{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:32:24Z","timestamp":1791750744798,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s42000-019-00106-8","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T03:02:43Z","timestamp":1555297363000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["68Ga-PSMA PET thyroid incidentalomas"],"prefix":"10.1007","volume":"18","author":[{"given":"Francesco","family":"Bertagna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Albano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Giovanella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Bonacina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rexhep","family":"Durmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Giubbini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Treglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"106_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00259-014-2949-6","volume":"42","author":"A Afshar-Oromieh","year":"2015","unstructured":"Afshar-Oromieh A, Avtzi E, Giesel FL et al (2015) The diagnostic value of PET\/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging 42:197\u2013209","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"106_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00259-014-2978-1","volume":"42","author":"C Kratochwil","year":"2015","unstructured":"Kratochwil C, Giesel FL, Eder M et al (2015) [(177)Lu]lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer. Eur J Nucl Med Mol Imaging 42:987\u2013988","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"106_CR3","unstructured":"Chang SS, Reuter VE, HestonWD et al (1999) Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res 59, 3192\u20133198"},{"key":"106_CR4","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.humpath.2009.06.003","volume":"40","author":"MC Haffner","year":"2009","unstructured":"Haffner MC, Kronberger IE, Ross JS et al (2009) Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. Hum Pathol 40:1754\u20131761","journal-title":"Hum Pathol"},{"key":"106_CR5","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1007\/s00268-005-0544-5","volume":"30","author":"Y Kinoshita","year":"2006","unstructured":"Kinoshita Y, Kuratsukuri K, Landas S et al (2006) Expression of prostate-specific membrane antigen in normal and malignant human tissues. World J Surg 30:628\u2013636","journal-title":"World J Surg"},{"key":"106_CR6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1148\/rg.2018170108","volume":"38","author":"MS Hofman","year":"2018","unstructured":"Hofman MS, Hicks RJ, Maurer T et al (2018) Prostate-specific membrane antigen PET: clinical utility in prostate cancer, normal patterns, pearls, and pitfalls. Radiographics 38:200\u2013217","journal-title":"Radiographics"},{"key":"106_CR7","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1007\/s00259-015-3065-y","volume":"42","author":"FA Verburg","year":"2015","unstructured":"Verburg FA, Krohn T, Heinzel A et al (2015) First evidence of PSMA expression in differentiated thyroid cancer using [68Ga]PSMA-HBED-CC PET\/CT. Eur J Nucl Med Mol Imaging 42:1622\u20131623","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"106_CR8","doi-asserted-by":"publisher","first-page":"e263","DOI":"10.1097\/RLU.0000000000001148","volume":"41","author":"SK Taywade","year":"2016","unstructured":"Taywade SK, Damle NA, Bal CS (2016) PSMA expression in papillary thyroid carcinoma opening a new horizon in management of thyroid cancer? Clin Nucl Med 41:e263\u2013e265","journal-title":"Clin Nucl Med"},{"key":"106_CR9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0378-1119(02)00397-9","volume":"285","author":"KR Noss","year":"2002","unstructured":"Noss KR, Wolfe SA, Grimes SR (2002) Upregulation of prostate specific membrane antigen\/folate hydrolase transcription by an enhancer. Gene 285:247\u2013256","journal-title":"Gene"},{"key":"106_CR10","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1097\/RLU.0000000000001335","volume":"41","author":"S Bourgeois","year":"2016","unstructured":"Bourgeois S, Gykiere P, Goethals L et al (2016) Aspecific uptake of 68GA-PSMA in Paget disease of the bone. Clin Nucl Med 41:877\u2013878","journal-title":"Clin Nucl Med"},{"key":"106_CR11","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s13139-016-0408-y","volume":"50","author":"NA Damle","year":"2016","unstructured":"Damle NA, Tripathi M, Chakraborty PS et al (2016) Unusual uptake of prostate specific tracer 68Ga-PSMA-HBED-CC in a benign thyroid nodule. Nucl Med Mol Imaging 