{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:53:04Z","timestamp":1772859184209,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T00:00:00Z","timestamp":1567814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T00:00:00Z","timestamp":1567814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"ARS-MP, Health Regional Institution"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Geriatr Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s41999-019-00234-9","type":"journal-article","created":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T11:02:51Z","timestamp":1567854171000},"page":"947-955","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["End of life care practice and symptom management outcomes of nursing home residents with dementia: secondary analyses of IQUARE trial"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-4351","authenticated-orcid":false,"given":"Antoine","family":"Elyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Sourdet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Morin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fati","family":"Nourhashemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Saffon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,7]]},"reference":[{"issue":"16","key":"234_CR1","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1056\/NEJMoa0902234","volume":"361","author":"SL Mitchell","year":"2009","unstructured":"Mitchell SL, Teno JM, Kiely DK et al (2009) The clinical course of advanced dementia. N Engl J Med 361(16):1529\u20131538","journal-title":"N Engl J Med"},{"issue":"7","key":"234_CR2","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/jgs.12318","volume":"61","author":"KT Unroe","year":"2013","unstructured":"Unroe KT, Meier DE (2013) Quality of hospice care for individuals with dementia. J Am Geriatr Soc 61(7):1212\u20131214","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"234_CR3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1017\/S1478951516000985","volume":"15","author":"JT van der Steen","year":"2017","unstructured":"van der Steen JT, Deliens L, Koopmans RTCM et al (2017) Physicians\u2019 perceptions of suffering in people with dementia at the end of life. Palliat Support Care 15(5):587\u2013599","journal-title":"Palliat Support Care"},{"issue":"3","key":"234_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1177\/0269216313493685","volume":"28","author":"JT van der Steen","year":"2014","unstructured":"van der Steen JT, Radbruch L, Hertogh CMPM, on behalf of the European Association for Palliative Care (EAPC) et al (2014) White paper defining optimal palliative care in older people with dementia: a Delphi study and recommendations from the European Association for Palliative Care. Palliat Med 28(3):197\u2013209","journal-title":"Palliat Med"},{"key":"234_CR5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12904-015-0053-8","volume":"14","author":"Paap J Van Riet","year":"2015","unstructured":"Van Riet Paap J, Mariani E, Chattat R et al (2015) Identification of the palliative phase in people with dementia: a variety of opinions between healthcare professionals. BMC Palliat Med 14:56","journal-title":"BMC Palliat Med"},{"key":"234_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.medpal.2015.02.005","volume":"14","author":"L Morin","year":"2015","unstructured":"Morin L, Aubry R (2015) End-of-life care for nursing home residents with dementia. M\u00e9d Palliat 14:191\u2013202 (French)","journal-title":"M\u00e9d Palliat"},{"key":"234_CR7","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/gps.2784","volume":"27","author":"S Lithgow","year":"2012","unstructured":"Lithgow S, Jackson GA, Browne D (2012) Estimating the prevalence of dementia: cognitive screening in Glasgow nursing homes. Int J Geriatr Psychiatry 27:785\u2013791","journal-title":"Int J Geriatr Psychiatry"},{"key":"234_CR8","unstructured":"Observatoire National de la fin de vie. La fin de vie en EHPAD. Rapport\u2009\u00ab\u2009Fin de vie des personnes \u00e2g\u00e9es\u2009\u00bb\u2009. Paris, 2013. \nhttps:\/\/www.parlons-fin-de-vie.fr\/wp-content\/uploads\/2018\/09\/Rapport-Fin-de-vie-des-personnes-\u00e2g\u00e9es.pdf\n\n. Accessed on 26 05 2019 (French)"},{"key":"234_CR9","first-page":"1","volume":"1015","author":"M Muller","year":"2017","unstructured":"Muller M (2017) 728 000 r\u00e9sidents en \u00e9tablissements d\u2019h\u00e9bergement