{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:00:10Z","timestamp":1792684810550,"version":"4.5.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Increasing levels of infertility in Western countries has drawn ever more scientific attention to the role in this trend of endocrine disruptors, such as bisphenol A, a substance now banned in some cases and some countries. Because this substance has been replaced by the structurally similar bisphenol S (BPS), this study focused on the effects of the latter on early mice embryo development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cultures of CD1 mice embryos with varying concentrations of BPS were compared with control blank cultures in order to examine the survival rate of embryos according to BPS concentration and culture day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The administration of BPS at any dose (1, 10, and 100 pg\/ml) in cultures of mice embryos led to a significant decrease in their survival rate. The negative effect of BPS was seen to start early (day 1 of experiment), even with the lowest employed dose (1 pg\/ml).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is, to the best of our knowledge, the first study to investigate the impact of BPS on the survival rate of mice embryos. In this study, potential adverse effects of BPS on early CD1 mice embryo development with regard to survival rate have been identified. Dose of BPS, timing of BPS administration, and time duration of exposure play a critical role in the decrease of mice embryo survival rate as compared to control cultures. These findings raise concerns regarding the safety of BPS and highlight the need for further research into the effect of this substance on human embryos.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s42000-025-00638-2","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T20:25:33Z","timestamp":1741033533000},"page":"533-542","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The deleterious effect of bisphenol S on early embryo development of mice"],"prefix":"10.1007","volume":"24","author":[{"given":"Christina","family":"Mantzouki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Mavrogianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Papagianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Konomos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Creatsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Drakakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-3275","authenticated-orcid":false,"given":"George","family":"Mastorakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"issue":"5","key":"638_CR1","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.3390\/ijms21051821","volume":"21","author":"S Amar","year":"2020","unstructured":"Amar S, Binet A, T\u00e9teau O, Desmarchais A, Papillier P, Lacroix MZ et al (2020) Bisphenol S impaired human granulosa cell steroidogenesis in vitro. Int J Mol Sci 21(5):1821","journal-title":"Int J Mol Sci"},{"issue":"6","key":"638_CR2","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1111\/1541-4337.12388","volume":"17","author":"S Almeida","year":"2018","unstructured":"Almeida S, Raposo A, Almeida-Gonz\u00e1lez M, Carrascosa (2018) Bisphenol A: food exposure and impact on human health. Compr Rev Food Sci Food Saf 17(6):1503\u20131517","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"638_CR3","unstructured":"ECHA (2017) Seven New Substances Added to the Candidate List entry for bisphenolA updated [WWW Document]. URL. https:\/\/echa.europa.eu\/fr\/-\/seven-new-substances-added-to-the-candidate-list-entry-for-bisphenol-a-updated-to-reflect-its-endocrine-disrupting-properties-for-the-environment"},{"key":"638_CR4","unstructured":"French government (2012) Le bisphenol A interdit dans les contenants alimentaires - Ministere de l\u2019Environnement, de l\u2019Energie et de la Mer [WWW Document].URL. http:\/\/www.developpement-durable.gouv.fr\/spip.php? page\u2009=\u2009article&id_article\u2009=\u200930371"},{"key":"638_CR5","unstructured":"USEPA (2014) Bisphenol A alternatives in thermal [WWW