{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:50:58Z","timestamp":1768276258209,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s42770-021-00553-9","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T06:02:17Z","timestamp":1626156137000},"page":"1921-1927","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Helicobacter pylori\u00a0virulence dupA gene: risk factor or protective factor?"],"prefix":"10.1007","volume":"52","author":[{"given":"Lucas Luiz","family":"de Lima Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karoline Silva","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Rodrigues","family":"Gama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Ferreira Paes Landim","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio M\u00e1rcio Teodoro Cordeiro","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel Jos\u00e9 Vieira","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Daniel Gon\u00e7alves","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Trevizani","family":"Rasmussem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Carla","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Santiago","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"553_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12403","volume":"22","author":"C Burucoa","year":"2017","unstructured":"Burucoa C, Axon A (2017) Epidemiology of Helicobacter pylori infection. Helicobacter 22:e12403. https:\/\/doi.org\/10.1111\/hel.12403","journal-title":"Helicobacter"},{"key":"553_CR2","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","volume":"153","author":"JKY Hooi","year":"2017","unstructured":"Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC (2017) Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology 153:420\u2013429. https:\/\/doi.org\/10.1053\/j.gastro.2017.04.022","journal-title":"Gastroenterology"},{"key":"553_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/1319-3767.54743","volume":"57","author":"M Guisset","year":"1997","unstructured":"Guisset M, Coton T, Rey P, Debonne JM (1997) Helicobacter pylori infection in developing countries. Med Trop (Mars) 57:77\u201382. https:\/\/doi.org\/10.4103\/1319-3767.54743","journal-title":"Med Trop (Mars)"},{"key":"553_CR4","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/apt.14561","volume":"47","author":"M Zamani","year":"2018","unstructured":"Zamani M, Ebrahimtabar F, Zamani V, Miller WH, Alizadeh-Navaei R, Shokri-Shirvani J, Derakhshan MH (2018) Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther 47:868\u2013876. https:\/\/doi.org\/10.1111\/apt.14561","journal-title":"Aliment Pharmacol Ther"},{"key":"553_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/cells10010027","volume":"10","author":"J Baj","year":"2020","unstructured":"Baj J, Forma A, Sitarz M, Portincasa P, Garruti G, Krasowska D, Maciejewski R (2020) Helicobacter pylori virulance factors-mechanisms of bacterial pathogenicity in the gastric microenvironment. Cells 10:27. https:\/\/doi.org\/10.3390\/cells10010027","journal-title":"Cells"},{"key":"553_CR6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.23736\/S1121-421X.18.02481-9","volume":"64","author":"GM Buz\u00e1s","year":"2018","unstructured":"Buz\u00e1s GM (2018) Benign and malignant gastroduodenal diseases associated with Helicobacter pylori: a narrative review and personal remarks in 2018. Minerva Gastroenterol Dietol 64:280\u2013296. https:\/\/doi.org\/10.23736\/S1121-421X.18.02481-9","journal-title":"Minerva Gastroenterol Dietol"},{"key":"553_CR7","unstructured":"IARC Working Group (1994) IARC monographs on the evaluation of carcinogenic risks to humans. In: Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr. Eval. Carcinog. Risks Hum, Lyon, pp 1\u2013241"},{"key":"553_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4291\/wjgp.v7.i1.97","volume":"7","author":"RG Zhang","year":"2016","unstructured":"Zhang RG, Duan GC, Fan QT, Chen SY (2016) Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma. World J Gastrointest Pathophysiol 7:97\u2013107. https:\/\/doi.org\/10.4291\/wjgp.v7.i1.97","journal-title":"World J Gastrointest Pathophysiol"},{"key":"553_CR9","doi-asserted-by":"publisher","unstructured":"Backert S, Tegtmeyer, Selback M (2010) The versatility of Helicobacter pylori CagA effector protein functions: the master key hypothesis. 