"Cumming JN, Ploypradith P, Posner GH (1997) Adv Pharmacol 37:253\u2013297","journal-title":"Adv Pharmacol"},{"key":"234_CR23","first-page":"54","volume":"58","author":"NJ White","year":"1998","unstructured":"White NJ, Olliaro P (1998) Med Trop (Mars) 58:54\u201356","journal-title":"Med Trop (Mars)"},{"key":"234_CR24","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1021\/jm990552w","volume":"43","author":"Y Li","year":"2000","unstructured":"Li Y, Zhu YM, Jiang JH, Pan JP, Wu GS, Wu JM, Shi YL, Yang JD, Wu BA (2000) J Med Chem 43:1635\u20131640","journal-title":"J Med Chem"},{"key":"234_CR25","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/nature02779","volume":"430","author":"JL Vennerstrom","year":"2004","unstructured":"Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FCK, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN (2004) Nature 430:900\u2013904","journal-title":"Nature"},{"key":"234_CR26","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1038\/srep02513","volume":"3","author":"A Shandilya","year":"2013","unstructured":"Shandilya A, Chacko S, Jayaram B, Ghosh I (2013) Sci Rep 3:2513. \n                    https:\/\/doi.org\/10.1038\/srep02513","journal-title":"Sci Rep"},{"key":"234_CR27","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.phrs.2016.11.012","volume":"117","author":"CS Ni Loo","year":"2017","unstructured":"Ni Loo CS, Kei Lam NS, Yu D, Su X, Lu F (2017) Pharmacol Res 117:192\u2013217","journal-title":"Pharmacol Res"},{"key":"234_CR28","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1093\/jac\/dks504","volume":"68","author":"GL Nixon","year":"2013","unstructured":"Nixon GL, Moss DM, Shone AE, Lalloo DG, Fisher N, O\u2019Neill PM, Ward SA, Biagini GA (2013) J Antimicrob Chemother 68:977\u2013985","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"234_CR29","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1128\/AAC.49.10.4421-4422.2005","volume":"49","author":"MD Edstein","year":"2005","unstructured":"Edstein MD, Kotecka BM, Anderson KL, Pombo DJ, Kyle DE, Rieckmann KH, Good MF (2005) Antimicrob Agents Chemother 49(10):4421\u20134422","journal-title":"Antimicrob Agents Chemother"},{"key":"234_CR30","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.1016\/j.ejmech.2009.07.021","volume":"44","author":"S Hage El","year":"2009","unstructured":"El Hage S, Ane M, Stigliani J-L, Marjorie M, Vial H, Baziard-Mouysset G, Payard M (2009) Eur J Med Chem 44:4778\u20134782","journal-title":"Eur J Med Chem"},{"key":"234_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S1473-3099(10)70079-7","volume":"10","author":"NM Douglas","year":"2010","unstructured":"Douglas NM, Anstey NM, Angus BJ, Nosten F, Price RN (2010) Lancet Infect Dis 10:405\u2013416","journal-title":"Lancet Infect Dis"},{"key":"234_CR32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nature12845","volume":"505","author":"CV Plowe","year":"2014","unstructured":"Plowe CV (2014) Nature 505:30\u201331","journal-title":"Nature"},{"key":"234_CR33","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1056\/NEJMc0805011","volume":"359","author":"H Noedl","year":"2008","unstructured":"Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM (2008) N Engl J Med 359:2619\u20132620","journal-title":"N Engl J Med"},{"key":"234_CR34","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/1475-2875-9-S3-S2","volume":"9","author":"B Greenwood","year":"2010","unstructured":"Greenwood B (2010) Malar J 9:S2","journal-title":"Malar J"},{"key":"234_CR35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.4269\/ajtmh.2007.77.181","volume":"77","author":"F Nosten","year":"2007","unstructured":"Nosten F, White NJ (2007) Am J Trop Med Hyg 77:181\u2013192","journal-title":"Am J Trop Med Hyg"},{"key":"234_CR36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.2165\/00003495-200363060-00006","volume":"63","author":"K McKeage","year":"2003","unstructured":"McKeage K, Scott L (2003) Drugs 