document]. URL. https:\/\/www.epa.gov\/sites\/production\/files\/2014-05\/documents\/bpa_final.pdf"},{"issue":"12","key":"638_CR6","doi-asserted-by":"publisher","first-page":"7095","DOI":"10.1021\/acs.est.9b02090","volume":"18","author":"L Wang","year":"2019","unstructured":"Wang L, Zhang Y, Liu Y, Gong X, Zhang T, Sun H (2019) Widespread occurrence of bisphenol A in daily clothes and its high exposure risk in humans. Environ Sci Technol 18(12):7095\u20137102","journal-title":"Environ Sci Technol"},{"key":"638_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.envint.2017.11.020","volume":"112","author":"J Oh","year":"2018","unstructured":"Oh J, Choi JW, Ahn YA, Kim S (2018) Pharmacokinetics of bisphenol S in humans after single oral administration. Environ Int 112:127\u2013133","journal-title":"Environ Int"},{"issue":"11","key":"638_CR8","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","volume":"50","author":"D Chen","year":"2016","unstructured":"Chen D, Kannan K, Tan H, Zheng Z, Feng YL, Wu Y et al (2016) Bisphenol analogues other than BPA: environmental occurrence, human exposure, and Toxicity - A review. Environ Sci Technol 50(11):5438\u20135453","journal-title":"Environ Sci Technol"},{"issue":"12","key":"638_CR9","doi-asserted-by":"publisher","first-page":"6860","DOI":"10.1021\/es301334j","volume":"46","author":"C Liao","year":"2012","unstructured":"Liao C, Liu F, Alomirah H, Loi VD, Mohd MA, Moon HB et al (2012) Bisphenol S in urine from the united States and seven Asian countries: occurrence and human exposures. Environ Sci Technol 46(12):6860\u20136866","journal-title":"Environ Sci Technol"},{"key":"638_CR10","unstructured":"The use of bisphenol A and its alternatives in thermal paper in the EU during 2014\u20132022 [Internet] (2020) Available from: http:\/\/echa.europa.eu\/contact"},{"issue":"6","key":"638_CR11","doi-asserted-by":"publisher","first-page":"6523","DOI":"10.1021\/acsomega.8b00824","volume":"3","author":"HJ Lehmler","year":"2018","unstructured":"Lehmler HJ, Liu B, Gadogbe M, Bao W (2018) Exposure to bisphenol A, bisphenol F, bisphenol S in U.S. Adults and children: the National health and nutrition examination survey 2013\u20132014. ACS Omega 3(6):6523\u20136532","journal-title":"ACS Omega"},{"key":"638_CR12","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.envres.2017.11.051","volume":"161","author":"EM Philips","year":"2018","unstructured":"Philips EM, Jaddoe VWV, Asimakopoulos AG, Kannan K, Steegers EAP, Santos S et al (2018) Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004\u20135. Environ Res 161:562\u2013572","journal-title":"Environ Res"},{"issue":"3","key":"638_CR13","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1016\/j.fertnstert.2017.07.276","volume":"108","author":"I Dimitriadis","year":"2017","unstructured":"Dimitriadis I, Minguez-Alarcon L, Williams P, Souter I, Toth TL, Ford JB et al (2017) Follicular fluid (FF) phenol concentrations and early in vitro fertilization (IVF) outcomes among women seeking fertility care. Fertil Steril 108(3):e89","journal-title":"Fertil Steril"},{"issue":"4","key":"638_CR14","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1289\/ehp.1409427","volume":"124","author":"KA Thayer","year":"2016","unstructured":"Thayer KA, Taylor KW, Garantziotis S, Schurman SH, Kissling GE, Hunt D et al (2016) Bisphenol A, bisphenol S, and 4-hydro Xyphenyl 4-isopro oxyphenyl sulfone (bpsip) in urine and blood of cashiers. Environ Health Perspect 124(4):437\u2013444","journal-title":"Environ Health Perspect"},{"key":"638_CR15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.chemosphere.2013.12.085","volume":"104","author":"SM Zimmers","year":"2014","unstructured":"Zimmers SM, Browne EP, O\u2019Keefe PW, Anderton DL, Kramer L, Reckhow DA et al (2014) Determination of free bisphenol A (BPA) concentrations in breast milk of U.S. Women using a sensitive LC\/MS\/MS method. Chemosphere 104:237\u2013243","journal-title":"Chemosphere"},{"issue":"6","key":"638_CR16","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/rcm.8051","volume":"32","author":"Y Song","year":"2018","unstructured":"Song Y, Xie P, Cai Z (2018) Metabolism of bisphenol S in mice after oral administration. Rapid Commun Mass Spectrom 32(6):495\u2013502","journal-title":"Rapid Commun Mass