{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:45:25Z","timestamp":1772102725501,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"JSPS KAKENHI","award":["19H03978"],"award-info":[{"award-number":["19H03978"]}]},{"DOI":"10.13039\/100008702","name":"Kagoshima University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008702","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Geriatr Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Polymorphisms (rs1815739; R577X) in the gene encoding alpha-actinin-3 (ACTN3) are thought to be associated with body composition and physical function in older people and athletes. RR homozygotes are associated with greater expression of ACTN3 protein in muscle than the X-allele carriers. We aimed to investigate the association between <jats:italic>ACTN3<\/jats:italic> R577X polymorphism and appendicular skeletal muscle mass, walking speed, and muscle strength in older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A cross-sectional analysis was performed on 265 community-dwelling older adults (mean age 74.0\u2009\u00b1\u20095.8\u00a0years, 63.4% female) who provided data on <jats:italic>ACTN3<\/jats:italic> gene polymorphisms and completed surveys in the Tarumizu study conducted between 2018 and 2019. Genetic polymorphisms were categorized as RR homozygous and X allele. Muscle mass was assessed using the appendicular skeletal muscle mass index (ASMI), and physical function was assessed based on walking speed and relative muscle strength. Those in the bottom 25% for each sex were considered \u201clow\u201d and the association with <jats:italic>ACTN3<\/jats:italic> genotype was examined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Considering <jats:italic>ACTN3<\/jats:italic> polymorphism, 72 participants were RR homozygotes (27.2%) and 193 were X-allele carriers (72.8%). After adjusting for potential confounders, RR homozygosity was associated with not having low muscle mass (odds ratio 0.39, 95% confidence interval 0.19\u20130.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) but not with low walking speed and muscle strength.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The association between <jats:italic>ACTN3<\/jats:italic> genotype and physical function in community-dwelling older adults is not clear; however, it is considered to be associated with muscle mass.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s41999-024-01080-0","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T20:29:33Z","timestamp":1729283373000},"page":"15-22","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults"],"prefix":"10.1007","volume":"16","author":[{"given":"Daijo","family":"Shiratsuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoma","family":"Akaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-675X","authenticated-orcid":false,"given":"Hyuma","family":"Makizako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"13","key":"1080_CR1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/hmg\/10.13.1335","volume":"10","author":"M Mills","year":"2001","unstructured":"Mills M, Yang N, Weinberger R et al (2001) Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. 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