{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:07:15Z","timestamp":1789063635567,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Operational Program European Regional Development Fund (OP ERDF) of the European Union under the \u201cPROHEALTH\u201d project","award":["PROJ-01003"],"award-info":[{"award-number":["PROJ-01003"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202007720083"],"award-info":[{"award-number":["202007720083"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Geriatr Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Impaired cerebral perfusion during postural changes may contribute to fall risk in older adults. This study used near-infrared spectroscopy (NIRS) as a proxy for cerebral blood flow to investigate the association between cerebral oxygenation responses during postural changes and falls in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed parameters of oxygenated hemoglobin (OxyHb), deoxygenated hemoglobin (DeoxyHb), total hemoglobin (tHb), and tissue saturation index (TSI) during supine-to-stand and sit-to-stand maneuvers in the PROHEALTH cohort of older adults (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930; 23% with positive falls history; mean age 74\u2009\u00b1\u20097\u00a0years). Associations with falls were assessed using logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant associations with falls history were observed during the supine-to-stand maneuver, despite no significant differences in orthostatic cardiovascular responses. After adjusting for age and sex, lower OxyHb nadir-to-overshoot (OR\u2009=\u20095.20, 95% CI 1.06\u201325.57), lower TSI overshoot (OR\u2009=\u20091.86, 95% CI 1.04\u20133.33), and lower TSI initial recovery amplitude (OR\u2009=\u20091.86, 95% CI 1.04\u20133.34), all within the first minute of standing, were significantly associated with falls history. In addition, lower TSI steady-state values at 60\u2013120\u00a0s after standing (OR\u2009=\u20091.56, 95% CI 1.01\u20132.42) also showed a significant association. No significant associations were observed for any of the parameters during the sit-to-stand maneuver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Impaired OxyHb and TSI responses, particularly within the first minute after standing and reduced TSI during sustained impaired recovery (60\u2013120\u00a0s), were associated with falls in older adults. Supine-to-stand testing outperformed sit-to-stand testing in identifying cerebral oxygenation impairments. These findings highlight the clinical potential of NIRS as a practical tool for identifying orthostatic cerebral hypoperfusion-related fall risk. Further validation in larger, prospective cohorts is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s41999-026-01538-3","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:05:05Z","timestamp":1782734705000},"page":"2301-2311","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral oxygenation response to postural change using continuous near-infrared spectroscopy (NIRS) and its association with falls in older adults"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-3290","authenticated-orcid":false,"given":"Liping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-5602","authenticated-orcid":false,"given":"Eveline P.","family":"van Poelgeest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Klop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen A. H. R.","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons G.","family":"Hoekstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"van der Velde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"1538_CR1","unstructured":"WHO (2021) Falls fact sheet [Internet: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/falls]. World Health Organisation. Accessed 20 Jan 2025"},{"issue":"3","key":"1538_CR2","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/jgs.14563","volume":"65","author":"C Finucane","year":"2017","unstructured":"Finucane C, O\u2019Connell MD, Donoghue O et al (2017) Impaired orthostatic blood pressure recovery is associated with unexplained and injurious falls. J Am Geriatr Soc 65(3):474\u2013482","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"1538_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jamda.2015.08.022","volume":"17","author":"S Jansen","year":"2016","unstructured":"Jansen S, Bhangu J, de Rooij S et al (2016) The association of cardiovascular disorders and falls: a systematic review. J Am Med Dir Assoc 17(3):193\u2013199","journal-title":"J Am Med Dir Assoc"},{"issue":"6","key":"1538_CR4","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/jcbfm.2008.13","volume":"28","author":"AH van Beek","year":"2008","unstructured":"van Beek AH, Claassen JA, Rikkert MG et al (2008) Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab 