{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:52:06Z","timestamp":1791395526916,"version":"4.3.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Geriatr Med"],"DOI":"10.1007\/s41999-026-01622-8","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:10:04Z","timestamp":1791349804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between early in-hospital physiological and functional changes and fall risk in older adults: a retrospective multicenter cohort study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5898-5241","authenticated-orcid":false,"given":"Takuya","family":"Nishino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nari","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Soh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniya","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"1622_CR1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/ageing\/afh017","volume":"33","author":"D Oliver","year":"2004","unstructured":"Oliver D, Daly F, Martin FC, McMurdo ME (2004) Risk factors and risk assessment tools for falls in hospital in-patients: a systematic review. Age Ageing 33:122\u2013130. https:\/\/doi.org\/10.1093\/ageing\/afh017","journal-title":"Age Ageing"},{"key":"1622_CR2","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1136\/qshc.2007.024695","volume":"17","author":"F Healey","year":"2008","unstructured":"Healey F, Scobie S, Oliver D, Pryce A, Thomson R, Glampson B (2008) Falls in English and Welsh hospitals: a national observational study based on retrospective analysis of 12 months of patient safety incident reports. Qual Saf Health Care 17:424\u2013430. https:\/\/doi.org\/10.1136\/qshc.2007.024695","journal-title":"Qual Saf Health Care"},{"key":"1622_CR3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/jgs.15304","volume":"66","author":"CS Florence","year":"2018","unstructured":"Florence CS, Bergen G, Atherly A, Burns E, Stevens J, Drake C (2018) Medical costs of fatal and nonfatal falls in older adults. J Am Geriatr Soc 66:693\u2013698. https:\/\/doi.org\/10.1111\/jgs.15304","journal-title":"J Am Geriatr Soc"},{"key":"1622_CR4","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac077","volume":"51","author":"ME Morris","year":"2022","unstructured":"Morris ME, Webster K, Jones C et al (2022) Interventions to reduce falls in hospitals: a systematic review and meta-analysis. Age Ageing 51:afab077. https:\/\/doi.org\/10.1093\/ageing\/afac077","journal-title":"Age Ageing"},{"key":"1622_CR5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/13872877251360031","volume":"107","author":"M Sultana","year":"2025","unstructured":"Sultana M, Taylor C, McPhee D et al (2025) Reducing falls in inpatient older adults: quality improvement initiative. J Alzheimers Dis 107:86\u201391. https:\/\/doi.org\/10.1177\/13872877251360031","journal-title":"J Alzheimers Dis"},{"key":"1622_CR6","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3928\/19404921-20240911-02","volume":"17","author":"H Yang","year":"2024","unstructured":"Yang H, Jiang Y, Yang X, Zhu C, Luo L, Hao W (2024) Assessment of risk factors for falls in hospitalized older adults: a meta-analysis. Res Gerontol Nurs 17:238\u2013245. https:\/\/doi.org\/10.3928\/19404921-20240911-02","journal-title":"Res Gerontol Nurs"},{"key":"1622_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.apmr.2024.06.015","volume":"106","author":"J Heinzmann","year":"2025","unstructured":"Heinzmann J, Rossen ML, Efthimiou O et al (2025) Risk factors for falls among hospitalized medical patients: a systematic review and meta-analysis. Arch Phys Med Rehabil 106:292\u2013299. https:\/\/doi.org\/10.1016\/j.apmr.2024.06.015","journal-title":"Arch Phys Med Rehabil"},{"key":"1622_CR8","doi-asserted-by":"publisher","DOI":"10.2196\/75958","volume":"13","author":"T Nishino","year":"2025","unstructured":"Nishino T, Matsuyama K, Miyagi Y et al (2025) Machine learning-based prediction of in-hospital falls in adult inpatients: retrospective observational multicenter study. JMIR Med Inform 