{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:03:04Z","timestamp":1792069384739,"version":"4.4.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI118807"],"award-info":[{"award-number":["AI118807"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI128151"],"award-info":[{"award-number":["AI128151"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-1969-20180324"],"award-info":[{"award-number":["I-1969-20180324"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1017880"],"award-info":[{"award-number":["1017880"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-17-048-01-MPC"],"award-info":[{"award-number":["RSG-17-048-01-MPC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s42770-021-00571-7","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T08:02:31Z","timestamp":1626076951000},"page":"1745-1753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["How microbiological tests reflect bacterial pathogenesis and host adaptation"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-7156","authenticated-orcid":false,"given":"Luisella","family":"Spiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-3874","authenticated-orcid":false,"given":"Angel G.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-0470","authenticated-orcid":false,"given":"Renato L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1532-9178","authenticated-orcid":false,"given":"Sebastian E.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"issue":"5","key":"571_CR1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1128\/JB.37.5.485-493.1939","volume":"37","author":"AP Hitchens","year":"1939","unstructured":"Hitchens AP, Leikind MC (1939) The Introduction of Agar-agar into Bacteriology. J Bacteriol 37(5):485\u2013493. https:\/\/doi.org\/10.1128\/JB.37.5.485-493.1939","journal-title":"J Bacteriol"},{"issue":"1744","key":"571_CR2","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1136\/bmj.1.1744.1177","volume":"1","author":"JL Smith","year":"1894","unstructured":"Smith JL (1894) A Note on a New Method of Preparing Culture Media. Br Med J 1(1744):1177. https:\/\/doi.org\/10.1136\/bmj.1.1744.1177","journal-title":"Br Med J"},{"key":"571_CR3","first-page":"279","volume":"1","author":"RJ Petri","year":"1887","unstructured":"Petri RJ (1887) Eine kleine Modifikation des Koch\u2019schen Plattenverfahrens. Zentralblatt f\u00fcr Bakteriologie 1:279\u2013280","journal-title":"Zentralblatt f\u00fcr Bakteriologie"},{"issue":"3","key":"571_CR4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1085\/jgp.17.3.349","volume":"17","author":"HH Walker","year":"1934","unstructured":"Walker HH, Winslow CE, Mooney MG (1934) Bacterial cell metabolism under anaerobic conditions. J Gen Physiol 17(3):349\u2013357. https:\/\/doi.org\/10.1085\/jgp.17.3.349","journal-title":"J Gen Physiol"},{"issue":"1","key":"571_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1084\/jem.7.1.111","volume":"7","author":"AE Taylor","year":"1905","unstructured":"Taylor AE (1905) On the preparation of salt-free culture media and the growth of bacteria upon them. J Exp Med 7(1):111\u2013118. https:\/\/doi.org\/10.1084\/jem.7.1.111","journal-title":"J Exp Med"},{"issue":"1","key":"571_CR6","first-page":"109","volume":"14","author":"MX Sullivan","year":"1905","unstructured":"Sullivan MX (1905) Synthetic Culture Media and the Biochemistry of bacterial Pigments. J Med Res 14(1):109\u2013160","journal-title":"J Med Res"},{"key":"571_CR7","doi-asserted-by":"crossref","unstructured":"Rosenbach FJ (1884) Mikro-organismen bei den Wund-Infections-Krankheiten des Menschen. J.F. Bergmann, Wiesbaden","DOI":"10.5962\/bhl.title.22955"},{"issue":"3","key":"571_CR8","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1128\/jb.147.3.900-913.1981","volume":"147","author":"JH