{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:09:04Z","timestamp":1786982944226,"version":"build-2736575974"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI103629"],"award-info":[{"award-number":["R01AI103629"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["PharmacoEconomics Open"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s41669-018-0071-6","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:00:45Z","timestamp":1520917245000},"page":"381-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Functional Status and Well-Being in People with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls"],"prefix":"10.1007","volume":"2","author":[{"given":"Caroline C.","family":"Kingdon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinna W.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Curran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nacul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana M.","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"71_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-349-20895-1","volume-title":"The politics of disablement: a sociological approach critical texts in social work and the welfare state","author":"M Olive","year":"1990","unstructured":"Olive M. The politics of disablement: a sociological approach critical texts in social work and the welfare state. Basingstoke: Macmillan and St Martin\u2019s Press; 1990."},{"key":"71_CR2","unstructured":"ME Association. ESA\u2014changes to the Working Capability Assessment descriptors. 2011. \n                    http:\/\/www.meassociation.org.uk\/2011\/02\/esa-\u2013-changes-to-the-working-capability-assessment-descriptors\/\n                    \n                  . Accessed 28 Feb 2018."},{"issue":"3","key":"71_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/21641846.2017.1333185","volume":"5","author":"V Strassheim","year":"2017","unstructured":"Strassheim V, et al. What is known about severe and very severe chronic fatigue syndrome? A scoping review. Fatigue Biomed Health Behav. 2017;5(3):167\u201383.","journal-title":"Fatigue Biomed Health Behav."},{"issue":"3","key":"71_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jpsychores.2011.02.009","volume":"71","author":"M Cella","year":"2011","unstructured":"Cella M, Sharpe M, Chalder T. Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale. J Psychosom Res. 2011;71(3):124\u20138.","journal-title":"J Psychosom Res"},{"key":"71_CR5","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1093\/ije\/dyp147","volume":"38","author":"S Dinos","year":"2009","unstructured":"Dinos S, et al. A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping. Int J Epidemiol. 2009;38:1554\u201370.","journal-title":"Int J Epidemiol"},{"key":"71_CR6","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0140-6736(06)68073-2","volume":"367","author":"J Prins","year":"2006","unstructured":"Prins J, van der Meer J, Bleijenberg G. Chronic fatigue syndrome. Lancet. 2006;367:346\u201355.","journal-title":"Lancet"},{"issue":"1","key":"71_CR7","first-page":"167","volume":"12","author":"I Bakken","year":"2014","unstructured":"Bakken I, et al. Two age peaks in the incidence of chronic fatigue syndrome\/myalgic encephalomyelitis: a population-based registry study from Norway 2008 inverted question mark 2012. BMC Med. 2014;12(1):167.","journal-title":"BMC Med."},{"issue":"1","key":"71_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1741-7015-9-91","volume":"9","author":"LC Nacul","year":"2011","unstructured":"Nacul LC, et al. Prevalence of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) in three regions of England: a repeated cross-sectional study in primary care. BMC Med. 2011;9(1):91.","journal-title":"BMC Med."},{"key":"71_CR9","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1001\/archinte.164.10.1098","volume":"164","author":"S Ross","year":"2004","unstructured":"Ross S, et al. Disability and chronic fatigue syndrome. Arch Intern Med. 2004;164:1098\u2013105.","journal-title":"Arch Intern Med"},{"issue":"1","key":"71_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21641846.2017.1273863","volume":"5","author":"LK Nacul","year":"2017","unstructured":"Nacul LK, Kingdon CC, Bowman EW, Curran H, Lacerda EM. Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis\/chronic fatigue syndrome. Fatigue Biomed Health Behav. 2017;5(1):1\u20134.","journal-title":"Fatigue Biomed Health Behav."},{"issue":"12","key":"71_CR11","doi-asserted-by":"publisher","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","volume":"121","author":"K Fukuda","year":"1994","unstructured":"Fukuda K, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121(12):953\u20139.","journal-title":"Ann Intern Med"},{"issue":"1","key":"71_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1300\/J092v11n01_02","volume":"11","author":"Carruthers","year":"2003","unstructured":"Carruthers, et al. Myalgic encephalomyelitis\/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. J Chronic Fatigue Syndr. 