{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:35:20Z","timestamp":1772120120473,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s42000-023-00509-8","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:02:01Z","timestamp":1700438521000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of osteoprotegerin and RANKL levels and several cardiovascular risk scoring systems in acromegaly"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-3179","authenticated-orcid":false,"given":"Gokcen Unal","family":"Kocabas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-2655","authenticated-orcid":false,"given":"Banu Sarer","family":"Yurekli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-8499","authenticated-orcid":false,"given":"Ilgin Yildirim","family":"Simsir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-674X","authenticated-orcid":false,"given":"Su","family":"Ozgur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-9130","authenticated-orcid":false,"given":"Murat","family":"Aksit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-5796","authenticated-orcid":false,"given":"Giray","family":"Bozkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"509_CR1","doi-asserted-by":"publisher","first-page":"1005681","DOI":"10.3389\/fcell.2022.1005681","volume":"10","author":"L Zhang","year":"2022","unstructured":"Zhang L, Zeng F, Jiang M, Han M, Huang B (2022) Roles of osteoprotegerin in endocrine and metabolic disorders through receptor activator of nuclear factor kappa-B ligand\/receptor activator of nuclear factor kappa-B signaling. Front Cell Dev Biol 10:1005681. https:\/\/doi.org\/10.3389\/fcell.2022.1005681","journal-title":"Front Cell Dev Biol"},{"key":"509_CR2","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.diabet.2016.02.004","volume":"42","author":"M Monseu","year":"2016","unstructured":"Monseu M, Dubois S, Boursier J, Aube C, Gagnadoux F, Leftheriotis G, Ducluzeau PH (2016) Osteoprotegerin levels are associated with liver fat and liver markers in dysmetabolic adults. Diabetes Metab 42:364\u2013367. https:\/\/doi.org\/10.1016\/j.diabet.2016.02.004","journal-title":"Diabetes Metab"},{"key":"509_CR3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.vph.2016.02.003","volume":"82","author":"E Harper","year":"2016","unstructured":"Harper E, Forde H, Davenport C, Rochfort KD, Smith D, Cummins PM (2016) Vascular calcification in type-2 diabetes and cardiovascular disease: Integrative roles for OPG, RANKL and TRAIL. Vascul Pharmacol 82:30\u201340. https:\/\/doi.org\/10.1016\/j.vph.2016.02.003","journal-title":"Vascul Pharmacol"},{"key":"509_CR4","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1161\/ATVBAHA.113.301755","volume":"33","author":"A Callegari","year":"2013","unstructured":"Callegari A, Coons ML, Ricks JL, Yang HL, Gross TS, Huber P, Rosenfeld ME, Scatena M (2013) Bone marrow- or vessel wall-derived osteoprotegerin is sufficient to reduce atherosclerotic lesion size and vascular calcification. Arterioscler Thromb Vasc Biol 33:2491\u20132500. https:\/\/doi.org\/10.1161\/ATVBAHA.113.301755","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"509_CR5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ihj.2021.05.005","volume":"73","author":"MM Harsha","year":"2021","unstructured":"Harsha MM, Tewari S, Gupta SK, Khanna R, Kumar S, Garg N, Kapoor A, Goel PK (2021) Acromegaly: cardiovascular risk factors, cardiovascular manifestations and early vascular alterations in relation to disease activity. Indian Heart J 73:499\u2013502. https:\/\/doi.org\/10.1016\/j.ihj.2021.05.005","journal-title":"Indian Heart J"},{"key":"509_CR6","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1210\/jc.2002-020656","volume":"87","author":"J Rubin","year":"2002","unstructured":"Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ (2002) IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo. J Clin Endocrinol Metab 87:4273\u20134279. https:\/\/doi.org\/10.1210\/jc.2002-020656","journal-title":"J Clin Endocrinol Metab"},{"key":"509_CR7","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA, Endocrine S (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:3933\u20133951. https:\/\/doi.org\/10.1210\/jc.2014-2700","journal-title":"J Clin Endocrinol Metab"},{"key":"509_CR8","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1161\/01.cir.97.18.1837","volume":"97","author":"PW Wilson","year":"1998","unstructured":"Wilson PW, D\u2019Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97:1837\u20131847. https:\/\/doi.org\/10.1161\/01.cir.97.18.1837","journal-title":"Circulation"},{"key":"509_CR9","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.jacc.2016.10.018","volume":"69","author":"DM