{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:52:44Z","timestamp":1765608764975,"version":"3.40.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s42000-020-00254-2","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T17:03:06Z","timestamp":1604595786000},"page":"315-321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adequate vitamin D supplementation does not ameliorate bone loss following long limb-biliopancreatic diversion in morbidly obese women"],"prefix":"10.1007","volume":"20","author":[{"given":"Sotirios","family":"Volonakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Koika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Tzavelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Skopeliti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Skroubis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotis","family":"Kalfarentzos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-6528","authenticated-orcid":false,"given":"Theodore","family":"Alexandrides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"254_CR1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.4239\/wjd.v8.i11.464","volume":"8","author":"R Lupoli","year":"2017","unstructured":"Lupoli R, Lembo E, Saldalamacchia G, Avola CK, Angrisani L, Capaldo B (2017) Bariatric surgery and long-term nutritional issues. World J Diabetes 8:464\u2013474","journal-title":"World J Diabetes"},{"key":"254_CR2","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1093\/ajcn\/72.3.690","volume":"72","author":"J Wortsman","year":"2000","unstructured":"Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:370\u2013373","journal-title":"Am J Clin Nutr"},{"key":"254_CR3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/jbmr.2017","volume":"29","author":"H Johansson","year":"2014","unstructured":"Johansson H, Kanis JA, Od\u00e9n A et al (2014) A meta-analysis of the association of fracture risk and body mass index in women. J Bone Miner Res 29:223\u2013233","journal-title":"J Bone Miner Res"},{"key":"254_CR4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/8756-3282(85)90003-1","volume":"6","author":"AM Parfitt","year":"1985","unstructured":"Parfitt AM, P\u00f8denphant J, Villanueva AR, Frame B (1985) Metabolic bone disease with and without osteomalacia after intestinal bypass surgery: a bone histomorphometric study. Bone 6:210\u2013220","journal-title":"Bone"},{"key":"254_CR5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ecl.2016.09.011","volume":"46","author":"NS Gregory","year":"2017","unstructured":"Gregory NS (2017) The effects of bariatric surgery on bone metabolism. Endocrinol Metab Clin N Am 46:105\u2013116","journal-title":"Endocrinol Metab Clin N Am"},{"key":"254_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1381\/096089203765887705","volume":"13","author":"E Guney","year":"2003","unstructured":"Guney E, Kisakol G, Ozgen G, Yilmaz C, Yilmaz R, Kabalak T (2003) Effect of weight loss on bone metabolism: comparison of vertical banded gastroplasty and medical intervention. Obes Surg 13:383\u2013388","journal-title":"Obes Surg"},{"key":"254_CR7","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1210\/jc.2003-031756","volume":"89","author":"PS Coates","year":"2004","unstructured":"Coates PS (2004) Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass. J Clin Endocrinol Metab 89:1061\u20131065","journal-title":"J Clin Endocrinol Metab"},{"key":"254_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00198-013-2463-x","volume":"25","author":"KM Nakamura","year":"2014","unstructured":"Nakamura KM, Haglind EGC, Clowes JA, Achenbach SJ, Atkinson EJ, Melton LJ, Kennel KA (2014) Fracture risk following bariatric surgery: a population-based study. Osteoporos Int 25:151\u2013158","journal-title":"Osteoporos Int"},{"key":"254_CR9","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1007\/s11695-009-9938-z","volume":"19","author":"DDA Tsiftsis","year":"2009","unstructured":"Tsiftsis DDA, Mylonas P, Mead N, Kalfarentzos F, Alexandrides TK (2009) Bone mass decreases in morbidly obese women after long limb-biliopancreatic diversion and marked weight loss without secondary