63:597\u2013623","journal-title":"Drugs"},{"issue":"1","key":"234_CR37","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4269\/ajtmh.2003.68.111","volume":"68","author":"GA Butcher","year":"2003","unstructured":"Butcher GA, Sinden RE (2003) Am J Trop Med Hyg 68(1):111\u2013114","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"234_CR38","first-page":"219","volume":"62","author":"JE Touze","year":"2002","unstructured":"Touze JE, Fourcade L, Pradines B, Hovette P, Paule P, Heno P (2002) Med Trop (Mars) 62(3):219\u2013224","journal-title":"Med Trop (Mars)"},{"issue":"3","key":"234_CR39","first-page":"225","volume":"62","author":"D Camus","year":"2002","unstructured":"Camus D, Dutoit E, Masson V, Inglebert P, Delhaes L (2002) Med Trop (Mars) 62(3):225\u2013228","journal-title":"Med Trop (Mars)"},{"issue":"8","key":"234_CR40","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1097\/00006454-200208000-00017","volume":"21","author":"PS Sehdev","year":"2002","unstructured":"Sehdev PS (2002) Pediatr Infect Dis J 21(8):787\u2013789","journal-title":"Pediatr Infect Dis J"},{"key":"234_CR41","unstructured":"Kyle DE, Gerena L, Pitzer K, Gettyacamin M (2005) Antimalarial activity of 4(1H)-quinolones. Presented at the 54th Annual Meeting of the American Society of Tropical Medicine and Hygiene. Washington, DC"},{"key":"234_CR42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.exppara.2007.10.016","volume":"118","author":"RW Winter","year":"2008","unstructured":"Winter RW, Kelly JX, Smilkstein MJ, Dodean R, Hinrichs D, Riscoe MK (2008) Exp Parasitol 118:487\u2013497","journal-title":"Exp Parasitol"},{"key":"234_CR43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/00034983.1970.11686683","volume":"64","author":"JF Ryley","year":"1970","unstructured":"Ryley JF, Peters W (1970) Ann Trop Med Parasitol 64:209\u2013222","journal-title":"Ann Trop Med Parasitol"},{"key":"234_CR44","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/00034983.1979.11687294","volume":"73","author":"W Raether","year":"1979","unstructured":"Raether W, Fink E (1979) Ann Trop Med Parasitol 73:505\u2013526","journal-title":"Ann Trop Med Parasitol"},{"key":"234_CR45","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1128\/AAC.16.4.475","volume":"16","author":"LH Schmidt","year":"1979","unstructured":"Schmidt LH (1979) Antimicrob Agents Chemother 16:475\u2013485","journal-title":"Antimicrob Agents Chemother"},{"key":"234_CR46","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1021\/jm00097a001","volume":"35","author":"SJ Kesten","year":"1992","unstructured":"Kesten SJ, Degnan MJ, Hung J, McNamara DJ, Ortwine DF, Uhlendorf SE, Werbel LM (1992) J Med Chem 35:3429\u20133447","journal-title":"J Med Chem"},{"key":"234_CR47","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1128\/AAC.38.8.1753","volume":"38","author":"J Berman","year":"1994","unstructured":"Berman J, Brown L, Miller R, Andersen SL, McGreevy P, Schuster BG, Ellis W, Ager A, Rossan R (1994) Antimicrob Agents Chemother 38:1753\u20131756","journal-title":"Antimicrob Agents Chemother"},{"key":"234_CR48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/cber.19480810103","volume":"81","author":"W Salzer","year":"1948","unstructured":"Salzer W, Timmler H, Andersag H (1948) Chem Ber 81:12\u201319","journal-title":"Chem Ber"},{"key":"234_CR49","doi-asserted-by":"publisher","unstructured":"Stephen JML, Tonkin IM, Walker J (1947) J Chem Soc. pp 1034\u20131039. \n                    https:\/\/doi.org\/10.1039\/JR9470001034","DOI":"10.1039\/JR9470001034"},{"key":"234_CR50","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2307\/3273690","volume":"34","author":"GR Coatey","year":"1948","unstructured":"Coatey GR, Cooper WC (1948) J Parasitol 34:275\u2013289","journal-title":"J Parasitol"},{"key":"234_CR51","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.exppara.2010.10.016","volume":"127","author":"R Winter","year":"2011","unstructured":"Winter R, Kelly JX, Smilkstein