{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:00Z","timestamp":1792783560928,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Cuiying Technology Innovation","award":["CY2018-ZD02"],"award-info":[{"award-number":["CY2018-ZD02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s42000-024-00593-4","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:03:37Z","timestamp":1725419017000},"page":"109-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical application of cluster analysis in patients with newly diagnosed type 2 diabetes"],"prefix":"10.1007","volume":"24","author":[{"given":"Yazhi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5651-361X","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"593_CR1","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","volume":"183","author":"H Sun","year":"2022","unstructured":"Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan J, Mbanya JC et al (2022) IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109119. https:\/\/doi.org\/10.1016\/j.diabres.2021.109119","journal-title":"Diabetes Res Clin Pract"},{"issue":"01","key":"593_CR2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1055\/a-1624-2897","volume":"130","author":"E Schleicher","year":"2022","unstructured":"Schleicher E, Gerdes C, Petersmann A, Muller-Wieland D, Muller UA, Freckmann G, Heinemann L, Nauck M, Landgraf R (2022) Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes 130(01):S1\u2013S8. https:\/\/doi.org\/10.1055\/a-1624-2897","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"7","key":"593_CR3","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00125-019-4909-y","volume":"62","author":"ER Pearson","year":"2019","unstructured":"Pearson ER (2019) Type 2 diabetes: a multifaceted disease. Diabetologia 62(7):1107\u20131112. https:\/\/doi.org\/10.1007\/s00125-019-4909-y","journal-title":"Diabetologia"},{"issue":"5","key":"593_CR4","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00125-017-4210-x","volume":"60","author":"MI McCarthy","year":"2017","unstructured":"McCarthy MI (2017) Painting a new picture of personalised medicine for diabetes. Diabetologia 60(5):793\u2013799. https:\/\/doi.org\/10.1007\/s00125-017-4210-x","journal-title":"Diabetologia"},{"issue":"5","key":"593_CR5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S2213-8587(18)30051-2","volume":"6","author":"E Ahlqvist","year":"2018","unstructured":"Ahlqvist E, Storm P, Karajamaki A, Martinell M, Dorkhan M, Carlsson A, Vikman P, Prasad RB, Aly DM, Almgren P et al (2018) Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol 6(5):361\u2013369. https:\/\/doi.org\/10.1016\/S2213-8587(18)30051-2","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"593_CR6","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.2337\/dbi20-0001","volume":"69","author":"E Ahlqvist","year":"2020","unstructured":"Ahlqvist E, Prasad RB, Groop L (2020) Subtypes of type 2 diabetes determined from clinical parameters. Diabetes 69(10):2086\u20132093. https:\/\/doi.org\/10.2337\/dbi20-0001","journal-title":"Diabetes"},{"issue":"6","key":"593_CR7","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S2213-8587(19)30087-7","volume":"7","author":"JM Dennis","year":"2019","unstructured":"Dennis JM, Shields BM, Henley WE, Jones AG, Hattersley AT (2019) Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. Lancet Diabetes Endocrinol 7(6):442\u2013451. https:\/\/doi.org\/10.1016\/S2213-8587(19)30087-7","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"593_CR8","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/S2213-8587(19)30187-1","volume":"7","author":"OP Zaharia","year":"2019","unstructured":"Zaharia OP, Strassburger K, Strom A, Bonhof GJ, Karusheva Y, Antoniou S, Bodis K, Markgraf DF, Burkart V, Mussig K et al (2019) Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 