Spectrom"},{"key":"638_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.scitotenv.2017.09.194","volume":"615","author":"LH Wu","year":"2018","unstructured":"Wu LH, Zhang XM, Wang F, Gao CJ, Chen D, Palumbo JR et al (2018) Occurrence of bisphenol S in the environment and implications for human exposure: A short review. Sci Total Environ 615:87\u201398","journal-title":"Sci Total Environ"},{"issue":"1","key":"638_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","volume":"103","author":"S Eladak","year":"2015","unstructured":"Eladak S, Grisin T, Moison D, Guerquin MJ, N\u2019Tumba-Byn T, Pozzi-Gaudin S et al (2015) A new chapter in the bisphenol a story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril 103(1):11\u201321","journal-title":"Fertil Steril"},{"key":"638_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.aquatox.2014.01.009","volume":"148","author":"M Naderi","year":"2014","unstructured":"Naderi M, Wong MYL, Gholami F (2014) Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults. Aquat Toxicol 148:195\u2013203","journal-title":"Aquat Toxicol"},{"key":"638_CR20","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.chemosphere.2017.12.118","volume":"197","author":"N Ahsan","year":"2018","unstructured":"Ahsan N, Ullah H, Ullah W, Jahan S (2018) Comparative effects of bisphenol S and bisphenol A on the development of female reproductive system in rats; a neonatal exposure study. Chemosphere 197:336\u2013343","journal-title":"Chemosphere"},{"issue":"1","key":"638_CR21","doi-asserted-by":"publisher","first-page":"1317690","DOI":"10.1080\/2331205X.2017.1317690","volume":"4","author":"CE Hill","year":"2017","unstructured":"Hill CE, Sapouckey SA, Suvorov A, Vandenberg LN (2017) Developmental exposures to bisphenol S, a BPA replacement, alter estrogen-responsiveness of the female reproductive tract: a pilot study HHS public access. Cogent Med 4(1):1317690","journal-title":"Cogent Med"},{"issue":"15","key":"638_CR22","doi-asserted-by":"publisher","first-page":"8793","DOI":"10.1021\/es400329t","volume":"47","author":"K Ji","year":"2013","unstructured":"Ji K, Hong S, Kho Y, Choi K (2013) Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish. Environ Sci Technol 47(15):8793\u20138800","journal-title":"Environ Sci Technol"},{"issue":"11","key":"638_CR23","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1210\/en.2017-00615","volume":"158","author":"Y Pu","year":"2017","unstructured":"Pu Y, Gingrich JD, Steibel JP, Veiga-Lopez A (2017) Sex-specific modulation of fetal adipogenesis by gestational bisphenol A and bisphenol S exposure. Endocrinology 158(11):3844\u20133858","journal-title":"Endocrinology"},{"issue":"2","key":"638_CR24","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1210\/en.2015-1785","volume":"157","author":"W Qiu","year":"2016","unstructured":"Qiu W, Zhao Y, Yang M, Farajzadeh M, Pan C, Wayne NL (2016) Actions of bisphenol A and bisphenol S on the reproductive neuroendocrine system during early development in zebrafish. Endocrinology 157(2):636\u2013647","journal-title":"Endocrinology"},{"issue":"3","key":"638_CR25","first-page":"516","volume":"158","author":"MC Catanese","year":"2017","unstructured":"Catanese MC, Vandenberg LN (2017) Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy\/lactation and their daughters. Endocrinology 158(3):516\u2013530","journal-title":"Endocrinology"},{"issue":"6","key":"638_CR26","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/etc.3313","volume":"35","author":"D Crump","year":"2016","unstructured":"Crump D, Chiu S, Williams KL (2016) Bisphenol S alters embryonic viability, development, gallbladder size, and messenger RNA expression in chicken embryos exposed via egg injection. Environ Toxicol Chem 35(6):1541\u20131549","journal-title":"Environ Toxicol Chem"},{"key":"638_CR27","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.chemosphere.2016.02.125","volume":"152","author":"H Ullah","year":"2016","unstructured":"Ullah H, Jahan S, Ain QU, Shaheen G, Ahsan N (2016) Effect of bisphenol S exposure on male reproductive system of rats: A histological and biochemical study. Chemosphere 152:383\u2013391","journal-title":"Chemosphere"},{"key":"638_CR28","doi-asserted-by":"publisher","first-page":"106298","DOI":"10.1016\/j.envint.2020.106298","volume":"147","author":"M