Marshall","year":"1981","unstructured":"Marshall JH, Wilmoth GJ (1981) Pigments of Staphylococcus aureus, a series of triterpenoid carotenoids. J Bacteriol 147(3):900\u2013913. https:\/\/doi.org\/10.1128\/jb.147.3.900-913.1981","journal-title":"J Bacteriol"},{"key":"571_CR9","doi-asserted-by":"publisher","unstructured":"Jorgensen JH, Pfaller MA, Carroll KC, Funke G, Landry ML, Richter SS, Warnock DW (2015) Manual of Clinical Microbiology, Eleventh Edition. American Society of Microbiology. https:\/\/doi.org\/10.1128\/9781555817381","DOI":"10.1128\/9781555817381"},{"issue":"3","key":"571_CR10","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/cmr.00134-14","volume":"28","author":"SY Tong","year":"2015","unstructured":"Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG Jr (2015) Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev 28(3):603\u2013661. https:\/\/doi.org\/10.1128\/cmr.00134-14","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"571_CR11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1128\/cmr.10.3.505-520.1997","volume":"10","author":"J Kluytmans","year":"1997","unstructured":"Kluytmans J, van Belkum A, Verbrugh H (1997) Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10(3):505\u2013520. https:\/\/doi.org\/10.1128\/cmr.10.3.505-520.1997","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"571_CR12","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1128\/jb.147.3.914-919.1981","volume":"147","author":"JH Marshall","year":"1981","unstructured":"Marshall JH, Wilmoth GJ (1981) Proposed pathway of triterpenoid carotenoid biosynthesis in Staphylococcus aureus: evidence from a study of mutants. J Bacteriol 147(3):914\u2013919. https:\/\/doi.org\/10.1128\/jb.147.3.914-919.1981","journal-title":"J Bacteriol"},{"issue":"4","key":"571_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1099\/00222615-26-4-251","volume":"26","author":"MA Beard-Pegler","year":"1988","unstructured":"Beard-Pegler MA, Stubbs E, Vickery AM (1988) Observations on the resistance to drying of staphylococcal strains. J Med Microbiol 26(4):251\u2013255. https:\/\/doi.org\/10.1099\/00222615-26-4-251","journal-title":"J Med Microbiol"},{"issue":"2","key":"571_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1084\/jem.20050846","volume":"202","author":"GY Liu","year":"2005","unstructured":"Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastian JF, Fierer J, Nizet V (2005) Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med 202(2):209\u2013215. https:\/\/doi.org\/10.1084\/jem.20050846","journal-title":"J Exp Med"},{"issue":"1","key":"571_CR15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.abb.2004.03.007","volume":"430","author":"A El-Agamey","year":"2004","unstructured":"El-Agamey A, Lowe GM, McGarvey DJ, Mortensen A, Phillip DM, Truscott TG, Young AJ (2004) Carotenoid radical chemistry and antioxidant\/pro-oxidant properties. Arch Biochem Biophys 430(1):37\u201348. https:\/\/doi.org\/10.1016\/j.abb.2004.03.007","journal-title":"Arch Biochem Biophys"},{"issue":"5868","key":"571_CR16","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1126\/science.1153018","volume":"319","author":"CI Liu","year":"2008","unstructured":"Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E (2008) A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science 319(5868):1391\u20131394. https:\/\/doi.org\/10.1126\/science.1153018","journal-title":"Science"},{"issue":"8","key":"571_CR17","doi-asserted-by":"publisher","first-page":"4950","DOI":"10.1128\/IAI.00204-06","volume":"74","author":"A Clauditz","year":"2006","unstructured":"Clauditz A, Resch A, Wieland K-P, Peschel A, G\u00f6tz F (2006) Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stress. Infect Immun 74(8):4950\u20134953. https:\/\/doi.org\/10.1128\/IAI.00204-06","journal-title":"Infect