7(9):684\u2013694. https:\/\/doi.org\/10.1016\/S2213-8587(19)30187-1","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"7","key":"593_CR9","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.3390\/jcm9072083","volume":"9","author":"H Tanabe","year":"2020","unstructured":"Tanabe H, Saito H, Kudo A, Machii N, Hirai H, Maimaituxun G, Tanaka K, Masuzaki H, Watanabe T, Asahi K et al (2020) Factors associated with risk of diabetic complications in novel cluster-based diabetes subgroups: a Japanese retrospective cohort study. J Clin Med 9(7):2083. https:\/\/doi.org\/10.3390\/jcm9072083","journal-title":"J Clin Med"},{"issue":"1","key":"593_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S2213-8587(18)30316-4","volume":"7","author":"X Zou","year":"2019","unstructured":"Zou X, Zhou X, Zhu Z, Ji L (2019) Novel subgroups of patients with adult-onset diabetes in Chinese and US populations. Lancet Diabetes Endocrinol 7(1):9\u201311. https:\/\/doi.org\/10.1016\/S2213-8587(18)30316-4","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"593_CR11","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s00125-021-05607-z","volume":"65","author":"H Maalmi","year":"2022","unstructured":"Maalmi H, Herder C, Bonhof GJ, Strassburger K, Zaharia OP, Rathmann W, Burkart V, Szendroedi J, Roden M, Ziegler D (2022) Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes. Diabetologia 65(3):552\u2013562. https:\/\/doi.org\/10.1007\/s00125-021-05607-z","journal-title":"Diabetologia"},{"key":"593_CR12","doi-asserted-by":"publisher","first-page":"155514","DOI":"10.1016\/j.metabol.2023.155514","volume":"141","author":"YC Hwang","year":"2023","unstructured":"Hwang YC, Ahn HY, Jun JE, Jeong IK, Ahn KJ, Chung HY (2023) Subtypes of type 2 diabetes and their association with outcomes in Korean adults - a cluster analysis of community-based prospective cohort. Metabolism 141:155514. https:\/\/doi.org\/10.1016\/j.metabol.2023.155514","journal-title":"Metabolism"},{"issue":"2","key":"593_CR13","doi-asserted-by":"publisher","first-page":"e002731","DOI":"10.1136\/bmjdrc-2021-002731","volume":"10","author":"DH Christensen","year":"2022","unstructured":"Christensen DH, Nicolaisen SK, Ahlqvist E, Stidsen JV, Nielsen JS, Hojlund K, Olsen MH, Garcia-Calzon S, Ling C, Rungby J et al (2022) Type 2 diabetes classification: a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 diabetes (DD2) cohort. Bmj Open Diabetes Res Care 10(2):e002731. https:\/\/doi.org\/10.1136\/bmjdrc-2021-002731","journal-title":"Bmj Open Diabetes Res Care"},{"key":"593_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12933-015-0319-8","volume":"15","author":"YC Hwang","year":"2016","unstructured":"Hwang YC, Jeon WS, Park CY, Youn BS (2016) The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype. Cardiovasc Diabetol 15:9. https:\/\/doi.org\/10.1186\/s12933-015-0319-8","journal-title":"Cardiovasc Diabetol"},{"issue":"10","key":"593_CR15","doi-asserted-by":"publisher","first-page":"dgaa524","DOI":"10.1210\/clinem\/dgaa524","volume":"105","author":"X Li","year":"2020","unstructured":"Li X, Yang S, Cao C, Yan X, Zheng L, Zheng L, Da J, Tang X, Ji L, Yang X et al (2020) Validation of the Swedish diabetes re-grouping scheme in adult-onset diabetes in China. J Clin Endocrinol Metab 105(10):dgaa524. https:\/\/doi.org\/10.1210\/clinem\/dgaa524","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"593_CR16","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00592-020-01484-x","volume":"57","author":"J Lyu","year":"2020","unstructured":"Lyu J, Li Z, Wei H, Liu D, Chi X, Gong DW, Zhao Q (2020) A potent risk model for predicting new-onset acute coronary syndrome in patients with type 2 diabetes mellitus in Northwest China. Acta Diabetol 57(6):705\u2013713. https:\/\/doi.org\/10.1007\/s00592-020-01484-x","journal-title":"Acta Diabetol"},{"issue":"7","key":"593_CR17","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"KG