{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:24:12Z","timestamp":1768314252215,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871389"],"award-info":[{"award-number":["81871389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172598"],"award-info":[{"award-number":["81172598"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s42000-019-00123-7","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T07:02:22Z","timestamp":1566630142000},"page":"267-272","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Radiosensitivity-related postirradiation hypothyroidism in Graves\u2019 disease patients"],"prefix":"10.1007","volume":"18","author":[{"given":"Xi","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,24]]},"reference":[{"key":"123_CR1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","volume":"388","author":"S De Leo","year":"2016","unstructured":"De Leo S, Lee SY, Braverman LE (2016) Hyperthyroidism. Lancet 388:906\u2013918","journal-title":"Lancet"},{"issue":"6","key":"123_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.remnie.2017.09.003","volume":"36","author":"O. Tabuenca-Dopico","year":"2017","unstructured":"Tabuenca-Dopico O, Boente-Varela R, Lamas-Ferreiro JL (2017) Study of factors that influence the outcome of 131I treatment in hyperthyroidism secondary to nodular goitre. Rev Esp Med Nucl Imagen Mol 36:356\u2013361","journal-title":"Revista Espa\u00f1ola de Medicina Nuclear e Imagen Molecular (English Edition)"},{"key":"123_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1055\/s-0043-119545","volume":"50","author":"Y Qin","year":"2018","unstructured":"Qin Y, Yao L, Shao F, Yang K, Tian L (2018) Methodological quality assessment of meta-analyses of hyperthyroidism treatment. Horm Metab Res 50:8\u201316","journal-title":"Horm Metab Res"},{"key":"123_CR4","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1089\/thy.2017.0063","volume":"27","author":"NMY Journy","year":"2017","unstructured":"Journy NMY, Bernier MO, Doody MM, Alexander BH, Linet MS et al (2017) Hyperthyroidism, hypothyroidism, and cause-specific mortality in a large cohort of women. Thyroid 27:1001\u20131010","journal-title":"Thyroid"},{"key":"123_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/MNM.0000000000000770","volume":"39","author":"D Yang","year":"2018","unstructured":"Yang D, Xue J, Ma W, Liu F, Fan Y et al (2018) Prognostic factor analysis in 325 patients with Graves\u2019 disease treated with radioiodine therapy. Nucl Med Commun 39:16\u201321","journal-title":"Nucl Med Commun"},{"key":"123_CR6","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","volume":"26","author":"DS Ross","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P et al (2016) 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 26:1343\u20131421","journal-title":"Thyroid"},{"key":"123_CR7","first-page":"1","volume":"11","author":"J Yu","year":"2016","unstructured":"Yu J, Tian A-J, Yuan X, Cheng X-X (2016) Subclinical hypothyroidism after 131I -treatment of Graves\u2019 disease: a risk factor for depression? PLoS One 11:1\u20139","journal-title":"PLoS One"},{"key":"123_CR8","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(17)30703-1","volume":"390","author":"L Chaker","year":"2017","unstructured":"Chaker L, Bianco AC, Jonklaas J, Peeters RP (2017) Hypothyroidism. Lancet 390:1550\u20131562","journal-title":"Lancet"},{"issue":"4","key":"123_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.17305\/bjbms.2018.2350","volume":"18","author":"Jing Zhou","year":"2018","unstructured":"Zhou J, Cheng G, Pang H, Liu Q, Liu Y (2018) The effect of 131I-induced hypothyroidism on the levels of nitric oxide (NO), interleukin 6 (IL\u20136), tumor necrosis factor alpha (TNF-alpha), total nitric oxide synthase (NOS) activity, and expression of NOS isoforms in rats. Bosn J Basic Med 18:305\u2013312","journal-title":"Bosnian Journal of Basic Medical Sciences"},{"key":"123_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/ct.2017;29.65-67","volume":"29","author":"EN Pearce","year":"2017","unstructured":"Pearce EN (2017) Radioactive iodine has the ,most favorable efficacy and safety profile for the treatment of