Immun"},{"issue":"7","key":"571_CR18","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1021\/ml5001118","volume":"5","author":"VS Khodade","year":"2014","unstructured":"Khodade VS, Sharath Chandra M, Banerjee A, Lahiri S, Pulipeta M, Rangarajan R, Chakrapani H (2014) Bioreductively Activated Reactive Oxygen Species (ROS) Generators as MRSA Inhibitors. ACS Med Chem Lett 5(7):777\u2013781. https:\/\/doi.org\/10.1021\/ml5001118","journal-title":"ACS Med Chem Lett"},{"issue":"24","key":"571_CR19","doi-asserted-by":"publisher","first-page":"7719","DOI":"10.1128\/jb.176.24.7719-7726.1994","volume":"176","author":"B Wieland","year":"1994","unstructured":"Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, G\u00f6tz F (1994) Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4\u2019-diaponeurosporene of Staphylococcus aureus. J Bacteriol 176(24):7719\u20137726. https:\/\/doi.org\/10.1128\/jb.176.24.7719-7726.1994","journal-title":"J Bacteriol"},{"key":"571_CR20","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.2147\/IDR.S193649","volume":"12","author":"L Xue","year":"2019","unstructured":"Xue L, Chen YY, Yan Z, Lu W, Wan D, Zhu H (2019) Staphyloxanthin: a potential target for antivirulence therapy. Infect Drug Resist 12:2151\u20132160. https:\/\/doi.org\/10.2147\/IDR.S193649","journal-title":"Infect Drug Resist"},{"key":"571_CR21","doi-asserted-by":"publisher","unstructured":"Saising J, Hiranrat A, Mahabusarakam W, Ongsakul M, Voravuthikunchai SP (2008) Rhodomyrtone from <i>Rhodomyrtus tomentosa<\/i> (Aiton) Hassk. as a Natural Antibiotic for Staphylococcal Cutaneous Infections. J Health Sci 54 (5):589\u2013595. https:\/\/doi.org\/10.1248\/jhs.54.589","DOI":"10.1248\/jhs.54.589"},{"issue":"6","key":"571_CR22","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s00284-012-0229-x","volume":"65","author":"JH Lee","year":"2012","unstructured":"Lee JH, Park JH, Cho MH, Lee J (2012) Flavone reduces the production of virulence factors, staphyloxanthin and \u03b1-hemolysin, in Staphylococcus aureus. Curr Microbiol 65(6):726\u2013732. https:\/\/doi.org\/10.1007\/s00284-012-0229-x","journal-title":"Curr Microbiol"},{"issue":"3","key":"571_CR23","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1128\/jcm.13.3.456-458.1981","volume":"13","author":"EA Reyes","year":"1981","unstructured":"Reyes EA, Bale MJ, Cannon WH, Matsen JM (1981) Identification of Pseudomonas aeruginosa by pyocyanin production on Tech agar. J Clin Microbiol 13(3):456\u2013458. https:\/\/doi.org\/10.1128\/jcm.13.3.456-458.1981","journal-title":"J Clin Microbiol"},{"issue":"2","key":"571_CR24","first-page":"301","volume":"44","author":"EO King","year":"1954","unstructured":"King EO, Ward MK, Raney DE (1954) Two simple media for the demonstration of pyocyanin and fluorescin. J Lab Clin Med 44(2):301\u2013307","journal-title":"J Lab Clin Med"},{"issue":"6","key":"571_CR25","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1128\/jcm.3.6.566-575.1976","volume":"3","author":"LA Otto","year":"1976","unstructured":"Otto LA, Pickett MJ (1976) Rapid method for identification of gram-negative, nonfermentative bacilli. J Clin Microbiol 3(6):566\u2013575","journal-title":"J Clin Microbiol"},{"issue":"1","key":"571_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/ajcp\/69.1.41","volume":"69","author":"MJ Morris","year":"1978","unstructured":"Morris MJ, Young VM, Moody MR (1978) Evaluation of a multitest system for identification of saccharolytic pseudomonads. Am J Clin Pathol 69(1):41\u201347. https:\/\/doi.org\/10.1093\/ajcp\/69.1.41","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"571_CR27","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/ajcp\/70.6.914","volume":"70","author":"SL Rosenthal","year":"1978","unstructured":"Rosenthal