{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:46:58Z","timestamp":1787060818008,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"CONACYT","award":["FOMIX-CONACYT-GOB HGO-2008-C01-96469"],"award-info":[{"award-number":["FOMIX-CONACYT-GOB HGO-2008-C01-96469"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s42770-021-00453-y","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T03:37:40Z","timestamp":1613273860000},"page":"1013-1019","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High exposure to pathogenic leptospires by the population residing in dairy farms in Hidalgo, Mexico"],"prefix":"10.1007","volume":"52","author":[{"given":"Miguel","family":"Galarde-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bobadilla-del Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Mar\u00eda","family":"S\u00e1nchez-Zamorano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel","family":"Ordaz-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Velazquez-Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orbel\u00edn","family":"Soberanis-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"453_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-3-662-45059-8_5","volume":"387","author":"DA Haake","year":"2015","unstructured":"Haake DA, Levett PN (2015) Leptospirosis in humans. Curr Top Microbiol Immunol 387:65\u201397. https:\/\/doi.org\/10.1007\/978-3-662-45059-8_5","journal-title":"Curr Top Microbiol Immunol"},{"key":"453_CR2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-3-662-45059-8_6","volume":"387","author":"WA Ellis","year":"2015","unstructured":"Ellis WA (2015) Animal leptospirosis. Curr Top Microbiol Immunol 387:99\u2013137. https:\/\/doi.org\/10.1007\/978-3-662-45059-8_6","journal-title":"Curr Top Microbiol Immunol"},{"key":"453_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003898","volume":"9","author":"F Costa","year":"2015","unstructured":"Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI (2015) Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis 9:e0003898. https:\/\/doi.org\/10.1371\/journal.pntd.0003898","journal-title":"PLoS Negl Trop Dis"},{"key":"453_CR4","unstructured":"World Health Organization (2017) General information: leptospirosis. WHO https:\/\/www.paho.org\/hq\/index.php?option=com_content&view=article&id=7821:2012-informacion-general-leptospirosis&Itemid=0&lang=es. Accessed 20 May 2020"},{"key":"453_CR5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","volume":"14","author":"PN Levett","year":"2001","unstructured":"Levett PN (2001) Leptospirosis. Clin Microbiol Rev 14:296\u2013326. https:\/\/doi.org\/10.1128\/CMR.14.2.296-326.2001","journal-title":"Clin Microbiol Rev"},{"key":"453_CR6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.vetmic.2009.03.012","volume":"140","author":"B Adler","year":"2010","unstructured":"Adler B, de la Pe\u00f1a MA (2010) Leptospira and leptospirosis. Vet Microbiol 140:287\u2013296. https:\/\/doi.org\/10.1016\/j.vetmic.2009.03.012","journal-title":"Vet Microbiol"},{"key":"453_CR7","doi-asserted-by":"publisher","first-page":"e00507","DOI":"10.1128\/AEM.00507-18","volume":"84","author":"A Casanovas-Massana","year":"2018","unstructured":"Casanovas-Massana A, Pedra GG, Wunder EA, Diggle PJ, Begon M, Ko AI (2018) Quantification of Leptospira interrogans survival in soil and water microcosms. Appl Environ Microbiol 84:e00507\u2013e00518. https:\/\/doi.org\/10.1128\/AEM.00507-18","journal-title":"Appl Environ Microbiol"},{"key":"453_CR8","doi-asserted-by":"publisher","first-page":"e0227055","DOI":"10.1371\/journal.pone.0227055","volume":"15","author":"E Bierque","year":"2020","unstructured":"Bierque E, Thibeaux R, Girault D, Soup\u00e9-Gilbert M-E, Goarant C (2020) A systematic review of Leptospira in water and soil environments. PLoS One 15:e0227055. https:\/\/doi.org\/10.1371\/journal.pone.0227055","journal-title":"PLoS One"},{"key":"453_CR9","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.jiph.2019.02.001","volume":"12","author":"M Fernandes","year":"2019","unstructured":"Fernandes