13:e75958. https:\/\/doi.org\/10.2196\/75958","journal-title":"JMIR Med Inform"},{"key":"1622_CR9","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/j.1532-5415.2007.01156.x","volume":"55","author":"SK Inouye","year":"2007","unstructured":"Inouye SK, Studenski S, Tinetti ME, Kuchel GA (2007) Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 55:780\u2013791. https:\/\/doi.org\/10.1111\/j.1532-5415.2007.01156.x","journal-title":"J Am Geriatr Soc"},{"key":"1622_CR10","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1001\/jama.2011.1556","volume":"306","author":"KE Covinsky","year":"2011","unstructured":"Covinsky KE, Pierluissi E, Johnston CB (2011) Hospitalization-associated disability: \u201cshe was probably able to ambulate, but I\u2019m not sure.\u201d JAMA 306:1782\u20131793. https:\/\/doi.org\/10.1001\/jama.2011.1556","journal-title":"JAMA"},{"key":"1622_CR11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/cen.13790","volume":"89","author":"G Corona","year":"2018","unstructured":"Corona G, Norello D, Parenti G, Sforza A, Maggi M, Peri A (2018) Hyponatremia, falls and bone fractures: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 89:505\u2013513. https:\/\/doi.org\/10.1111\/cen.13790","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1622_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2188\/jea.JE20200288","volume":"31","author":"K Hayashida","year":"2021","unstructured":"Hayashida K, Murakami G, Matsuda S, Fushimi K (2021) History and profile of Diagnosis Procedure Combination (DPC): development of a real data collection system for acute inpatient care in Japan. J Epidemiol 31:1\u201311. https:\/\/doi.org\/10.2188\/jea.JE20200288","journal-title":"J Epidemiol"},{"key":"1622_CR13","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/mpr.329","volume":"20","author":"MJ Azur","year":"2011","unstructured":"Azur MJ, Stuart EA, Frangakis C, Leaf PJ (2011) Multiple imputation by chained equations: what is it and how does it work? Int J Methods Psychiatr Res 20:40\u201349. https:\/\/doi.org\/10.1002\/mpr.329","journal-title":"Int J Methods Psychiatr Res"},{"key":"1622_CR14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.36518\/2689-0216.1982","volume":"5","author":"T Locklear","year":"2024","unstructured":"Locklear T, Kontos J, Brock CA et al (2024) Inpatient falls: epidemiology, risk assessment, and prevention measures A narrative review. HCA Healthc J Med 5:517\u2013525. https:\/\/doi.org\/10.36518\/2689-0216.1982","journal-title":"HCA Healthc J Med"},{"key":"1622_CR15","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.gerinurse.2012.01.008","volume":"33","author":"M Boltz","year":"2012","unstructured":"Boltz M, Resnick B, Capezuti E, Shuluk J, Secic M (2012) Functional decline in hospitalized older adults: can nursing make a difference? Geriatr Nurs 33:272\u2013279. https:\/\/doi.org\/10.1016\/j.gerinurse.2012.01.008","journal-title":"Geriatr Nurs"},{"key":"1622_CR16","doi-asserted-by":"publisher","first-page":"390","DOI":"10.7326\/0003-4819-158-5-201303051-00005","volume":"158","author":"IM Miake-Lye","year":"2013","unstructured":"Miake-Lye IM, Hempel S, Ganz DA, Shekelle PG (2013) Inpatient fall prevention programs as a patient safety strategy: a systematic review. Ann Intern Med 158:390\u2013396. https:\/\/doi.org\/10.7326\/0003-4819-158-5-201303051-00005","journal-title":"Ann Intern Med"},{"key":"1622_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.maturitas.2015.02.009","volume":"81","author":"S Cabrerizo","year":"2015","unstructured":"Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Mar\u00edn-Ciancas F, Malafarina V (2015) Serum albumin and health in older people: review and meta-analysis. Maturitas 81:17\u201327. https:\/\/doi.org\/10.1016\/j.maturitas.2015.02.009","journal-title":"Maturitas"},{"key":"1622_CR18","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.jamda.2015.06.018","volume":"16","author":"G Kojima","year":"2015","unstructured":"Kojima G (2015) Frailty as a predictor of future falls among community-dwelling older people: a systematic review and meta-analysis. J Am Med Dir Assoc 16:1027\u20131033. https:\/\/doi.org\/10.1016\/j.jamda.2015.06.018","journal-title":"J Am Med Dir Assoc"},{"key":"1622_CR19","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.0894-0959.2004.17603.x","volume":"17","author":"BR Don","year":"2004","unstructured":"Don BR, Kaysen G (2004) Serum albumin: relationship to inflammation and nutrition. Semin Dial 17:432\u2013437. https:\/\/doi.org\/10.1111\/j.0894-0959.2004.17603.x","journal-title":"Semin Dial"},{"key":"1622_CR20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/s0002-9343(03)00263-8","volume":"115","author":"BW Penninx","year":"2003","unstructured":"Penninx BW, Guralnik JM, Onder G, Ferrucci L, Wallace RB, Pahor M (2003) Anemia and decline in physical performance among older persons. Am J Med 115:104\u2013110. https:\/\/doi.org\/10.1016\/s0002-9343(03)00263-8","journal-title":"Am J Med"},{"key":"1622_CR21","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s40520-021-02064-x","volume":"34","author":"DK Jang","year":"2022","unstructured":"Jang DK, Kang HW, Kim YH (2022) Association between anemia and dynapenia in older adults: a population-based study. Aging Clin Exp Res 34:1373\u20131379. https:\/\/doi.org\/10.1007\/s40520-021-02064-x","journal-title":"Aging Clin Exp Res"},{"key":"1622_CR22","doi-asserted-by":"publisher","first-page":"71.e1","DOI":"10.1016\/j.amjmed.2005.09.026","volume":"119","author":"B Renneboog","year":"2006","unstructured":"Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G (2006) Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 119:71.e1\u20138. https:\/\/doi.org\/10.1016\/j.amjmed.2005.09.026","journal-title":"Am J Med"},{"key":"1622_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0300784","volume":"19","author":"DY Lee","year":"2024","unstructured":"Lee DY, Jeong J, Choi WI (2024) Association between hemoglobin trajectories and the incidence of dementia in a cohort of females aged 55\u201379 years. PLoS ONE 19:e0300784. https:\/\/doi.org\/10.1371\/journal.pone.0300784","journal-title":"PLoS ONE"},{"key":"1622_CR24","doi-asserted-by":"publisher","first-page":"600","DOI":"10.2215\/CJN.12281019","volume":"15","author":"A Chewcharat","year":"2020","unstructured":"Chewcharat A, Thongprayoon C, Cheungpasitporn W et al (2020) Trajectories of serum sodium on in-hospital and 1-year survival among hospitalized patients. Clin J Am Soc Nephrol 15:600\u2013607. https:\/\/doi.org\/10.2215\/CJN.12281019","journal-title":"Clin J Am Soc Nephrol"},{"key":"1622_CR25","unstructured":"National Institute for Health and Care Excellence. Falls: assessment and prevention in older people and in people 50 and over at higher risk. NICE guideline NG249. 2025. https:\/\/www.nice.org.uk\/guidance\/ng249. Accessed 21 Jul 2026"}],"container-title":["European Geriatric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-026-01622-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s41999-026-01622-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s41999-026-01622-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:02:21Z","timestamp":1791392541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s41999-026-01622-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":25,"alternative-id":["1622"],"URL":"https:\/\/doi.org\/10.1007\/s41999-026-01622-8","relation":{},"ISSN":["1878-7657"],"issn-type":[{"value":"1878-7657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"27 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Central Ethics Review Committee of Nippon Medical School (approval number M-2023-137) and conducted in accordance with the Declaration of Helsinki. \u00a0","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The requirement for individual informed consent was waived by the ethics committee because of the retrospective nature of the study. Information about the study was disclosed to eligible patients, who were provided with the opportunity to opt out of participation.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}