{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:17:57Z","timestamp":1792685877080,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s42000-022-00384-9","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T14:02:36Z","timestamp":1657116156000},"page":"467-476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology and blood parameter changes in Cushing\u2019s syndrome \u2014 a population-based study"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-8207","authenticated-orcid":false,"given":"Jessica","family":"Mangion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Giordano","family":"Imbroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Craus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josanne","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gruppetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"384_CR1","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1365-2265.2011.04124.x","volume":"75","author":"MJ Bolland","year":"2011","unstructured":"Bolland MJ, Holdaway IM, Berkeley JE, Lim S, Dransfield WJ, Conaglen JV, Croxson MS, Gamble GD, Hunt PJ, Toomath RJ (2011) Mortality and morbidity in Cushing\u2019s syndrome in New Zealand. Clin Endocrinol (Oxf) 75:436\u2013442. https:\/\/doi.org\/10.1111\/j.1365-2265.2011.04124.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"384_CR2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1530\/EJE-13-0569","volume":"169","author":"G Ntali","year":"2013","unstructured":"Ntali G, Asimakopoulou A, Siamatras T, Komninos J, Vassiliadi D, Tzanela M, Tsagarakis S, Grossman AB, Wass JAH, Karavitaki N (2013) Mortality in Cushing\u2019s syndrome: systematic analysis of a large series with prolonged follow-up. Eur J Endocrinol 169:715\u2013723. https:\/\/doi.org\/10.1530\/EJE-13-0569","journal-title":"Eur J Endocrinol"},{"key":"384_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/cen.14014","volume":"91","author":"S Wengander","year":"2019","unstructured":"Wengander S, Trimpou P, Papakokkinou E, Ragnarsson O (2019) The incidence of endogenous Cushing\u2019s syndrome in the modern era. Clin Endocrinol (Oxf) 91:263\u2013270. https:\/\/doi.org\/10.1111\/cen.14014","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"384_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1365-2265.2009.03667.x","volume":"72","author":"A Fernandez","year":"2010","unstructured":"Fernandez A, Karavitaki N, Wass JA (2010) Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK). Clin Endocrinol (Oxf) 72(3):377\u2013382. https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03667.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"384_CR5","doi-asserted-by":"publisher","first-page":"4268","DOI":"10.1210\/jc.2010-0537","volume":"95","author":"A Raappana","year":"2010","unstructured":"Raappana A, Koivukangas J, Ebeling T, Pirila T (2010) Incidence of pituitary adenomas in northern Finland in 1992\u20132007. J Clin Endocrinol Metab 95(9):4268\u20134275. https:\/\/doi.org\/10.1210\/jc.2010-0537","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"384_CR6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/cen.13064","volume":"85","author":"M Gruppetta","year":"2016","unstructured":"Gruppetta M, Vassallo J (2016) Epidemiology and radiological geometric assessment of pituitary macroadenomas: population-based study. Clin Endocrinol (Oxf) 85(2):223\u2013231. https:\/\/doi.org\/10.1111\/cen.13064","journal-title":"Clin Endocrinol (Oxf)"},{"key":"384_CR7","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1530\/EJE-14-0144","volume":"171","author":"A Tj\u00f6rnstrand","year":"2014","unstructured":"Tj\u00f6rnstrand A, Gunnarsson K, Evert M, Holmberg E, Ragnarsson O, Ros\u00e9n T, Nystr\u00f6m HF (2014) The incidence rate of pituitary adenomas in western Sweden for the period 2001\u20132011. Eur J Endocrinol 171:519\u2013526. https:\/\/doi.org\/10.1530\/EJE-14-0144","journal-title":"Eur