M, Vieira ML, Carreira T, Teod\u00f3sio R (2019) Sanitation workers from Portugal: is there evidence of Leptospira spp? J Infect Public Health 12:738\u2013740. https:\/\/doi.org\/10.1016\/j.jiph.2019.02.001","journal-title":"J Infect Public Health"},{"key":"453_CR10","doi-asserted-by":"publisher","first-page":"12E.5.1","DOI":"10.1002\/9780471729259.mc12e05s32","volume":"32","author":"MGA Goris","year":"2014","unstructured":"Goris MGA, Hartskeerl RA (2014) Leptospirosis serodiagnosis by the microscopic agglutination test. Curr Protoc Microbiol 32:12E.5.1\u201312E.5.18. https:\/\/doi.org\/10.1002\/9780471729259.mc12e05s32","journal-title":"Curr Protoc Microbiol"},{"key":"453_CR11","doi-asserted-by":"publisher","first-page":"S162","DOI":"10.12980\/APJTB.4.2014C580","volume":"4","author":"C Chirathaworn","year":"2014","unstructured":"Chirathaworn C, Inwattana R, Poovorawan Y, Suwancharoen D (2014) Interpretation of microscopic agglutination test for leptospirosis diagnosis and seroprevalence. Asian Pac J Trop Biomed 4:S162\u2013S164. https:\/\/doi.org\/10.12980\/APJTB.4.2014C580","journal-title":"Asian Pac J Trop Biomed"},{"key":"453_CR12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2460\/javma.237.3.293","volume":"237","author":"R Gautam","year":"2010","unstructured":"Gautam R, Wu CC, Guptill LE, Potter A, Moore GE (2010) Detection of antibodies against Leptospira serovars via microscopic agglutination tests in dogs in the United States, 2000-2007. J Am Vet Med Assoc 237:293\u2013298. https:\/\/doi.org\/10.2460\/javma.237.3.293","journal-title":"J Am Vet Med Assoc"},{"key":"453_CR13","unstructured":"OIE (2018) Manual Terrestre de la OIE. https:\/\/wwwoieint\/es\/normas\/manual-terrestre\/. Accessed 20 May 2020"},{"key":"453_CR14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.11144\/Javeriana.SC19-3.selh","volume":"19","author":"A Pulido-Villamar\u00edn","year":"2014","unstructured":"Pulido-Villamar\u00edn A, Carre\u00f1o-Beltr\u00e1n G, Mercado-Reyes M, Ram\u00edrez-Bulla P (2014) Situaci\u00f3n epidemiol\u00f3gica de la leptospirosis humana en Centroam\u00e9rica, Suram\u00e9rica y el Caribe. Univ Sci 19:247\u2013264. https:\/\/doi.org\/10.11144\/Javeriana.SC19-3.selh","journal-title":"Univ Sci"},{"key":"453_CR15","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.26633\/RPSP.2017.81","volume":"41","author":"MC Schneider","year":"2017","unstructured":"Schneider MC, Leonel DG, Hamrick PN, de Caldas EP, Vel\u00e1squez RT, Mendiga\u00f1a-Paez FA, Gonzalez-Arrebato JC, Gerger A, Pereira MM, Aldighieri S (2017) Leptospirosis in Latin America: exploring the first set of regional data. Rev Panam Salud P\u00fabl 41:e81. https:\/\/doi.org\/10.26633\/RPSP.2017.81","journal-title":"Rev Panam Salud P\u00fabl"},{"key":"453_CR16","first-page":"71","volume":"33","author":"IR Z\u00fa\u00f1iga Carrasco","year":"2013","unstructured":"Z\u00fa\u00f1iga Carrasco IR, Caro Lozano J (2013) Panorama epidemiol\u00f3gico de la leptospirosis, Estados Unidos Mexicanos 2000-2010. Enferm Infecc Microbiol 33:71\u201376","journal-title":"Enferm Infecc Microbiol"},{"key":"453_CR17","doi-asserted-by":"publisher","first-page":"10366","DOI":"10.3390\/ijerph111010366","volume":"11","author":"R Gracie","year":"2014","unstructured":"Gracie R, Barcellos C, Magalh\u00e3es M, Souza-Santos R, Guimar\u00e3es-Barrocas PR (2014) Geographical scale effects on the analysis of leptospirosis determinants. Int J Environ Res Public Health 11:10366\u201310383. https:\/\/doi.org\/10.3390\/ijerph111010366","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"453_CR18","doi-asserted-by":"publisher","first-page":"e2177","DOI":"10.1371\/journal.pntd.0002177","volume":"7","author":"P Torres-Gonzalez","year":"2013","unstructured":"Torres-Gonzalez P, Soberanis-Ramos O, Martinez-Gamboa A, Chavez-Mazari B, Barrios-Herrera MT, Torres-Rojas M, Cruz-Hervert LP, Garcia-Garcia L, Singh M, Gonzalez-Aguirre A, Ponce de Leon-Gardu\u00f1o A, Sifuentes-Osornio J, Bobadilla-del-Valle M (2013) Prevalence of latent and active tuberculosis