Alberti","year":"1998","unstructured":"Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15(7):539\u2013553. https:\/\/doi.org\/10.1002\/(SICI)1096-9136(199807)15:7%3C539::AID-DIA668%3E3.0.CO;2-S","journal-title":"Diabet Med"},{"issue":"12","key":"593_CR18","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1007\/s40618-021-01608-2","volume":"44","author":"M Mirr","year":"2021","unstructured":"Mirr M, Skrypnik D, Bogdanski P, Owecki M (2021) Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome. J Endocrinol Invest 44(12):2831\u20132843. https:\/\/doi.org\/10.1007\/s40618-021-01608-2","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"593_CR19","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.2215\/CJN.06870909","volume":"5","author":"WM Michels","year":"2010","unstructured":"Michels WM, Grootendorst DC, Verduijn M, Elliott EG, Dekker FW, Krediet RT (2010) Performance of the Cockcroft-Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size. Clin J Am Soc Nephrol 5(6):1003\u20131009. https:\/\/doi.org\/10.2215\/CJN.06870909","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11","key":"593_CR20","doi-asserted-by":"publisher","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","volume":"158","author":"PE Stevens","year":"2013","unstructured":"Stevens PE, Levin A (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158(11):825\u2013830. https:\/\/doi.org\/10.7326\/0003-4819-158-11-201306040-00007","journal-title":"Ann Intern Med"},{"issue":"10","key":"593_CR21","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.ophtha.2018.04.007","volume":"125","author":"TY Wong","year":"2018","unstructured":"Wong TY, Sun J, Kawasaki R, Ruamviboonsuk P, Gupta N, Lansingh VC, Maia M, Mathenge W, Moreker S, Muqit M et al (2018) Guidelines on diabetic eye care: the international council of ophthalmology recommendations for screening, follow-up, referral, and treatment based on resource settings. Ophthalmology 125(10):1608\u20131622. https:\/\/doi.org\/10.1016\/j.ophtha.2018.04.007","journal-title":"Ophthalmology"},{"issue":"1","key":"593_CR22","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2337\/dc16-2042","volume":"40","author":"R Pop-Busui","year":"2017","unstructured":"Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D (2017) Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care 40(1):136\u2013154. https:\/\/doi.org\/10.2337\/dc16-2042","journal-title":"Diabetes Care"},{"issue":"12","key":"593_CR23","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.2337\/diacare.26.12.3333","volume":"26","author":"American Diabetes Association","year":"2003","unstructured":"American Diabetes Association (2003) Peripheral arterial disease in people with diabetes. Diabetes Care 26(12):3333\u20133341. https:\/\/doi.org\/10.2337\/diacare.26.12.3333","journal-title":"Diabetes Care"},{"issue":"1","key":"593_CR24","doi-asserted-by":"publisher","first-page":"10056","DOI":"10.1038\/s41598-021-89401-2","volume":"11","author":"S Opoku","year":"2021","unstructured":"Opoku S, Gan Y, Yobo EA, Tenkorang-Twum D, Yue W, Wang Z, Lu Z (2021) Awareness, treatment, control, and determinants of dyslipidemia among adults in China. Sci Rep 11(1):10056. https:\/\/doi.org\/10.1038\/s41598-021-89401-2","journal-title":"Sci Rep"},{"issue":"30","key":"593_CR25","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.3748\/wjg.v24.i30.3361","volume":"24","author":"S Leoni","year":"2018","unstructured":"Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L (2018) Current guidelines for the management of non-alcoholic fatty liver disease: a systematic review with comparative analysis. World J Gastroenterol 24(30):3361\u20133373. https:\/\/doi.org\/10.3748\/wjg.v24.i30.3361","journal-title":"World J Gastroenterol"},{"issue":"3","key":"593_CR26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.tcm.2019.05.003","volume":"30","author":"JM Flack","year":"2020","unstructured":"Flack JM, Adekola B (2020) Blood pressure and the new ACC\/AHA hypertension guidelines. Trends Cardiovasc Med 30(3):160\u2013164. https:\/\/doi.org\/10.1016\/j.tcm.2019.05.003","journal-title":"Trends Cardiovasc Med"},{"issue":"1","key":"593_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2012.05.007","volume":"223","author":"J Perk","year":"2012","unstructured":"Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren WM, Albus C, Benlian P, Boysen G, Cifkova R et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Atherosclerosis 223(1):1\u201368. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.05.007","journal-title":"Atherosclerosis"},{"issue":"1","key":"593_CR28","doi-asserted-by":"publisher","first-page":"e13890","DOI":"10.1111\/eci.13890","volume":"53","author":"AF Pina","year":"2023","unstructured":"Pina AF, Meneses MJ, Sousa-Lima I, Henriques R, Raposo JF, Macedo MP (2023) Big data and machine learning to tackle diabetes management. Eur J Clin Invest 53(1):e13890. https:\/\/doi.org\/10.1111\/eci.13890","journal-title":"Eur J Clin Invest"},{"issue":"12","key":"593_CR29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3390\/jcm6120113","volume":"6","author":"J Inaishi","year":"2017","unstructured":"Inaishi J, Saisho Y (2017) Ethnic similarities and differences in the relationship between beta cell mass and diabetes. J Clin Med 6(12):113. https:\/\/doi.org\/10.3390\/jcm6120113","journal-title":"J Clin Med"},{"issue":"12","key":"593_CR30","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.2337\/db22-0622","volume":"71","author":"A Sharma","year":"2022","unstructured":"Sharma A, Lee-Odegard S, Qvigstad E, Sommer C, Sattar N, Gill J, Gulseth HL, Sollid ST, Nermoen I, Birkeland KI (2022) Beta-cell function, hepatic insulin clearance, and insulin sensitivity in south Asian and nordic women after gestational diabetes mellitus. Diabetes 71(12):2530\u20132538. https:\/\/doi.org\/10.2337\/db22-0622","journal-title":"Diabetes"},{"issue":"6","key":"593_CR31","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.pcd.2022.09.007","volume":"16","author":"JS Varghese","year":"2022","unstructured":"Varghese JS, Narayan K (2022) Ethnic differences between asians and non-asians in clustering-based phenotype classification of adult-onset diabetes mellitus: a systematic narrative review. Prim Care Diabetes 16(6):853\u2013856. https:\/\/doi.org\/10.1016\/j.pcd.2022.09.007","journal-title":"Prim Care Diabetes"},{"issue":"28","key":"593_CR32","doi-asserted-by":"publisher","first-page":"9330","DOI":"10.3748\/wjg.v20.i28.9330","volume":"20","author":"S Milic","year":"2014","unstructured":"Milic S, Lulic D, Stimac D (2014) Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. World J Gastroenterol 20(28):9330\u20139337. https:\/\/doi.org\/10.3748\/wjg.v20.i28.9330","journal-title":"World J Gastroenterol"},{"issue":"1","key":"593_CR33","doi-asserted-by":"publisher","first-page":"15958","DOI":"10.1038\/s41598-023-43028-7","volume":"13","author":"J Huang","year":"2023","unstructured":"Huang J, Gao T, Zhang H, Wang X (2023) Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999\u20132016. Sci Rep 13(1):15958. https:\/\/doi.org\/10.1038\/s41598-023-43028-7","journal-title":"Sci Rep"},{"issue":"1","key":"593_CR34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3350\/cmh.2022.0237","volume":"29","author":"KC Lee","year":"2023","unstructured":"Lee KC, Wu PS, Lin HC (2023) Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis. Clin Mol Hepatol 29(1):77\u201398. https:\/\/doi.org\/10.3350\/cmh.2022.0237","journal-title":"Clin Mol Hepatol"},{"key":"593_CR35","doi-asserted-by":"publisher","first-page":"927661","DOI":"10.3389\/fendo.2022.927661","volume":"13","author":"X Song","year":"2022","unstructured":"Song X, Lv Y, Huang N, Sun J, Yang T, Wang X, Zhang J, Zhou Z, Gao H, Li J et al (2022) Clinical characteristics of inpatients with new-onset diabetes mellitus in Eastern China: based on Novel Clustering Analysis. Front Endocrinol (Lausanne) 13:927661. https:\/\/doi.org\/10.3389\/fendo.2022.927661","journal-title":"Front Endocrinol (Lausanne)"},{"key":"593_CR36","doi-asserted-by":"publisher","first-page":"617628","DOI":"10.3389\/fendo.2021.617628","volume":"12","author":"L Xing","year":"2021","unstructured":"Xing L, Peng F, Liang Q, Dai X, Ren J, Wu H, Yang S, Zhu Y, Jia L, Zhao S (2021) Clinical characteristics and risk of diabetic complications in data-driven clusters among type 2 diabetes. Front Endocrinol (Lausanne) 12:617628. https:\/\/doi.org\/10.3389\/fendo.2021.617628","journal-title":"Front Endocrinol (Lausanne)"},{"key":"593_CR37","doi-asserted-by":"publisher","first-page":"994836","DOI":"10.3389\/fendo.2022.994836","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang J, Deng Y, Wan Y, Wang J, Xu J (2022) Diabetes duration and types of diabetes treatment in data-driven clusters of patients with diabetes. Front Endocrinol (Lausanne) 13:994836. https:\/\/doi.org\/10.3389\/fendo.2022.994836","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"593_CR38","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrneph.2016.75","volume":"12","author":"VD D\u2019Agati","year":"2016","unstructured":"D\u2019Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M, Praga M (2016) Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol 12(8):453\u2013471. https:\/\/doi.org\/10.1038\/nrneph.2016.75","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"593_CR39","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1097\/01.asn.0000068462.38661.89","volume":"14","author":"A Chagnac","year":"2003","unstructured":"Chagnac A, Weinstein T, Herman M, Hirsh J, Gafter U, Ori Y (2003) The effects of weight loss on renal function in patients with severe obesity. J Am Soc Nephrol 14(6):1480\u20131486. https:\/\/doi.org\/10.1097\/01.asn.0000068462.38661.89","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"593_CR40","doi-asserted-by":"publisher","first-page":"E871","DOI":"10.1152\/ajpendo.00135.2019","volume":"317","author":"E Rebelos","year":"2019","unstructured":"Rebelos E, Dadson P, Oikonen V, Iida H, Hannukainen JC, Iozzo P, Ferrannini E, Nuutila P (2019) Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss. Am J Physiol Endocrinol Metab 317(5):E871\u2013E878. https:\/\/doi.org\/10.1152\/ajpendo.00135.2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"593_CR41","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s13679-019-00335-3","volume":"8","author":"A Yerevanian","year":"2019","unstructured":"Yerevanian A, Soukas AA (2019) Metformin: mechanisms in human obesity and weight loss. Curr Obes Rep 8(2):156\u2013164. https:\/\/doi.org\/10.1007\/s13679-019-00335-3","journal-title":"Curr Obes Rep"},{"key":"593_CR42","doi-asserted-by":"publisher","first-page":"637945","DOI":"10.3389\/fgene.2021.637945","volume":"12","author":"O Fedotkina","year":"2021","unstructured":"Fedotkina O, Sulaieva O, Ozgumus T, Cherviakova L, Khalimon N, Svietleisha T, Buldenko T, Ahlqvist E, Asplund O, Groop L et al (2021) Novel reclassification of adult diabetes is useful to distinguish stages of beta-cell function linked to the risk of vascular complications: the DOLCE study from Northern Ukraine. Front Genet 12:637945. https:\/\/doi.org\/10.3389\/fgene.2021.637945","journal-title":"Front Genet"},{"key":"593_CR43","doi-asserted-by":"publisher","first-page":"115119","DOI":"10.1016\/j.ejmech.2023.115119","volume":"249","author":"A Mushtaq","year":"2023","unstructured":"Mushtaq A, Azam U, Mehreen S, Naseer MM (2023) Synthetic alpha-glucosidase inhibitors as promising anti-diabetic agents: recent developments and future challenges. Eur J Med Chem 249:115119. https:\/\/doi.org\/10.1016\/j.ejmech.2023.115119","journal-title":"Eur J Med Chem"},{"issue":"4","key":"593_CR44","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1111\/dom.13613","volume":"21","author":"S