28(6):1071\u20131085. https:\/\/doi.org\/10.1038\/jcbfm.2008.13","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"1538_CR5","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1152\/physrev.00022.2020","volume":"101","author":"J Claassen","year":"2021","unstructured":"Claassen J, Thijssen DHJ, Panerai RB et al (2021) Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation. Physiol Rev 101(4):1487\u20131559. https:\/\/doi.org\/10.1152\/physrev.00022.2020","journal-title":"Physiol Rev"},{"issue":"8","key":"1538_CR6","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1161\/hc3301.094908","volume":"104","author":"BJ Carey","year":"2001","unstructured":"Carey BJ, Manktelow BN, Panerai RB et al (2001) Cerebral autoregulatory responses to head-up tilt in normal subjects and patients with recurrent vasovagal syncope. Circulation 104(8):898\u2013902. https:\/\/doi.org\/10.1161\/hc3301.094908","journal-title":"Circulation"},{"issue":"5","key":"1538_CR7","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00421-019-04101-0","volume":"119","author":"A Mol","year":"2019","unstructured":"Mol A, Woltering JHH, Colier W et al (2019) Sensitivity and reliability of cerebral oxygenation responses to postural changes measured with near-infrared spectroscopy. Eur J Appl Physiol 119(5):1117\u20131125. https:\/\/doi.org\/10.1007\/s00421-019-04101-0","journal-title":"Eur J Appl Physiol"},{"issue":"6","key":"1538_CR8","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1093\/gerona\/glab219","volume":"77","author":"JD O'Connor","year":"2022","unstructured":"O\u2019Connor JD, O\u2019Connell MDL, Knight SP et al (2022) Impaired stabilization of orthostatic cerebral oxygenation is associated with slower gait speed: evidence from The Irish longitudinal Study on Ageing. J Gerontol A Biol Sci Med Sci 77(6):1216\u20131221. https:\/\/doi.org\/10.1093\/gerona\/glab219","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"1538_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1161\/HYPERTENSIONAHA.121.17111","volume":"78","author":"L Newman","year":"2021","unstructured":"Newman L, O\u2019Connor JD, Romero-Ortuno R et al (2021) Supine hypertension is associated with an impaired cerebral oxygenation response to orthostasis: finding from The Irish Longitudinal Study on Ageing. Hypertension 78(1):210\u2013219. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.17111","journal-title":"Hypertension"},{"key":"1538_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2022.102942","volume":"238","author":"A Mol","year":"2022","unstructured":"Mol A, Claassen J, Maier AB et al (2022) Determinants of orthostatic cerebral oxygenation assessed using near-infrared spectroscopy. Auton Neurosci 238:102942. https:\/\/doi.org\/10.1016\/j.autneu.2022.102942","journal-title":"Auton Neurosci"},{"issue":"9","key":"1538_CR11","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1093\/europace\/eux298","volume":"20","author":"E Bachus","year":"2018","unstructured":"Bachus E, Holm H, Hamrefors V et al (2018) Monitoring of cerebral oximetry during head-up tilt test in adults with history of syncope and orthostatic intolerance. Europace 20(9):1535\u20131542. https:\/\/doi.org\/10.1093\/europace\/eux298","journal-title":"Europace"},{"key":"1538_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00791-9","author":"M Klop","year":"2023","unstructured":"Klop M, de Heus RAA, Maier AB et al (2023) Capturing postural blood pressure dynamics with near-infrared spectroscopy-measured cerebral oxygenation. Geroscience. https:\/\/doi.org\/10.1007\/s11357-023-00791-9","journal-title":"Geroscience"},{"key":"1538_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00055","volume":"13","author":"YH Kim","year":"2019","unstructured":"Kim YH, Paik SH, V ZP et al (2019) Cerebral perfusion monitoring using near-infrared spectroscopy during head-up tilt table test in patients with orthostatic intolerance. Front Hum Neurosci 13:55. https:\/\/doi.org\/10.3389\/fnhum.2019.00055","journal-title":"Front Hum Neurosci"},{"issue":"4","key":"1538_CR14","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1088\/0967-3334\/25\/4\/004","volume":"25","author":"E Szufladowicz","year":"2004","unstructured":"Szufladowicz E, Maniewski R, Kozluk E et al (2004) Near-infrared spectroscopy in evaluation of cerebral oxygenation during vasovagal syncope. Physiol Meas 25(4):823\u2013836. https:\/\/doi.org\/10.1088\/0967-3334\/25\/4\/004","journal-title":"Physiol Meas"},{"issue":"1","key":"1538_CR15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/hbm.10026","volume":"16","author":"DJ Mehagnoul-Schipper","year":"2002","unstructured":"Mehagnoul-Schipper DJ, van der Kallen BF, Colier WN et al (2002) Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects. Hum Brain Mapp 16(1):14\u201323. https:\/\/doi.org\/10.1002\/hbm.10026","journal-title":"Hum Brain Mapp"},{"key":"1538_CR16","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fphys.2020.00168","volume":"11","author":"A