among dairy farm workers exposed to cattle infected by Mycobacterium bovis. PLoS Negl Trop Dis 7(4):e2177. https:\/\/doi.org\/10.1371\/journal.pntd.0002177","journal-title":"PLoS Negl Trop Dis"},{"key":"453_CR19","volume-title":"Stata statistical software: release 14","author":"StataCorp","year":"2015","unstructured":"StataCorp (2015) Stata statistical software: release 14. StataCorp LP, College Station"},{"key":"453_CR20","unstructured":"Romero RP, Torres Barranca JI, Moles y Cervantes LP, Cisneros Puebla M, Angel, Rojas Serrania N, et al. (1999) Leptospira serological diagnosis in bovines from the quarenteen area of the Tizayuca dairy basin. Inst Nac Investig For Agr\u00edc Ganad 207"},{"key":"453_CR21","first-page":"24","volume":"54","author":"L Moles","year":"2002","unstructured":"Moles L, Cisneros M, Gavald\u00f3n D, Rojas N, Torres J (2002) Estudio serol\u00f3gico de leptospirosis bovina en M\u00e9xico. Rev Cubana Med Trop 54:24\u201327","journal-title":"Rev Cubana Med Trop"},{"key":"453_CR22","doi-asserted-by":"publisher","first-page":"e0005228","DOI":"10.1371\/journal.pntd.0005228","volume":"11","author":"S Chadsuthi","year":"2017","unstructured":"Chadsuthi S, Bicout DJ, Wiratsudakul A, Suwancharoen D, Petkanchanapong W, Modchang C, Triampo W, Ratanakorn P, Chavel-Monfray K (2017) Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. PLoS Negl Trop Dis 11:e0005228. https:\/\/doi.org\/10.1371\/journal.pntd.0005228","journal-title":"PLoS Negl Trop Dis"},{"key":"453_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4103\/0974-777X.127941","volume":"6","author":"R Kamath","year":"2014","unstructured":"Kamath R, Swain S, Pattanshetty S, Nair NS (2014) Studying risk factors associated with human leptospirosis. J Global Infect Dis 6:3\u20139. https:\/\/doi.org\/10.4103\/0974-777X.127941","journal-title":"J Global Infect Dis"},{"key":"453_CR24","doi-asserted-by":"publisher","first-page":"e0008309","DOI":"10.1371\/journal.pntd.0008309","volume":"14","author":"S Rajapakse","year":"2020","unstructured":"Rajapakse S, Weeratunga PN, Balaji K, Ramchandani KC, de Silva US, Ranasinghe SA, Gunarathne D, Wijerathne PPB, Fernando N, Handunneti SM, Fernando SD (2020) Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting\u2014a community-based study in the district of Colombo, Sri Lanka. PLoS Negl Trop Dis 14:e0008309. https:\/\/doi.org\/10.1371\/journal.pntd.0008309","journal-title":"PLoS Negl Trop Dis"},{"key":"453_CR25","first-page":"620","volume":"54","author":"M Torres-Castro","year":"2016","unstructured":"Torres-Castro M, Hern\u00e1ndez-Betancourt S, Agudelo-Fl\u00f3rez P, Arroyave-Sierra E, Zavala-Castro J, Puerto FI (2016) Revisi\u00f3n actual de la epidemiolog\u00eda de la leptospirosis. Rev Med Inst Mex Seguro Soc 54:620\u2013625","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"453_CR26","doi-asserted-by":"publisher","first-page":"e0133720","DOI":"10.1371\/journal.pone.0133720","volume":"10","author":"S S\u00e1nchez-Montes","year":"2015","unstructured":"S\u00e1nchez-Montes S, Espinosa-Mart\u00ednez DV, R\u00edos-Mu\u00f1oz CA, Berzunza-Cruz M, Becker I (2015) Leptospirosis in Mexico: epidemiology and potential distribution of human cases. PLoS One 10:e0133720. https:\/\/doi.org\/10.1371\/journal.pone.0133720","journal-title":"PLoS One"},{"key":"453_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4061\/2011\/408604","volume":"2011","author":"J Navarrete Espinosa","year":"2011","unstructured":"Navarrete Espinosa J, Moreno Mu\u00f1oz M, S\u00e1nchez Rivas B, Castrej\u00f3n Velasco O (2011) Leptospirosis prevalence in a population of Yucatan, Mexico. J Pathog 2011:1\u20135. https:\/\/doi.org\/10.4061\/2011\/408604","journal-title":"J Pathog"},{"key":"453_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1590\/S1517-83822007000100019","volume":"38","author":"DM Aguiar","year":"2007","unstructured":"Aguiar DM, Cavalcante GT, Camargo LMA, Labruna MB, Vasconcellos SA, Souza GO, Gennari SM (2007) Anti-Leptospira spp and anti-Brucella spp antibodies in humans from rural area