2003;11(1):7\u2013115.","journal-title":"J Chronic Fatigue Syndr."},{"issue":"4","key":"71_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1365-2796.2011.02428.x","volume":"270","author":"BM Carruthers","year":"2011","unstructured":"Carruthers BM, et al. Myalgic encephalomyelitis: international Consensus Criteria. J Intern Med. 2011;270(4):327\u201338.","journal-title":"J Intern Med"},{"key":"71_CR14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1136\/bmj.39302.509005.AE","volume":"335","author":"R Baker","year":"2007","unstructured":"Baker R, Shaw E. Diagnosis and management of chronic fatigue syndrome or myalgic encephalomyelitis (or encephalopathy): summary of NICE guidance. BMJ. 2007;335:446\u20138.","journal-title":"BMJ"},{"issue":"7","key":"71_CR15","first-page":"115","volume":"11","author":"B Carruthers","year":"2003","unstructured":"Carruthers B, et al. Myalgic encephalomyelitis\/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. J Chronic Fatigue Syndr. 2003;11(7):115.","journal-title":"J Chronic Fatigue Syndr."},{"key":"71_CR16","doi-asserted-by":"publisher","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","volume":"121","author":"K Fukuda","year":"1994","unstructured":"Fukuda K, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121:953\u20139.","journal-title":"Ann Intern Med"},{"issue":"2","key":"71_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.pec.2011.04.016","volume":"86","author":"V Anderson","year":"2012","unstructured":"Anderson V, et al. A review and meta-synthesis of qualitative studies on myalgic encephalomyelitis\/chronic fatigue syndrome. Patient Educ Couns. 2012;86(2):147\u201355.","journal-title":"Patient Educ Couns."},{"issue":"2","key":"71_CR18","first-page":"148","volume":"12","author":"P \u00c5sbring","year":"2002","unstructured":"\u00c5sbring P, N\u00e4rv\u00e4nen A-L. Women\u2019s experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia. Qual Health Res. 2002;12(2):148\u201360.","journal-title":"Qual Health Res"},{"key":"71_CR19","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1136\/medethics-2016-103691","volume":"43","author":"C Blease","year":"2017","unstructured":"Blease C, Carel H, Geraghty K. Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome. J Med Ethics. 2017;43:549\u201357.","journal-title":"J Med Ethics"},{"key":"71_CR20","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/1471-2458-9-458","volume":"9","author":"L Drachler Mde","year":"2009","unstructured":"Drachler Mde L, et al. The expressed needs of people with chronic fatigue syndrome\/myalgic encephalomyelitis: a systematic review. BMC Public Health. 2009;9:458.","journal-title":"BMC Public Health."},{"key":"71_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1471-2296-6-49","volume":"6","author":"MA Thomas","year":"2005","unstructured":"Thomas MA, Smith AP. Primary healthcare provision and chronic fatigue syndrome: a survey of patients\u2019 and general practitioners\u2019 beliefs. BMC Fam Pract. 2005;6:49.","journal-title":"BMC Fam Pract."},{"key":"71_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1471-2296-11-89","volume":"11","author":"SM Horton","year":"2010","unstructured":"Horton SM, et al. Chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) in adults: a qualitative study of perspectives from professional practice. BMC Fam Pract. 2010;11:89.","journal-title":"BMC Fam Pract."},{"issue":"12","key":"71_CR23","doi-asserted-by":"publisher","first-page":"860","DOI":"10.7326\/M15-0338","volume":"162","author":"C Green","year":"2015","unstructured":"Green C, et al. Pathways to prevention workshop: advancing the research on myalgic encephalomyelitis\/chronic fatigue syndrome. Ann Intern Med. 2015;162(12):860\u20135.","journal-title":"Ann Intern Med"},{"key":"71_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/1471-2458-11-402","volume":"11","author":"L Nacul","year":"2011","unstructured":"Nacul L, et al. The functional status and well being of people with myalgic encephalomyelitis\/chronic fatigue syndrome and their carers. BMC Public Health. 2011;11:402.","journal-title":"BMC Public Health."},{"issue":"7","key":"71_CR25","doi-asserted-by":"publisher","first-page":"e0132421","DOI":"10.1371\/journal.pone.0132421","volume":"10","author":"M Falk Hvidberg","year":"2015","unstructured":"Falk Hvidberg M, et al. The health-related quality of life for patients with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). PLoS ONE. 2015;10(7):e0132421.","journal-title":"PLoS ONE"},{"key":"71_CR26","unstructured":"Ware JJ, et al. User\u2019s manual for the SF-36v2\u2122 health survey 2007: Lincoln, RI: QualityMetric Incorporated."},{"issue":"1","key":"71_CR27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.5334\/ojb.28","volume":"4","author":"EM Lacerda","year":"2017","unstructured":"Lacerda EM, et al. The UK ME\/CFS biobank for biomedical research on myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) and multiple sclerosis. Open J Bioresour. 2017;4(1):4.","journal-title":"Open J Bioresour."