{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:52:23Z","timestamp":1788454343046,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s42000-020-00227-5","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:02:46Z","timestamp":1594166566000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Graves\u2019 hyperthyroidism-related pancytopenia: a case report with literature review"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-9551","authenticated-orcid":false,"given":"Lorenzo","family":"Scappaticcio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bellastella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ida","family":"Maiorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Paolisso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"227_CR1","first-page":"434","volume-title":"Werner & Ingbar\u2019s The Thyroid","author":"HB Burch","year":"2013","unstructured":"Burch HB (2013) Overview of the clinical manifestations of thyrotoxicosis. In: Braverman LE (ed) Werner & Ingbar\u2019s The Thyroid, 10th edn. LippincottWilliams &Wilkins, Philadelphia, pp 434\u2013440","edition":"10"},{"issue":"6","key":"227_CR2","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/cen.13133","volume":"85","author":"A Aggarwal","year":"2017","unstructured":"Aggarwal A, Tee SA, Saqib W, Fretwell T, Summerfield GP, Razvi S (2017) Treatment of hyperthyroidism with antithyroid drugs corrects mild neutropenia in Graves\u2019 disease. Clin Endocrinol (Oxf) 85(6):949\u2013953","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"227_CR3","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/cen.13312","volume":"86","author":"TY Lin","year":"2017","unstructured":"Lin TY, Shekar AO, Li N, Yeh MW et al (2017) Incidence of abnormal liver biochemical tests in hyperthyroidism. Clin Endocrinol (Oxf) 86(5):755\u2013759","journal-title":"Clin Endocrinol (Oxf)"},{"key":"227_CR4","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","volume":"26","author":"DS Ross","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC et al (2016) 2016 American Thyroid Association Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 26:1343\u20131421","journal-title":"Thyroid"},{"key":"227_CR5","unstructured":"Jameson JL, Kasper DL, Longo DL (Dan Louis) 1949-, Fauci AS 1940-, Hauser SL, Loscalzo J (2018) Harrison\u2019s principles of internal medicine. 20th edn. New York: McGraw-Hill Education"},{"key":"227_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1507\/endocrj.48.181","volume":"48","author":"S Nakamura","year":"2001","unstructured":"Nakamura S, Isaji M, Ishimori M (2001) Morning granulocytopenia in a case of Graves\u2019 disease. Endocr J 48:181\u2013184","journal-title":"Endocr J"},{"key":"227_CR7","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1172\/JCI100471","volume":"11","author":"S Hertz","year":"1932","unstructured":"Hertz S, Lerman J (1932) The blood picture in exophthalmic goitre and its changes resulting from iodine and operation: a study by means of the supravital technique. J Clin Invest 11:1179\u20131196","journal-title":"J Clin Invest"},{"key":"227_CR8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1089\/thy.2006.16.403","volume":"16","author":"CS Lima","year":"2006","unstructured":"Lima CS, Wittmann DE, Catro V, Tambascia et al (2006) Pancytopenia in untreated patients with Graves\u2019 disease. Thyroid 16:403\u2013409","journal-title":"Thyroid"},{"issue":"3","key":"227_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1507\/endocrj.48.385","volume":"48","author":"T Soeki","year":"2001","unstructured":"Soeki T, Tamura Y, Kondo N et al (2001) A case of thyrotoxicosis with pancytopenia. Endocr J 48(3):385\u2013389","journal-title":"Endocr J"},{"issue":"6","key":"227_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1046\/j.1365-2257.2002.00460.x","volume":"24","author":"B Shaw","year":"2002","unstructured":"Shaw B, Mehta AB (2002) Pancytopenia responding to treatment of hyperthyroidism: a clinical case and review of the literature. Clin Lab Haematol 24(6):385\u2013387","journal-title":"Clin Lab Haematol"},{"issue":"2","key":"227_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/bjh.13853","volume":"172","author":"SB Killick","year":"2016","unstructured":"Killick SB, Bown N, Cavenagh J et al (2016) British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol 172(2):187\u2013207","journal-title":"Br J Haematol"},{"issue":"17","key":"227_CR12","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1056\/NEJMra1413485","volume":"379","author":"NS Young","year":"2018","unstructured":"Young NS (2018) Aplastic anemia. N Engl J Med 379(17):1643\u20131656","journal-title":"N Engl J Med"},{"issue":"1","key":"227_CR13","doi-asserted-by":"publisher","first-page":"E49","DOI":"10.1210\/jc.2011-2221","volume":"97","author":"N Watanabe","year":"2012","unstructured":"Watanabe N, Narimatsu H, Noh JY et al (2012) Antithyroid drug-induced hematopoietic damage: a retrospective cohort study of agranulocytosis and pancytopenia involving 50,385 patients with Graves\u2019 disease. J Clin Endocrinol Metab 97(1):E49\u2013E53","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"227_CR14","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1001\/archinte.1981.00340040140037","volume":"141","author":"AL Talansky","year":"1981","unstructured":"Talansky AL, Schulman P, Vinciguerra VP, Margouleff D, Budman DR, Degnan TJ (1981) Pancytopenia complicating Graves\u2019 disease and drug-induced hypothyroidism. Arch Intern Med 141(4):544\u2013545","journal-title":"Arch Intern Med"},{"issue":"4","key":"227_CR15","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1479-828X.1995.tb02168.x","volume":"35","author":"P Ladwig","year":"1995","unstructured":"Ladwig P, Coles R, Fischer E, Spurrett B (1995) Thyrotoxicosis in pregnancy presenting as pancytopenia. Aust N Z J Obstet Gynaecol 35(4):457\u2013460","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"4","key":"227_CR16","first-page":"180","volume":"89","author":"G Bertola","year":"1998","unstructured":"Bertola G, Bocchia M, Ribotto P, Orlandini B, Torchio G (1998) Hematological changes in hyperthyroidism. A case report. Recenti Prog Med 89(4):180\u2013182","journal-title":"Recenti Prog Med"},{"issue":"1","key":"227_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4103\/0973-1482.31972","volume":"3","author":"R Akoum","year":"2007","unstructured":"Akoum R, Michel S, Wafic T et al (2007) Myelodysplastic syndrome and pancytopenia responding to treatment of hyperthyroidism: peripheral blood and bone marrow analysis before and after antihormonal treatment. J Cancer Res Ther 3(1):43\u201346","journal-title":"J Cancer Res Ther"},{"issue":"2","key":"227_CR18","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/pbc.20640","volume":"49","author":"PK Das","year":"2007","unstructured":"Das PK, Wherrett D, Dror Y (2007) Remission of aplastic anemia induced by treatment for Graves disease in a pediatric patient. Pediatr Blood Cancer 49(2):210\u2013212","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"227_CR19","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/SMJ.0b013e318172fcb8","volume":"101","author":"Y Aydin","year":"2008","unstructured":"Aydin Y, Berker D, Ust\u00fcn I et al (2008) A very rare cause of aplastic anemia: Graves disease. South Med J 101(6):666\u2013667","journal-title":"South Med J"},{"issue":"1","key":"227_CR20","first-page":"48","volume":"28","author":"M Hegazi","year":"2008","unstructured":"Hegazi M, Kumar R, Bitar Z, Ibrahim E (2008) Pancytopenia related to Graves\u2019 disease. Ann Saudi Med 28(1):48\u201349","journal-title":"Ann Saudi Med"},{"issue":"1","key":"227_CR21","first-page":"23","volume":"1","author":"B-H Low","year":"2009","unstructured":"Low B-H, Victor Kok VC-K (2009) Hyperthyroidism with pancytopenia: a case report and literature review. Formos J Endocrin Metab 1(1):23\u201328","journal-title":"Formos J Endocrin Metab"},{"issue":"2","key":"227_CR22","first-page":"258.e1-2","volume":"27","author":"YH Chen","year":"2009","unstructured":"Chen YH, Lin HJ, Chen KT (2009) Rare presentations of hyperthyroidism\u2014Basedow\u2019s paraplegia and pancytopenia. Am J Emerg Med 27(2):258.e1-2","journal-title":"Am J Emerg Med"},{"issue":"3","key":"227_CR23","doi-asserted-by":"publisher","first-page":"478","DOI":"10.4103\/2230-8210.95739","volume":"16","author":"S Raina","year":"2012","unstructured":"Raina S, Kaul R, Mruthyunjaya M (2012) Pancytopenia with cellular bone marrow related to Graves\u2019 hyperthyroidism. Indian J Endocrinol Metab 16(3):478\u2013479","journal-title":"Indian J Endocrinol Metab"},{"issue":"4","key":"227_CR24","first-page":"372","volume":"68","author":"HH