15:163\u2013176. https:\/\/doi.org\/10.1111\/j.1523-5378.2010.00759.x","DOI":"10.1111\/j.1523-5378.2010.00759.x"},{"key":"553_CR10","doi-asserted-by":"publisher","first-page":"DC23","DOI":"10.7860\/JCDR\/2017\/27812.10457","volume":"11","author":"HB Pandya","year":"2017","unstructured":"Pandya HB, Agravat HH, Patel JS (2017) Prevalence of specific Helicobacter pylori cagA, vacA, iceA, ureC genotypes and its clinical relevance in the patients with acid-peptic diseases. J Clin Diagn Res 11:DC23\u2013DC26. https:\/\/doi.org\/10.7860\/JCDR\/2017\/27812.10457","journal-title":"J Clin Diagn Res"},{"key":"553_CR11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s12223-017-0514-y","volume":"62","author":"E Paredes-Osses","year":"2017","unstructured":"Paredes-Osses E, S\u00e1ez K, Sanhueza E, Hebel S, Gonz\u00e1lez C, Brice\u00f1o C, Garc\u00eda Cancino A (2017) Association between cagA, vacAi, and dupA genes of Helicobacter pylori and gastroduodenal pathologies in Chilean patients. Folia Microbiol (Praha) 62:437\u2013444. https:\/\/doi.org\/10.1007\/s12223-017-0514-y","journal-title":"Folia Microbiol (Praha)"},{"key":"553_CR12","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3855\/jidc.5970","volume":"9","author":"F Sayehmiri","year":"2015","unstructured":"Sayehmiri F, Kiani F, Sayehmiri K, Soroush S, Asadollahi K, Alikhani MY, Delpisheh A, Emaneini M, Bogdanovi\u0107 L, Varzi AM, Zarrilli R, Taherikalani M (2015) Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis. J Infect Dev Ctries 9:686\u2013696. https:\/\/doi.org\/10.3855\/jidc.5970","journal-title":"J Infect Dev Ctries"},{"key":"553_CR13","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1053\/j.gastro.2005.01.009","volume":"128","author":"H Lu","year":"2005","unstructured":"Lu H, Hsu PI, Graham DY, Yamaoka Y (2005) Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology 128:833\u2013848. https:\/\/doi.org\/10.1053\/j.gastro.2005.01.009","journal-title":"Gastroenterology"},{"key":"553_CR14","doi-asserted-by":"publisher","first-page":"4739","DOI":"10.3748\/wjg.v26.i32.4739","volume":"26","author":"J Alam","year":"2020","unstructured":"Alam J, Sarkar A, Karmakar BC, Ganguly M, Paul S, Mukhopadhyay AK (2020) Novel virulence factor dupA of Helicobacter pylori as an important risk determinant for disease manifestation: an overview. World J Gastroenterol 26:4739\u20134752. https:\/\/doi.org\/10.3748\/wjg.v26.i32.4739","journal-title":"World J Gastroenterol"},{"key":"553_CR15","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1128\/JCM.05562-11","volume":"50","author":"O Matsunari","year":"2012","unstructured":"Matsunari O, Shiota S, Suzuki R, Watada M, Kinjo N, Murakami K, Fujioka T, Kinjo F, Yamaoka Y (2012) Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan. J Clin Microbiol 50:876\u2013883. https:\/\/doi.org\/10.1128\/JCM.05562-11","journal-title":"J Clin Microbiol"},{"key":"553_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/hel.12405","volume":"22","author":"V Camilo","year":"2017","unstructured":"Camilo V, Sugiyama T, Touati E (2017) Pathogenesis of Helicobacter pylori infection. Helicobacter 22:1\u20136. https:\/\/doi.org\/10.1111\/hel.12405","journal-title":"Helicobacter"},{"key":"553_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1590\/S0004-28032015000400004","volume":"52","author":"IDF Vinagre","year":"2015","unstructured":"Vinagre IDF, de Queiroz AL, da Silva J\u00fanior MR, Vinagre RMDF, Martins LC (2015) Infec\u00e7\u00e3o pelo Helicobacter pylori em pacientes com diferentes doen\u00e7as gastrointestinais do Norte do Brasil. Arq Gastroenterol 52:266\u2013271. https:\/\/doi.org\/10.1590\/S0004-28032015000400004","journal-title":"Arq Gastroenterol"},{"key":"553_CR18","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1099\/jmm.0.038398-0","volume":"61","author":"J Alam","year":"2012","unstructured":"Alam J, Maiti S, Ghosh P, De R, Chowdhury A, Das S, Macaden R, Devarbhavi H, Ramamurthy T, Mukhopadhyay AK (2012) Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population. J Med Microbiol 61:1295\u20131302. https:\/\/doi.org\/10.1099\/jmm.0.038398-0","journal-title":"J Med Microbiol"},{"key":"553_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1099\/jmm.0.027052-0","volume":"61","author":"BAA Talebi","year":"2012","unstructured":"Talebi BAA, Taghvaei T, Wolfram L, Kusters JG (2012) Infection with Helicobacter pylori strains lacking dupA is associated with an increased risk of gastric ulcer and gastric cancer development. J Med Microbiol 61:23\u201330. https:\/\/doi.org\/10.1099\/jmm.0.027052-0","journal-title":"J Med Microbiol"},{"key":"553_CR20","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1128\/CMR.00054-05","volume":"19","author":"JG Kusters","year":"2006","unstructured":"Kusters JG, Van Vliet AHM, Kuipers EJ (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19:449\u2013490. https:\/\/doi.org\/10.1128\/CMR.00054-05","journal-title":"Clin