hyperparathyroidism. A physiological adaptation to weight loss? Obes Surg 19:1497\u20131503","journal-title":"Obes Surg"},{"key":"254_CR10","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1210\/jcem-66-6-1247","volume":"66","author":"Y Liel","year":"1988","unstructured":"Liel Y, Edwards J, Shary J, Spicer KM, Gordon L, Bell NH (1988) The effects of race and body habitus on bone mineral density of the radius, hip, and spine in premenopausal women. J Clin Endocrinol Metab 66:1247\u20131250","journal-title":"J Clin Endocrinol Metab"},{"key":"254_CR11","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/jbmr.5650050614","volume":"5","author":"RB Mazess","year":"1990","unstructured":"Mazess RB, Barden HS, Drinka PJ, Bauwens SF, Orwoll ES, Bell NH (1990) Influence of age and body weight on spine and femur bone mineral density in US White men. J Bone Miner Res 5:645\u2013652","journal-title":"J Bone Miner Res"},{"key":"254_CR12","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1023\/A:1007309722100","volume":"13","author":"P Orozco","year":"1997","unstructured":"Orozco P, Nolla JM (1997) Associations between body morphology and bone mineral density in premenopausal women. Eur J Epidemiol 13:919\u2013924","journal-title":"Eur J Epidemiol"},{"key":"254_CR13","doi-asserted-by":"publisher","unstructured":"Lean JM, Jagger CJ, Chambers TJ, Chow JWM (1995) Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol - Endocrinol Metab. https:\/\/doi.org\/10.1152\/ajpendo.1995.268.2.e318","DOI":"10.1152\/ajpendo.1995.268.2.e318"},{"key":"254_CR14","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1007\/s11695-011-0532-9","volume":"21","author":"F Kalfarentzos","year":"2011","unstructured":"Kalfarentzos F, Skroubis G, Karamanakos S, Argentou M, Mead N, Kehagias I, Alexandrides TK (2011) Biliopancreatic diversion with Roux-en-Y gastric bypass and long limbs: advances in surgical treatment for super-obesity. Obes Surg 21:1849\u20131858","journal-title":"Obes Surg"},{"key":"254_CR15","doi-asserted-by":"publisher","unstructured":"Scibora LM, Ikramuddin S, Buchwald H, Petit MA (2012) Examining the link between bariatric surgery, bone loss, and osteoporosis: a review of bone density studies. Obes Surg. https:\/\/doi.org\/10.1007\/s11695-012-0596-1","DOI":"10.1007\/s11695-012-0596-1"},{"key":"254_CR16","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1007\/s11695-008-9431-0","volume":"17","author":"DH Schweitzer","year":"2007","unstructured":"Schweitzer DH (2007) Mineral metabolism and bone disease after bariatric surgery and ways to optimize bone health. Obes Surg 17:1510\u20131516","journal-title":"Obes Surg"},{"key":"254_CR17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s11695-007-9289-6","volume":"18","author":"CW Compher","year":"2008","unstructured":"Compher CW, Badellino KO, Boullata JI (2008) Vitamin D and the bariatric surgical patient: a review. Obes Surg 18:220\u2013224","journal-title":"Obes Surg"},{"key":"254_CR18","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1381\/0960892053576758","volume":"15","author":"J Ybarra","year":"2005","unstructured":"Ybarra J, S\u00e1nchez-Hern\u00e1ndez J, Gich I, De Leiva A, Rius X, Rodr\u00edguez-Espinosa J, P\u00e9rez A (2005) Unchanged hypovitaminosis D and secondary hyperparathyroidism in morbid obesity after bariatric surgery. Obes Surg 15:330\u2013335","journal-title":"Obes Surg"},{"key":"254_CR19","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/ejcn.2010.270","volume":"65","author":"Y Manios","year":"2011","unstructured":"Manios Y, Moschonis G, Lyritis GP (2011) Seasonal variations of vitamin D status in Greek postmenopausal women receiving enriched dairy products for 30 months: the postmenopausal health study. Eur J Clin Nutr 65:412\u2013414","journal-title":"Eur J Clin Nutr"},{"key":"254_CR20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11657-018-0526-5","volume":"13","author":"EV Grigoriou","year":"2018","unstructured":"Grigoriou EV, Trovas G, Papaioannou N, Makras P, Kokkoris P, Dontas I, Makris K, Tournis S, Dedoussis GV (2018) Serum 25-hydroxyvitamin D status, quantitative ultrasound