Mol","year":"2020","unstructured":"Mol A, Maier AB, van Wezel RJA et al (2020) Multimodal monitoring of cardiovascular responses to postural changes. Front Physiol 11:168. https:\/\/doi.org\/10.3389\/fphys.2020.00168","journal-title":"Front Physiol"},{"issue":"7","key":"1538_CR17","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1161\/01.str.32.7.1546","volume":"32","author":"JJ van Lieshout","year":"2001","unstructured":"van Lieshout JJ, Pott F, Madsen PL et al (2001) Muscle tensing during standing: effects on cerebral tissue oxygenation and cerebral artery blood velocity. Stroke 32(7):1546\u20131551. https:\/\/doi.org\/10.1161\/01.str.32.7.1546","journal-title":"Stroke"},{"issue":"2","key":"1538_CR18","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.neuroimage.2005.08.065","volume":"29","author":"TJ Huppert","year":"2006","unstructured":"Huppert TJ, Hoge RD, Diamond SG et al (2006) A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans. Neuroimage 29(2):368\u2013382. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.08.065","journal-title":"Neuroimage"},{"key":"1538_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2024.114574","volume":"281","author":"RK Shali","year":"2024","unstructured":"Shali RK, Setarehdan SK, Seifi B (2024) Functional near-infrared spectroscopy based blood pressure variations and hemodynamic activity of brain monitoring following postural changes: a systematic review. Physiol Behav 281:114574. https:\/\/doi.org\/10.1016\/j.physbeh.2024.114574","journal-title":"Physiol Behav"},{"issue":"6","key":"1538_CR20","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1007\/s11357-024-01241-w","volume":"46","author":"M Klop","year":"2024","unstructured":"Klop M, Claassen J, Floor-Westerdijk MJ et al (2024) Home-based monitoring of cerebral oxygenation in response to postural changes using near-infrared spectroscopy. Geroscience 46(6):6331\u20136346. https:\/\/doi.org\/10.1007\/s11357-024-01241-w","journal-title":"Geroscience"},{"key":"1538_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111903","volume":"167","author":"L Newman","year":"2022","unstructured":"Newman L, O\u2019Connor JD, Nolan H et al (2022) Age and sex related differences in orthostatic cerebral oxygenation: findings from 2764 older adults in the Irish Longitudinal Study on Ageing (TILDA). Exp Gerontol 167:111903. https:\/\/doi.org\/10.1016\/j.exger.2022.111903","journal-title":"Exp Gerontol"},{"issue":"7","key":"1538_CR22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/ajh\/hpad025","volume":"36","author":"JM Kim","year":"2023","unstructured":"Kim JM, Park KI, Choi SY et al (2023) Dynamic alterations in cerebral hemodynamics measured by portable near-infrared spectroscopy in orthostatic hypotension and intolerance. Am J Hypertens 36(7):385\u2013393. https:\/\/doi.org\/10.1093\/ajh\/hpad025","journal-title":"Am J Hypertens"},{"key":"1538_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fcvm.2019.00171","volume":"6","author":"I Kharraziha","year":"2019","unstructured":"Kharraziha I, Holm H, Bachus E et al (2019) Cerebral oximetry in syncope and syndromes of orthostatic intolerance. Front Cardiovasc Med 6:171. https:\/\/doi.org\/10.3389\/fcvm.2019.00171","journal-title":"Front Cardiovasc Med"},{"key":"1538_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.828474","volume":"14","author":"N Lehmann","year":"2022","unstructured":"Lehmann N, Kuhn YA, Keller M et al (2022) Brain activation during active balancing and its behavioral relevance in younger and older adults: a functional near-infrared spectroscopy (fNIRS) study. Front Aging Neurosci 14:828474. https:\/\/doi.org\/10.3389\/fnagi.2022.828474","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"1538_CR25","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1093\/gerona\/glaa194","volume":"76","author":"LK Fitzgibbon-Collins","year":"2021","unstructured":"Fitzgibbon-Collins LK, Heckman GA, Bains I et al (2021) Older adults\u2019 drop in cerebral oxygenation on standing correlates with postural instability and may improve with sitting prior to standing. J Gerontol A Biol Sci Med Sci 76(6):1124\u20131133. https:\/\/doi.org\/10.1093\/gerona\/glaa194","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1538_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2025.103291","volume":"260","author":"M Klop","year":"2025","unstructured":"Klop M, Claassen J, Mol A et al (2025) Age and orthostatic hypotension are associated with baroreflex sensitivity and cerebral oxygenation after postural change. Auton Neurosci 260:103291. https:\/\/doi.org\/10.1016\/j.autneu.2025.103291","journal-title":"Auton Neurosci"},{"issue":"7","key":"1538_CR27","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1111\/jgs.17810","volume":"70","author":"L Perez-Denia","year":"2022","unstructured":"Perez-Denia