pour personnes \u00e2g\u00e9es en 2015. Premiers r\u00e9sultats de l\u2019enqu\u00eate EHPA 2015. \u00c9tudes R\u00e9sultats 1015:1\u20138 (French)","journal-title":"\u00c9tudes R\u00e9sultats"},{"key":"234_CR10","first-page":"1","volume":"989","author":"Y Makdessi","year":"2016","unstructured":"Makdessi Y, Pradines N (2016) En EHPAD, les r\u00e9sidents les plus d\u00e9pendants souffrent davantage de pathologies aigu\u00ebs. \u00c9tudes R\u00e9sultats 989:1\u20134 (French)","journal-title":"\u00c9tudes R\u00e9sultats"},{"issue":"3","key":"234_CR11","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/ageing\/afu197","volume":"44","author":"L Morin","year":"2015","unstructured":"Morin L, Johnell K, Aubry R (2015) Variation in the place of death among nursing home residents in France. Age Ageing 44(3):415\u2013421","journal-title":"Age Ageing"},{"key":"234_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jamda.2014.11.003","volume":"16","author":"T Reyniers","year":"2015","unstructured":"Reyniers T, Deliens L, Pasman HR et al (2015) International variation in place of death of older people who died from dementia in 14 European and non-European Countries. J Am Med Dir Assoc 16:165\u2013171","journal-title":"J Am Med Dir Assoc"},{"issue":"11","key":"234_CR13","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.pain.2013.07.017","volume":"154","author":"Barreto P De Souto","year":"2013","unstructured":"De Souto Barreto P, Lapeyre-Mestre M, Vellas B et al (2013) Potential underuse of analgesics for recognized pain in nursing home residents with dementia: a cross-sectional study. Pain 154(11):2427\u20132431","journal-title":"Pain"},{"issue":"3","key":"234_CR14","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1177\/0269216317726443","volume":"32","author":"EL Sampson","year":"2018","unstructured":"Sampson EL, Candy B, David S et al (2018) Living and dying with advanced dementia: a prospective cohort study of symptoms, service use and care at the end of life. Palliat Med 32(3):668\u2013681","journal-title":"Palliat Med"},{"key":"234_CR15","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12603-013-0008-9","volume":"17","author":"Barreto P De Souto","year":"2013","unstructured":"De Souto Barreto P, Lapeyre-Mestre M, Mathieu C et al (2013) A multicentric individually tailored controlled trial of education and professional support to nursing home staff: research protocol and baseline data of the IQUARE study. J Nutr Health Aging 17:173\u2013178","journal-title":"J Nutr Health Aging"},{"issue":"8","key":"234_CR16","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00228-007-0324-2","volume":"63","author":"ML Laroche","year":"2007","unstructured":"Laroche ML, Charmes JP, Merle L et al (2007) Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol 63(8):725\u2013731","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"234_CR17","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2165\/11631740-000000000-00000","volume":"29","author":"AJ Cruz-Jentoft","year":"2012","unstructured":"Cruz-Jentoft AJ, Boland B, Rexach L et al (2012) Drug therapy optimization at the end of life. Drugs Aging 29(6):511\u2013521","journal-title":"Drugs Aging"},{"key":"234_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12877-015-0125-x","volume":"15","author":"H Hofmann","year":"2015","unstructured":"Hofmann H, Schorro E, Haastert B et al (2015) Use of physical restraints in nursing homes: a multicentre cross-sectional study. BMC Geriatr 15:129","journal-title":"BMC Geriatr"},{"issue":"7","key":"234_CR19","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jamda.2013.01.016","volume":"14","author":"A Vandervoort","year":"2013","unstructured":"Vandervoort A, Van den Block L, Van der Steen JT et al (2013) Nursing home residents dying with dementia in Flanders, Belgium: a natiowide postmortem study on clinical characteristics and quality of dying. J Am Med Dir Assoc 14(7):485\u2013492","journal-title":"J Am Med Dir Assoc"},{"issue":"6","key":"234_CR20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1017\/S1041610216000028","volume":"28","author":"B Willemse","year":"2016","unstructured":"Willemse B, de Jonge J, Smit D et al (2016) Is an unhealthy work environment in nursing home care for people with dementia associated with the prescription of psychotropic drugs and physical restraints? Int Psychogeriatr 28(6):983\u2013994","journal-title":"Int