parameters, and their determinants in Greek population. Arch Osteoporos 13:111","journal-title":"Arch Osteoporos"},{"key":"254_CR21","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1007\/s11695-018-3617-x","volume":"29","author":"AF Turcotte","year":"2019","unstructured":"Turcotte AF, Grenier-Larouche T, Ung RV et al (2019) Effects of biliopancreatic diversion on bone turnover markers and association with hormonal factors in patients with severe obesity. Obes Surg 29:990\u2013998","journal-title":"Obes Surg"},{"key":"254_CR22","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/S1091-255X(01)00086-5","volume":"6","author":"P Marceau","year":"2002","unstructured":"Marceau P, Biron S, Lebel S, Marceau S, Hould FS, Simard S, Dumont M, Fitzpatrick LA (2002) Does bone change after biliopancreatic diversion? J Gastrointest Surg 6:690\u2013698","journal-title":"J Gastrointest Surg"},{"key":"254_CR23","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0889-8553(21)00320-4","volume":"16","author":"N Scopinaro","year":"1987","unstructured":"Scopinaro N, Gianetta E, Friedman D, Adami GF, Traverso E, Vitale B, Castagnola M, Semino G, Summa M, Bachi V (1987) Surgical revision of biliopancreatic diversion. Gastroenterol Clin N Am 16:529\u2013531","journal-title":"Gastroenterol Clin N Am"},{"key":"254_CR24","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1007\/s11695-018-3353-2","volume":"28","author":"M Luger","year":"2018","unstructured":"Luger M, Kruschitz R, Winzer E et al (2018) Changes in bone mineral density following weight loss induced by one-anastomosis gastric bypass in patients with vitamin D supplementation. Obes Surg 28:3454\u20133465","journal-title":"Obes Surg"},{"key":"254_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bone.2015.12.001","volume":"84","author":"K Sakhaee","year":"2016","unstructured":"Sakhaee K, Poindexter J, Aguirre C (2016) The effects of bariatric surgery on bone and nephrolithiasis. Bone 84:1\u20138","journal-title":"Bone"},{"key":"254_CR26","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.ijsu.2014.08.002","volume":"12","author":"Y Rodr\u00edguez-Carmona","year":"2014","unstructured":"Rodr\u00edguez-Carmona Y, L\u00f3pez-Alavez FJ, Gonz\u00e1lez-Garay AG, Sol\u00eds-Galicia C, Mel\u00e9ndez G, Serralde-Z\u00fa\u00f1iga AE (2014) Bone mineral density after bariatric surgery: a systematic review. Int J Surg 12:976\u2013982","journal-title":"Int J Surg"},{"key":"254_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s11695-019-04119-5","volume":"30","author":"Z Tian","year":"2020","unstructured":"Tian Z, Fan XT, Li SZ, Zhai T, Dong J (2020) Changes in bone metabolism after sleeve gastrectomy versus gastric bypass: a meta-analysis. Obes Surg 30:77\u201386","journal-title":"Obes Surg"},{"key":"254_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3109\/10408363.2010.536429","volume":"47","author":"JC Fleet","year":"2010","unstructured":"Fleet JC, Schoch RD (2010) Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors. Crit Rev Clin Lab Sci 47:181\u2013195","journal-title":"Crit Rev Clin Lab Sci"},{"key":"254_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bonr.2018.02.002","volume":"8","author":"K Corbeels","year":"2018","unstructured":"Corbeels K, Verlinden L, Lannoo M, Simoens C, Matthys C, Verstuyf A, Meulemans A, Carmeliet G, Van der Schueren B (2018) Thin bones: vitamin D and calcium handling after bariatric surgery. Bone Reports 8:57\u201363","journal-title":"Bone Reports"},{"key":"254_CR30","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1002\/jbmr.2467","volume":"30","author":"AL Schafer","year":"2015","unstructured":"Schafer AL, Weaver CM, Black DM et al (2015) Intestinal calcium absorption decreases dramatically after gastric bypass surgery despite optimization of vitamin D status. J Bone Miner Res 30:1377\u20131385","journal-title":"J Bone Miner Res"},{"key":"254_CR31","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1038\/oby.2006.226","volume":"14","author":"CS Riedt","year":"2006","unstructured":"Riedt CS, Brolin RE, Sherrell RM, Field MP, Shapses SA (2006) True fractional calcium absorption