Lin","year":"2021","unstructured":"Lin M, Hua R, Ma J, Zhou Y, Li P, Xu X et al (2021) Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK\/mTOR\/ULK1 signaling pathway. Environ Int 147:106298","journal-title":"Environ Int"},{"issue":"1","key":"638_CR29","doi-asserted-by":"publisher","first-page":"9595","DOI":"10.1038\/s41598-021-87175-1","volume":"11","author":"S Aftabsavad","year":"2021","unstructured":"Aftabsavad S, Noormohammadi Z, Moini A, Karimipoor M (2021) Effect of bisphenol A on alterations of ICAM-1 and HLA-G genes expression and DNA methylation profiles in cumulus cells of infertile women with poor response to ovarian stimulation. Sci Rep 11(1):9595","journal-title":"Sci Rep"},{"issue":"1","key":"638_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.rbmo.2021.04.010","volume":"43","author":"NN Yenig\u00fcl","year":"2021","unstructured":"Yenig\u00fcl NN, Dilbaz S, Dilbaz B, Kaplano\u011flu \u0130, G\u00fc\u00e7el F, Aldemir O et al (2021) The effect of plastic bottled water consumption on outcomes of ICSI cycles undertaken for unexplained infertility. Reprod Biomed Online 43(1):91\u201399","journal-title":"Reprod Biomed Online"},{"key":"638_CR31","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.reprotox.2015.12.002","volume":"59","author":"J Ferris","year":"2016","unstructured":"Ferris J, Mahboubi K, MacLusky N, King WA, Favetta LA (2016) BPA exposure during in vitro oocyte maturation results in dose-dependent alterations to embryo development rates, apoptosis rate, sex ratio and gene expression. Reprod Toxicol 59:128\u2013138","journal-title":"Reprod Toxicol"},{"issue":"1","key":"638_CR32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000381321","volume":"145","author":"J Ferris","year":"2015","unstructured":"Ferris J, Favetta LA, King WA (2015) Bisphenol A exposure during oocyte maturation in vitro results in spindle abnormalities and chromosome misalignment in Bos taurus. Cytogenet Genome Res 145(1):50\u201358","journal-title":"Cytogenet Genome Res"},{"issue":"1","key":"638_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/14647273.2017.1358828","volume":"22","author":"A Karwacka","year":"2019","unstructured":"Karwacka A, Zamkowska D, Radwan M, Jurewicz J (2019) Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: an overview of current epidemiological evidence. Hum Fertil 22(1):2\u201325","journal-title":"Hum Fertil"},{"issue":"4","key":"638_CR34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.rbmo.2014.06.013","volume":"29","author":"R Machtinger","year":"2014","unstructured":"Machtinger R, Orvieto R (2014) Bisphenol A, oocyte maturation, implantation, and IVF outcome: review of animal and human data. Reprod Biomed Online 29(4):404\u2013410","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"638_CR35","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1021\/acs.est.6b05718","volume":"51","author":"J Liu","year":"2017","unstructured":"Liu J, Li J, Wu Y, Zhao Y, Luo F, Li S et al (2017) Bisphenol A metabolites and bisphenol S in paired maternal and cord serum. Environ Sci Technol 51(4):2456\u20132463","journal-title":"Environ Sci Technol"},{"key":"638_CR36","doi-asserted-by":"publisher","first-page":"105407","DOI":"10.1016\/j.envint.2019.105407","volume":"136","author":"B Zhang","year":"2020","unstructured":"Zhang B, He Y, Zhu H, Huang X, Bai X, Kannan K et al (2020) Concentrations of bisphenol A and its alternatives in paired maternal\u2013fetal urine, serum and amniotic fluid from an e-waste dismantling area in China. Environ Int 136:105407","journal-title":"Environ Int"},{"key":"638_CR37","unstructured":"Directive (2010) \/63\/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes. Official Journal of the European Union L 276, 20 October 2010, pp. 33\u201379"},{"key":"638_CR38","unstructured":"Russell WM StrattoN, Rex Leonard Burch (1959) The principles of humane experimental technique. Methuen"},{"issue":"9","key":"638_CR39","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1177\/0271678X20943823","volume":"40","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M et al (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. J