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After treatment with benzodiazepines was started, the patient began to experience episodes of confusion, which persisted even after reducing the dosage. During one of these episodes, he was admitted to the emergency department and a glucose level of 26\u00a0mg\/dL was found. Differential diagnosis led to detection of an insulin-secreting neuroendocrine tumor of the pancreas; thus, a paraneoplastic origin of SPS was hypothesized. However, antiamphiphysin Ab were negative, anti-GAD Ab were persistently elevated, and symptoms only transiently improved after removal of the tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first case, to our knowledge, demonstrating association between type 1 SPS and insulinoma, along with describing partial and transient improvement of neurological symptoms after resolution of the associated hypoglycemic syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s42000-025-00666-y","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T21:42:18Z","timestamp":1747086138000},"page":"883-890","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of type 1 stiff-person syndrome and insulinoma: a case report and narrative review"],"prefix":"10.1007","volume":"24","author":[{"given":"Michela","family":"Sibilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Beccuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Belcastro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Mortara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata","family":"Campra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Piovesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-0138","authenticated-orcid":false,"given":"Mauro","family":"Maccario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Papotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Maria","family":"Berton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"issue":"8","key":"666_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1136\/jnnp-2014-309201","volume":"86","author":"JF Baizabal-Carvallo","year":"2015","unstructured":"Baizabal-Carvallo JF, Jankovic J (2015) Stiff-person syndrome: insights into a complex autoimmune disorder. 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