of Monte Negro municipality, state of Rond\u00f4nia, Brazilian Western Amazon. Braz J Microbiol 38:93\u201396. https:\/\/doi.org\/10.1590\/S1517-83822007000100019","journal-title":"Braz J Microbiol"},{"key":"453_CR29","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1017\/S0950268814003549","volume":"143","author":"G Arteaga-Troncoso","year":"2015","unstructured":"Arteaga-Troncoso G, Jim\u00e9nez-Estrada JM, Montes De Oca-Jimenez R, L\u00f3pez-Hurtado M, Luna-Alvarez M, Hernandez-Andrade L, Moreno-Alfaro A, Galan-Herrera JF, Guerra-Infante FM (2015) Seroprevalence and risk factors associated with within-flock transmission of Leptospira interrogans in transhumant farming systems in Mexico. Epidemiol Infect 143:2894\u20132902. https:\/\/doi.org\/10.1017\/S0950268814003549","journal-title":"Epidemiol Infect"},{"key":"453_CR30","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1590\/S0102-311X2007000900017","volume":"23","author":"P Agudelo-Fl\u00f3rez","year":"2007","unstructured":"Agudelo-Fl\u00f3rez P, Restrepo-Jaramillo BN, Arboleda-Naranjo M (2007) Situaci\u00f3n de la leptospirosis en el Urab\u00e1 antioque\u00f1o colombiano: estudio seroepidemiol\u00f3gico y factores de riesgo en poblaci\u00f3n general urbana. Cad Saude Publ 23:2094\u20132102. https:\/\/doi.org\/10.1590\/S0102-311X2007000900017","journal-title":"Cad Saude Publ"},{"key":"453_CR31","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1590\/S0036-36342005000300008","volume":"47","author":"S N\u00e1jera","year":"2005","unstructured":"N\u00e1jera S, Alvis N, Babilonia D, Alvarez L, M\u00e1ttar S (2005) Leptospirosis ocupacional en una regi\u00f3n del Caribe colombiano. Salud Publica Mex 47:240\u2013244. https:\/\/doi.org\/10.1590\/S0036-36342005000300008","journal-title":"Salud Publica Mex"},{"key":"453_CR32","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.3390\/ijerph110201756","volume":"11","author":"A Dreyfus","year":"2014","unstructured":"Dreyfus A, Benschop J, Collins-Emerson J, Wilson P, Baker MG, Heuer C (2014) Sero-prevalence and risk factors for leptospirosis in abattoir workers in New Zealand. Int J Environ Res Public Health 11:1756\u20131775. https:\/\/doi.org\/10.3390\/ijerph110201756","journal-title":"Int J Environ Res Public Health"},{"key":"453_CR33","first-page":"158","volume":"53","author":"BL Lugo-Ch\u00e1vez","year":"2015","unstructured":"Lugo-Ch\u00e1vez BL, Velasco-Rodr\u00edguez LC, Canales-Vel\u00e1squez G, Vel\u00e1zquez-Hern\u00e1ndez JF, Herrera-Huerta EV (2015) Detection of antiLeptospira antibodies in a vulnerable population of Ixhuatlancillo, Veracruz. Rev Med Inst Mex Seguro Soc 53:158\u2013163","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"453_CR34","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jiph.2019.07.021","volume":"13","author":"CY Fish-Low","year":"2020","unstructured":"Fish-Low CY, Balami AD, Than LTL, Ling KH, Mohd Taib N, Md. Shah A, Sekawi Z (2020) Hypocalcemia, hypochloremia, and eosinopenia as clinical predictors of leptospirosis: a retrospective study. J Infect Public Health 13:216\u2013220. https:\/\/doi.org\/10.1016\/j.jiph.2019.07.021","journal-title":"J Infect Public Health"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00453-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-021-00453-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00453-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:41:35Z","timestamp":1620348095000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-021-00453-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,13]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["453"],"URL":"https:\/\/doi.org\/10.1007\/s42770-021-00453-y","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,13]]},"assertion":[{"value":"2 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This protocol was approved by the Research Ethics Committee and the Research and Biosecurity Committees of the National Institute of Public Health, in Mexico Reg. No. 17CEI00120130424.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}