Microbiol Rev"},{"key":"553_CR21","doi-asserted-by":"publisher","first-page":"e750","DOI":"10.1016\/j.ijid.2013.03.004","volume":"17","author":"MA Chiurillo","year":"2013","unstructured":"Chiurillo MA, Moran Y, Ca\u00f1as M, Valderrama E, Granda N, Sayegh M, Ram\u00edrez JL (2013) Genotyping of Helicobacter pylori virulence-associated genes shows high diversity of strains infecting patients in western Venezuela. Int J Infect Dis 17:e750\u2013e756. https:\/\/doi.org\/10.1016\/j.ijid.2013.03.004","journal-title":"Int J Infect Dis"},{"key":"553_CR22","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1186\/1471-2334-13-555","volume":"13","author":"J Liu","year":"2013","unstructured":"Liu J, He C, Chen M, Wang Z, Xing C, Yuan Y (2013) Association of presence\/absence and on\/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis. BMC Infect Dis 13:555. https:\/\/doi.org\/10.1186\/1471-2334-13-555","journal-title":"BMC Infect Dis"},{"key":"553_CR23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2334-13-555","volume":"13","author":"X Yong","year":"2015","unstructured":"Yong X, Tang B, Li BS, Xie R, Hu CJ, Luo G, Qin Y, Dong H, Yang SM (2015) Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways. Cell Commun Signal 13:30. https:\/\/doi.org\/10.1186\/1471-2334-13-555","journal-title":"Cell Commun Signal"},{"key":"553_CR24","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3390\/toxins9100316","volume":"9","author":"M McClain","year":"2017","unstructured":"McClain M, Beckett AC, Cover TL (2017) Helicobacter pylori vacuolating toxin and gastric cancer. Toxins (Basel) 9:316. https:\/\/doi.org\/10.3390\/toxins9100316","journal-title":"Toxins (Basel)"},{"key":"553_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.micpath.2013.04.001","volume":"59\u201360","author":"MY Wang","year":"2013","unstructured":"Wang MY, Chen C, Gao XZ, Li J, Yue J, Ling F, Wang XC, Shao SH (2013) Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in a region at high risk of gastric cancer. Microb Pathog 59\u201360:13\u201318. https:\/\/doi.org\/10.1016\/j.micpath.2013.04.001","journal-title":"Microb Pathog"},{"key":"553_CR26","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1038\/srep04143","volume":"4","author":"J Liu","year":"2014","unstructured":"Liu J, Liu H, Zhang T, Ren X, Nadolny C, Dong X, Huang L, Yuan K, Tian W, Jia Y (2014) Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer. Sci Rep 4:4143. https:\/\/doi.org\/10.1038\/srep04143","journal-title":"Sci Rep"},{"key":"553_CR27","first-page":"S47","volume":"8","author":"N Souod","year":"2015","unstructured":"Souod N, Sarshar M, Dabiri H, Momtaz H, Kargar M, Mohammadzadeh A, Abdi S (2015) The study of the oipA and dupA genes in Helicobacter pylori strains and their relationship with different gastroduodenal diseases. Gastroenterol Hepatol Bed Bench 8:S47\u2013S53","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"553_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4236\/aim.2017.71001","volume":"7","author":"ML Sallas","year":"2017","unstructured":"Sallas ML, Melchiades JL, Zabaglia LM, Moreno JRP, Orcini WA, Chen ES, Smith MAC, Pay\u00e3o SLM, Rasmussen LT (2017) Prevalence of Helicobacter pylori vacA, cagA, dupA and oipA genotypes in patients with gastric disease. Adv Microbiol 7:1\u20139. https:\/\/doi.org\/10.4236\/aim.2017.71001","journal-title":"Adv Microbiol"},{"key":"553_CR29","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/den.13530","volume":"32","author":"F Emura","year":"2019","unstructured":"Emura F, Sharma P, Arantes V, Cerisoli C, Parra-Blanco A, Sumiyama K, Araya R, Sobrino S, Chiu P, Matsuda K, Gonz\u00e1lez R, Fujishiro M, Tajiri H (2019) Principles and practice to facilitate complete photodocumentation of the upper gastrointestinal tract: World Endoscopy Organization position statement. Dig Endosc 32:168\u2013179. https:\/\/doi.org\/10.1111\/den.13530","journal-title":"Dig Endosc"},{"key":"553_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1590\/s0004-2803.201800000-20","volume":"55","author":"LGV Coelho","year":"2018","unstructured":"Coelho LGV, Marinho JR, Genta R, Ribeiro LT, Passoss MDCF, Zaterka S et al (2018) IVth Brazilian consensus conference on Helicobacter pylori infection. Arq Gastroenterol 55:97\u2013121. https:\/\/doi.org\/10.1590\/s0004-2803.201800000-20","journal-title":"Arq Gastroenterol"},{"key":"553_CR31","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1155\/2001\/367832","volume":"15","author":"M Stolte","year":"2001","unstructured":"Stolte M, Meining A (2001) The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment. Can