SL, Freundlich LF, Washington W (1978) Laboratory evaluation of a multitest system for identification of gram-negative organisms. Am J Clin Pathol 70(6):914\u2013917. https:\/\/doi.org\/10.1093\/ajcp\/70.6.914","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"571_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1469-0691.2007.01925.x","volume":"14","author":"R Le Berre","year":"2008","unstructured":"Le Berre R, Nguyen S, Nowak E, Kipnis E, Pierre M, Ader F, Courcol R, Guery BP, Faure K (2008) Quorum-sensing activity and related virulence factor expression in clinically pathogenic isolates of Pseudomonas aeruginosa. Clin Microbiol Infect 14(4):337\u2013343. https:\/\/doi.org\/10.1111\/j.1469-0691.2007.01925.x","journal-title":"Clin Microbiol Infect"},{"issue":"9","key":"571_CR29","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1128\/iai.56.9.2515-2517.1988","volume":"56","author":"R Wilson","year":"1988","unstructured":"Wilson R, Sykes DA, Watson D, Rutman A, Taylor GW, Cole PJ (1988) Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium. Infect Immun 56(9):2515\u20132517. https:\/\/doi.org\/10.1128\/iai.56.9.2515-2517.1988","journal-title":"Infect Immun"},{"issue":"6","key":"571_CR30","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.2353\/ajpath.2009.090166","volume":"175","author":"CC Caldwell","year":"2009","unstructured":"Caldwell CC, Chen Y, Goetzmann HS, Hao Y, Borchers MT, Hassett DJ, Young LR, Mavrodi D, Thomashow L, Lau GW (2009) Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. Am J Pathol 175(6):2473\u20132488. https:\/\/doi.org\/10.2353\/ajpath.2009.090166","journal-title":"Am J Pathol"},{"issue":"12","key":"571_CR31","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.molmed.2004.10.002","volume":"10","author":"GW Lau","year":"2004","unstructured":"Lau GW, Hassett DJ, Ran H, Kong F (2004) The role of pyocyanin in Pseudomonas aeruginosa infection. Trends Mol Med 10(12):599\u2013606. https:\/\/doi.org\/10.1016\/j.molmed.2004.10.002","journal-title":"Trends Mol Med"},{"issue":"8","key":"571_CR32","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.tim.2005.05.011","volume":"13","author":"GW Lau","year":"2005","unstructured":"Lau GW, Hassett DJ, Britigan BE (2005) Modulation of lung epithelial functions by Pseudomonas aeruginosa. Trends Microbiol 13(8):389\u2013397. https:\/\/doi.org\/10.1016\/j.tim.2005.05.011","journal-title":"Trends Microbiol"},{"issue":"9","key":"571_CR33","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1128\/iai.60.9.3913-3915.1992","volume":"60","author":"J Shellito","year":"1992","unstructured":"Shellito J, Nelson S, Sorensen RU (1992) Effect of pyocyanine, a pigment of Pseudomonas aeruginosa, on production of reactive nitrogen intermediates by murine alveolar macrophages. Infect Immun 60(9):3913\u20133915. https:\/\/doi.org\/10.1128\/iai.60.9.3913-3915.1992","journal-title":"Infect Immun"},{"issue":"6","key":"571_CR34","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.4049\/jimmunol.174.6.3643","volume":"174","author":"L Allen","year":"2005","unstructured":"Allen L, Dockrell DH, Pattery T, Lee DG, Cornelis P, Hellewell PG, Whyte MK (2005) Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J Immunol 174(6):3643\u20133649. https:\/\/doi.org\/10.4049\/jimmunol.174.6.3643","journal-title":"J Immunol"},{"issue":"4","key":"571_CR35","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.4049\/jimmunol.168.4.1861","volume":"168","author":"LR Usher","year":"2002","unstructured":"Usher LR, Lawson RA, Geary I, Taylor CJ, Bingle CD, Taylor GW, Whyte MK (2002) Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol 168(4):1861\u20131868. https:\/\/doi.org\/10.4049\/jimmunol.168.4.1861","journal-title":"J