{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:37:16Z","timestamp":1789043836714,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"None"},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Geriatr Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Key summary points<\/jats:title>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aim<\/jats:title>\n            <jats:p>To examine the association between early mobilization after hip fracture surgery and the risk of long-term opioid therapy at 1-year follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Findings<\/jats:title>\n            <jats:p>Long-term opioid therapy is a common complication after hip fracture surgery.<\/jats:p>\n            <jats:p>Mobilization within 24\u00a0h after surgery is associated with a lower risk of long-term opioid therapy compared to mobilization between 24 and 36\u00a0h.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Message<\/jats:title>\n            <jats:p>Early mobilization is one of the key elements of the successful patient recovery for reducing risk of complications and mortality after hip fracture surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Abstract<\/jats:title>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Early mobilization after hip fracture operation is associated with better clinical outcomes, but its impact on long-term opioid therapy (LTOT) remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Using Danish population-based registries we included patients aged\u2009\u2265\u200965 who underwent surgery for a first-time hip fracture between 2016 and 2021 (<jats:italic>n<\/jats:italic>\u2009=\u200936,229). LTOT was defined as redeeming\u2009\u2265\u20092 prescriptions between 31 and 365\u00a0days of surgery. Using stabilized inverse probability of treatment (sIPT) weighing, we calculated risks and risk differences with 95% confidence intervals (CI) for opioid use balancing mobilization groups\u2009\u2264\u200924\u00a0h vs 24\u201336\u00a0h on measured confounders and taking death into consideration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>67.3% of all patients were women and the median age was 82.6\u00a0years (75.8; 88.6). 75% of patients were mobilized\u2009\u2264\u200924\u00a0h of surgery, whereas 8% were mobilized between 24 and 36\u00a0h, 4.9%\u2009&gt;\u200936\u00a0h, and 12.1% had missing data on mobilization. Patients mobilized\u2009\u2264\u200924\u00a0h and 24\u201336\u00a0h were similar in age, fracture type, and marital status, but those mobilized\u2009\u2264\u200924\u00a0h had fewer comorbidities, better pre-fracture mobility, and a higher social position. They also had a lower risk of LTOT (29.99%) compared to those mobilized 24\u201336\u00a0h (33.42%), with a weighted risk difference of 3.44% (95% CI 1.58\u20135.30).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>LTOT is common after hip fracture surgery. Mobilization\u2009\u2264\u200924\u00a0h after surgery is associated with a lower risk of LTOT compared to mobilization between 24 and 36\u00a0h. Early mobilization is one of the key elements of successful patient recovery for reducing complications and mortality after hip fracture surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s41999-025-01227-7","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T14:04:40Z","timestamp":1746626680000},"page":"921-931","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between early mobilization after hip fracture surgery and risk of long-term opioid therapy"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0131-4383","authenticated-orcid":false,"given":"Yasmina Maria","family":"Tudorache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina Trolle","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-5801","authenticated-orcid":false,"given":"Thomas J.","family":"Hjelholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-4677","authenticated-orcid":false,"given":"Morten Tange","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-7454","authenticated-orcid":false,"given":"Katie J.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-9401","authenticated-orcid":false,"given":"Alma B.