},{"key":"71_CR28","volume-title":"International classification of statistical classification of diseases and related health problems\u2014ICD-10","author":"World Health Organization","year":"2001","unstructured":"World Health Organization. International classification of statistical classification of diseases and related health problems\u2014ICD-10. Geneva: World Health Organization; 2001."},{"key":"71_CR29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/1741-7015-11-205","volume":"11","author":"G Morris","year":"2013","unstructured":"Morris G, Maes M. Myalgic encephalomyelitis\/chronic fatigue syndrome and encephalomyelitis disseminata\/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. BMC Med. 2013;11:205.","journal-title":"BMC Med."},{"key":"71_CR30","volume-title":"SF-36\u00ae Health Survey Manual and Interpretation Guide","author":"JJ Ware","year":"2005","unstructured":"Ware JJ, Kosinski M, Gandek B. SF-36\u00ae Health Survey Manual and Interpretation Guide. Lincoln: QualityMetric Inc; 2005."},{"key":"71_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1023\/A:1026459027453","volume":"8","author":"C Myers","year":"1999","unstructured":"Myers C, Wilks D. Comparison of Euroqol EQ-5D and SF-36 in patients with chronic fatigue syndrome. Qual Life Res. 1999;8:9\u201316.","journal-title":"Qual Life Res"},{"issue":"1","key":"71_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1136\/jech.53.1.46","volume":"53","author":"C Jenkinson","year":"1999","unstructured":"Jenkinson C, et al. Assessment of the SF-36 version 2 in the United Kingdom. J Epidemiol Comm Health. 1999;53(1):46\u201350.","journal-title":"J Epidemiol Comm Health"},{"key":"71_CR33","unstructured":"Bell D. The doctors\u2019 guide to chronic fatigue syndrome: understanding, treating, and living with Cfids. Bell DS, editors. DC Press;1996. pp. 124\u2013125. Boston, MA: Da Capo Press."},{"issue":"6","key":"71_CR34","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540\u20135.","journal-title":"Sleep"},{"issue":"10","key":"71_CR35","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","volume":"46","author":"LB Krupp","year":"1989","unstructured":"Krupp LB, et al. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46(10):1121\u20133.","journal-title":"Arch Neurol"},{"issue":"5","key":"71_CR36","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1023\/A:1012588218728","volume":"10","author":"JEJ Ware","year":"2001","unstructured":"Ware JEJ, Kosinski M. Interpreting SF-36 Summary Health Measures: a response. Qual Life Res. 2001;10(5):405\u201313.","journal-title":"Qual Life Res."},{"key":"71_CR37","volume-title":"Stata statistical software: release 14","author":"Stata Corp.","year":"2015","unstructured":"Stata Corp. Stata statistical software: release 14. College Station: StataCorp LP; 2015."},{"key":"71_CR38","volume-title":"Medical statistics","author":"BR Kirkwood","year":"2003","unstructured":"Kirkwood BR, Sterne JAC. Medical statistics. 2nd ed. Oxford: Blackwell Science; 2003.","edition":"2"},{"key":"71_CR39","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/1472-6963-11-217","volume":"11","author":"SM Collin","year":"2011","unstructured":"Collin SM, et al. The impact of CFS\/ME on employment and productivity in the UK: a cross-sectional study based on the CFS\/ME national outcomes database. BMC Health Serv Res. 2011;11:217.","journal-title":"BMC Health Serv Res."},{"key":"71_CR40","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/1741-7015-11-205","volume":"11","author":"G Morris","year":"2013","unstructured":"Morris G, Maes M. Myalgic encephalomyelitis\/chronic fatigue syndrome and encephalomyelitis disseminata\/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. BMC Med. 2013;11:205.","journal-title":"BMC Med."},{"issue":"4","key":"71_CR41","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1177\/01632789922034400","volume":"22","author":"JL Shlaes","year":"1999","unstructured":"Shlaes JL, Jason LA, Ferrari JR. The development of the chronic fatigue syndrome attitudes test. A psychometric analysis. Eval Health Prof. 1999;22(4):442\u201365.","journal-title":"Eval Health Prof."},{"key":"71_CR42","volume-title":"Living with M.E,. the chronic post-viral fatigue syndrome","author":"C Shepherd","year":"1999","unstructured":"Shepherd C. Living with M.E, the chronic post-viral fatigue syndrome. Reading: Vermilion; 1999."},{"issue":"6","key":"71_CR43","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1093\/occmed\/kqq048","volume":"60","author":"E Brohan","year":"2010","unstructured":"Brohan E, Thornicroft G. Stigma and discrimination of mental health problems: workplace implications. Occup Med (Lond). 2010;60(6):414\u20135.","journal-title":"Occup Med (Lond)."},{"key":"71_CR44","unstructured":"Brunt-Seymour K. How employers\u2019 unsympathetic attitudes towards staff absence affect staff productivity. Workplace savings and Benefits 2015. \n                    http:\/\/www.wsandb.co.uk\/wsb\/news\/2424354\/how-employers-unsympathetic-attitudes-towards-staff-absence-affect-staff-productivity\n                    \n                  . Accessed 28 Feb 2018."