Cereb Blood Flow Metab 40(9):1769\u20131777","journal-title":"J Cereb Blood Flow Metab"},{"key":"638_CR40","first-page":"3621","volume":"10","author":"AJ Smith","year":"2020","unstructured":"Smith AJ (2020) Guidelines for planning and conducting high-quality research and testing on animals. Lab Anim Res 10:3621","journal-title":"Lab Anim Res"},{"issue":"3","key":"638_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1095\/biolreprod.112.101899","volume":"87","author":"J Peretz","year":"2012","unstructured":"Peretz J, Craig ZR, Flaws JA (2012) Bisphenol A inhibits follicle growth and induces Atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway. Biol Reprod 87(3):63","journal-title":"Biol Reprod"},{"issue":"1","key":"638_CR42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12958-021-00773-6","volume":"19","author":"AC Saleh","year":"2021","unstructured":"Saleh AC, Sabry R, Mastromonaco GF, Favetta LA (2021) BPA and BPS affect the expression of anti-Mullerian hormone (AMH) and its receptor during bovine oocyte maturation and early embryo development. Reproductive Biology Endocrinol 19(1):119","journal-title":"Reproductive Biology Endocrinol"},{"issue":"1","key":"638_CR43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1530\/REP-18-0092","volume":"156","author":"J Nevoral","year":"2018","unstructured":"Nevoral J, Kolinko Y, Moravec J, \u017dalmanov\u00e1 T, Ho\u0161kov\u00e1 K, Proke\u0161ov\u00e1 \u0160 et al (2018) Long-term exposure to very low doses of bisphenol S affects female reproduction. Reproduction 156(1):47\u201357","journal-title":"Reproduction"},{"issue":"4","key":"638_CR44","first-page":"341","volume":"8","author":"A Nourian","year":"2017","unstructured":"Nourian A, Soleimanzadeh A, Jalali AS, Najafi G (2017) Effects of bisphenol-S low concentrations on oxidative stress status and in vitro fertilization potential in mature female mice. Vet Res Forum 8(4):341\u2013345","journal-title":"Vet Res Forum"},{"key":"638_CR45","doi-asserted-by":"publisher","first-page":"113096","DOI":"10.1016\/j.ecoenv.2021.113096","volume":"229","author":"A Desmarchais","year":"2022","unstructured":"Desmarchais A, T\u00e9teau O, Kasal-Hoc N, Cogni\u00e9 J, Lasserre O, Papillier P et al (2022) Chronic low BPS exposure through diet impairs in vitro embryo production parameters according to metabolic status in the Ewe. Ecotoxicol Environ Saf 229:113096","journal-title":"Ecotoxicol Environ Saf"},{"key":"638_CR46","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.crtox.2021.11.001","volume":"2","author":"KG Harnett","year":"2021","unstructured":"Harnett KG, Moore LG, Chin A, Cohen IC, Lautrup RR, Schuh SM (2021) Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development. Curr Res Toxicol 2:399\u2013410","journal-title":"Curr Res Toxicol"},{"key":"638_CR47","doi-asserted-by":"publisher","first-page":"102347","DOI":"10.1016\/j.bpobgyn.2023.102347","volume":"88","author":"P Panagopoulos","year":"2023","unstructured":"Panagopoulos P, Mavrogianni D, Christodoulaki C, Drakaki E, Chrelias G, Panagiotopoulos D et al (2023) Effects of endocrine disrupting compounds on female fertility. Best Pract Res Clin Obstet Gynaecol 88:102347","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"638_CR48","doi-asserted-by":"publisher","first-page":"29318","DOI":"10.1038\/srep29318","volume":"6","author":"BI Choi","year":"2016","unstructured":"Choi BI, Harvey AJ, Green MP (2016) Bisphenol A affects early bovine embryo development and metabolism that is negated by an oestrogen receptor inhibitor. Sci Rep 6:29318","journal-title":"Sci Rep"},{"key":"638_CR49","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.reprotox.2018.12.005","volume":"84","author":"AL Arancio","year":"2019","unstructured":"Arancio AL, Cole KD, Dominguez AR, Cohenour ER, Kadie J, Maloney WC et al (2019) Bisphenol A, bisphenol AF, di-n-butyl phthalate, and 17\u03b2-estradiol have shared and unique dose-dependent effects on early embryo cleavage divisions and development in Xenopus laevis. Reprod Toxicol 84:65\u201374","journal-title":"Reprod Toxicol"},{"issue":"10","key":"638_CR50","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.3390\/ijms22105363","volume":"22","author":"IC