Immunol"},{"issue":"6","key":"571_CR36","doi-asserted-by":"publisher","first-page":"L893","DOI":"10.1152\/ajplung.1998.274.6.L893","volume":"274","author":"GM Denning","year":"1998","unstructured":"Denning GM, Railsback MA, Rasmussen GT, Cox CD, Britigan BE (1998) Pseudomonas pyocyanine alters calcium signaling in human airway epithelial cells. Am J Physiol 274(6):L893-900. https:\/\/doi.org\/10.1152\/ajplung.1998.274.6.L893","journal-title":"Am J Physiol"},{"issue":"1","key":"571_CR37","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1128\/jb.141.1.156-163.1980","volume":"141","author":"HM Hassan","year":"1980","unstructured":"Hassan HM, Fridovich I (1980) Mechanism of the antibiotic action pyocyanine. J Bacteriol 141(1):156\u2013163. https:\/\/doi.org\/10.1128\/jb.141.1.156-163.1980","journal-title":"J Bacteriol"},{"issue":"2","key":"571_CR38","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1128\/iai.57.2.546-552.1989","volume":"57","author":"X Nassif","year":"1989","unstructured":"Nassif X, Fournier JM, Arondel J, Sansonetti PJ (1989) Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect Immun 57(2):546\u2013552. https:\/\/doi.org\/10.1128\/iai.57.2.546-552.1989","journal-title":"Infect Immun"},{"issue":"4","key":"571_CR39","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1099\/00207713-36-4-581","volume":"36","author":"MP Starr","year":"1986","unstructured":"Starr MP (1986) Edwards and Ewing\u2019s Identification of Enterobacteriaceae. Int J Syst Evol Microbiol 36(4):581\u2013582. https:\/\/doi.org\/10.1099\/00207713-36-4-581","journal-title":"Int J Syst Evol Microbiol"},{"issue":"3b","key":"571_CR40","doi-asserted-by":"publisher","first-page":"72s","DOI":"10.1016\/0002-9343(91)90346-y","volume":"91","author":"DR Schaberg","year":"1991","unstructured":"Schaberg DR, Culver DH, Gaynes RP (1991) Major trends in the microbial etiology of nosocomial infection. Am J Med 91(3b):72s\u201375s. https:\/\/doi.org\/10.1016\/0002-9343(91)90346-y","journal-title":"Am J Med"},{"issue":"6","key":"571_CR41","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1128\/am.25.6.900-904.1973","volume":"25","author":"C Brown","year":"1973","unstructured":"Brown C, Seidler RJ (1973) Potential pathogens in the environment: Klebsiella pneumoniae, a taxonomic and ecological enigma. Appl Microbiol 25(6):900\u2013904","journal-title":"Appl Microbiol"},{"issue":"2","key":"571_CR42","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/cid\/cix270","volume":"65","author":"CL Gorrie","year":"2017","unstructured":"Gorrie CL, Mirceta M, Wick RR, Edwards DJ, Thomson NR, Strugnell RA, Pratt NF, Garlick JS, Watson KM, Pilcher DV, McGloughlin SA, Spelman DW, Jenney AWJ, Holt KE (2017) Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients. Clin Infect Dis 65(2):208\u2013215. https:\/\/doi.org\/10.1093\/cid\/cix270","journal-title":"Clin Infect Dis"},{"issue":"4","key":"571_CR43","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1128\/CMR.11.4.589","volume":"11","author":"R Podschun","year":"1998","unstructured":"Podschun R, Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11(4):589\u2013603","journal-title":"Clin Microbiol Rev"},{"key":"571_CR44","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3389\/fcimb.2019.00367","volume":"9","author":"LPP Patro","year":"2019","unstructured":"Patro LPP, Rathinavelan T (2019) Targeting the Sugary Armor of Klebsiella Species. Front Cell Infect Microbiol 9:367. https:\/\/doi.org\/10.3389\/fcimb.2019.00367","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"571_CR45","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1128\/aem.60.2.740-745.1994","volume":"60","author":"T Ophir","year":"1994","unstructured":"Ophir T, Gutnick DL (1994) A role for exopolysaccharides in the protection of microorganisms from desiccation. Appl Environ Microbiol 