J Gastroenterol 15:591\u2013598. https:\/\/doi.org\/10.1155\/2001\/367832","journal-title":"Can J Gastroenterol"},{"key":"553_CR32","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/molbev\/msy096","volume":"35","author":"S Kumar","year":"2018","unstructured":"Kumar S, Stecher G, Li M, Knyaz C, Tamura K (2018) MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol 35:1547\u20131549. https:\/\/doi.org\/10.1093\/molbev\/msy096","journal-title":"Mol Biol Evol"},{"key":"553_CR33","doi-asserted-by":"publisher","first-page":"10118","DOI":"10.3748\/wjg.v22.i46.10118","volume":"22","author":"AT Abadi","year":"2016","unstructured":"Abadi AT, Perez-Perez G (2016) Role of dupA in virulence of Helicobacter pylori. World J Gastroenterol 22:10118\u201310123. https:\/\/doi.org\/10.3748\/wjg.v22.i46.10118","journal-title":"World J Gastroenterol"},{"key":"553_CR34","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijmm.2007.05.006","volume":"298","author":"LI Gomes","year":"2008","unstructured":"Gomes LI, Rocha GA, Rocha AM, Soares TF, Oliveira CA, Bittencourt PF, Queiroz DM (2008) Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol 298:223\u2013230. https:\/\/doi.org\/10.1016\/j.ijmm.2007.05.006","journal-title":"Int J Med Microbiol"},{"key":"553_CR35","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s10096-008-0549-8","volume":"11","author":"AR Pacheco","year":"2008","unstructured":"Pacheco AR, Proen\u00e7a-M\u00f3dena JL, Sales AI, Fukuhara Y, da Silveira WD, Pimenta-M\u00f3dena JL, de Oliveira RB, Brocchi M (2008) Involvement of the Helicobacter pylori plasticity region and cag pathogenicity island genes in the development of gastroduodenal diseases. Eur J Clin Microbiol Infect Dis 11:1053\u20131059. https:\/\/doi.org\/10.1007\/s10096-008-0549-8","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"553_CR36","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1086\/522177","volume":"45","author":"RH Argent","year":"2007","unstructured":"Argent RH, Burette A, Miendje Deyi VY, Atherton JC (2007) The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis 45:1204\u20131206. https:\/\/doi.org\/10.1086\/522177","journal-title":"Clin Infect Dis"},{"key":"553_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1757-4749-1-5","volume":"1","author":"HM Schmidt","year":"2009","unstructured":"Schmidt HM, Andres S, Kaakoush NO, Engstrand L, Eriksson L, Goh KL, Fock KM, Hilmi I, Dhamodaran S, Forman D, Mitchell H (2009) The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study. Gut pathogens 1:1\u20135. https:\/\/doi.org\/10.1186\/1757-4749-1-5","journal-title":"Gut pathogens"},{"key":"553_CR38","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/1471-2180-10-218","volume":"10","author":"YC Yeh","year":"2010","unstructured":"Yeh YC, Cheng HC, Chang WL, Yang HB, Sheu BS (2010) Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females. BMC Microbiol 10:218. https:\/\/doi.org\/10.1186\/1471-2180-10-218","journal-title":"BMC Microbiol"},{"key":"553_CR39","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.meegid.2011.12.002","volume":"12","author":"R Suzuki","year":"2012","unstructured":"Suzuki R, Shiota S, Yamaoka Y (2012) Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori. Infect Genet Evol 12:203\u2013213. https:\/\/doi.org\/10.1016\/j.meegid.2011.12.002","journal-title":"Infect Genet Evol"},{"key":"553_CR40","doi-asserted-by":"publisher","first-page":"14625","DOI":"10.1073\/pnas.251551698","volume":"98","author":"DA Israel","year":"2001","unstructured":"Israel DA, Salama N, Krishna U, Rieger UM, Atherton JC, Falkow S, Peek RM Jr (2001) Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci USA 98:14625\u201314630. https:\/\/doi.org\/10.1073\/pnas.251551698","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00553-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-021-00553-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00553-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T02:08:44Z","timestamp":1636510124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-021-00553-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["553"],"URL":"https:\/\/doi.org\/10.1007\/s42770-021-00553-9","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]},"assertion":[{"value":"15 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted according to the ethical standards of the Research Ethics Committee of the University Hospital of the Federal University of Goias (HC\/UFG), under the opinion number 2.519.032, according to Resolution CNS\/196\/96.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}