MJ, Hinrichs D, Koop DR, Riscoe MK (2011) Exp Parasitol 127:545\u2013551","journal-title":"Exp Parasitol"},{"key":"234_CR52","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0035-9203(90)90066-N","volume":"84","author":"SK Puri","year":"1990","unstructured":"Puri SK, Dutta GP (1990) Trans R Soc Trop Med Hyg 84:759\u2013760","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"234_CR53","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/0006-2952(92)90213-3","volume":"43","author":"M Fry","year":"1992","unstructured":"Fry M, Pudney M (1992) Biochem Pharmacol 43:1545","journal-title":"Biochem Pharmacol"},{"key":"234_CR54","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1006\/expr.2001.4639","volume":"98","author":"E Suswam","year":"2001","unstructured":"Suswam E, Kyle D, Lang-Unnasch N (2001) Exp Parasitol 98:180\u2013187","journal-title":"Exp Parasitol"},{"key":"234_CR55","doi-asserted-by":"publisher","first-page":"7076","DOI":"10.1021\/jm1007903","volume":"53","author":"RM Cross","year":"2010","unstructured":"Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R (2010) J Med Chem 53:7076\u20137094","journal-title":"J Med Chem"},{"key":"234_CR56","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1021\/jm0705760","volume":"51","author":"CL Yeates","year":"2008","unstructured":"Yeates CL, Batchelor JF, Capon EC, Cheesman NJ, Fry M, Hudson AT, Pudney M, Trimming H, Woolven J, Bueno JM, Chicharro J, Fern\u00e1ndez E, Fiandor JM, Gargallo-Viola D, G\u00f3mez de las Heras F, Herreros E, Le\u00f3n ML (2008) J Med Chem 51:2845\u20132852","journal-title":"J Med Chem"},{"issue":"Suppl. 6","key":"234_CR57","first-page":"272","volume":"73","author":"FJ Gamo","year":"2005","unstructured":"Gamo FJ, Sanz LM, Mendoza A, Llergo JL, Lopez EM, G\u00f3mez de las Heras FM, Pompliano DL, Vaidya AB, Garc\u00eda-Bustos JF (2005) Am J Trop Med Hyg 73(Suppl. 6):272","journal-title":"Am J Trop Med Hyg"},{"issue":"Suppl. 5","key":"234_CR58","first-page":"49","volume":"77","author":"FJ Gamo","year":"2007","unstructured":"Gamo FJ, Sanz LM, Lafuente MJ, Mendoza A, de Cozar C, Rodr\u00edguez A, Llergo JL, Lopez EM, G\u00f3mez de las Heras F, Garc\u00eda-Bustos JF (2007) Am J Trop Med Hyg 77(Suppl. 5):49\u201350","journal-title":"Am J Trop Med Hyg"},{"key":"234_CR59","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1021\/jm200015a","volume":"54","author":"RM Cross","year":"2011","unstructured":"Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R (2011) J Med Chem 54:4399\u20134426","journal-title":"J Med Chem"},{"key":"234_CR60","doi-asserted-by":"publisher","first-page":"8321","DOI":"10.1021\/jm200718m","volume":"54","author":"RM Cross","year":"2011","unstructured":"Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R (2011) J Med Chem 54:8321\u20138327","journal-title":"J Med Chem"},{"key":"234_CR61","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1021\/jm201642z","volume":"55","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, Guy RK (2012) J Med Chem 55:4205\u20134219","journal-title":"J Med Chem"},{"key":"234_CR62","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature05572","volume":"446","author":"HJ Painter","year":"2007","unstructured":"Painter HJ, Morrisey JM, Mather MW, Vaidya AB (2007) Nature 446:88\u201391","journal-title":"Nature"},{"key":"234_CR63","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature01097","volume":"419","author":"MJ Gardner","year":"2002","unstructured":"Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan M-S, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DMA, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B (2002) Nature 419:498\u2013511","journal-title":"Nature"},{"key":"234_CR64","first-page":"233","volume":"295","author":"AB Vaidya","year":"2005","unstructured":"Vaidya AB, Mather MW (2005) Curr Top Microbiol Immunol 295:233\u2013250","journal-title":"Curr Top Microbiol