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"issue":"10","key":"1227_CR1","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1007\/s00198-017-4153-6","volume":"28","author":"S Williamson","year":"2017","unstructured":"Williamson S, Landeiro F, McConnell T et al (2017) Costs of fragility hip fractures globally: a systematic review and meta-regression analysis. Osteoporos Int 28(10):2791\u20132800. https:\/\/doi.org\/10.1007\/s00198-017-4153-6","journal-title":"Osteoporos Int"},{"issue":"8","key":"1227_CR2","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/jbmr.4821","volume":"38","author":"CW Sing","year":"2023","unstructured":"Sing CW, Lin TC, Bartholomew S et al (2023) Global epidemiology of hip fractures: secular trends in incidence rate, post-fracture treatment, and all-cause mortality. J Bone Miner Res 38(8):1064\u20131075. https:\/\/doi.org\/10.1002\/jbmr.4821","journal-title":"J Bone Miner Res"},{"key":"1227_CR3","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab233","author":"TJ Hjelholt","year":"2022","unstructured":"Hjelholt TJ, Johnsen SP, Brynningsen PK, Knudsen JS, Prieto-Alhambra D, Pedersen AB (2022) Development and validation of a model for predicting mortality in patients with hip fracture. Age Ageing. https:\/\/doi.org\/10.1093\/ageing\/afab233","journal-title":"Age Ageing"},{"key":"1227_CR4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.bone.2019.07.023","volume":"127","author":"KE Kjorholt","year":"2019","unstructured":"Kjorholt KE, Kristensen NR, Prieto-Alhambra D, Johnsen SP, Pedersen AB (2019) Increased risk of mortality after postoperative infection in hip fracture patients. Bone 127:563\u2013570. https:\/\/doi.org\/10.1016\/j.bone.2019.07.023","journal-title":"Bone"},{"issue":"2","key":"1227_CR5","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1093\/aje\/kwy251","volume":"188","author":"A Lunde","year":"2019","unstructured":"Lunde A, Tell GS, Pedersen AB et al (2019) The Role of Comorbidity in Mortality After Hip Fracture: A Nationwide Norwegian Study of 38,126 Women With Hip Fracture Matched to a General-Population Comparison Cohort. Am J Epidemiol 188(2):398\u2013407. https:\/\/doi.org\/10.1093\/aje\/kwy251","journal-title":"Am J Epidemiol"},{"issue":"8","key":"1227_CR6","doi-asserted-by":"publisher","first-page":"e016939","DOI":"10.1136\/bmjopen-2017-016939","volume":"7","author":"KJ Sheehan","year":"2017","unstructured":"Sheehan KJ, Sobolev B, Vill\u00e1n Vill\u00e1n YF, Guy P (2017) Patient and system factors of time to surgery after hip fracture: a scoping review. BMJ Open 7(8):e016939","journal-title":"BMJ Open"},{"issue":"9","key":"1227_CR7","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/ejp.2271","volume":"28","author":"IM Melsen","year":"2024","unstructured":"Melsen IM, Sz\u00e9pligeti SK, Gundtoft PH, Pedersen AB (2024) Time trends in opioid use for patients undergoing hip fracture surgery in 1997\u20132018: A Danish population-based cohort study. Eur J Pain 28(9):1486\u20131496","journal-title":"Eur J Pain"},{"issue":"7","key":"1227_CR8","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1002\/ejp.1392","volume":"23","author":"AH Simoni","year":"2019","unstructured":"Simoni AH, Nikolajsen L, Olesen AE, Christiansen CF, Pedersen AB (2019) Opioid use after hip fracture surgery: a Danish nationwide cohort study from 2005 to 2015. Eur J Pain 23(7):1309\u20131317. https:\/\/doi.org\/10.1002\/ejp.1392","journal-title":"Eur J Pain"},{"issue":"2 Suppl","key":"1227_CR9","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","volume":"11","author":"R Benyamin","year":"2008","unstructured":"Benyamin R, Trescot AM, Datta S et al (2008) Opioid complications and side effects. Pain Phys 11(2 Suppl):S105\u2013S120","journal-title":"Pain Phys"},{"issue":"1","key":"1227_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.7861\/clinmedicine.15-1-47","volume":"15","author":"O Mukhtar","year":"2015","unstructured":"Mukhtar O, Jackson SH (2015) Drug therapies in older adults (part 1). Clin Med (Lond) 15(1):47\u201353. https:\/\/doi.org\/10.7861\/clinmedicine.15-1-47","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"1227_CR11","doi-asserted-by":"publisher","first-page":"E432","DOI":"10.1503\/cjs.006822","volume":"66","author":"I Horton","year":"2023","unstructured":"Horton I, Bourget-Murray J, Buth O et al (2023) Delayed mobilization following admission for hip fracture is associated with increased morbidity and length of hospital stay. Can J Surg Jul-Aug 66(4):E432-e438. https:\/\/doi.org\/10.1503\/cjs.006822","journal-title":"Can