60(2):740\u2013745. https:\/\/doi.org\/10.1128\/aem.60.2.740-745.1994","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"571_CR46","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1128\/iai.70.5.2583-2590.2002","volume":"70","author":"G Cort\u00e9s","year":"2002","unstructured":"Cort\u00e9s G, Borrell N, de Astorza B, G\u00f3mez C, Sauleda J, Albert\u00ed S (2002) Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect Immun 70(5):2583\u20132590. https:\/\/doi.org\/10.1128\/iai.70.5.2583-2590.2002","journal-title":"Infect Immun"},{"issue":"1","key":"571_CR47","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1128\/iai.00864-09","volume":"78","author":"B Evrard","year":"2010","unstructured":"Evrard B, Balestrino D, Dosgilbert A, Bouya-Gachancard JL, Charbonnel N, Forestier C, Tridon A (2010) Roles of capsule and lipopolysaccharide O antigen in interactions of human monocyte-derived dendritic cells and Klebsiella pneumoniae. Infect Immun 78(1):210\u2013219. https:\/\/doi.org\/10.1128\/iai.00864-09","journal-title":"Infect Immun"},{"issue":"7","key":"571_CR48","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1099\/00221287-129-7-2181","volume":"129","author":"P Williams","year":"1983","unstructured":"Williams P, Lambert PA, Brown MR, Jones RJ (1983) The role of the O and K antigens in determining the resistance of Klebsiella aerogenes to serum killing and phagocytosis. J Gen Microbiol 129(7):2181\u20132191. https:\/\/doi.org\/10.1099\/00221287-129-7-2181","journal-title":"J Gen Microbiol"},{"issue":"1","key":"571_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.micinf.2019.08.003","volume":"22","author":"TS Jensen","year":"2020","unstructured":"Jensen TS, Opstrup KV, Christiansen G, Rasmussen PV, Thomsen ME, Justesen DL, Sch\u00f8nheyder HC, Lausen M, Birkelund S (2020) Complement mediated Klebsiella pneumoniae capsule changes. Microbes Infect 22(1):19\u201330. https:\/\/doi.org\/10.1016\/j.micinf.2019.08.003","journal-title":"Microbes Infect"},{"issue":"6","key":"571_CR50","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1128\/iai.59.6.2043-2050.1991","volume":"59","author":"Y Arakawa","year":"1991","unstructured":"Arakawa Y, Ohta M, Wacharotayankun R, Mori M, Kido N, Ito H, Komatsu T, Sugiyama T, Kato N (1991) Biosynthesis of Klebsiella K2 capsular polysaccharide in Escherichia coli HB101 requires the functions of rmpA and the chromosomal cps gene cluster of the virulent strain Klebsiella pneumoniae Chedid (O1:K2). Infect Immun 59(6):2043\u20132050. https:\/\/doi.org\/10.1128\/iai.59.6.2043-2050.1991","journal-title":"Infect Immun"},{"issue":"7","key":"571_CR51","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1128\/jb.177.7.1788-1796.1995","volume":"177","author":"Y Arakawa","year":"1995","unstructured":"Arakawa Y, Wacharotayankun R, Nagatsuka T, Ito H, Kato N, Ohta M (1995) Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid. J Bacteriol 177(7):1788\u20131796. https:\/\/doi.org\/10.1128\/jb.177.7.1788-1796.1995","journal-title":"J Bacteriol"},{"issue":"3","key":"571_CR52","doi-asserted-by":"publisher","first-page":"e4982","DOI":"10.1371\/journal.pone.0004982","volume":"4","author":"S Brisse","year":"2009","unstructured":"Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, Grimont P (2009) Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS ONE 4(3):e4982. https:\/\/doi.org\/10.1371\/journal.pone.0004982","journal-title":"PLoS ONE"},{"issue":"9","key":"571_CR53","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1001\/archinte.162.9.1021","volume":"162","author":"RW Tsay","year":"2002","unstructured":"Tsay RW, Siu LK, Fung CP, Chang FY (2002) Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection. Arch Intern Med 162(9):1021\u20131027. https:\/\/doi.org\/10.1001\/archinte.162.9.1021","journal-title":"Arch