{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:56:47Z","timestamp":1787907407859,"version":"build-2784847793"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Geriatr Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Dysphagia in persons living with dementia (PLWD) is raising concern due to the absence of swallowing treatments specific to this population. Dysphagia can result in detrimental effects, such as malnutrition, dehydration, and aspiration pneumonia. This systematic review aimed to evaluate the existing literature on dysphagia management of PLWD and reveal their limitations to facilitate clinical practitioners in decision-making.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Five electronic databases were searched systematically from the date of inception to January 2024 by two independent reviewers. Eligible studies investigated any treatments with outcome measurements evaluating swallowing function. Qualitative analyses were performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 10 studies, involving 1360 participants, were included in the systematic review. They were analyzed qualitatively and evaluated for quality. Studies included were observational (<jats:italic>n<\/jats:italic>\u2009=\u20095) with prospective or retrospective designs, and randomized controlled trials (<jats:italic>n<\/jats:italic>\u2009=\u20095). Compensatory, rehabilitative, stimulation, and pharmacological treatments were addressed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>There is currently limited evidence available revealing the efficacy of dysphagia treatments for PLWD. Based on the current evidence, no definitive conclusions can be drawn on which treatments are more effective for this population. In the future, more randomized controlled trials with large sample sizes investigating the long-term effects of treatments are warranted.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s41999-024-01107-6","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T09:30:29Z","timestamp":1732872629000},"page":"1573-1585","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A systematic review on dysphagia treatments for persons living with dementia"],"prefix":"10.1007","volume":"15","author":[{"given":"Charis Tsz Wun","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsz Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-7976","authenticated-orcid":false,"given":"Ivy","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"issue":"17","key":"1107_CR1","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1001\/jama.2019.11653","volume":"322","author":"Z Arvanitakis","year":"2019","unstructured":"Arvanitakis Z, Bennett D (2019) What is dementia? JAMA 322(17):1728","journal-title":"JAMA"},{"key":"1107_CR2","unstructured":"WHO (2023) World Health Organization"},{"issue":"1","key":"1107_CR3","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1038\/s41467-022-31037-5","volume":"13","author":"S Qiu","year":"2022","unstructured":"Qiu S, Miller MI, Joshi PS et al (2022) Multimodal deep learning for Alzheimer\u2019s disease dementia assessment. Nat Commun 13(1):3404","journal-title":"Nat Commun"},{"issue":"1","key":"1107_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/archneur.64.1.58","volume":"64","author":"SE Langmore","year":"2007","unstructured":"Langmore SE, Olney RK, Lomen-Hoerth C et al (2007) Dysphagia in patients with frontotemporal lobar dementia. Arch Neurol 64(1):58","journal-title":"Arch Neurol"},{"issue":"1","key":"1107_CR5","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/1471-2377-13-140","volume":"13","author":"E Londos","year":"2013","unstructured":"Londos E, Hanxsson O, Alm Hirsch I et al (2013) Dysphagia in Lewy body dementia\u2014a clinical observational study of swallowing function by videofluoroscopic examination. BMC Neurol 13(1):140","journal-title":"BMC Neurol"},{"issue":"3","key":"1107_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neucli.2015.12.007","volume":"46","author":"Y Se\u00e7il","year":"2016","unstructured":"Se\u00e7il Y, Ar\u0131c\u0131 \u015e, \u0130ncesu TK et al (2016) Dysphagia in Alzheimer\u2019s disease. Neurophysiol Clin 46(3):171\u2013178","journal-title":"Neurophysiol Clin"},{"issue":"12","key":"1107_CR7","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1111\/jgs.12553","volume":"61","author":"RH Affoo","year":"2013","unstructured":"Affoo RH, Foley N, Rosenbek J et al (2013) Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer\u2019s disease: a scoping review of the evidence. J Am Geriatr Soc 61(12):2203\u20132213","journal-title":"J Am Geriatr Soc"},{"key":"1107_CR8","unstructured":"Leonard R, Kendall K (2019) Dysphagia assessment and treatment planning: a team approach, 4th edn. Plural Publishing Inc"},{"key":"1107_CR9","doi-asserted-by":"publisher","first-page":"233372142211429","DOI":"10.1177\/23337214221142949","volume":"8","author":"C Estupi\u00f1\u00e1n Artiles","year":"2022","unstructured":"Estupi\u00f1\u00e1n Artiles C, Regan J, Donnellan C (2022) Physiological mechanisms and associated pathophysiology of dysphagia in older adults. Gerontol Geriatr Med 8:233372142211429","journal-title":"Gerontol Geriatr Med"},{"issue":"12","key":"1107_CR10","first-page":"1407","volume":"57","author":"R Gallagher","year":"2011","unstructured":"Gallagher R (2011) Swallowing difficulties: a prognostic signpost. Can Fam Physician 57(12):1407\u20131409","journal-title":"Can Fam Physician"},{"issue":"4","key":"1107_CR11","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/PL00009539","volume":"12","author":"BA Priefer","year":"1997","unstructured":"Priefer BA, Robbins J (1997) Eating changes in mild-stage Alzheimer\u2019s disease: a pilot study. Dysphagia 12(4):212\u2013221","journal-title":"Dysphagia"},{"issue":"1","key":"1107_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archger.2012.04.011","volume":"56","author":"K Alagiakrishnan","year":"2013","unstructured":"Alagiakrishnan K, Bhanji RA, Kurian M (2013) Evaluation and management of oropharyngeal dysphagia in different types of dementia: a systematic review. Arch Gerontol Geriatr 56(1):1\u20139","journal-title":"Arch Gerontol Geriatr"},{"key":"1107_CR13","doi-asserted-by":"crossref","unstructured":"Aslan Kirazoglu D, Heybeli C, Atc\u0131yurt K et al (2024) The relationship between dehydration and etiologic subtypes of major neurocognitive disorder in older patients. Eur Geriatr Med 1\u201310","DOI":"10.1007\/s41999-024-00986-z"},{"issue":"3","key":"1107_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/ageing\/afn064","volume":"37","author":"N Foley","year":"2008","unstructured":"Foley N, Teasell R, Salter K et al (2008) Dysphagia treatment post stroke: a systematic review of randomised controlled trials. Age Ageing 37(3):258\u2013264","journal-title":"Age Ageing"},{"issue":"8","key":"1107_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14517","volume":"35","author":"I Cheng","year":"2023","unstructured":"Cheng I, Sasegbon A, Hamdy S (2023) Dysphagia treatments in Parkinson\u2019s disease: a systematic review and meta-analysis. Neurogastroenterol Motil 35(8):e14517","journal-title":"Neurogastroenterol Motil"},{"key":"1107_CR16","unstructured":"Ashford J, McCabe D, Wheeler-Hegland K et al. (2009) Evidence-based systematic review: Oropharyngeal dysphagia behavioral treatments. Part III\u2014impact of dysphagia treatments on populations with neurological disorders. J Rehabil Res Dev 46(2)"},{"issue":"3","key":"1107_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583","volume":"18","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med 18(3):e1003583","journal-title":"PLoS Med"},{"key":"1107_CR18","doi-asserted-by":"crossref","unstructured":"Sterne, JAC, Savovi\u0107, J, Page, MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ l4898","DOI":"10.1136\/bmj.l4898"},{"key":"1107_CR19","doi-asserted-by":"crossref","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ i4919","DOI":"10.1136\/bmj.i4919"},{"issue":"10","key":"1107_CR20","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s12603-014-0487-3","volume":"18","author":"MTG Cintra","year":"2014","unstructured":"Cintra MTG, De Rezende NA, De Moraes EN et al (2014) A comparison of survival, pneumonia, and hospitalization in patients with advanced dementia and dysphagia receiving either oral or enteral nutrition. J Nutr Health Aging 18(10):894\u2013899","journal-title":"J Nutr Health Aging"},{"issue":"9","key":"1107_CR21","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.jamda.2022.03.011","volume":"23","author":"JK Yuen","year":"2022","unstructured":"Yuen JK, Luk JKH, Chan T-C et al (2022) Reduced pneumonia risk in advanced dementia patients on careful hand feeding compared with nasogastric tube feeding. J Am Med Dir Assoc 23(9):1541-1547.e2","journal-title":"J Am Med Dir Assoc"},{"issue":"10","key":"1107_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217120","volume":"14","author":"S