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This study assesses the association between the cumulative effect of STOPPFall medications and OH, on future falls\/fractures, over 4-year follow-up among community-dwelling older people\u2009\u2265\u200965\u00a0years using The Irish Longitudinal Study on Ageing(TILDA) data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>STOPPFall medications were recorded at Wave1. Orthostatic blood pressure(BP) was measured by active stand using a Finometer at Wave1, recording delayed BP recovery(drop in systolicBP(sBP)\u2009\u2265\u200920\u00a0mmHg and\/or diastolicBP\u2009\u2265\u200910\u00a0mmHg from baseline at 30\u00a0s post-stand) and \u201cany OH\u201d(same BP drop at any of 30,60,90,120\u00a0s post-stand). Falls\/fractures were self-reported. Logistic regression models using interaction terms generated odds ratios(ORs) assessing the association between the interaction of STOPPFall medications and delayed BP recovery\/any OH at baseline, and falls(including injurious\/unexplained falls) and all fractures at follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      1390 participants were included, mean age at baseline 71.0\u00a0years, 51% female. One STOPPFall medication was prescribed in 27%(372\/1390) participants, 11%(147\/1390) were prescribed\u2009\u2265\u20092STOPPFall medications. Over 40% participants fell during follow-up(592\/1390,42.6%), 12%(160\/1390) sustained fractures. The cumulative effect of\u2009\u2265\u20092STOPPFall medications and delayed BP recovery was independently associated with all falls[OR1.93(95%CI1.04\u20133.59);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036], injurious falls[OR2.97(95%CI1.55\u20135.68);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001] and all fractures[OR3.50(95%CI1.66\u20137.41);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001]. Prescription of\u2009\u2265\u20092STOPPFall medications and any OH was independently associated with all falls[OR1.98(95%CI1.11\u20133.54);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021], injurious falls[OR2.25(95%CI1.21\u20134.20);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011] and all fractures[OR2.81(95%CI1.34\u20135.90);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prescription of\u2009\u2265\u20092 STOPPFall medications and delayed BP recovery, and prescription of\u2009\u2265\u20092 STOPPFall medications and any OH, was associated with all falls, injurious falls and all fractures. This highlights the importance of multidomain interventions during multifactorial falls assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s41999-026-01473-3","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:08:50Z","timestamp":1776089330000},"page":"1229-1241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The combined association of STOPPFall medication use and orthostatic blood pressure abnormalities with future falls and fractures in community-dwelling older people"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-6281","authenticated-orcid":false,"given":"Kate","family":"Doyle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Scarlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvin P.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Lavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose-Anne","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"1473_CR1","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","volume":"392","author":"HH Kyu","year":"2018","unstructured":"Kyu HH, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N et al (2018) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. 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