J Surg Jul-Aug"},{"issue":"4","key":"1227_CR12","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s41999-020-00317-y","volume":"11","author":"H Ferris","year":"2020","unstructured":"Ferris H, Brent L, Coughlan T (2020) Early mobilisation reduces the risk of in-hospital mortality following hip fracture. Eur Geriatr Med 11(4):527\u2013533. https:\/\/doi.org\/10.1007\/s41999-020-00317-y","journal-title":"Eur Geriatr Med"},{"issue":"2","key":"1227_CR13","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/ageing\/afaa204","volume":"50","author":"KJ Sheehan","year":"2021","unstructured":"Sheehan KJ, Goubar A, Almilaji O et al (2021) Discharge after hip fracture surgery by mobilisation timing: secondary analysis of the UK National Hip Fracture Database. Age Ageing 50(2):415\u2013422. https:\/\/doi.org\/10.1093\/ageing\/afaa204","journal-title":"Age Ageing"},{"issue":"7","key":"1227_CR14","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1177\/02692155241231225","volume":"38","author":"MT Kristensen","year":"2024","unstructured":"Kristensen MT, Turabi R, Sheehan KJ (2024) The relationship between extent of mobilisation within the first postoperative day and 30-day mortality after hip fracture surgery. Clin Rehabil 38(7):990\u2013997. https:\/\/doi.org\/10.1177\/02692155241231225","journal-title":"Clin Rehabil"},{"issue":"7","key":"1227_CR15","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.injury.2021.04.037","volume":"52","author":"JD Vesterager","year":"2021","unstructured":"Vesterager JD, Kristensen MT, Pedersen AB (2021) Loss of pre-fracture basic mobility status at hospital discharge for hip fracture is associated with 30-day post-discharge risk of infections - a four-year nationwide cohort study of 23,309 Danish patients. Injury 52(7):1833\u20131840. https:\/\/doi.org\/10.1016\/j.injury.2021.04.037","journal-title":"Injury"},{"issue":"1","key":"1227_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1863","volume":"22","author":"N Agarwal","year":"2024","unstructured":"Agarwal N, Feng T, Maclullich A, Duckworth A, Clement N (2024) Early mobilisation after hip fracture surgery is associated with improved patient outcomes: a systematic review and meta-analysis. Musculoskeletal Care 22(1):e1863. https:\/\/doi.org\/10.1002\/msc.1863","journal-title":"Musculoskeletal Care"},{"key":"1227_CR17","doi-asserted-by":"publisher","DOI":"10.1177\/23779608231167825","author":"NN Aprisunadi","year":"2023","unstructured":"Aprisunadi NN, Mustikasari M, Ifadah E, Hapsari ED (2023) Effect of early mobilization on hip and lower extremity postoperative: a literature review. SAGE Open Nurs. https:\/\/doi.org\/10.1177\/23779608231167825","journal-title":"SAGE Open Nurs"},{"issue":"8","key":"1227_CR18","doi-asserted-by":"publisher","first-page":"e185909","DOI":"10.1001\/jamanetworkopen.2018.5909","volume":"1","author":"E Sun","year":"2018","unstructured":"Sun E, Moshfegh J, Rishel CA, Cook CE, Goode AP, George SZ (2018) Association of early physical therapy with long-term opioid use among opioid-naive patients with musculoskeletal pain. JAMA Netw Open 1(8):e185909","journal-title":"JAMA Netw Open"},{"key":"1227_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/CLEP.S231578","volume":"12","author":"PK Kristensen","year":"2020","unstructured":"Kristensen PK, Rock ND, Christensen HC, Pedersen AB (2020) The Danish multidisciplinary hip fracture registry 13-year results from a population-based cohort of hip fracture patients. Clin Epidemiol 12:9\u201321. https:\/\/doi.org\/10.2147\/CLEP.S231578","journal-title":"Clin Epidemiol"},{"key":"1227_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2147\/CLEP.S179083","volume":"11","author":"M Schmidt","year":"2019","unstructured":"Schmidt M, Schmidt SAJ, Adelborg K et al (2019) The Danish health care system and epidemiological research: from health care contacts to database records. Clin Epidemiol 11:563\u2013591. https:\/\/doi.org\/10.2147\/CLEP.S179083","journal-title":"Clin Epidemiol"},{"key":"1227_CR21","unstructured":"Denmark S. Quality in the production of statistics. 