Graves\u2019 disease at the Mayo Clinic. Clin Thyroidol 29:65\u201367","journal-title":"Clin Thyroidol"},{"key":"123_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3413\/Nukmed-0692-14-08","volume":"54","author":"T Krohn","year":"2015","unstructured":"Krohn T, Behrendt FF, Heinzel A, Mueller B, Mottaghy FM et al (2015) Pretherapeutic dosimetry before 131I therapy of benign thyroid disease. A clinical practice assessment of dosimetric parameters. Nuklearmed-Nucl Med 54:131\u2013136","journal-title":"Nuklearmed-Nucl Med"},{"key":"123_CR12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/RLU.0000000000000840","volume":"40","author":"MT Sapienza","year":"2015","unstructured":"Sapienza MT, Coura-Filho GB, Willegaignon J, Watanabe T, Duarte PS et al (2015) Clinical and dosimetric variables related to outcome after treatment of Graves\u2019 disease with 550 and 1110 MBq of I-131. Clin Nucl Med 40:715\u2013719","journal-title":"Clin Nucl Med"},{"issue":"6","key":"123_CR13","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/codi.13212","volume":"18","author":"FG Marinelli","year":"2016","unstructured":"Marinelli FG, Baguena G, Lucas E, Frasson M, Herv\u00e1s D et al (2016) Anastomotic leakage after colon cancer resection: does the individual surgeon matter? Color Dis 18(6):562\u2013569","journal-title":"Color Dis"},{"key":"123_CR14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s12020-016-1074-7","volume":"54","author":"P Szumowski","year":"2016","unstructured":"Szumowski P, Mojsak M, Abdelrazek S, Sykala M, Amelian-Filonowicz A et al (2016) Calculation of therapeutic activity of radioiodine in Graves\u2019 disease by means of Marinelli\u2019s formula, using technetium (Tc-99m) scintigraphy. Endocrine 54:751\u2013756","journal-title":"Endocrine"},{"key":"123_CR15","doi-asserted-by":"publisher","first-page":"4109","DOI":"10.1210\/jc.2014-1347","volume":"99","author":"T Krohn","year":"2014","unstructured":"Krohn T, Haenscheid H, Mueller B, Behrendt FF, Heinzel A et al (2014) Maximum dose rate is a determinant of hypothyroidism after I-131 therapy of Graves\u2019 disease but the total thyroid absorbed dose is not. J Clin Endocrinol Metab 99:4109\u20134115","journal-title":"J Clin Endocrinol Metab"},{"key":"123_CR16","doi-asserted-by":"publisher","first-page":"7673","DOI":"10.3892\/mmr.2015.4350","volume":"12","author":"K Guo","year":"2015","unstructured":"Guo K, Gao R, Yu Y, Zhang W, Yang Y et al (2015) Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131. Mol Med Rep 12:7673\u20137680","journal-title":"Mol Med Rep"},{"key":"123_CR17","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1089\/thy.2016.0343","volume":"27","author":"V Sundaresh","year":"2017","unstructured":"Sundaresh V, Brito JP, Thapa P, Bahn RS, Stan MN (2017) Comparative effectiveness of treatment choices for Graves\u2019 hyperthyroidism: a historical cohort study. Thyroid 27:497\u2013505","journal-title":"Thyroid"},{"issue":"16","key":"123_CR18","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1056\/NEJMra1510030","volume":"375","author":"TJ Smith","year":"2016","unstructured":"Smith TJ, Hegedus L (2016) Graves\u2019 disease. N Engl J Med 375(16):1552\u20131565","journal-title":"N Engl J Med"},{"issue":"5","key":"123_CR19","first-page":"8262","volume":"8","author":"H Xiao","year":"2015","unstructured":"Xiao H, Xie P, Zhou K, Qiu X, Hong Y et al (2015) Clavien-Dindo classification and risk factors of gastrectomy-related complications: an analysis of 1049 patients. Int J Clin Exp Med 8(5):8262\u20138268","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"123_CR20","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jtcvs.2004.06.028","volume":"129","author":"K Karkouti","year":"2005","unstructured":"Karkouti K, Beattie WS, Wijeysundera DN, Rao V, Chan C et al (2005) Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery. J Thorac Cardiovasc Surg 129(2):391\u2013400","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"123_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.jp.7211429","volume":"26","author":"J Attridge","year":"2006","unstructured":"Attridge J, Clark R, Walker M, Gordon P (2006) New insights into spontaneous