J Endocrinol"},{"key":"384_CR8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s11102-019-00951-1","volume":"22","author":"O Ragnarsson","year":"2019","unstructured":"Ragnarsson O, Olsson DS, Chantzichristos D, Papakokkinou E, Dahlqvist P, Segerstedt E, Olsson T, Petersson M, Berinder K, Bensing S, H\u04e7ybye C, Engstr\u04e7m BE, Burman P, Bonelli L, Follin C, Petranek D, Erfurth EM, Wahlberg J, Ekman B, \u00c5kerman AK, Schwarcz E, Bryngelsson IL, Johannsson G (2019) The incidence of Cushing\u2019s disease: a nationwide Swedish study. Pituitary 22:179\u2013186. https:\/\/doi.org\/10.1007\/s11102-019-00951-1","journal-title":"Pituitary"},{"issue":"4","key":"384_CR9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s11102-012-0454-0","volume":"16","author":"M Gruppetta","year":"2013","unstructured":"Gruppetta M, Mercieca C, Vassallo J (2013) Prevalence and incidence of pituitary adenomas: a population based study in Malta. Pituitary 16(4):545\u2013553. https:\/\/doi.org\/10.1007\/s11102-012-0454-0","journal-title":"Pituitary"},{"issue":"9","key":"384_CR10","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.tem.2020.04.004","volume":"31","author":"V Hasenmajer","year":"2020","unstructured":"Hasenmajer V, Sbardella E, Sciarra F, Minnetti M, Isidori AM, Venneri MA (2020) The immune system in Cushing\u2019s syndrome. Trends Endocrinol Metab 31(9):655\u2013669. https:\/\/doi.org\/10.1016\/j.tem.2020.04.004","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"384_CR11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s11102-020-01112-5","volume":"24","author":"P Marques","year":"2021","unstructured":"Marques P, deVries F, Dekkers OM, van Furth WR, Korbonits M, Biermasz NR, Pereira AM (2021) Pre-operative serum inflammation-based scores in patients with pituitary adenomas. Pituitary 24(3):334\u2013350. https:\/\/doi.org\/10.1007\/s11102-020-01112-5","journal-title":"Pituitary"},{"issue":"2","key":"384_CR12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/pr.2017.278","volume":"83","author":"C Tatsi","year":"2018","unstructured":"Tatsi C, Boden R, Sinaii N, Keil M, Lyssikatos C, Belyavskaya E, Rosenzweig SD, Stratakis CA, Lodish MB (2018) Decreased lymphocytes and increased risk for infection are common in endogenous pediatric Cushing syndrome. Pediatr Res 83(2):431\u2013437. https:\/\/doi.org\/10.1038\/pr.2017.278","journal-title":"Pediatr Res"},{"issue":"5","key":"384_CR13","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s11102-013-0522-0","volume":"17","author":"H Masri-Iraqi","year":"2014","unstructured":"Masri-Iraqi H, Robenshtok E, Tzvetov G, Manistersky Y, Shimon I (2014) Elevated white blood cell counts in Cushing\u2019s disease: association with hypercortisolism. Pituitary 17(5):436\u2013440. https:\/\/doi.org\/10.1007\/s11102-013-0522-0","journal-title":"Pituitary"},{"key":"384_CR14","unstructured":"National Statistics Office (2021) World Population Day: 11 July 2021. Malta: National Statistics Office"},{"issue":"5","key":"384_CR15","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1210\/jc.2008-0125","volume":"93","author":"LK Nieman","year":"2008","unstructured":"Nieman LK, Biller B, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM (2008) The diagnosis of Cushing\u2019s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93(5):1526\u20131540. https:\/\/doi.org\/10.1210\/jc.2008-0125","journal-title":"J Clin Endocrinol Metab"},{"key":"384_CR16","volume-title":"Age standardization of rates: a new WHO standard","author":"OB Ahmad","year":"2001","unstructured":"Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M (2001) Age standardization of rates: a new WHO standard. World Health Organization, Geneva"},{"issue":"4","key":"384_CR17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1365-2265.1994.tb02486.x","volume":"40","author":"J Etxabe","year":"1994","unstructured":"Etxabe J, Vazquez JA (1994) Morbidity and mortality in Cushing\u2019s disease: an epidemiological approach. Clin Endocrinol (Oxf) 40(4):479\u2013484. https:\/\/doi.org\/10.1111\/j.1365-2265.1994.tb02486.