Masaki","year":"2019","unstructured":"Masaki S, Kawamoto T (2019) Comparison of long-term outcomes between enteral nutrition via gastrostomy and total parenteral nutrition in older persons with dysphagia: a propensity-matched cohort study. PLoS ONE 14(10):e0217120","journal-title":"PLoS ONE"},{"issue":"24","key":"1107_CR23","doi-asserted-by":"publisher","first-page":"7739","DOI":"10.3748\/wjg.v20.i24.7739","volume":"20","author":"AA Rahnemai-Azar","year":"2014","unstructured":"Rahnemai-Azar AA (2014) Percutaneous endoscopic gastrostomy: indications, technique, complications and management. World J Gastroenterol 20(24):7739","journal-title":"World J Gastroenterol"},{"issue":"2","key":"1107_CR24","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3390\/nu5020608","volume":"5","author":"S Abunnaja","year":"2013","unstructured":"Abunnaja S, Cuviello A, Sanchez J (2013) Enteral and parenteral nutrition in the perioperative period: state of the art. Nutrients 5(2):608\u2013623","journal-title":"Nutrients"},{"issue":"9","key":"1107_CR25","doi-asserted-by":"publisher","first-page":"755","DOI":"10.2340\/16501977-0243","volume":"40","author":"I Bautmans","year":"2008","unstructured":"Bautmans I, Demarteau J, Cruts B et al (2008) Dysphagia in elderly nursing home residents with severe cognitive impairment can be attenuated by cervical spine mobilization. J Rehabil Med 40(9):755\u2013760","journal-title":"J Rehabil Med"},{"issue":"5\u20136","key":"1107_CR26","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/jocn.13013","volume":"25","author":"LL Chen","year":"2016","unstructured":"Chen LL, Li H, Lin R et al (2016) Effects of a feeding intervention in patients with Alzheimer\u2019s disease and dysphagia. J Clin Nurs 25(5\u20136):699\u2013707","journal-title":"J Clin Nurs"},{"issue":"1","key":"1107_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1044\/1092-4388(2008\/013)","volume":"51","author":"JA Logemann","year":"2008","unstructured":"Logemann JA, Gensler G, Robbins J et al (2008) A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson\u2019s disease. J Speech Lang Hear Res 51(1):173\u2013183","journal-title":"J Speech Lang Hear Res"},{"issue":"7","key":"1107_CR28","doi-asserted-by":"publisher","first-page":"509","DOI":"10.7326\/0003-4819-148-7-200804010-00007","volume":"148","author":"J Robbins","year":"2008","unstructured":"Robbins J (2008) Comparison of 2 interventions for liquid aspiration on pneumonia incidence: a randomized trial. Ann Intern Med 148(7):509","journal-title":"Ann Intern Med"},{"key":"1107_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2023.104649","volume":"150","author":"J Ye","year":"2024","unstructured":"Ye J, Wu C, Chen J et al (2024) Effectiveness of nurse-delivered stepwise swallowing training on dysphagia in patients with Alzheimer\u2019s disease: a multi-center randomized controlled trial. Int J Nurs Stud 150:104649","journal-title":"Int J Nurs Stud"},{"key":"1107_CR30","doi-asserted-by":"crossref","unstructured":"Tang, Y, Lin, X, Lin, X-j, et al (2017) Therapeutic efficacy of neuromuscular electrical stimulation and electromyographic biofeedback on Alzheimer's disease patients with dysphagia. Medicine 96(36): e8008","DOI":"10.1097\/MD.0000000000008008"},{"issue":"4","key":"1107_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/MD.0b013e318224413b","volume":"90","author":"T Nakashima","year":"2011","unstructured":"Nakashima T, Hattori N, Okimoto M et al (2011) Nicergoline improves dysphagia by upregulating substance P in the elderly. Medicine 90(4):279\u2013283","journal-title":"Medicine"},{"issue":"9","key":"1107_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.2165\/00044011-200828090-00001","volume":"28","author":"B Winblad","year":"2008","unstructured":"Winblad B, Fioravanti M, Dolezal T et al (2008) Therapeutic use of nicergoline. Clin Drug Investig 28(9):533\u2013552","journal-title":"Clin Drug Investig"},{"issue":"9144","key":"1107_CR33","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/S0140-6736(05)60437-0","volume":"352","author":"T Arai","year":"1998","unstructured":"Arai T, Yasuda Y, Toshima S et al (1998) ACE inhibitors and pneumonia in elderly people. Lancet 352(9144):1937\u20131938","journal-title":"Lancet"},{"issue":"9133","key":"1107_CR34","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/S0140-6736(05)60114-6","volume":"352","author":"K