intestinal perforation using a national data set:(1) SIP is associated with early indomethacin exposure. J Perinatol 26(2):93","journal-title":"J Perinatol"},{"issue":"1","key":"123_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1054\/bjoc.2001.1822","volume":"85","author":"A Rohatiner","year":"2001","unstructured":"Rohatiner A, Radford J, Deakin D, Earl H, Love SB et al (2001) A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma. Br J Cancer 85(1):29\u201335","journal-title":"Br J Cancer"},{"key":"123_CR23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41598-017-00056-4","volume":"7","author":"R Zhang","year":"2017","unstructured":"Zhang R, Tan J, Wang R, Zhang G, Jia Q et al (2017) Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves\u2019 disease patients. Sci Rep 7:32\u201338","journal-title":"Sci Rep"},{"key":"123_CR24","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1002\/jcb.26327","volume":"119","author":"X-R Han","year":"2018","unstructured":"Han X-R, Wen X, Wang S, Fan S-H, Zhuang J et al (2018) Correlations of CTLA-4 exon-1 49 A\/G and promoter region 318C\/T polymorphisms with the therapeutic efficacy of I-131 radionuclide in Graves\u2019 disease in Chinese Han population. J Cell Biochem 119:6383\u20136390","journal-title":"J Cell Biochem"},{"key":"123_CR25","first-page":"544","volume":"25","author":"W Qi-jin","year":"2009","unstructured":"Qi-jin W, Da-jin ZOU (2009) Ku70 antisense oligo-nucleotide enhances the radiosensitivity of thyroid carcinoma cells. Chin J Endocrinol Metab 25:544\u2013548","journal-title":"Chin J Endocrinol Metab"},{"key":"123_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3724\/SP.J.1008.2011.00033","volume":"32","author":"Q Wang","year":"2011","unstructured":"Wang Q, Zou D (2011) Therapeutic effects of radioisotope labeled Ku70 antisense oligodeoxynuclecotide on thyroid carcinoma implanted in nude mice. Acad J Second Military Med Univ 32:33\u201336","journal-title":"Acad J Second Military Med Univ"},{"key":"123_CR27","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.bbrc.2017.01.146","volume":"484","author":"J Ma","year":"2017","unstructured":"Ma J, Hui P, Meng W, Wang N, Xiang S (2017) Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis. Biochem Biophys Res Commun 484:746\u2013752","journal-title":"Biochem Biophys Res Commun"},{"key":"123_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.dnarep.2016.03.014","volume":"43","author":"E Weterings","year":"2016","unstructured":"Weterings E, Gallegos AC, Dominick LN, Cooke LS, Bartels TN et al (2016) A novel small molecule inhibitor of the DNA repair protein Ku70\/80. DNA Repair 43:98\u2013106","journal-title":"DNA Repair"},{"key":"123_CR29","doi-asserted-by":"publisher","first-page":"514","DOI":"10.2741\/4406","volume":"21","author":"BB Kragelund","year":"2016","unstructured":"Kragelund BB, Weterings E, Hartmann-Petersen R, Keijzers G (2016) The Ku70\/80 ring in non-homologous end-joining: easy to slip on, hard to remove. Front Biosci 21:514\u2013527","journal-title":"Front Biosci"},{"issue":"3","key":"123_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s11033-018-4158-z","volume":"45","author":"Amrita Singh","year":"2018","unstructured":"Singh A, Singh N, Behera D, Sharma S (2018) Role of polymorphic XRCC6 (Ku70)\/XRCC7 (DNA-PKcs) genes towards susceptibility and prognosis of lung cancer patients undergoing platinum based doublet chemotherapy. Mol Biol Rep 45: 253\u2013261","journal-title":"Molecular Biology Reports"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-019-00123-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s42000-019-00123-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-019-00123-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T23:28:35Z","timestamp":1598138915000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s42000-019-00123-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,24]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["123"],"URL":"https:\/\/doi.org\/10.1007\/s42000-019-00123-7","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,24]]},"assertion":[{"value":"26 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}