02.10, 2024. https:\/\/www.dst.dk\/en\/OmDS\/strategi-og-kvalitet\/kvalitet-for-statistikproduktion. Accessed 3 May 2025"},{"key":"1227_CR22","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/clep.S91125","volume":"7","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Schmidt SA, Sandegaard JL, Ehrenstein V, Pedersen L, S\u00f8rensen HT (2015) The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol 7:449\u2013490. https:\/\/doi.org\/10.2147\/clep.S91125","journal-title":"Clin Epidemiol"},{"key":"1227_CR23","unstructured":"Dansk Tv\u00e6rfagligt Register for Hoften\u00e6re L\u00e5rbensbrud \u00c5rsrapport 2023. 2023. https:\/\/www.rkkp.dk\/siteassets\/de-kliniske-kvalitetsdatabaser\/databaser\/hoftenare-larbensbrud\/aarsrapporter\/hoftebrud-2023-offentlig-version.pdf"},{"issue":"Suppl 4","key":"1227_CR24","doi-asserted-by":"publisher","first-page":"228s","DOI":"10.1038\/oby.2001.123","volume":"9","author":"PT James","year":"2001","unstructured":"James PT, Leach R, Kalamara E, Shayeghi M (2001) The worldwide obesity epidemic. Obes Res 9(Suppl 4):228s\u2013233s. https:\/\/doi.org\/10.1038\/oby.2001.123","journal-title":"Obes Res"},{"issue":"8","key":"1227_CR25","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1191\/0269215506cre987oa","volume":"20","author":"NB Foss","year":"2006","unstructured":"Foss NB, Kristensen MT, Kehlet H (2006) Prediction of postoperative morbidity, mortality and rehabilitation in hip fracture patients: the cumulated ambulation score. Clin Rehabil 20(8):701\u2013708. https:\/\/doi.org\/10.1191\/0269215506cre987oa","journal-title":"Clin Rehabil"},{"issue":"4","key":"1227_CR26","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s41999-024-00989-w","volume":"15","author":"NR Gadgaard","year":"2024","unstructured":"Gadgaard NR, Varnum C, Nelissen R, Vandenbroucke-Grauls C, S\u00f8rensen HT, Pedersen AB (2024) Major comorbid diseases as predictors of infection in the first month after hip fracture surgery: a population-based cohort study in 92,239 patients. Eur Geriatr Med 15(4):1069\u20131080. https:\/\/doi.org\/10.1007\/s41999-024-00989-w","journal-title":"Eur Geriatr Med"},{"issue":"3","key":"1227_CR27","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1586\/17512433.1.3.391","volume":"1","author":"MJ Zhang","year":"2008","unstructured":"Zhang MJ, Zhang X, Scheike TH (2008) Modeling cumulative incidence function for competing risks data. Expert Rev Clin Pharmacol 1(3):391\u2013400. https:\/\/doi.org\/10.1586\/17512433.1.3.391","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"1","key":"1227_CR28","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/ckj\/sfab158","volume":"15","author":"NC Chesnaye","year":"2022","unstructured":"Chesnaye NC, Stel VS, Tripepi G et al (2022) An introduction to inverse probability of treatment weighting in observational research. Clin Kidney J 15(1):14\u201320. https:\/\/doi.org\/10.1093\/ckj\/sfab158","journal-title":"Clin Kidney J"},{"issue":"1","key":"1227_CR29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3906\/sag-1906-57","volume":"50","author":"T Kuru","year":"2020","unstructured":"Kuru T, Ol\u00e7ar HA (2020) Effects of early mobilization and weight bearing on postoperative walking ability and pain in geriatric patients operated due to hip fracture: a retrospective analysis. Turk J Med Sci 50(1):117\u2013125. https:\/\/doi.org\/10.3906\/sag-1906-57","journal-title":"Turk J Med Sci"},{"issue":"3","key":"1227_CR30","doi-asserted-by":"publisher","first-page":"230949902110589","DOI":"10.1177\/23094990211058902","volume":"29","author":"Z Xiang","year":"2021","unstructured":"Xiang Z, Chen Z, Wang P et al (2021) The effect of early mobilization on functional outcomes after hip surgery in the Chinese population - A multicenter prospective cohort study. J Orthop Surg (Hong Kong) 29(3):23094990211058904","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"1227_CR31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1051\/sicotj\/2019005","volume":"5","author":"M Baer","year":"2019","unstructured":"Baer M, Neuhaus V, Pape HC, Ciritsis B (2019) Influence of mobilization and weight bearing on in-hospital outcome in geriatric patients with hip fractures. Sicot j 5:4. https:\/\/doi.org\/10.1051\/sicotj\/2019005","journal-title":"Sicot j"},{"issue":"1","key":"1227_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/17453674.2019.1683790","volume":"91","author":"TW Wainwright","year":"2020","unstructured":"Wainwright TW, Gill M, McDonald DA et al (2020) Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS(\u00ae)) Society recommendations. Acta Orthop 91(1):3\u201319. https:\/\/doi.org\/10.1080\/17453674.2019.1683790","journal-title":"Acta