Cohen","year":"2021","unstructured":"Cohen IC, Cohenour ER, Harnett KG, Schuh SM (2021) BPA, BPAF and TMBPF alter adipogenesis and fat accumulation in human mesenchymal stem cells, with implications for obesity. Int J Mol Sci 22(10):5363","journal-title":"Int J Mol Sci"},{"key":"638_CR51","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tox.2018.12.001","volume":"413","author":"H Kojima","year":"2019","unstructured":"Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N et al (2019) Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors. Toxicology 413:48\u201355","journal-title":"Toxicology"},{"issue":"1","key":"638_CR52","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/toxsci\/kfw178","volume":"155","author":"S Liang","year":"2017","unstructured":"Liang S, Yin L, Yu KS, Hofmann MC, Yu X (2017) High-content analysis provides mechanistic insights into the testicular toxicity of bisphenol A and selected analogues in mouse spermatogonial cells. Toxicol Sci 155(1):43\u201360","journal-title":"Toxicol Sci"},{"issue":"7","key":"638_CR53","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.tiv.2015.05.012","volume":"29","author":"J Micha\u0142owicz","year":"2015","unstructured":"Micha\u0142owicz J, Mokra K, Bak A (2015) Bisphenol A and its analogs induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study). Toxicol in Vitro 29(7):1464\u20131472","journal-title":"Toxicol in Vitro"},{"issue":"21","key":"638_CR54","doi-asserted-by":"publisher","first-page":"12796","DOI":"10.1021\/acs.est.7b03283","volume":"51","author":"J Moreman","year":"2017","unstructured":"Moreman J, Lee O, Trznadel M, David A, Kudoh T, Tyler CR (2017) Acute toxicity, teratogenic, and estrogenic effects of bisphenol A and its alternative replacements bisphenol S, bisphenol F, and bisphenol AF in zebrafish Embryo-Larvae. Environ Sci Technol 51(21):12796\u201312805","journal-title":"Environ Sci Technol"},{"issue":"2","key":"638_CR55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s42000-022-00370-1","volume":"21","author":"A Mina","year":"2022","unstructured":"Mina A, Boutzios G, Papoutsis I, Kaparos G, Christopoulos P, Kousta E et al (2022) Bisphenol A correlates with fewer retrieved oocytes in women with tubal factor infertility. Hormones 21(2):305\u2013315","journal-title":"Hormones"},{"issue":"12","key":"638_CR56","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1093\/humrep\/des328","volume":"27","author":"S Ehrlich","year":"2012","unstructured":"Ehrlich S, Williams PL, Missmer SA, Flaws JA, Ye X, Calafat AM et al (2012) Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Hum Reprod 27(12):3583\u20133592","journal-title":"Hum Reprod"},{"issue":"7","key":"638_CR57","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.3390\/nu13072426","volume":"13","author":"N Vrachnis","year":"2021","unstructured":"Vrachnis N, Loukas N, Vrachnis D, Antonakopoulos N, Zygouris D, Kolialexi A et al (2021) A systematic review of bisphenol a from dietary and non-dietary sources during pregnancy and its possible connection with fetal growth restriction: investigating its potential effects and the window of fetal vulnerability. Nutrients 13(7):2426","journal-title":"Nutrients"},{"issue":"3","key":"638_CR58","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.yrtph.2015.01.002","volume":"71","author":"DM Goldinger","year":"2015","unstructured":"Goldinger DM, Demierre AL, Zoller O, Rupp H, Reinhard H, Magnin R et al (2015) Endocrine activity of alternatives to BPA found in thermal paper in Switzerland. Regul Toxicol Pharmacol 71(3):453\u2013462","journal-title":"Regul Toxicol Pharmacol"},{"issue":"7","key":"638_CR59","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1289\/ehp.1408989","volume":"123","author":"JR Rochester","year":"2015","unstructured":"Rochester JR, Bolden AL (2015) Bisphenol S and F: A systematic review and comparison of the hormonal activity of bisphenol a substitutes. Environ Health Perspect 123(7):643\u2013650","journal-title":"Environ Health Perspect"},{"key":"638_CR60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tox.2015.01.003","volume":"329","author":"MJE Roelofs","year":"2015","unstructured":"Roelofs MJE, Berg M, van den, Bovee TFH, Piersma