Intern Med"},{"key":"571_CR54","doi-asserted-by":"publisher","first-page":"64","DOI":"10.12703\/p6-64","volume":"6","author":"CA Broberg","year":"2014","unstructured":"Broberg CA, Palacios M, Miller VL (2014) Klebsiella: a long way to go towards understanding this enigmatic jet-setter. F1000Prime Rep 6:64. https:\/\/doi.org\/10.12703\/p6-64","journal-title":"F1000Prime Rep"},{"key":"571_CR55","doi-asserted-by":"publisher","unstructured":"Hadano Y (2013) String test. BMJ Case Rep 2013. https:\/\/doi.org\/10.1136\/bcr-2012-008328","DOI":"10.1136\/bcr-2012-008328"},{"issue":"10","key":"571_CR56","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1086\/503420","volume":"42","author":"WL Yu","year":"2006","unstructured":"Yu WL, Ko WC, Cheng KC, Lee HC, Ke DS, Lee CC, Fung CP, Chuang YC (2006) Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis 42(10):1351\u20131358. https:\/\/doi.org\/10.1086\/503420","journal-title":"Clin Infect Dis"},{"key":"571_CR57","doi-asserted-by":"publisher","unstructured":"Walker KA, Treat LP, Sep\u00falveda VE, Miller VL (2020) The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae. mBio 11(5). https:\/\/doi.org\/10.1128\/mBio.01750-20","DOI":"10.1128\/mBio.01750-20"},{"key":"571_CR58","doi-asserted-by":"publisher","unstructured":"Barrett EL, Clark MA (1987) Tetrathionate reduction and production of hydrogen sulfide from thiosulfate. Microbiol Rev 51(2):192\u2013205. https:\/\/doi.org\/10.1128\/mr.51.2.192-205.1987","DOI":"10.1128\/mr.51.2.192-205.1987"},{"issue":"5","key":"571_CR59","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0038-0717(97)00177-6","volume":"30","author":"VL Barbosa-Jefferson","year":"1998","unstructured":"Barbosa-Jefferson VL, Zhao FJ, McGrath SP, Magan N (1998) Thiosulphate and tetrathionate oxidation in arable soils. Soil Biol Biochem 30(5):553\u2013559. https:\/\/doi.org\/10.1016\/S0038-0717(97)00177-6","journal-title":"Soil Biol Biochem"},{"key":"571_CR60","first-page":"434","volume":"89","author":"L Muller","year":"1923","unstructured":"Muller L (1923) Un nouveau milieu d\u2019enrichissement pour la recherche du Bacille Typhique at Paratyphique. C R Seances Soc Biol Fil 89:434\u2013437","journal-title":"C R Seances Soc Biol Fil"},{"issue":"3","key":"571_CR61","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1017\/s0022172400012766","volume":"43","author":"R Knox","year":"1943","unstructured":"Knox R, Gell PG, Pollock MR (1943) The selective action of tetrathionate in bacteriological media: A report to the Medical Research Council. J Hyg (Lond) 43(3):147\u2013158. https:\/\/doi.org\/10.1017\/s0022172400012766 (141)","journal-title":"J Hyg (Lond)"},{"issue":"6","key":"571_CR62","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1128\/am.21.6.1036-1039.1971","volume":"21","author":"PB Smith","year":"1971","unstructured":"Smith PB, Rhoden DL, Tomfohrde KM, Dunn CR, Balows A, Hermann GJ (1971) R-B enteric differential system for identification of Enterobacteriaceae. Appl Microbiol 21(6):1036\u20131039","journal-title":"Appl Microbiol"},{"issue":"2","key":"571_CR63","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1046\/j.1365-2958.1999.01345.x","volume":"32","author":"M Hensel","year":"1999","unstructured":"Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC (1999) The genetic basis of tetrathionate respiration in Salmonella typhimurium. Mol Microbiol 32(2):275\u2013287. https:\/\/doi.org\/10.1046\/j.1365-2958.1999.01345.x","journal-title":"Mol Microbiol"},{"issue":"6","key":"571_CR64","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1136\/jcp.12.6.568","volume":"12","author":"L Jeffries","year":"1959","unstructured":"Jeffries L (1959) Novobiocin-tetrathionate broth: a medium of improved selectivity for the isolation of Salmonellae from