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"384_CR18","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1111\/j.1365-2265.2010.03961.x","volume":"74","author":"S Arnard\u00f3ttir","year":"2011","unstructured":"Arnard\u00f3ttir S, Sigurjonsd\u00f3ttir A (2011) The incidence and prevalence of Cushing\u2019s disease may be higher than previously thought: results from a retrospective study in Iceland 1955 through 2009. Clin Endocrinol (Oxf) 74(6):792\u2013793. https:\/\/doi.org\/10.1111\/j.1365-2265.2010.03961.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"384_CR19","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1210\/jc.2010-1942","volume":"96","author":"RN Clayton","year":"2011","unstructured":"Clayton RN, Raskauskiene D, Ruelen RC, Jones PW (2011) Mortality and morbidity in Cushing\u2019s disease over 50 years in Stoke-on-Trent, UK: audit and meta-analysis of literature. J Clin Endocrinol Metab 96(3):632\u2013642. https:\/\/doi.org\/10.1210\/jc.2010-1942","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"384_CR20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s11102-014-0569-6","volume":"18","author":"MS Broder","year":"2015","unstructured":"Broder MS, Neary MP, Chang E, Cherepanov D, Ludlam WH (2015) Incidence of Cushing\u2019s syndrome and Cushing\u2019s disease in commercially-insured patients <65 years old in the United States. Pituitary 18(3):283\u2013289. https:\/\/doi.org\/10.1007\/s11102-014-0569-6","journal-title":"Pituitary"},{"issue":"1","key":"384_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1210\/jcem.86.1.7093","volume":"86","author":"J Lindholm","year":"2001","unstructured":"Lindholm J, Juul S, J\u00f8rgensen JOL, Astrup J, Bjerre P, Feldt-Rasmussen U, Hagen C, J\u00f8rgensen J, Kosteljanetz M, Kristensen L\u00d8, Laurberg P (2001) Incidence and late prognosis of Cushing\u2019s syndrome: a population-based study. J Clin Endocrinol Metab 86(1):117\u2013123. https:\/\/doi.org\/10.1210\/jcem.86.1.7093","journal-title":"J Clin Endocrinol Metab"},{"key":"384_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1530\/EJE-16-0631","volume":"176","author":"D Hirsch","year":"2017","unstructured":"Hirsch D, Tsvetov G, Manisterski Y, Aviran-Barak N, Nadler V, Albolm S, Kopel V (2017) Incidence of Cushing\u2019s syndrome in patients with significant hypercortisoluria. Eur J Endocrinol 176:41\u201348. https:\/\/doi.org\/10.1530\/EJE-16-0631","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"384_CR23","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/nyas.14205","volume":"1463","author":"L Fan","year":"2019","unstructured":"Fan L, Zhuang Y, Wang Y, Liu X, Liu D, Xiang B, He M, Zhang Z, Li Y, Wang Y, Xiaoming Z, Hongying Y (2019) Association of hypokalemia with cortisol and ACTH levels in Cushing\u2019s disease. Ann N Y Acad Sci 1463(1):60\u201366. https:\/\/doi.org\/10.1111\/nyas.14205","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"384_CR24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1210\/edrv.18.1.0288","volume":"18","author":"CP White","year":"1997","unstructured":"White CP, Mune T, Agarwal AK (1997) 11\u03b2-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocrine Rev 18(1):135\u2013136. https:\/\/doi.org\/10.1210\/edrv.18.1.0288","journal-title":"Endocrine Rev"},{"key":"384_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1210\/jcem-6-4-312","volume":"6","author":"FA De la Balze","year":"1946","unstructured":"De la Balze FA, Reifenstein JR, Albright F (1946) Differential blood counts in certain adrenal cortical disorders (Cushing\u2019s syndrome, Addison\u2019s disease and panhypopituitarism). J Clin Endocrinol Metab 