Orthop"},{"issue":"2","key":"1227_CR33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2217\/cer-2021-0258","volume":"11","author":"R Tazreean","year":"2022","unstructured":"Tazreean R, Nelson G, Twomey R (2022) Early mobilization in enhanced recovery after surgery pathways: current evidence and recent advancements. J Comp Eff Res 11(2):121\u2013129. https:\/\/doi.org\/10.2217\/cer-2021-0258","journal-title":"J Comp Eff Res"},{"issue":"3","key":"1227_CR34","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.21037\/apm-20-891","volume":"9","author":"J Chen","year":"2020","unstructured":"Chen J, Wang X, Qian H, Ye J, Qian J, Hua J (2020) Correlation between common postoperative complications of prolonged bed rest and quality of life in hospitalized elderly hip fracture patients. Ann Palliat Med 9(3):1125\u20131133. https:\/\/doi.org\/10.21037\/apm-20-891","journal-title":"Ann Palliat Med"},{"issue":"2","key":"1227_CR35","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/ageing\/afaa241","volume":"50","author":"H Sallehuddin","year":"2021","unstructured":"Sallehuddin H, Ong T (2021) Get up and get moving-early mobilisation after hip fracture surgery. Age Ageing 50(2):356\u2013357. https:\/\/doi.org\/10.1093\/ageing\/afaa241","journal-title":"Age Ageing"},{"issue":"9","key":"1227_CR36","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.3390\/jcm11092587","volume":"11","author":"S Watanabe","year":"2022","unstructured":"Watanabe S, Liu K, Nakamura K et al (2022) Association between Early Mobilization in the ICU and Psychiatric Symptoms after Surviving a Critical Illness: A Multi-Center Prospective Cohort Study. J Clin Med 11(9):2587","journal-title":"J Clin Med"},{"key":"1227_CR37","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2147\/dddt.S342409","volume":"16","author":"A Kotli\u0144ska-Lemieszek","year":"2022","unstructured":"Kotli\u0144ska-Lemieszek A, \u017bylicz Z (2022) Less well-known consequences of the long-term use of opioid analgesics: a comprehensive literature review. Drug Des Devel Ther 16:251\u2013264. https:\/\/doi.org\/10.2147\/dddt.S342409","journal-title":"Drug Des Devel Ther"},{"issue":"6","key":"1227_CR38","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1080\/09638288.2020.1783002","volume":"44","author":"J Southwell","year":"2022","unstructured":"Southwell J, Potter C, Wyatt D, Sadler E, Sheehan KJ (2022) Older adults\u2019 perceptions of early rehabilitation and recovery after hip fracture surgery: a UK qualitative study. Disabil Rehabil 44(6):940\u2013947. https:\/\/doi.org\/10.1080\/09638288.2020.1783002","journal-title":"Disabil Rehabil"},{"issue":"2","key":"1227_CR39","doi-asserted-by":"publisher","first-page":"2266751","DOI":"10.1080\/24740527.2023.2266751","volume":"7","author":"R Darville-Beneby","year":"2023","unstructured":"Darville-Beneby R, Lomanowska AM, Yu HC et al (2023) The impact of preoperative patient education on postoperative pain, opioid use, and psychological outcomes: a narrative review. Can J Pain 7(2):2266751. https:\/\/doi.org\/10.1080\/24740527.2023.2266751","journal-title":"Can J Pain"},{"issue":"6","key":"1227_CR40","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1037\/amp0000663","volume":"75","author":"TB Crouch","year":"2020","unstructured":"Crouch TB, Wedin S, Kilpatrick RL et al (2020) Pain rehabilitation\u2019s dual power: Treatment for chronic pain and prevention of opioid-related risks. Am Psychol 75(6):825\u2013839. https:\/\/doi.org\/10.1037\/amp0000663","journal-title":"Am Psychol"},{"issue":"6","key":"1227_CR41","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1097\/sla.0000000000003409","volume":"270","author":"VX Liu","year":"2019","unstructured":"Liu VX, Eaton A, Lee DC et al (2019) Postoperative opioid use before and after enhanced recovery after surgery program implementation. Ann Surg 270(6):e69\u2013e71. https:\/\/doi.org\/10.1097\/sla.0000000000003409","journal-title":"Ann Surg"},{"issue":"4","key":"1227_CR42","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/bja\/aex304","volume":"119","author":"Joshi GP, Kehlet H, Group PW","year":"2017","unstructured":"Joshi GP, Kehlet H, Group PW (2017) Guidelines for perioperative pain management: need for re-evaluation. Br J Anaesth 119(4):703\u2013706. https:\/\/doi.org\/10.1093\/bja\/aex304","journal-title":"Br J