50:344\u2013347","journal-title":"Nucl Med Mol Imaging"},{"key":"106_CR12","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1097\/MNM.0000000000000566","volume":"37","author":"E Demirci","year":"2016","unstructured":"Demirci E, Sahin OE, Ocak M et al (2016) Normal distribution pattern and physiological variants of 68Ga-PSMA-11 PET\/CT imaging. Nucl Med Commun 37:1169\u20131179","journal-title":"Nucl Med Commun"},{"key":"106_CR13","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1097\/RLU.0000000000001487","volume":"42","author":"T Derlin","year":"2017","unstructured":"Derlin T, Kreipe HH, Schumacher U et al (2017) PSMA expression in tumor neovasculature endothelial cells of follicular thyroid adenoma as identified by molecular imaging using 68Ga-PSMA ligand PET\/CT. Clin Nucl Med 42:e173\u2013e174","journal-title":"Clin Nucl Med"},{"key":"106_CR14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/RLU.0000000000001084","volume":"41","author":"GL Kanthan","year":"2016","unstructured":"Kanthan GL, Drummond J, Schembri GP et al (2016) Follicular thyroid adenoma showing avid uptake on 68Ga PSMA-HBED-CC PET\/CT. Clin Nucl Med 41:331\u2013332","journal-title":"Clin Nucl Med"},{"key":"106_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s40644-018-0175-3","volume":"18","author":"Z Keidar","year":"2018","unstructured":"Keidar Z, Gill R, Goshen E et al (2018) 68Ga-PSMA PET\/CT in prostate cancer patients - patterns of disease, benign findings and pitfalls. Cancer Imaging 18:39","journal-title":"Cancer Imaging"},{"key":"106_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.4103\/ijnm.IJNM_81_18","volume":"33","author":"D Malik","year":"2018","unstructured":"Malik D, Sood A, Mittal BR et al (2018) Nonspecific uptake of 68Ga-prostate-specific membrane antigen in diseases other than prostate malignancy on positron emission tomography\/computed tomography imaging: a pictorial assay and review of literature. Indian J Nucl Med 33:317\u2013325","journal-title":"Indian J Nucl Med"},{"key":"106_CR17","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.2967\/jnumed.117.190215","volume":"58","author":"MM Osman","year":"2017","unstructured":"Osman MM, Iravani A, Hicks RJ et al (2017) Detection of synchronous primary malignancies with 68Ga-labeled prostate-specific membrane antigen PET\/CT in patients with prostate cancer: frequency in 764 patients. J Nucl Med 58:1938\u20131942","journal-title":"J Nucl Med"},{"key":"106_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2967\/jnmt.115.171660","volume":"44","author":"S Sager","year":"2016","unstructured":"Sager S, Vatankulu B, Uslu L et al (2016) Incidental detection of follicular thyroid carcinoma in 68Ga-PSMA PET\/CT imaging. J Nucl Med Technol 44:199\u2013200","journal-title":"J Nucl Med Technol"},{"key":"106_CR19","first-page":"145","volume":"21","author":"D Singh","year":"2018","unstructured":"Singh D, Horneman R, Nagra NK (2018) More than the prostate: intrapancreatic accessory spleen and papillary thyroid cancer detected with 18F-PSMA PET\/CT. Hell J Nucl Med 21:145\u2013147","journal-title":"Hell J Nucl Med"},{"key":"106_CR20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/RLU.0000000000001522","volume":"42","author":"HD Zacho","year":"2017","unstructured":"Zacho HD, Nielsen JB, Dettmann K et al (2017) Incidental detection of thyroid metastases from renal cell carcinoma using 68Ga-PSMA PET\/CT to assess prostate cancer recurrence. Clin Nucl Med 42:221\u2013222","journal-title":"Clin Nucl Med"},{"key":"106_CR21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4103\/0972-3919.202248","volume":"32","author":"A Jena","year":"2017","unstructured":"Jena A, Zaidi S, Kashyap V et al (2017) PSMA expression in multinodular thyroid neoplasm on simultaneous Ga-68-PSMA PET\/MRI. Indian J Nucl Med 32:159\u2013161","journal-title":"Indian J Nucl Med"},{"key":"106_CR22","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1016\/j.urology.2017.03.018","volume":"104","author":"A Joshi","year":"2017","unstructured":"Joshi A, Nicholson C, Rhee H et al (2017) Incidental malignancies identified during staging for prostate cancer with 68Ga prostate-specific membrane antigen HBED-CC positron emission tomography imaging. Urology 104:e3\u2013e4","journal-title":"Urology"},{"key":"106_CR23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3413\/Nukmed-0568-13-03","volume":"52","author":"G Treglia","year":"2013","unstructured":"Treglia G, Bertagna F, Sadeghi R et al (2013) Focal thyroid incidental uptake detected by 