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We explored the potential clinical associations of motor manifestations in AD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Our sample consisted of older adults (\u2265\u200960\u00a0years) with AD from NACC. Individuals with Parkinson\u2019s disease or other Parkinsonian syndrome or under anti-parkinsonian agents were excluded. UPDRS III was used to assess motor signs in nine domains: hypophonia; masked facies; resting tremor; action\/postural tremor; rigidity; bradykinesia; impaired chair rise; impaired posture\/gait; postural instability. A global motor variable assessed the presence of at least one motor sign. Binary logistic models were estimated for the global (primary) and individual motor domain variables (secondary outcomes).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 4771 older, predominantly female, well-educated participants were analysed: 3556 without (75.4\u2009\u00b1\u20097.6\u00a0years, 45.6% males) and 1215 with motor manifestations (79.4\u2009\u00b1\u20097.8\u00a0years, 44.4% males). The most influential risk factor for motor manifestations in AD was the Clinical Dementia Rating stage: stage one increased the odds of motor signs by\u2009~\u200944%, stage two by\u2009~\u2009168% and stage three by\u2009~\u2009437%. Each additional point on the Geriatric Depression Scale elevated the odds of motor manifestations by\u2009~\u20095%, whereas each additional point on the Mini-Mental State Examination decreased these odds by\u2009~\u20092.5%. Cerebrovascular disease (by\u2009~\u200944%), diabetes mellitus (by\u2009~\u200925%), traumatic brain injury (by\u2009~\u200930%), alcohol abuse (by\u2009~\u200933%), anxiolytics (by\u2009~\u200936%), antidepressants (by\u2009~\u200931%), antipsychotics (by\u2009~\u200948%) and \u03b2-blockers (by\u2009~\u200933%) elevated the odds of motor manifestations. Angiotensin II receptor blockers decreased the odds of motor manifestations (by\u2009~\u200933%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Disease progression constitutes the most crucial clinical risk factor for motor manifestations in AD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s41999-025-01259-z","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T14:15:54Z","timestamp":1753107354000},"page":"1667-1677","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors associated with motor manifestations in older adults with Alzheimer\u2019s dementia: a cross-sectional analysis"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-5220","authenticated-orcid":false,"given":"Ioannis","family":"Liampas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Demiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polyxeni","family":"Stamati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lefteris","family":"Lazarou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Michailides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysoula","family":"Marogianni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Tsika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Siokas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthimios","family":"Dardiotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"1259_CR1","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.3390\/brainsci14111054","volume":"14","author":"J Andrade-Guerrero","year":"2024","unstructured":"Andrade-Guerrero J, Mart\u00ednez-Orozco H, Villegas-Rojas MM, Santiago-Balmaseda A, Delgado-Minjares KM, P\u00e9rez-Segura I et al (2024) Alzheimer\u2019s disease: understanding motor impairments. 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