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A comprehensive geriatric assessment (CGA) was performed by geriatricians, including the assessment of frailty using the Clinical Frailty Scale (CFS), and PU assessment, carried out by a trained nurse. Long-term mortality (median duration: 18\u00a0months) was collected through the regional electronic health data system with an 18-month follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Older adults with PU had advanced frailty, higher nutritional risk, increased disability, and higher polypharmacy. Multivariate analysis showed that both frailty (CFS: HR 1.535, 95% CI 1.314\u20131.793,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and PU (HR 1.500, 95% CI 1.059\u20132.126,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020) were significant predictors of long-term mortality. Namely, each increment in CFS score was associated with a 53% increased risk in PU carriers. No significant interaction between CFS and PU on survival outcomes was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study underscored the independent prognostic significance of both PU and frailty in predicting long-term mortality in hospitalized older adults. A multidimensional approach considering both frailty and PU is crucial for accurate prognostication and improving care strategies for older patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s41999-025-01331-8","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:46:52Z","timestamp":1763142412000},"page":"665-672","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of pressure ulcers and frailty on long-term mortality: a prospective cohort study of hospitalized older adults"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-793X","authenticated-orcid":false,"given":"Silvia","family":"Ottaviani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Rondanina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Arnone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virna","family":"Brucato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Campigli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo Della","family":"Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-9999","authenticated-orcid":false,"given":"Luca","family":"Tagliafico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6605-3951","authenticated-orcid":false,"given":"Stefania","family":"Peruzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-8884","authenticated-orcid":false,"given":"Alessio","family":"Nencioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-7252","authenticated-orcid":false,"given":"Fiammetta","family":"Monacelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"1331_CR1","doi-asserted-by":"publisher","first-page":"21750","DOI":"10.1038\/s41598-021-01188-4","volume":"11","author":"X Zhang","year":"2021","unstructured":"Zhang X, Zhu N, Li Z, Xie X, Liu T, Ouyang G (2021) The global burden of decubitus ulcers from 1990 to 2019. 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