L, Claffey P, Byrne L et al (2022) Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing. J Am Geriatr Soc 70(7):1973\u20131986. https:\/\/doi.org\/10.1111\/jgs.17810","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"1538_CR28","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1093\/gerona\/glaa315","volume":"76","author":"F Maguire","year":"2021","unstructured":"Maguire F, Romero-Ortuno R, O\u2019Connor JD et al (2021) One-dimensional statistical parametric mapping identifies impaired orthostatic cerebrovascular and cardiovascular response in frailty index. J Gerontol A Biol Sci Med Sci 76(5):885\u2013892. https:\/\/doi.org\/10.1093\/gerona\/glaa315","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"1538_CR29","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, Bedirian V et al (2005) The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695\u2013699. https:\/\/doi.org\/10.1111\/j.1532-5415.2005.53221.x","journal-title":"J Am Geriatr Soc"},{"issue":"10","key":"1538_CR30","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jval.2018.02.011","volume":"21","author":"AMM Santoso","year":"2018","unstructured":"Santoso AMM, Lutomski JE, Hofman CS et al (2018) Development of a patient-reported outcome measure for geriatric care: the older persons and informal caregivers survey short form. Value Health 21(10):1198\u20131204. https:\/\/doi.org\/10.1016\/j.jval.2018.02.011","journal-title":"Value Health"},{"issue":"7","key":"1538_CR31","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1161\/01.str.31.7.1615","volume":"31","author":"DJ Mehagnoul-Schipper","year":"2000","unstructured":"Mehagnoul-Schipper DJ, Vloet LC, Colier WN et al (2000) Cerebral oxygenation declines in healthy elderly subjects in response to assuming the upright position. Stroke 31(7):1615\u20131620. https:\/\/doi.org\/10.1161\/01.str.31.7.1615","journal-title":"Stroke"},{"key":"1538_CR32","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1117\/12.356862","volume":"3597","author":"S Suzuki","year":"1999","unstructured":"Suzuki S, Takasaki S, Ozaki T, Kobayashi Y (1999) Tissue oxygenation monitor using NIR spatially resolved spectroscopy. Opt tomogr spectrosc of tissue III. 3597:582\u2013592. https:\/\/doi.org\/10.1117\/12.356862","journal-title":"Opt tomogr spectrosc of tissue III."},{"issue":"4","key":"1538_CR33","doi-asserted-by":"publisher","first-page":"041102","DOI":"10.1117\/1.2335429","volume":"11","author":"BW Pogue","year":"2006","unstructured":"Pogue BW, Patterson MS (2006) Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. J Biomed Opt 11(4):041102. https:\/\/doi.org\/10.1117\/1.2335429","journal-title":"J Biomed Opt"},{"key":"1538_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134202","author":"L Perez-Denia","year":"2023","unstructured":"Perez-Denia L, Claffey P, O\u2019Reilly A et al (2023) Cerebral oxygenation responses to standing in young patients with vasovagal syncope. J Clin Med. https:\/\/doi.org\/10.3390\/jcm12134202","journal-title":"J Clin Med"},{"issue":"21","key":"1538_CR35","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","volume":"39","author":"M Brignole","year":"2018","unstructured":"Brignole M, Moya A, de Lange FJ et al (2018) 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J 39(21):1883\u20131948. https:\/\/doi.org\/10.1093\/eurheartj\/ehy037","journal-title":"Eur Heart J"},{"issue":"20","key":"1538_CR36","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1161\/CIRCULATIONAHA.114.009831","volume":"130","author":"C Finucane","year":"2014","unstructured":"Finucane C, O\u2019Connell MD, Fan CW et al (2014) Age-related normative changes in phasic orthostatic blood pressure in a large population study: findings from The Irish Longitudinal Study on Ageing (TILDA). Circulation 130(20):1780\u20131789","journal-title":"Circulation"},{"issue":"5","key":"1538_CR37","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1093\/ageing\/afab090","volume":"50","author":"J Tran","year":"2021","unstructured":"Tran J, Hillebrand SL, Meskers CGM et al (2021) Prevalence of initial orthostatic hypotension in older adults: a systematic review and meta-analysis. Age Ageing 50(5):1520\u20131528. https:\/\/doi.org\/10.1093\/ageing\/afab090","journal-title":"Age Ageing"},{"issue":"5","key":"1538_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252212","volume":"16","author":"OA Donoghue","year":"2021","unstructured":"Donoghue OA, O\u2019Connell MDL, Bourke R et al (2021) Is orthostatic hypotension and co-existing supine and seated hypertension associated with future falls in community-dwelling older adults? Results from The Irish Longitudinal Study on Ageing (TILDA). PLoS ONE 16(5):e0252212. https:\/\/doi.org\/10.1371\/journal.pone.0252212","journal-title":"PLoS ONE"},{"issue":"5","key":"1538_CR39","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.jamda.2018.11.003","volume":"20","author":"A