Psychogeriatr"},{"issue":"2","key":"234_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3109\/15622975.2015.1132007","volume":"17","author":"M Garriga","year":"2016","unstructured":"Garriga M, Pacchiarotti I, Kasper S et al (2016) Assessment and management of agitation in psychiatry: expert consensus. World J Biol Psychiatry 17(2):86\u2013128","journal-title":"World J Biol Psychiatry"},{"key":"234_CR22","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3233\/JAD-180647","volume":"66","author":"R Palm","year":"2018","unstructured":"Palm R, Sorg CGG, Str\u00f6bel A, Gerritsen DL, Holle B (2018) Severe agitation in dementia: an explorative secondary data analysis on the prevalence and associated factors in nursing home residents. J Alzheimer\u2019s Dis 66:1463\u20131470","journal-title":"J Alzheimer\u2019s Dis"},{"key":"234_CR23","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.jagp.2017.08.002","volume":"25","author":"AE Veldwijk-Rouwenhorst","year":"2017","unstructured":"Veldwijk-Rouwenhorst AE, Smalbrugge M, Wetzels R et al (2017) Nursing home residents with dementia and very frequent agitation: a particular group. Am J Geriatr Psychiatry 25:1339\u20131348","journal-title":"Am J Geriatr Psychiatry"},{"issue":"7","key":"234_CR24","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.jagp.2012.12.006","volume":"22","author":"BS Husebo","year":"2014","unstructured":"Husebo BS, Ballard C, Cohen-Mansfield J et al (2014) The response of agitated behaviour to pain management in persons with dementia. Am J Geriatr Psychiatry 22(7):708\u2013717","journal-title":"Am J Geriatr Psychiatry"},{"issue":"6","key":"234_CR25","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.jpainsymman.2018.09.005","volume":"56","author":"LJ Hunt","year":"2018","unstructured":"Hunt LJ, Ritchie CS, Cataldo JK, Patel K, Stephens CE, Smith AK (2018) Pain and emergency department use in the last month of life among older adults with dementia. J Pain Symptom Manag 56(6):871\u2013877","journal-title":"J Pain Symptom Manag"},{"issue":"10","key":"234_CR26","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1111\/jgs.15519","volume":"66","author":"SE Bronskill","year":"2018","unstructured":"Bronskill SE, Campitelli MA, Laboni A et al (2018) Low-dose trazodone, benzodiazepines, and fall-related injuries in nursing homes: a matched-cohort study. J Am Geriatr Soc 66(10):1963\u20131971","journal-title":"J Am Geriatr Soc"},{"key":"234_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12877-019-1159-2","volume":"19","author":"M Boyd","year":"2019","unstructured":"Boyd M, Frey R, Balmer D et al (2019) End of life care for long-term care residents with dementia, chronic illness and cancer: prospective staff survey. BMC Geriatr 19:137","journal-title":"BMC Geriatr"},{"issue":"10","key":"234_CR28","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1177\/0269216318800610","volume":"32","author":"L Pivodic","year":"2018","unstructured":"Pivodic L, Smets T, Van den Noortgate N et al (2018) Quality of dying and quality of end-of-life care of nursing home residents in six countries: an epidemiological study. Palliat Med 32(10):1584\u20131595","journal-title":"Palliat Med"},{"key":"234_CR29","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1136\/bmjspcare-2013-000527","volume":"3","author":"EAT Maas","year":"2013","unstructured":"Maas EAT, Murray SA, Engels Y et al (2013) What tools are available to identify patients with palliative care needs in primary care: a systematic literature review and survey of European practice. Br Med J Support Palliat Care 3:444\u2013451","journal-title":"Br Med J Support Palliat Care"},{"key":"234_CR30","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12916-017-0907-4","volume":"15","author":"N White","year":"2017","unstructured":"White N, Kupeli N, Vickerstaff V et al (2017) How accurate is the \u201cSurprise Question\u201d at identifying patients at the end of life? A systematic review and meta-analysis. BMC Med 15:139","journal-title":"BMC Med"},{"key":"234_CR31","doi-asserted-by":"publisher","first-page":"E484","DOI":"10.1503\/cmaj.160775","volume":"189","author":"J Downar","year":"2017","unstructured":"Downar J, Goldman R, Pinto R et al (2017) The \u201csurprise question\u201d for predicting death in seriously ill patients: a systematic review and meta-analysis. Can Med Assoc J 189:E484\u2013E493","journal-title":"Can Med