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This study aimed also to examine how comorbidities and comorbidity indices were associated with both stages and etiologies of NCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross-sectional study including participants from the MEMORA real-life cohort, aged\u2009\u2265\u200960\u00a0years. Patients had to be in either MCI or dementia stage, with the following etiological diagnoses of NCD: AD, VD (vascular dementia), mixed dementia (MD), dementia with Lewy bodies, frontotemporal dementia and Parkinson\u2019s disease. Three comorbidity indices were used to measure comorbidity burden: the Charlson comorbidity index, the multimorbidity-weighted index (MWI) and the health-related quality of life comorbidity index (HRQOL-CI). Prevalence of comorbidities involved in the calculation of at least one comorbidity index were reported. The associations between comorbidities\/comorbidity indices and groups were assessed using binary and multinomial logistic regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 3470 patients (66.9% dementia; 50.9% AD) were included. The most frequent comorbidities were hypertension (50.2%), depression (28.0%) and hypercholesterolemia (22.6%). The MWI and the HRQOL-CI were associated with increased odds of dementia (vs. MCI). Upon stratifying population according to the etiological diagnoses of NCD, the highest mean of the three comorbidity indices were found in patients with VD and MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comorbidities and comorbidity burden vary according to the stage and etiological diagnoses of NCD. Future studies should consider the stage and the etiological diagnoses, when studying the effect of the comorbidity burden on the progression of NCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s41999-025-01288-8","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:58:42Z","timestamp":1756310322000},"page":"2153-2167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comorbidities and comorbidity burden in patients with neurocognitive disorders: findings from the MEMORA Cohort Study"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1495-5799","authenticated-orcid":false,"given":"Mohamed Nour","family":"Temedda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Garnier-Crussard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Moutet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Mouchoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Dauphinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"1288_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00215-2","volume":"6","author":"TLP Health","year":"2021","unstructured":"Health TLP (2021) Reinvigorating the public health response to dementia. 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M.N.T, C.Mt, C.Mc and VD declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article. This manuscript has not been published or submitted elsewhere. All authors have contributed significantly, and all authors are in agreement with the content of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The MEMORA cohort protocol (clinicaltrial.gov number NCT02302482) has been approved by the regional ethics committee (Comit\u00e9 de protection des personnes Sud Est III) on July 29, 2014. Data processing has been approved by the national data protection commission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}