Wu","year":"2019","unstructured":"Wu S, Gao L, Cipriani A, Huang Y, Yang Z, Yang J, Yu S, Zhang Y, Chai S, Zhang Z et al (2019) The effects of incretin-based therapies on beta-cell function and insulin resistance in type 2 diabetes: a systematic review and network meta-analysis combining 360 trials. Diabetes Obes Metab 21(4):975\u2013983. https:\/\/doi.org\/10.1111\/dom.13613","journal-title":"Diabetes Obes Metab"},{"issue":"4","key":"593_CR45","doi-asserted-by":"publisher","first-page":"693","DOI":"10.2337\/dc18-2207","volume":"42","author":"PI Georgianos","year":"2019","unstructured":"Georgianos PI, Agarwal R (2019) Ambulatory blood pressure reduction with SGLT-2 inhibitors: dose-response meta-analysis and comparative evaluation with low-dose hydrochlorothiazide. Diabetes Care 42(4):693\u2013700. https:\/\/doi.org\/10.2337\/dc18-2207","journal-title":"Diabetes Care"},{"issue":"6","key":"593_CR46","doi-asserted-by":"publisher","first-page":"e003145","DOI":"10.1136\/bmjdrc-2022-003145","volume":"10","author":"L Preechasuk","year":"2022","unstructured":"Preechasuk L, Khaedon N, Lapinee V, Tangjittipokin W, Srivanichakorn W, Sriwijitkamol A, Plengvidhya N, Likitmaskul S, Thongtang N (2022) Cluster analysis of Thai patients with newly diagnosed type 2 diabetes mellitus to predict disease progression and treatment outcomes: a prospective cohort study. Bmj Open Diabetes Res Care 10(6):e003145. https:\/\/doi.org\/10.1136\/bmjdrc-2022-003145","journal-title":"Bmj Open Diabetes Res Care"},{"issue":"12","key":"593_CR47","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1007\/s00125-022-05741-2","volume":"65","author":"J Wang","year":"2022","unstructured":"Wang J, Liu JJ, Gurung RL, Liu S, Lee J, M Y, Ang K, Shao YM, Tang JI, Benke PI et al (2022) Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes. Diabetologia 65(12):2146\u20132156. https:\/\/doi.org\/10.1007\/s00125-022-05741-2","journal-title":"Diabetologia"},{"issue":"1","key":"593_CR48","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12916-021-01936-3","volume":"19","author":"G Penno","year":"2021","unstructured":"Penno G, Solini A, Orsi E, Bonora E, Fondelli C, Trevisan R, Vedovato M, Cavalot F, Zerbini G, Lamacchia O et al (2021) Insulin resistance, diabetic kidney disease, and all-cause mortality in individuals with type 2 diabetes: a prospective cohort study. Bmc Med 19(1):66. https:\/\/doi.org\/10.1186\/s12916-021-01936-3","journal-title":"Bmc Med"},{"issue":"9","key":"593_CR49","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s00125-019-4959-1","volume":"62","author":"S Eid","year":"2019","unstructured":"Eid S, Sas KM, Abcouwer SF, Feldman EL, Gardner TW, Pennathur S, Fort PE (2019) New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism. Diabetologia 62(9):1539\u20131549. https:\/\/doi.org\/10.1007\/s00125-019-4959-1","journal-title":"Diabetologia"},{"issue":"4","key":"593_CR50","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11886-021-01455-w","volume":"23","author":"E Bahiru","year":"2021","unstructured":"Bahiru E, Hsiao R, Phillipson D, Watson KE (2021) Mechanisms and treatment of dyslipidemia in diabetes. Curr Cardiol Rep 23(4):26. https:\/\/doi.org\/10.1007\/s11886-021-01455-w","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"593_CR51","doi-asserted-by":"publisher","first-page":"e142241","DOI":"10.1172\/JCI142241","volume":"131","author":"AR Saltiel","year":"2021","unstructured":"Saltiel AR (2021) Insulin signaling in health and disease. J Clin Invest 131(1):e142241. https:\/\/doi.org\/10.1172\/JCI142241","journal-title":"J Clin Invest"},{"issue":"1","key":"593_CR52","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s00125-021-05567-4","volume":"65","author":"M Pigeyre","year":"2022","unstructured":"Pigeyre M, Hess S, Gomez MF, Asplund O, Groop L, Pare G, Gerstein H (2022) Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial. Diabetologia 