Lloyd-Jones","year":"2017","unstructured":"Lloyd-Jones DM, Huffman MD, Karmali KN, Sanghavi DM, Wright JS, Pelser C, Gulati M, Masoudi FA, Goff DC Jr (2017) Estimating longitudinal risks and benefits from cardiovascular preventive therapies among medicare patients: the Million Hearts Longitudinal ASCVD Risk Assessment Tool: a special report from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 69:1617\u20131636. https:\/\/doi.org\/10.1016\/j.jacc.2016.10.018","journal-title":"J Am Coll Cardiol"},{"key":"509_CR10","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1515\/med-2022-0590","volume":"17","author":"JR Ulloque-Badaracco","year":"2022","unstructured":"Ulloque-Badaracco JR, Hernandez-Bustamante EA, Alarcon-Braga EA, Mosquera-Rojas MD, Campos-Aspajo A, Salazar-Valdivia FE, Valdez-Cornejo VA, Benites-Zapata VA, Herrera-Anazco P, Valenzuela-Rodriguez G, Hernandez AV (2022) Atherogenic index of plasma and coronary artery disease: a systematic review. Open Med (Wars) 17:1915\u20131926. https:\/\/doi.org\/10.1515\/med-2022-0590","journal-title":"Open Med (Wars)"},{"key":"509_CR11","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1055\/a-0630-1529","volume":"50","author":"FF Ozer","year":"2018","unstructured":"Ozer FF, Dagdelen S, Erbas T (2018) Relation of RANKL and OPG levels with bone resorption in patients with acromegaly and prolactinoma. Horm Metab Res 50:562\u2013567. https:\/\/doi.org\/10.1055\/a-0630-1529","journal-title":"Horm Metab Res"},{"key":"509_CR12","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00198-007-0440-y","volume":"19","author":"HY Zhao","year":"2008","unstructured":"Zhao HY, Liu JM, Ning G, Zhao YJ, Chen Y, Sun LH, Zhang LZ, Xu MY, Chen JL (2008) Relationships between insulin-like growth factor-I (IGF-I) and OPG, RANKL, bone mineral density in healthy Chinese women. Osteoporos Int 19:221\u2013226. https:\/\/doi.org\/10.1007\/s00198-007-0440-y","journal-title":"Osteoporos Int"},{"key":"509_CR13","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1210\/jc.2016-3693","volume":"102","author":"T Constantin","year":"2017","unstructured":"Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu OC, Ritchie J, Ioachimescu AG (2017) Calcium and bone turnover markers in acromegaly: a prospective, controlled study. J Clin Endocrinol Metab 102:2416\u20132424. https:\/\/doi.org\/10.1210\/jc.2016-3693","journal-title":"J Clin Endocrinol Metab"},{"key":"509_CR14","doi-asserted-by":"publisher","first-page":"862845","DOI":"10.3389\/fendo.2022.862845","volume":"13","author":"A Jawiarczyk-Przybylowska","year":"2022","unstructured":"Jawiarczyk-Przybylowska A, Halupczok-Zyla J, Syrycka J, Zembska A, Kuliczkowska-Plaksej J, Bolanowski M (2022) Trabecular bone score and osteoprotegerin as useful tools in the assessment of bone deterioration in acromegaly. Front Endocrinol (Lausanne) 13:862845. https:\/\/doi.org\/10.3389\/fendo.2022.862845","journal-title":"Front Endocrinol (Lausanne)"},{"key":"509_CR15","doi-asserted-by":"publisher","first-page":"101599","DOI":"10.1016\/j.bonr.2022.101599","volume":"17","author":"NMS Goluke","year":"2022","unstructured":"Goluke NMS, Schoffelmeer MA, De Jonghe A, Emmelot-Vonk MH, De Jong PA, Koek HL (2022) Serum biomarkers for arterial calcification in humans: a systematic review. Bone Rep 17:101599. https:\/\/doi.org\/10.1016\/j.bonr.2022.101599","journal-title":"Bone Rep"},{"key":"509_CR16","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3390\/ijms20030705","volume":"20","author":"L Rochette","year":"2019","unstructured":"Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Vergely C (2019) The role of osteoprotegerin and its ligands in vascular function. Int J Mol Sci 20:705. https:\/\/doi.org\/10.3390\/ijms20030705","journal-title":"Int J Mol Sci"},{"key":"509_CR17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1210\/er.2002-0022","volume":"25","author":"A Colao","year":"2004","unstructured":"Colao A, Ferone D, Marzullo P, Lombardi G (2004) Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 25:102\u2013152. https:\/\/doi.org\/10.1210\/er.2002-0022","journal-title":"Endocr Rev"},{"key":"509_CR18","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1210\/jcem.83.8.5007","volume":"83","author":"SM Orme","year":"1998","unstructured":"Orme SM, McNally RJ, Cartwright RA, Belchetz PE (1998) Mortality and cancer incidence in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group. J Clin Endocrinol Metab 83:2730\u20132734. https:\/\/doi.org\/10.1210\/jcem.83.8.5007","journal-title":"J Clin Endocrinol Metab"},{"key":"509_CR19","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.1210\/jc.2007-1213","volume":"92","author":"F