6:312\u2013319. https:\/\/doi.org\/10.1210\/jcem-6-4-312","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"384_CR26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1530\/EJE-13-0824","volume":"170","author":"AG Ambrogio","year":"2014","unstructured":"Ambrogio AG, De Martin M, Ascoli P, Cavagnini F (2014) Gender-dependent changes in haematological parameters in patients with Cushing\u2019s disease before and after remission. Eur J Endocrinol 170(3):393\u2013400. https:\/\/doi.org\/10.1530\/EJE-13-0824","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"384_CR27","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1620\/tjem.142.195","volume":"142","author":"T Sato","year":"1984","unstructured":"Sato T, Hiramatsu R, Iwaoka T, Fujii Y, Shimada T, Umeda T (1984) Changes of platelets, serum lactic dehydrogenase, \u03b3-glutamyltranspeptidase, choline esterase and creatine phosphokinase levels in patients with Cushing\u2019s syndrome. Tohoku J Exp Med 142(2):195\u2013200. https:\/\/doi.org\/10.1620\/tjem.142.195","journal-title":"Tohoku J Exp Med"},{"issue":"2","key":"384_CR28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF03345709","volume":"32","author":"C Erem","year":"2009","unstructured":"Erem C, Nuhoglu I, Yilmaz M, Kocak M, Demirel A, Ucuncu O, Ersoz HO (2009) Blood coagulation and fibrinolysis in patients with Cushing\u2019s syndrome: increased plasminogen activator inhibitor-1, decreased tissue factor pathway inhibitor, and unchanged thrombin-activatable fibrinolysis inhibitor levels. J Endocrinol Invest 32(2):169\u2013174. https:\/\/doi.org\/10.1007\/BF03345709","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"384_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000103216","volume":"118","author":"V Deutsch","year":"2007","unstructured":"Deutsch V, Lerner-Geva L, Reches A, Boyko V, Limor R, Grisaru D (2007) Sustained leukocyte count during rising cortisol level. Acta haematol 118(2):73\u201376. https:\/\/doi.org\/10.1159\/000103216","journal-title":"Acta haematol"},{"key":"384_CR30","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/bjc.2017.243","volume":"117","author":"N Cirillo","year":"2017","unstructured":"Cirillo N, Morgan DJ, Pedicillo MC, Celentano A, Lo Muzio L, McCullough MJ, Prime SS (2017) Characterisation of the cancer-associated glucocorticoid system: key role of 11\u03b2-hydroxysteroid dehydrogenase type 2. Br J Cancer 117:984\u2013993. https:\/\/doi.org\/10.1038\/bjc.2017.243","journal-title":"Br J Cancer"},{"key":"384_CR31","doi-asserted-by":"publisher","first-page":"142425","DOI":"10.1155\/2014\/142425","volume":"2014","author":"D Bugada","year":"2014","unstructured":"Bugada D, Allegri M, Lavand\u2019Homme P, De Kock M, Fanelli G (2014) Inflammation-based scores: a new method for patient-targeted strategies and improved perioperative outcome in cancer patients. BioMed Res Int 2014:142425. https:\/\/doi.org\/10.1155\/2014\/142425","journal-title":"BioMed Res Int"},{"issue":"6","key":"384_CR32","doi-asserted-by":"publisher","first-page":"dju124","DOI":"10.1093\/jnci\/dju124","volume":"106","author":"AJ Templeton","year":"2014","unstructured":"Templeton AJ, McNamara MG, Seruga B, Vera-Badillo FE, Aneja P, Ocana A, Leibowitz-Amit R, Sonpavde G, Knox JJ, Tran B, Tannock IF, Amir E (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 106(6):dju124. https:\/\/doi.org\/10.1093\/jnci\/dju124","journal-title":"J Natl Cancer Inst"},{"key":"384_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1758835920942378","volume":"12","author":"A Galvano","year":"2020","unstructured":"Galvano A, Peri M, Guarini AA, Castiglia M, Grassadonia A, De Tursi M, Irtelli L, Rizzo S, Bertani A, Gristina V, Barraco N (2020) Analysis of systemic inflammatory biomarkers in neuroendocrine carcinomas of the lung: prognostic and predictive significance of NLR, LDH, ALI, and LIPI score. Ther Adv Med Oncol 