Mol","year":"2019","unstructured":"Mol A, Bui Hoang PTS, Sharmin S et al (2019) Orthostatic hypotension and falls in older adults: a systematic review and meta-analysis. J Am Med Dir Assoc 20(5):589-597.e5","journal-title":"J Am Med Dir Assoc"},{"key":"1538_CR40","first-page":"04","volume":"4","author":"D Moloney","year":"2020","unstructured":"Moloney D, O\u2019Connor J, Newman L et al (2020) Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA). Age Ageing 4:04","journal-title":"Age Ageing"},{"issue":"3","key":"1538_CR41","first-page":"439","volume":"46","author":"C McDonald","year":"2017","unstructured":"McDonald C, Pearce M, Kerr SR et al (2017) A prospective study of the association between orthostatic hypotension and falls: definition matters. Age Ageing 46(3):439\u2013445","journal-title":"Age Ageing"},{"issue":"12","key":"1538_CR42","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1249\/MSS.0000000000001028","volume":"48","author":"I Helmich","year":"2016","unstructured":"Helmich I, Berger A, Lausberg H (2016) Neural control of posture in individuals with persisting postconcussion symptoms. Med Sci Sports Exerc 48(12):2362\u20132369. https:\/\/doi.org\/10.1249\/MSS.0000000000001028","journal-title":"Med Sci Sports Exerc"},{"key":"1538_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2021.104482","volume":"96","author":"SL Hillebrand","year":"2021","unstructured":"Hillebrand SL, Reijnierse EM, Meskers CGM et al (2021) Orthostatic hypotension assessed by active standing is associated with worse cognition in geriatric rehabilitation inpatients. RESORT Arch Gerontol Geriatr Sep-Oct 96:104482. https:\/\/doi.org\/10.1016\/j.archger.2021.104482","journal-title":"RESORT Arch Gerontol Geriatr Sep-Oct"},{"key":"1538_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102756","volume":"231","author":"MPM Harms","year":"2021","unstructured":"Harms MPM, Finucane C, Perez-Denia L et al (2021) Systemic and cerebral circulatory adjustment within the first 60 s after active standing: an integrative physiological view. Auton Neurosci 231:102756. https:\/\/doi.org\/10.1016\/j.autneu.2020.102756","journal-title":"Auton Neurosci"},{"issue":"8","key":"1538_CR45","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S1474-4422(22)00169-7","volume":"21","author":"W Wieling","year":"2022","unstructured":"Wieling W, Kaufmann H, Claydon VE et al (2022) Diagnosis and treatment of orthostatic hypotension. Lancet Neurol 21(8):735\u2013746. https:\/\/doi.org\/10.1016\/S1474-4422(22)00169-7","journal-title":"Lancet Neurol"},{"key":"1538_CR46","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaf379","author":"P Claffey","year":"2026","unstructured":"Claffey P, Perez-Denia L, Newman L et al (2026) Cerebral hypoperfusion and future falls risk among community dwelling older adults with orthostatic hypotension. Age Ageing. https:\/\/doi.org\/10.1093\/ageing\/afaf379","journal-title":"Age Ageing"},{"issue":"9","key":"1538_CR47","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1093\/ajh\/hpw023","volume":"29","author":"M Gutkin","year":"2016","unstructured":"Gutkin M, Stewart JM (2016) Orthostatic circulatory disorders: from nosology to nuts and bolts. Am J Hypertens 29(9):1009\u20131019. https:\/\/doi.org\/10.1093\/ajh\/hpw023","journal-title":"Am J Hypertens"},{"issue":"8","key":"1538_CR48","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1111\/jgs.17804","volume":"70","author":"SP Juraschek","year":"2022","unstructured":"Juraschek SP, Appel LJ, C MM et al (2022) Comparison of supine and seated orthostatic hypotension assessments and their association with falls and orthostatic symptoms. J Am Geriatr Soc 70(8):2310\u20132319. https:\/\/doi.org\/10.1111\/jgs.17804","journal-title":"J Am Geriatr Soc"}],"container-title":["European Geriatric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-026-01538-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s41999-026-01538-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-026-01538-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:24:26Z","timestamp":1789061066000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s41999-026-01538-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["1538"],"URL":"https:\/\/doi.org\/10.1007\/s41999-026-01538-3","relation":{},"ISSN":["1878-7657"],"issn-type":[{"value":"1878-7657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"24 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflicts of interest to report.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided written informed consent. The PROHEALTH study was deemed exempt from formal ethical review by the local ethics committee (CMO Radboud UMC), as it was concluded that it did not fall under the Medical Research Involving Human Subjects Act (WMO). The study was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}