Sekizawa","year":"1998","unstructured":"Sekizawa K, Matsui T, Nakagawa T et al (1998) ACE inhibitors and pneumonia. Lancet 352(9133):1069","journal-title":"Lancet"},{"issue":"8","key":"1107_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137260","volume":"10","author":"R Clark","year":"2015","unstructured":"Clark R, Freedberg M, Hazeltine E et al (2015) Are there age-related differences in the ability to learn configural responses? PLoS ONE 10(8):e0137260","journal-title":"PLoS ONE"},{"issue":"2","key":"1107_CR36","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1097\/WAD.0b013e318192a539","volume":"23","author":"MK Suh","year":"2009","unstructured":"Suh MK, Kim H, Na DL (2009) Dysphagia in patients with dementia: alzheimer versus vascular. Alzheimer Dis Assoc Disord 23(2):178\u2013184","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"4","key":"1107_CR37","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1136\/jnnp.73.4.371","volume":"73","author":"M Ikeda","year":"2002","unstructured":"Ikeda M (2002) Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer\u2019s disease. J Neurol Neurosurg Psychiatry 73(4):371\u2013376","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"1107_CR38","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12877-017-0531-3","volume":"17","author":"M Arahata","year":"2017","unstructured":"Arahata M, Oura M, Tomiyama Y et al (2017) A comprehensive intervention following the clinical pathway of eating and swallowing disorder in the elderly with dementia: historically controlled study. BMC Geriatr 17(1):146\u2013146","journal-title":"BMC Geriatr"},{"issue":"6","key":"1107_CR39","doi-asserted-by":"publisher","first-page":"544","DOI":"10.7861\/clinmedicine.9-6-544","volume":"9","author":"HA Smith","year":"2009","unstructured":"Smith HA, Kindell J, Baldwin RC et al (2009) Swallowing problems and dementia in acute hospital settings: practical guidance for the management of dysphagia. Clin Med (Lond) 9(6):544\u2013548","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"1107_CR40","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/BF02407267","volume":"4","author":"JA O'Gara","year":"1990","unstructured":"O\u2019Gara JA (1990) Dietary adjustments and nutritional therapy during treatment for Oral-Pharyngeal Dysphagia. Dysphagia 4(4):209\u2013212","journal-title":"Dysphagia"},{"issue":"4","key":"1107_CR41","first-page":"221","volume":"31","author":"BJ Smith","year":"2015","unstructured":"Smith BJ, Chong L, Nam S et al (2015) Dysphagia in a palliative care setting\u2014a coordinated overview of caregivers\u2019 responses to dietary changes: the DysCORD qualitative study. J Palliat Med 31(4):221\u2013227","journal-title":"J Palliat Med"},{"issue":"11","key":"1107_CR42","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1111\/j.1532-5415.2011.03629.x","volume":"59","author":"LC Hanson","year":"2011","unstructured":"Hanson LC, Carey TS, Caprio AJ et al (2011) Improving decision-making for feeding options in advanced dementia: a randomized. Controlled Trial J Am Geriatr Soc 59(11):2009\u20132016","journal-title":"Controlled Trial J Am Geriatr Soc"},{"key":"1107_CR43","unstructured":"World Health Organization (2001) International Classification of Functioning, Disability and Health"},{"issue":"8","key":"1107_CR44","first-page":"637","volume":"69","author":"ML Splaingard","year":"1988","unstructured":"Splaingard ML, Hutchins B, Sulton L et al (1988) Aspiration in rehabilitation patients: videofluoroscopy vs bedside clinical assessment. Arch Phys Med Rehabil 69(8):637\u2013640","journal-title":"Arch Phys Med Rehabil"}],"container-title":["European Geriatric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-024-01107-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s41999-024-01107-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-024-01107-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T01:25:19Z","timestamp":1733880319000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s41999-024-01107-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1107"],"URL":"https:\/\/doi.org\/10.1007\/s41999-024-01107-6","relation":{},"ISSN":["1878-7657"],"issn-type":[{"value":"1878-7657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]},"assertion":[{"value":"8 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was not required for this study because it was based exclusively on published literature.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}