12:1\u201311. https:\/\/doi.org\/10.1177\/1758835920942378","journal-title":"Ther Adv Med Oncol"},{"issue":"20","key":"384_CR34","doi-asserted-by":"publisher","first-page":"e19686","DOI":"10.1097\/MD.0000000000019686","volume":"99","author":"J Feng","year":"2020","unstructured":"Feng J, Wang Y, Shan G, Gao L (2020) Clinical and prognostic value of neutrophil-lymphocyte ratio for patients with thyroid cancer: a meta-analysis. Medicine 99(20):e19686. https:\/\/doi.org\/10.1097\/MD.0000000000019686","journal-title":"Medicine"},{"issue":"4","key":"384_CR35","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.3892\/ol.2017.5716","volume":"13","author":"G Luo","year":"2017","unstructured":"Luo G, Liu C, Cheng H, Jin K, Guo M, Lu Y, Long J, Xu J, Ni Q, Chen J, Yu X (2017) Neutrophil-lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors. Oncol Lett 13(4):2454\u20132458. https:\/\/doi.org\/10.3892\/ol.2017.5716","journal-title":"Oncol Lett"},{"issue":"37","key":"384_CR36","doi-asserted-by":"publisher","first-page":"e12375","DOI":"10.1097\/MD.0000000000012375","volume":"97","author":"J Zhang","year":"2018","unstructured":"Zhang J, He M, Liu Z, Songm Y, Wang Y, Liang R, Chen H, Xu J (2018) Impact of neutrophil\u2013lymphocyte ratio on long-term outcome in patients with craniopharyngioma. Medicine 97(37):e12375. https:\/\/doi.org\/10.1097\/MD.0000000000012375","journal-title":"Medicine"},{"issue":"2","key":"384_CR37","doi-asserted-by":"publisher","first-page":"e1393134","DOI":"10.1080\/2162402X.2017.1393134","volume":"7","author":"G Varricchi","year":"2018","unstructured":"Varricchi G, Galdiero MR, Loffredo S, Lucarini V, Marone G, Mattei F, Marone G, Schiavoni G (2018) Eosinophils: the unsung heroes in cancer? Oncoimmunology 7(2):e1393134. https:\/\/doi.org\/10.1080\/2162402X.2017.1393134","journal-title":"Oncoimmunology"},{"issue":"10","key":"384_CR38","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41568-020-0283-9","volume":"20","author":"S Grisaru-Tal","year":"2020","unstructured":"Grisaru-Tal S, Itan M, Klion AD, Munitz A (2020) A new dawn for eosinophils in the tumour microenvironment. Nat Rev Cancer 20(10):594\u2013607. https:\/\/doi.org\/10.1038\/s41568-020-0283-9","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"384_CR39","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/S1499-3872(14)60284-8","volume":"13","author":"J Ahmad","year":"2014","unstructured":"Ahmad J, Grimes N, Farid S, Morris-Stiff G (2014) Inflammatory response related scoring systems in assessing the prognosis of patients with pancreatic ductal adenocarcinoma: a systematic review. Hepatobiliary Pancreat Dis Int 13(5):474\u2013481. https:\/\/doi.org\/10.1016\/S1499-3872(14)60284-8","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"13","key":"384_CR40","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1158\/0008-5472.CAN-08-3845","volume":"69","author":"I Ray-Coquard","year":"2009","unstructured":"Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C, Le Cesne A, Judson I, Tredan O, Verweij J, Biron P, Labidi I, Guastalla JP (2009) Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res 69(13):5383\u20135391. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-3845","journal-title":"Cancer Res"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-022-00384-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42000-022-00384-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-022-00384-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T01:09:43Z","timestamp":1662944983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42000-022-00384-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["384"],"URL":"https:\/\/doi.org\/10.1007\/s42000-022-00384-9","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"28 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from the University of Malta.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}