},{"key":"71_CR45","unstructured":"UK Government. The UK Equality Act 2010. 2010. \n                    https:\/\/www.hesa.ac.uk\/dox\/manual_documents\/ea-guide.pdf?v=)\n                    \n                  . Accessed 28 Feb 2018."},{"key":"71_CR46","unstructured":"National Institute of Clinical Excellence. Chronic fatigue syndrome\/myalgic encephalomyelitis (or encephalopathy): diagnosis and management of CFS\/ME in adults and children. NICE guidelines 2014. \n                    https:\/\/www.nice.org.uk\/guidance\/cg53\n                    \n                  . Accessed 17 Jul 2017."},{"issue":"5288","key":"71_CR47","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1126\/science.274.5288.740","volume":"274","author":"CJ Murray","year":"1996","unstructured":"Murray CJ, Lopez AD. Evidence-based health policy: lessons from the Global Burden of Disease Study. Science. 1996;274(5288):740\u20133.","journal-title":"Science"},{"key":"71_CR48","unstructured":"Hunter R, James M, Paxman J. Counting the Cost: chronic fatigue syndrome\/myalgic encephalomyelitis. Full report 2017. \n                    http:\/\/www.theoptimumhealthclinic.com\/wpcontent\/uploads\/2017\/09\/Counting-the-Cost.pdf\n                    \n                  . Accessed 28 Feb 2018."},{"issue":"10","key":"71_CR49","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1001\/archinte.164.10.1098","volume":"164","author":"SD Ross","year":"2004","unstructured":"Ross SD, et al. Disability and chronic fatigue syndrome: a focus on function. Arch Intern Med. 2004;164(10):1098\u2013107.","journal-title":"Arch Intern Med"},{"key":"71_CR50","unstructured":"Organisation for Economic Co-operation and Development. Tackling the Jobs Crisis: Pathways onto (and off) Disability Benefits: Assessing the Role of Policy and Individual Circumstances. OECD Employment Outlook. OECD; 2009. \n                    http:\/\/www.oecd.org\/employment\/emp\/43687710.pdf?TSPD_101_R0=d00ce51dafceec68e8eaf52ee5d42645h0400000000000000005d6d5a92ffff00000000000000000000000000005a96ce4e00c96b26ba\n                    \n                  . Accessed 28 Feb 2018."},{"key":"71_CR51","volume-title":"Introduction to Epidemiology. Understanding Public Health. Bungay","author":"I Carneiro","year":"2011","unstructured":"Carneiro I, Howard N. Introduction to Epidemiology. Understanding Public Health. Bungay. 2nd ed. McGraw Hill: Open University Press; 2011.","edition":"2"},{"key":"71_CR52","unstructured":"Ubido J, Scott-Samuel A. Loneliness. The prevalence of loneliness, its impact on health and wellbeing and effective interventions that can be used to ameliorate these effects. Rapid Evidence Review Series, number 1, 2014. LPHO Report Series, number 97."},{"key":"71_CR53","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-5918-7-6","volume":"7","author":"L Jason","year":"2008","unstructured":"Jason L, et al. The Economic impact of ME\/CFS: individual and societal costs. Dyn Med. 2008;7:6.","journal-title":"Dyn Med."}],"container-title":["PharmacoEconomics - Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s41669-018-0071-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s41669-018-0071-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s41669-018-0071-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:42:18Z","timestamp":1589679738000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s41669-018-0071-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,13]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["71"],"URL":"https:\/\/doi.org\/10.1007\/s41669-018-0071-6","relation":{},"ISSN":["2509-4262","2509-4254"],"issn-type":[{"value":"2509-4262","type":"print"},{"value":"2509-4254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,13]]},"assertion":[{"value":"13 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The UK ME\/CFS Biobank was established with a joint grant from the charities Action for ME, the ME Association, and ME Research UK, as well as a private donor. Research reported in this publication was supported by the above-named charities and the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) under Award Number R01AI103629. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Caroline Kingdon, Erinna Bowman, Hayley Curran, Luis Nacul, and Eliana Lacerda declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Participants"}},{"value":"The UK ME\/CFS Biobank received ethical approval from the London School of Hygiene & Tropical Medicine (LSHTM) Ethics Committee (ref. 6123), the National Research Ethics Service (NRES) London-Bloomsbury Research Ethics Committee (REC; ref. 11\/LO\/1760, IRAS ID: 77765), and the NHS Research Governance and Developments Offices (R&D), which oversee the recruitment of research participants from government health services.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study. Participants were encouraged to ask questions and were free to withdraw at any time.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}