is decreased after Roux-en-Y gastric bypass surgery. Obesity 14:1940\u20131948","journal-title":"Obesity"},{"key":"254_CR32","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","volume":"759","author":"T Komori","year":"2015","unstructured":"Komori T (2015) Animal models for osteoporosis. Eur J Pharmacol 759:287\u2013294","journal-title":"Eur J Pharmacol"},{"key":"254_CR33","doi-asserted-by":"publisher","unstructured":"Lalmohamed A, De Vries F, Bazelier MT, Cooper A, Van Staa TP, Cooper C, Harvey NC (2012) Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study. BMJ. https:\/\/doi.org\/10.1136\/bmj.e5085","DOI":"10.1136\/bmj.e5085"},{"key":"254_CR34","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/ijo.2012.115","volume":"36","author":"F Folli","year":"2012","unstructured":"Folli F, Sabowitz BN, Schwesinger W, Fanti P, Guardado-Mendoza R, Muscogiuri G (2012) Bariatric surgery and bone disease: from clinical perspective to molecular insights. Int J Obes 36:1373\u20131379","journal-title":"Int J Obes"},{"key":"254_CR35","doi-asserted-by":"publisher","unstructured":"Cornejo-Pareja I, Clemente-Postigo M, Tinahones FJ (2019) Metabolic and endocrine consequences of bariatric surgery. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/fendo.2019.00626","DOI":"10.3389\/fendo.2019.00626"},{"key":"254_CR36","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1056\/NEJM199503233321202","volume":"332","author":"SR Cummings","year":"1995","unstructured":"Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in White women. N Engl J Med 332:767\u2013774","journal-title":"N Engl J Med"},{"key":"254_CR37","doi-asserted-by":"publisher","unstructured":"Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int. https:\/\/doi.org\/10.1007\/s00198-002-1345-4","DOI":"10.1007\/s00198-002-1345-4"},{"key":"254_CR38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11914-010-0018-z","volume":"8","author":"EM Lewiecki","year":"2010","unstructured":"Lewiecki EM (2010) Bone densitometry and vertebral fracture assessment. Curr Osteoporos Rep 8:123\u2013130","journal-title":"Curr Osteoporos Rep"},{"key":"254_CR39","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/jbmr.506","volume":"27","author":"EW Yu","year":"2012","unstructured":"Yu EW, Thomas BJ, Brown JK, Finkelstein JS (2012) Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT. J Bone Miner Res 27:119\u2013124","journal-title":"J Bone Miner Res"},{"key":"254_CR40","first-page":"39","volume":"46","author":"MA Laskey","year":"1992","unstructured":"Laskey MA, Lyttle KD, Flaxman ME, Barber RW (1992) The influence of tissue depth and composition on the performance of the lunar dual-energy X-ray absorptiometer whole-body scanning mode. Eur J Clin Nutr 46:39\u201345","journal-title":"Eur J Clin Nutr"},{"key":"254_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/jbm4.10048","volume":"2","author":"C Gagnon","year":"2018","unstructured":"Gagnon C, Schafer AL (2018) Bone health after bariatric surgery. JBMR Plus 2:121\u2013133","journal-title":"JBMR Plus"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-020-00254-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42000-020-00254-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-020-00254-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T02:16:33Z","timestamp":1620699393000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42000-020-00254-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,5]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["254"],"URL":"https:\/\/doi.org\/10.1007\/s42000-020-00254-2","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"type":"print","value":"1109-3099"},{"type":"electronic","value":"2520-8721"}],"subject":[],"published":{"date-parts":[[2020,11,5]]},"assertion":[{"value":"5 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethical Committee of the University Hospital of Patras, Greece.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients were informed of the nature, risks, and benefits of the study and provided written informed consent before enrolling in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}