Assoc J"},{"key":"234_CR32","unstructured":"Online access: \nhttp:\/\/www.goldstandardsframework.org.uk\/library-tools-amp-resources\n\n. Accessed on 26th May 2019"},{"key":"234_CR33","unstructured":"Online access: \nhttp:\/\/www.spict.org.uk\/\n\n. Accessed on 26th May 2019"},{"key":"234_CR34","unstructured":"Online access: \nhttp:\/\/www.sfap.org\/system\/files\/pallia10.pdf\n\n. Accessed on 26th May 2019"},{"issue":"6","key":"234_CR35","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jamda.2018.08.015","volume":"20","author":"MG Oosterveld-Vlug","year":"2018","unstructured":"Oosterveld-Vlug MG, Pasman HRW, ten Koppel M et al (2018) Physician visits and recognition of residents\u2019 terminal phase in long-term care facilities: findings from the PACE cross-sectional study in 6 EU Countries. J Am Med Dir Assoc 20(6):696\u2013702","journal-title":"J Am Med Dir Assoc"},{"key":"234_CR36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1472-6963-12-5","volume":"12","author":"G Onder","year":"2012","unstructured":"Onder G, Carpenter I, Finne-Soveri H et al (2012) Assessment of nursing home residents in Europe: the service and health for elderly in long term care (SHELTER) study. BMC Health Serv Res 12:5","journal-title":"BMC Health Serv Res"},{"issue":"2","key":"234_CR37","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12603-012-0403-7","volume":"17","author":"Y Rolland","year":"2013","unstructured":"Rolland Y, Tavassoli N, Gillette-Guyonnet S et al (2013) Multidisciplinary team meetings in detection of Alzheimer\u2019s disease: data from the IDEM study. J Nutr Health Ageing 17(2):137\u2013141","journal-title":"J Nutr Health Ageing"},{"key":"234_CR38","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/ageing\/afz015","volume":"48","author":"N Wiggins","year":"2019","unstructured":"Wiggins N, Droney J, Mohammed K, Riley J, Sleeman KE (2019) Understanding the factors associated with dementia achieving their preferred place of death: a retrospective cohort study. Age Ageing 48:433\u2013439","journal-title":"Age Ageing"},{"issue":"4","key":"234_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/0269216319834227","volume":"33","author":"S Amador","year":"2019","unstructured":"Amador S, Sampson EL, Goodman C, Robinson L, Seed Research Team (2019) A systematic review and critical appraisal of quality indicators to assess optimal palliative care for older people with dementia. Palliat Med 33(4):415\u2013429","journal-title":"Palliat Med"},{"issue":"8","key":"234_CR40","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1111\/jgs.15927","volume":"67","author":"SE Hickman","year":"2019","unstructured":"Hickman SE, Unroe KT, Ersek M et al (2019) Systematic advance care planning and potentially avoidable hospitalizations of nursing facility residents. J Am Geriatr Soc 67(8):1649\u20131655","journal-title":"J Am Geriatr Soc"}],"container-title":["European Geriatric Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-019-00234-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s41999-019-00234-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-019-00234-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T23:24:28Z","timestamp":1599348268000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s41999-019-00234-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,7]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["234"],"URL":"https:\/\/doi.org\/10.1007\/s41999-019-00234-9","relation":{},"ISSN":["1878-7657"],"issn-type":[{"value":"1878-7657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,7]]},"assertion":[{"value":"11 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no conflict of interest related to this research article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol follow the principles of the 1964 Helskinki declaration and was approved by the ethic committee of the Toulouse University Hospital and the Consultative Committee for the Treatment of Research Information on Health (\u201cCommission Nationale de l\u2019Informatique et des Libert\u00e9s\u201d, CNIL decision no 07-438).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Nursing homes volunteered to participate in IQUARE trial. Individual consent to participate was sought for each of the residents participating in the study. Residents who expressed a refusal to participate were not included.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}