AH, van Duursen MBM (2015) Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor. Toxicology 329:10\u201320","journal-title":"Toxicology"},{"issue":"1","key":"638_CR61","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/toxsci\/kfu030","volume":"139","author":"AK Rosenmai","year":"2014","unstructured":"Rosenmai AK, Dybdahl M, Pedersen M, van Vugt-Lussenburg BMA, Wedebye EB, Taxvig C et al (2014) Are structural analogues to bisphenol a safe alternatives? Toxicol Sci 139(1):35\u201347","journal-title":"Toxicol Sci"},{"key":"638_CR62","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.reprotox.2018.06.005","volume":"79","author":"JS Siracusa","year":"2018","unstructured":"Siracusa JS, Yin L, Measel E, Liang S, Yu X (2018) Effects of bisphenol A and its analogs on reproductive health: A mini review. Reprod Toxicol 79:96\u2013123","journal-title":"Reprod Toxicol"},{"issue":"2","key":"638_CR63","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1021\/acs.est.7b03958","volume":"16","author":"H Jin","year":"2018","unstructured":"Jin H, Zhu J, Chen Z, Hong Y, Cai Z (2018) Occurrence and partitioning of bisphenol analogues in adults\u2019 blood from China. Environ Sci Technol 16(2):812\u2013820","journal-title":"Environ Sci Technol"},{"key":"638_CR64","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.chemosphere.2018.02.040","volume":"199","author":"Y Wan","year":"2018","unstructured":"Wan Y, Xia W, Yang S, Pan X, He Z, Kannan K (2018) Spatial distribution of bisphenol S in surface water and human serum from Yangtze river watershed, China: implications for exposure through drinking water. Chemosphere 199:595\u2013602","journal-title":"Chemosphere"},{"key":"638_CR65","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.ecoenv.2015.09.029","volume":"122","author":"E Yamazaki","year":"2015","unstructured":"Yamazaki E, Yamashita N, Taniyasu S, Lam J, Lam PK, Moon HB, Jeong Y, Kannan P, Achyuthan H, Munuswamy N, Kannan K (2015) Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan, China, Korea and India. Ecotoxicol Environ Saf 122:565\u2013572","journal-title":"Ecotoxicol Environ Saf"},{"key":"638_CR66","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.envpol.2013.11.023","volume":"186","author":"S Song","year":"2014","unstructured":"Song S, Song M, Zeng L, Wang T, Liu R, Ruan T, Jiang G (2014) Occurrence and profiles of bisphenol analogues in municipal sewage sludge in China. Environ Pollut 186:14\u201319","journal-title":"Environ Pollut"},{"key":"638_CR67","doi-asserted-by":"publisher","first-page":"4655","DOI":"10.1021\/jf400445n","volume":"61","author":"C Liao","year":"2013","unstructured":"Liao C, Kannan K (2013) Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the united States and their implications for human exposure. J Agric Food Chem 61:4655\u20134662","journal-title":"J Agric Food Chem"},{"key":"638_CR68","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00216-010-3464-7","volume":"397","author":"P Vinas","year":"2010","unstructured":"Vinas P, Campillo N, Martinez-Castillo N, Hernandez-Cordoba M (2010) Comparison of two derivatization-based methods for solid-phase microextraction-gas chromatography-mass spectrometric determination of bisphenol A, bisphenol S and biphenol migrated from food cans. Anal Bioanal Chem 397:115\u2013125","journal-title":"Anal Bioanal Chem"},{"key":"638_CR69","doi-asserted-by":"publisher","first-page":"9138","DOI":"10.1021\/es302004w","volume":"46","author":"C Liao","year":"2012","unstructured":"Liao C, Liu F, Guo Y, Moon HB, Nakata H, Wu Q, Kannan K (2012) Occurrence of eight bisphenol analogues in indoor dust from the united States and several Asian countries: implications for human exposure. Environ Sci Technol 46:9138\u20139145","journal-title":"Environ Sci Technol"},{"key":"638_CR70","doi-asserted-by":"crossref","unstructured":"Skledar DG, Schmidt J, Fic A, Klop\u010di\u010d I, Trontelj J, Dolenc MS, Finel M, Ma\u0161i\u010d LP (2016) Influence of metabolism on endocrine activities of bisphenol S. Chemosphere 157(Supplement C) 152\u2013159","DOI":"10.1016\/j.chemosphere.2016.05.027"},{"issue":"2","key":"638_CR71","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.yrtph.2015.04.009","volume":"72","author":"DA