18F-fluorodeoxyglucose positron emission tomography. Meta-analysis on prevalence and malignancy risk. Nuklearmedizin 52:130\u2013136","journal-title":"Nuklearmedizin"},{"key":"106_CR24","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1089\/thy.2012.0216","volume":"23","author":"G Treglia","year":"2013","unstructured":"Treglia G, Giovanella L, Bertagna F et al (2013) Prevalence and risk of malignancy of thyroid incidentalomas detected by (18)f-fluorodeoxyglucose positron-emission tomography. Thyroid 23:124\u2013126","journal-title":"Thyroid"},{"key":"106_CR25","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s12020-012-9837-2","volume":"43","author":"F Bertagna","year":"2013","unstructured":"Bertagna F, Treglia G, Piccardo A et al (2013) F18-FDG-PET\/CT thyroid incidentalomas: a wide retrospective analysis in three Italian centres on the significance of focal uptake and SUV value. Endocrine 43:678\u2013685","journal-title":"Endocrine"},{"key":"106_CR26","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.1210\/jc.2012-2390","volume":"97","author":"F Bertagna","year":"2012","unstructured":"Bertagna F, Treglia G, Piccardo A et al (2012) Diagnostic and clinical significance of F-18-FDG-PET\/CT thyroid incidentalomas. J Clin Endocrinol Metab 97:3866\u20133875","journal-title":"J Clin Endocrinol Metab"},{"key":"106_CR27","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1038\/s41598-017-05481-z","volume":"7","author":"A Bychkov","year":"2017","unstructured":"Bychkov A, Vutrapongwatana U, Tepmongkol S et al (2017) PSMA expression by microvasculature of thyroid tumors - potential implications for PSMA theranostics. Sci Rep 7:5202","journal-title":"Sci Rep"},{"key":"106_CR28","doi-asserted-by":"publisher","first-page":"e265","DOI":"10.1097\/RLU.0000000000002161","volume":"43","author":"P Verma","year":"2018","unstructured":"Verma P, Malhotra G, Agrawal R et al (2018) Evidence of prostate-specific membrane antigen expression in metastatic differentiated thyroid Cancer using 68Ga-PSMA-HBED-CC PET\/CT. Clin Nucl Med 43:e265\u2013e268","journal-title":"Clin Nucl Med"},{"key":"106_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/RLU.0000000000002103","volume":"43","author":"D Malik","year":"2018","unstructured":"Malik D, Kumar R, Mittal BR et al (2018) 68Ga-labeled PSMA uptake in nonprostatic malignancies: has the time come to remove \u201cPS\u201d from PSMA? Clin Nucl Med 43:529\u2013532","journal-title":"Clin Nucl Med"},{"key":"106_CR30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/RLU.0000000000001454","volume":"42","author":"S L\u00fctje","year":"2017","unstructured":"L\u00fctje S, Gomez B, Cohnen J et al (2017) Imaging of prostate-specific membrane antigen expression in metastatic differentiated thyroid cancer using 68Ga-HBED-CC-PSMA PET\/CT. Clin Nucl Med 42:20\u201325","journal-title":"Clin Nucl Med"},{"key":"106_CR31","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12022-017-9500-9","volume":"28","author":"M Moore","year":"2017","unstructured":"Moore M, Panjwani S, Mathew R et al (2017) Well-differentiated thyroid cancer neovasculature expresses prostate-specific membrane antigen-a possible novel therapeutic target. Endocr Pathol 28:339\u2013344","journal-title":"Endocr Pathol"},{"key":"106_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00259-017-3904-0","volume":"45","author":"NA Damle","year":"2018","unstructured":"Damle NA, Bal C, Singh TP et al (2018) Anaplastic thyroid carcinoma on 68 Ga-PSMA PET\/CT: opening new frontiers. Eur J Nucl Med Mol Imaging 45:667\u2013668","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"106_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CCO.0000000000000338","volume":"29","author":"M Luster","year":"2017","unstructured":"Luster M, Pfestroff A, Verburg FA (2017) Recent advances in nuclear medicine in endocrine oncology. Curr Opin Oncol 29:1\u20136","journal-title":"Curr Opin Oncol"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-019-00106-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s42000-019-00106-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-019-00106-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T19:26:42Z","timestamp":1586806002000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s42000-019-00106-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["106"],"URL":"https:\/\/doi.org\/10.1007\/s42000-019-00106-8","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]},"assertion":[{"value":"19 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}