Anaesth"},{"issue":"8","key":"1227_CR43","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1111\/anae.15498","volume":"76","author":"M Anger","year":"2021","unstructured":"Anger M, Valovska T, Beloeil H et al (2021) PROSPECT guideline for total hip arthroplasty: a systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia 76(8):1082\u20131097. https:\/\/doi.org\/10.1111\/anae.15498","journal-title":"Anaesthesia"},{"key":"1227_CR44","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/JPR.S144066","volume":"10","author":"TJ Gan","year":"2017","unstructured":"Gan TJ (2017) Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res 10:2287\u20132298. https:\/\/doi.org\/10.2147\/JPR.S144066","journal-title":"J Pain Res"},{"key":"1227_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad154","author":"MN Sarkies","year":"2023","unstructured":"Sarkies MN, Testa L, Carrigan A et al (2023) Perioperative interventions to improve early mobilisation and physical function after hip fracture: a systematic review and meta-analysis. Age Ageing. https:\/\/doi.org\/10.1093\/ageing\/afad154","journal-title":"Age Ageing"},{"issue":"4","key":"1227_CR46","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1515\/sjpain-2019-0170","volume":"20","author":"AH Simoni","year":"2020","unstructured":"Simoni AH, Nikolajsen L, Olesen AE, Christiansen CF, Johnsen SP, Pedersen AB (2020) The association between initial opioid type and long-term opioid use after hip fracture surgery in elderly opioid-naive patients. Scand J Pain 20(4):755\u2013764. https:\/\/doi.org\/10.1515\/sjpain-2019-0170","journal-title":"Scand J Pain"},{"issue":"1","key":"1227_CR47","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/jgs.15659","volume":"67","author":"AJ Rose","year":"2019","unstructured":"Rose AJ, McBain R, Schuler MS et al (2019) Effect of age on opioid prescribing, overdose, and mortality in Massachusetts, 2011 to 2015. J Am Geriatr Soc 67(1):128\u2013132. https:\/\/doi.org\/10.1111\/jgs.15659","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"1227_CR48","doi-asserted-by":"publisher","first-page":"0afaf05","DOI":"10.1093\/ageing\/afaf007","volume":"54","author":"TJ Hjelholt","year":"2025","unstructured":"Hjelholt TJ, Andersen IT, Kristensen MT et al (2025) Early mobilisation after hip fracture surgery reduces the risk of infection: an inverse probability of treatment weeighted analysis. Age Aging 54(1):0afaf05","journal-title":"Age Aging"},{"issue":"4","key":"1227_CR49","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jclinepi.2004.10.012","volume":"58","author":"S Schneeweiss","year":"2005","unstructured":"Schneeweiss S, Avorn J (2005) A review of uses of health care utilization databases for epidemiologic research on therapeutics. J Clin Epidemiol 58(4):323\u2013337","journal-title":"J Clin Epidemiol"}],"container-title":["European Geriatric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-025-01227-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s41999-025-01227-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-025-01227-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:20:29Z","timestamp":1750141229000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s41999-025-01227-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["1227"],"URL":"https:\/\/doi.org\/10.1007\/s41999-025-01227-7","relation":{},"ISSN":["1878-7657"],"issn-type":[{"value":"1878-7657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]},"assertion":[{"value":"20 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors report no personal conflicts of interest. The Department of Clinical Epidemiology, Aarhus University Hospital, receives funding for other studies from companies in the form of research grants to (and administered by) Aarhus University. None of those studies have any relation to the present study. The abstract of this study has been previously presented at the Global Fragility Fracture Network (FFN) Congress, which was held from October 10 to 12, 2024, in Istanbul, T\u00fcrkiye.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was reported to the Danish Data Protection Agency through registration at Aarhus University (record number: AU-2016-051-000001, sequential number 880). Patient consent is not required by Danish law for registry-based studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and patient consent"}}]}}