Loh","year":"2013","unstructured":"Loh HH, Tan F (2013) Pancytopenia in a patient with Grave\u2019s disease. Med J Malaysia 68(4):372\u2013373","journal-title":"Med J Malaysia"},{"key":"227_CR25","doi-asserted-by":"publisher","first-page":"194542","DOI":"10.1155\/2013\/194542","volume":"2013","author":"P Naji","year":"2013","unstructured":"Naji P, Kumar G, Dewani S, Diedrich WA, Gupta A (2013) Graves\u2019 disease causing pancytopenia and autoimmune hemolytic anemia at different time intervals: a case report and a review of the literature. Case Rep Med 2013:194542","journal-title":"Case Rep Med"},{"issue":"9","key":"227_CR26","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1590\/0004-2730000003216","volume":"58","author":"J Garcia","year":"2014","unstructured":"Garcia J, Ld F, Ellinger V, Wolff M (2014) Marrow hypoplasia: a rare complication of untreated Grave\u2019s disease. Arq Bras Endocrinol Metabol 58(9):953\u2013957","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"227_CR27","doi-asserted-by":"crossref","unstructured":"Garla VV, Abdul Salim S, Yanes-Cardozo LL (2018) Pancytopenia: a rare complication of Graves\u2019 disease. BMJ Case Rep 9","DOI":"10.1136\/bcr-2017-223887"},{"key":"227_CR28","doi-asserted-by":"publisher","first-page":"117954761878109","DOI":"10.1177\/1179547618781090","volume":"11","author":"L Pincet","year":"2018","unstructured":"Pincet L, Gorostidi F (2018) Graves disease causing pancytopenia: case report and literature review. Clin Med Insights Case Rep 11:1179547618781090","journal-title":"Clin Med Insights Case Rep"},{"issue":"6","key":"227_CR29","doi-asserted-by":"publisher","first-page":"E388","DOI":"10.4158\/ACCR-2019-0170","volume":"5","author":"JC Li","year":"2019","unstructured":"Li JC, Nandiraju D, Jabbour S, Kubey AA (2019) Pancytopenia and lymphoid organ hyperplasia in a patient with Graves disease: response to antithyroid drug therapy. AACE Clin Case Rep 5(6):E388\u2013E392","journal-title":"AACE Clin Case Rep"},{"issue":"1","key":"227_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000506440","volume":"13","author":"OA Hamid","year":"2020","unstructured":"Hamid OA, Fadul AM, Batia TB, Yassin MA (2020) Graves\u2019 disease-related pancytopenia improved after radioactive iodine ablation. Case Rep Oncol 13(1):295\u2013298","journal-title":"Case Rep Oncol"},{"issue":"3","key":"227_CR31","first-page":"877","volume":"6","author":"AN Rafhati","year":"2014","unstructured":"Rafhati AN, See CK, Hoo FK, Badrulnizam LB (2014) A report of three cases of untreated Graves\u2019 disease associated with pancytopenia in Malaysia. Electron Physician 6(3):877\u2013882","journal-title":"Electron Physician"},{"issue":"3","key":"227_CR32","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000204203","volume":"92","author":"M Hinterberger-Fischer","year":"1994","unstructured":"Hinterberger-Fischer M, Kier P, Forstinger I et al (1994) Coincidence of severe aplastic anaemia with multiple sclerosis or thyroid disorders. Report of 5 cases. Acta Haematol 92(3):136\u2013139","journal-title":"Acta Haematol"},{"issue":"1220","key":"227_CR33","first-page":"U1615","volume":"118","author":"L Kebapcilar","year":"2005","unstructured":"Kebapcilar L, Ye\u015fil S, Bayraktar F et al (2005) Recovery from pancytopaenia and liver dysfunction after administration of propylthiouracil for Graves\u2019 disease. N Z Med J 118(1220):U1615","journal-title":"N Z Med J"},{"issue":"1","key":"227_CR34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.4103\/ijnm.IJNM_134_18","volume":"34","author":"KK Behera","year":"2019","unstructured":"Behera KK, Agrawal K, Adhya AK (2019) Graves\u2019 disease with pancytopenia and hepatic dysfunction: a rare case presentation. Indian J Nucl Med 34(1):38\u201341","journal-title":"Indian J Nucl Med"},{"key":"227_CR35","first-page":"6087135","volume":"2017","author":"KA Baagar","year":"2017","unstructured":"Baagar KA, Siddique MA, Arroub SA, Ebrahim AH, Jayyousi AA (2017) Atypical complications of Graves\u2019 disease: a case report and literature review. Case Rep Endocrinol 2017:6087135","journal-title":"Case Rep Endocrinol"},{"key":"227_CR36","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1136\/pgmj.64.756.735","volume":"64","author":"HC Ford","year":"1988","unstructured":"Ford HC, Carter JM (1988) The haematology of hyperthyroidism: abnormalities of erythrocytes, leucocytes, thrombocytes and haemostasis. Postgrad Med J 64:735\u2013742","journal-title":"Postgrad Med J"},{"issue":"2","key":"227_CR37","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1530\/EJE-09-0875","volume":"162","author":"MP Kawa","year":"2010","unstructured":"Kawa MP, Grymula K, Paczkowska E et al (2010) Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies. Eur J Endocrinol 162(2):295\u2013305","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"227_CR38","first-page":"601","volume":"63","author":"Y Gao","year":"2014","unstructured":"Gao Y, Shen HJ, Zhou P et al (2014) Relationship between leukopenia and intercellular adhesion molecules in Graves\u2019 disease. West Indian Med J 63(6):601\u2013604","journal-title":"West Indian Med J"},{"key":"227_CR39","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1210\/jcem-70-2-491","volume":"70","author":"S Panzer","year":"1990","unstructured":"Panzer S, Haubenstock A, Minar E (1990) Platelets in hyperthyroidism: studies on platelet counts, mean platelet volume, 111-indium-labeled platelet kinetics, and platelet-associated immunoglobulins G and M. J Clin Endocrinol Metab 70:491\u2013496","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"227_CR40","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.hoc.2009.08.003","volume":"23","author":"E Cheung","year":"2009","unstructured":"Cheung E, Liebman HA (2009) Thyroid disease in patients with immune thrombocytopenia. Hematol Oncol Clin North Am 23(6):1251\u20131260","journal-title":"Hematol Oncol Clin North Am"},{"key":"227_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1172\/JCI111663","volume":"75","author":"SA Weitzman","year":"1985","unstructured":"Weitzman SA, Stossel TP, Harmon DC, Daniels G, Maloof F, Ridgway EC (1985) Antineutrophil autoantibodies in Graves\u2019 disease: implications of thyrotropin binding to neutrophils. J Clin Invest 75:119\u2013123","journal-title":"J Clin Invest"},{"issue":"6","key":"227_CR42","doi-asserted-by":"publisher","first-page":"451","DOI":"10.2174\/1381612013397898","volume":"7","author":"R Volp\u00e9","year":"2001","unstructured":"Volp\u00e9 R (2001) The immunomodulatory effects of anti-thyroid drugs are mediated via actions on thyroid cells, affecting thyrocyte immunocyte signalling: a review. Curr Pharm Des 7(6):451\u2013460","journal-title":"Curr Pharm Des"},{"key":"227_CR43","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1440-1746.1995.tb01106.x","volume":"10","author":"MJ Huang","year":"1995","unstructured":"Huang MJ (1995) Liaw YF (1995) Clinical associations between thyroid and liver diseases. J Gastroenterol Hepatol 10:344\u2013350","journal-title":"J Gastroenterol Hepatol"},{"key":"227_CR44","doi-asserted-by":"publisher","first-page":"m41","DOI":"10.1136\/bmj.m41","volume":"368","author":"M Vasileiou","year":"2020","unstructured":"Vasileiou M, Gilbert J, Fishburn S, Boelaert K, Guideline Committee (2020) Thyroid disease assessment and management: summary of NICE guidance. BMJ 368:m41","journal-title":"BMJ"},{"issue":"4","key":"227_CR45","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1159\/000490384","volume":"7","author":"GJ Kahaly","year":"2018","unstructured":"Kahaly GJ, Bartalena L, Heged\u00fcs L, Leenhardt L, Poppe K, Pearce SH (2018) 2018 European Thyroid Association Guideline for the Management of Graves\u2019 Hyperthyroidism. Eur Thyroid J 7(4):167\u2013186","journal-title":"Eur Thyroid J"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-020-00227-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42000-020-00227-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-020-00227-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T23:06:16Z","timestamp":1625699176000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42000-020-00227-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,8]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["227"],"URL":"https:\/\/doi.org\/10.1007\/s42000-020-00227-5","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,8]]},"assertion":[{"value":"22 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The patient gave his written informed consent to have his case published. The local institute\u2019s committee on human research approved this study protocol.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}