65(1):206\u2013215. https:\/\/doi.org\/10.1007\/s00125-021-05567-4","journal-title":"Diabetologia"},{"key":"593_CR53","doi-asserted-by":"publisher","first-page":"155294","DOI":"10.1016\/j.metabol.2022.155294","volume":"136","author":"J Ye","year":"2022","unstructured":"Ye J, Zhuang X, Li X, Gong X, Sun Y, Wang W, Feng S, Wu T, Zhong B (2022) Novel metabolic classification for extrahepatic complication of metabolic associated fatty liver disease: a data-driven cluster analysis with international validation. Metabolism 136:155294. https:\/\/doi.org\/10.1016\/j.metabol.2022.155294","journal-title":"Metabolism"},{"issue":"1","key":"593_CR54","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2337\/dc20-2806","volume":"45","author":"A Sharma","year":"2022","unstructured":"Sharma A, Zheng Y, Ezekowitz JA, Westerhout CM, Udell JA, Goodman SG, Armstrong PW, Buse JB, Green JB, Josse RG et al (2022) Cluster analysis of cardiovascular phenotypes in patients with type 2 diabetes and established atherosclerotic cardiovascular disease: a potential Approach to precision medicine. Diabetes Care 45(1):204\u2013212. https:\/\/doi.org\/10.2337\/dc20-2806","journal-title":"Diabetes Care"},{"issue":"1","key":"593_CR55","doi-asserted-by":"publisher","first-page":"e001506","DOI":"10.1136\/bmjdrc-2020-001506","volume":"8","author":"RM Anjana","year":"2020","unstructured":"Anjana RM, Baskar V, Nair A, Jebarani S, Siddiqui MK, Pradeepa R, Unnikrishnan R, Palmer C, Pearson E, Mohan V (2020) Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study. Bmj Open Diabetes Res Care 8(1):e001506. https:\/\/doi.org\/10.1136\/bmjdrc-2020-001506","journal-title":"Bmj Open Diabetes Res Care"},{"issue":"1","key":"593_CR56","doi-asserted-by":"publisher","first-page":"10756","DOI":"10.1038\/s41598-023-37494-2","volume":"13","author":"I Danquah","year":"2023","unstructured":"Danquah I, Mank I, Hampe CS, Meeks K, Agyemang C, Owusu-Dabo E, Smeeth L, Klipstein-Grobusch K, Bahendeka S, Spranger J et al (2023) Subgroups of adult-onset diabetes: a data-driven cluster analysis in a Ghanaian population. Sci Rep 13(1):10756. https:\/\/doi.org\/10.1038\/s41598-023-37494-2","journal-title":"Sci Rep"},{"key":"593_CR57","doi-asserted-by":"publisher","unstructured":"Papachristou S, Pafili K, Trypsianis G, Papazoglou D, Vadikolias K, Papanas N (2021) Skin advanced glycation end products among subjects with type 2 diabetes mellitus with or without distal sensorimotor polyneuropathy. J Diabetes Res 2021:6045677. https:\/\/doi.org\/10.1155\/2021\/6045677","DOI":"10.1155\/2021\/6045677"},{"issue":"3","key":"593_CR58","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1161\/ATVBAHA.122.318439","volume":"43","author":"A Vinaiphat","year":"2023","unstructured":"Vinaiphat A, Pazhanchamy K, JebaMercy G, Ngan SC, Leow MK, Ho HH, Gao YG, Lim KL, Richards AM, de Kleijn D et al (2023) Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling. Arterioscler Thromb Vasc Biol 43(3):427\u2013442. https:\/\/doi.org\/10.1161\/ATVBAHA.122.318439","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-024-00593-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42000-024-00593-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-024-00593-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:53:21Z","timestamp":1742201601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42000-024-00593-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["593"],"URL":"https:\/\/doi.org\/10.1007\/s42000-024-00593-4","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"25 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was supported by the Ethics Committee of the Second Hospital of Lanzhou University. It was in accordance with the 1964 Declaration of Helsinki and its subsequent revisions. All patients participating in this study have provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}