Dreier","year":"2015","unstructured":"Dreier DA, Connors KA, Brooks BW (2015) Comparative endpoint sensitivity of in vitro Estrogen agonist assays. Regul Toxicol Pharmacol 72(2):185\u2013193","journal-title":"Regul Toxicol Pharmacol"},{"key":"638_CR72","doi-asserted-by":"publisher","first-page":"5664","DOI":"10.1038\/srep05664","volume":"4","author":"R Huang","year":"2014","unstructured":"Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M (2014) Profiling of the Tox21 10K compound library for agonists and antagonists of the Estrogen receptor alpha signaling pathway. Sci Rep 4:5664","journal-title":"Sci Rep"},{"issue":"7","key":"638_CR73","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1289\/ehp.1408989","volume":"123","author":"JR Rochester","year":"2015","unstructured":"Rochester JR, Bolden AL (2015) Bisphenol S and F: A systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ Health Persp 123(7):643\u2013650","journal-title":"Environ Health Persp"},{"issue":"1","key":"638_CR74","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bj.2021.01.004","volume":"45","author":"KT Chang","year":"2022","unstructured":"Chang KT, Su YT, Tsai YR, Lan KC, Hsuuw YD, Kang HY, Chan WH, Huang FJ (2022) High levels estradiol affect blastocyst implantation and post-implantation development directly in mice. Biomed J 45(1):179\u2013189","journal-title":"Biomed J"},{"issue":"5","key":"638_CR75","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1530\/REP-19-0575","volume":"159","author":"O T\u00e9teau","year":"2020","unstructured":"T\u00e9teau O, Jaubert M, Desmarchais A, Papillier P, Binet A, Maillard V et al (2020) Bisphenol A and S impaired ovine granulosa cell steroidogenesis. Reproduction 159(5):571\u2013583 \u03b1\u03c0\u03cc 57","journal-title":"Reproduction"},{"issue":"2","key":"638_CR76","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/humupd\/dmq036","volume":"17","author":"S Assou","year":"2011","unstructured":"Assou S, Boumela I, Haouzi D, Anahory T, Dechaud H, DeVos J, Hamamah S (2011) Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications. Hum Reprod Update 17(2):272\u2013290","journal-title":"Hum Reprod Update"},{"key":"638_CR77","doi-asserted-by":"publisher","first-page":"115382","DOI":"10.1016\/j.envpol.2020.115382","volume":"267","author":"MY Zhang","year":"2020","unstructured":"Zhang MY, Tian Y, Yan ZH, Li WD, Zang CJ, Li L, Sun XF, Shen W, Cheng SF (2020) Maternal bisphenol S exposure affects the reproductive capacity of F1 and F2 offspring in mice. Environ Pollut 267:115382","journal-title":"Environ Pollut"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-025-00638-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42000-025-00638-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42000-025-00638-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:26:51Z","timestamp":1757143611000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42000-025-00638-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["638"],"URL":"https:\/\/doi.org\/10.1007\/s42000-025-00638-2","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"5 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures complied with PD 56\/2013 and European Directive 2010\/63\/EU, welfare and ethical use of laboratory animals based on the 3R\u2019s, Replacement, Reduction, and Refinement, and the guidelines of PREPARE (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence), and ARRIVE (Animal Research: Reporting in vivo experiments\n                      ).\n                      The animal study was reviewed and approved by the Committee for Evaluation of Experimental Procedures, Department of Experimental Animal Models, Hellenic Pasteur Institute, Athens, Greece.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study did not need informed consent as it did not include any human related data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Data regarding any of the subjects in the study have not been previously published.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Attestation statements"}},{"value":"All authors declare they have no financial interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial interests"}}]}}