Immunol"},{"key":"234_CR65","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1128\/EC.05049-11","volume":"10","author":"H Ke","year":"2011","unstructured":"Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB (2011) Eukaryot Cell 10:1053\u20131061","journal-title":"Eukaryot Cell"},{"key":"234_CR66","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1021\/jm201179h","volume":"55","author":"C Pidathala","year":"2012","unstructured":"Pidathala C, Amewu R, Pacorel B, Nixon GL, Gibbons P, Hong WD, Leung SC, Berry NG, Sharma R, Stocks PA, Srivastava A, Shone AE, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Hill A, Fisher NE, Warman AJ, Biagini GA, Ward SA, O\u2019Neill PM (2012) J Med Chem 55:1831\u20131843","journal-title":"J Med Chem"},{"key":"234_CR67","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1021\/jm201184h","volume":"55","author":"SC Leung","year":"2012","unstructured":"Leung SC, Gibbons P, Amewu R, Nixon GL, Pidathala C, Hong WD, Pacorel B, Berry NG, Sharma R, Stocks PA, Srivastava A, Shone AE, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Hill A, Fisher NE, Warman AJ, Biagini GA, Ward SA, O\u2019Neill PM (2012) J Med Chem 55:1844\u20131857","journal-title":"J Med Chem"},{"key":"234_CR68","doi-asserted-by":"publisher","first-page":"8298","DOI":"10.1073\/pnas.1205651109","volume":"109","author":"GA Biagini","year":"2012","unstructured":"Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, Pacorel B, Lawrenson AS, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Stocks PA, Nixon GL, Chadwick J, Hemingway J, Delves MJ, Sinden RE, Zeeman AM, Kocken CHM, Berry NG, O\u2019Neill PM, Ward SA (2012) PNAS 109:8298\u20138303","journal-title":"PNAS"},{"key":"234_CR69","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1039\/C1MD00183C","volume":"3","author":"R Cowley","year":"2012","unstructured":"Cowley R, Leung S, Fisher N, Al-Helal M, Berry NG, Lawrenson AS, Sharma R, Shone AE, Ward SA, Biagini GA, O\u2019Neill PM (2012) Med Chem Commun 3:39\u201344","journal-title":"Med Chem Commun"},{"key":"234_CR70","doi-asserted-by":"publisher","first-page":"4811","DOI":"10.1021\/jm400246e","volume":"56","author":"T Rodrigues","year":"2013","unstructured":"Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Goncalves D, Ressurreicao AS, Sito AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudencio M, Gamo FJ, Lopes F, Moreira R (2013) J Med Chem 56:4811\u20134815","journal-title":"J Med Chem"},{"key":"234_CR71","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1021\/jm500147k","volume":"57","author":"A Nilsen","year":"2014","unstructured":"Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Stone Doggett J, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK (2014) J Med Chem 57:3818\u20133834","journal-title":"J Med Chem"},{"key":"234_CR72","doi-asserted-by":"publisher","first-page":"8860","DOI":"10.1021\/jm500942v","volume":"57","author":"RM Cross","year":"2014","unstructured":"Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Saenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, Kyle DE, Manetsch R (2014) J Med Chem 57:8860\u20138879","journal-title":"J Med Chem"}],"container-title":["Topics in Current Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s41061-019-0234-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s41061-019-0234-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s41061-019-0234-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T19:11:50Z","timestamp":1583262710000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s41061-019-0234-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["234"],"URL":"https:\/\/doi.org\/10.1007\/s41061-019-0234-7","relation":{},"ISSN":["2365-0869","2364-8961"],"issn-type":[{"value":"2365-0869","type":"print"},{"value":"2364-8961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]},"assertion":[{"value":"24 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The author declares no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"9"}}