Bogazzi","year":"2007","unstructured":"Bogazzi F, Battolla L, Spinelli C, Rossi G, Gavioli S, Di Bello V, Cosci C, Sardella C, Volterrani D, Talini E, Pepe P, Falaschi F, Mariani G, Martino E (2007) Risk factors for development of coronary heart disease in patients with acromegaly: a five-year prospective study. J Clin Endocrinol Metab 92:4271\u20134277. https:\/\/doi.org\/10.1210\/jc.2007-1213","journal-title":"J Clin Endocrinol Metab"},{"key":"509_CR20","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1530\/EJE-09-0945","volume":"162","author":"H Akutsu","year":"2010","unstructured":"Akutsu H, Kreutzer J, Wasmeier G, Ropers D, Rost C, Mohlig M, Wallaschofski H, Buchfelder M, Schofl C (2010) Acromegaly per se does not increase the risk for coronary artery disease. Eur J Endocrinol 162:879\u2013886. https:\/\/doi.org\/10.1530\/EJE-09-0945","journal-title":"Eur J Endocrinol"},{"key":"509_CR21","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.jacc.2006.10.001","volume":"49","author":"P Greenland","year":"2007","unstructured":"Greenland P, Bonow RO, Brundage BH, Budoff MJ, Eisenberg MJ, Grundy SM, Lauer MS, Post WS, Raggi P, Redberg RF, Rodgers GP, Shaw LJ, Taylor AJ, Weintraub WS, American College of Cardiology Foundation Clinical Expert Consensus Task F, Society of Atherosclerosis I, Prevention, Society of Cardiovascular Computed T (2007) ACCF\/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF\/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 49:378\u2013402. https:\/\/doi.org\/10.1016\/j.jacc.2006.10.001","journal-title":"J Am Coll Cardiol"},{"key":"509_CR22","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jacc.2005.02.088","volume":"46","author":"Y Arad","year":"2005","unstructured":"Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD (2005) Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St. Francis Heart Study. J Am Coll Cardiol 46:158\u2013165. https:\/\/doi.org\/10.1016\/j.jacc.2005.02.088","journal-title":"J Am Coll Cardiol"},{"key":"509_CR23","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1001\/jama.291.2.210","volume":"291","author":"P Greenland","year":"2004","unstructured":"Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC (2004) Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 291:210\u2013215. https:\/\/doi.org\/10.1001\/jama.291.2.210","journal-title":"JAMA"},{"key":"509_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12020-013-0115-8","volume":"47","author":"M Ragonese","year":"2014","unstructured":"Ragonese M, Alibrandi A, Di Bella G, Salamone I, Puglisi S, Cotta OR, Torre ML, Ferrau F, Ruggeri RM, Trimarchi F, Cannavo S (2014) Cardiovascular events in acromegaly: distinct role of Agatston and Framingham score in the 5-year prediction. Endocrine 47:206\u2013212. https:\/\/doi.org\/10.1007\/s12020-013-0115-8","journal-title":"Endocrine"},{"key":"509_CR25","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1161\/ATVBAHA.109.184101","volume":"29","author":"AG Semb","year":"2009","unstructured":"Semb AG, Ueland T, Aukrust P, Wareham NJ, Luben R, Gullestad L, Kastelein JJ, Khaw KT, Boekholdt SM (2009) Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993\u20132003. Arterioscler Thromb Vasc Biol 29:975\u2013980. https:\/\/doi.org\/10.1161\/ATVBAHA.109.184101","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"509_CR26","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/j.jacc.2010.03.013","volume":"55","author":"SM Venuraju","year":"2010","unstructured":"Venuraju SM, Yerramasu A, Corder R, Lahiri A (2010) Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity. J Am Coll Cardiol 55:2049\u20132061. https:\/\/doi.org\/10.1016\/j.jacc.2010.03.013","journal-title":"J Am Coll Cardiol"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-023-00509-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42000-023-00509-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-023-00509-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T23:51:15Z","timestamp":1707263475000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42000-023-00509-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["509"],"URL":"https:\/\/doi.org\/10.1007\/s42000-023-00509-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3072428\/v1","asserted-by":"object"}]},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"19 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committe of Izmir Bozyaka Training and Research Hospital. The patients gave oral and written informed consent before recruitment (ethics approval number 7, date 24 December 2013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Gokcen Unal Kocabas is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}}]}}