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Frailty was assessed using the Clinical Frailty Scale (CFS) and sarcopenia was evaluated according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) guidelines. Outcomes of falls (past year), and depression (Geriatric Depression Scale 15) were self-reported.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Totally, 505 mobility-limited older adults (mean age 79.7\u2009\u00b1\u20096.3 years, 64.8% females) were included. Of these, 400 (79.2%) had experienced one or more falls within the past year (fallers), while 105 (20.8%) had not experienced a fall (at risk). Patients with experienced falls were more likely to feel depressed, had reduced handgrip strength, and reduced performance in both STS tests compared to those who had not fallen.<\/jats:p>\n Frailty was the strongest individual parameter associated with a history of prior falls, even after adjusting for covariates such as depression and 30-s STS (aOR 3.80; 95% CI 1.70\u20138.50).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Present study identified frailty as a key factor independently associated with a history of falls in this population. Additionally, handgrip strength and STS performance were key characteristics distinguishing between older adults with a history of falls within the past 12 months and those at risk of falling.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n NCT05795556<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s41999-025-01239-3","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:46:37Z","timestamp":1748321197000},"page":"1283-1293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Frailty is associated with a history of falls among mobility-limited older adults\u2014cross-sectional multivariate analysis from the BIOFRAIL study"],"prefix":"10.1007","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct05795556","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5545-1105","authenticated-orcid":false,"given":"Pernille","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8609-8755","authenticated-orcid":false,"given":"H.","family":"Nygaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1259-645X","authenticated-orcid":false,"given":"M.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-9535","authenticated-orcid":false,"given":"F.","family":"Dela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-7361","authenticated-orcid":false,"given":"P.","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-3062","authenticated-orcid":false,"given":"Jesper","family":"Ryg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-6508","authenticated-orcid":false,"given":"C.","family":"Suetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"1239_CR1","doi-asserted-by":"publisher","first-page":"i3","DOI":"10.1136\/injuryprev-2019-043286","volume":"26","author":"SL James","year":"2020","unstructured":"James SL, Lucchesi LR, Bisignano C, Castle CD, Dingels ZV, Fox JT et al (2020) The global burden of falls: global, regional and national estimates of morbidity and mortality from the global burden of disease study 2017. 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