faeces. J Clin Pathol 12(6):568\u2013571. https:\/\/doi.org\/10.1136\/jcp.12.6.568","journal-title":"J Clin Pathol"},{"issue":"7314","key":"571_CR65","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature09415","volume":"467","author":"SE Winter","year":"2010","unstructured":"Winter SE, Thiennimitr P, Winter MG, Butler BP, Huseby DL, Crawford RW, Russell JM, Bevins CL, Adams LG, Tsolis RM, Roth JR, Baumler AJ (2010) Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature 467(7314):426\u2013429. https:\/\/doi.org\/10.1038\/nature09415","journal-title":"Nature"},{"issue":"1","key":"571_CR66","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1128\/iai.01189-07","volume":"76","author":"TD Lawley","year":"2008","unstructured":"Lawley TD, Bouley DM, Hoy YE, Gerke C, Relman DA, Monack DM (2008) Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota. Infect Immun 76(1):403\u2013416. https:\/\/doi.org\/10.1128\/iai.01189-07","journal-title":"Infect Immun"},{"issue":"4","key":"571_CR67","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.chom.2016.03.004","volume":"19","author":"F Rivera-Chavez","year":"2016","unstructured":"Rivera-Chavez F, Zhang LF, Faber F, Lopez CA, Byndloss MX, Olsan EE, Xu G, Velazquez EM, Lebrilla CB, Winter SE, Baumler AJ (2016) Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. Cell Host Microbe 19(4):443\u2013454. https:\/\/doi.org\/10.1016\/j.chom.2016.03.004","journal-title":"Cell Host Microbe"},{"issue":"19","key":"571_CR68","doi-asserted-by":"publisher","first-page":"10567","DOI":"10.1073\/pnas.180094797","volume":"97","author":"GM Pupo","year":"2000","unstructured":"Pupo GM, Lan R, Reeves PR (2000) Multiple independent origins of Shigella clones of Escherichia coli and convergent evolution of many of their characteristics. Proc Natl Acad Sci U S A 97(19):10567\u201310572. https:\/\/doi.org\/10.1073\/pnas.180094797","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"571_CR69","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1128\/iai.72.9.5080-5088.2004","volume":"72","author":"R Lan","year":"2004","unstructured":"Lan R, Alles MC, Donohoe K, Martinez MB, Reeves PR (2004) Molecular evolutionary relationships of enteroinvasive Escherichia coli and Shigella spp. Infect Immun 72(9):5080\u20135088. https:\/\/doi.org\/10.1128\/iai.72.9.5080-5088.2004","journal-title":"Infect Immun"},{"issue":"1","key":"571_CR70","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1128\/CMR.00032-07","volume":"21","author":"GN Schroeder","year":"2008","unstructured":"Schroeder GN, Hilbi H (2008) Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion. Clin Microbiol Rev 21(1):134\u2013156. https:\/\/doi.org\/10.1128\/CMR.00032-07","journal-title":"Clin Microbiol Rev"},{"issue":"19","key":"571_CR71","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1093\/nar\/gki954","volume":"33","author":"F Yang","year":"2005","unstructured":"Yang F, Yang J, Zhang X, Chen L, Jiang Y, Yan Y, Tang X, Wang J, Xiong Z, Dong J, Xue Y, Zhu Y, Xu X, Sun L, Chen S, Nie H, Peng J, Xu J, Wang Y, Yuan Z, Wen Y, Yao Z, Shen Y, Qiang B, Hou Y, Yu J, Jin Q (2005) Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res 33(19):6445\u20136458. https:\/\/doi.org\/10.1093\/nar\/gki954","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"571_CR72","doi-asserted-by":"publisher","first-page":"5472","DOI":"10.1128\/iai.71.10.5472-5479.2003","volume":"71","author":"M Casalino","year":"2003","unstructured":"Casalino M, Latella MC, Prosseda G, Colonna B (2003) CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype. Infect Immun 71(10):5472\u20135479. https:\/\/doi.org\/10.1128\/iai.71.10.5472-5479.2003","journal-title":"Infect Immun"},{"issue":"6","key":"571_CR73","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1086\/323035","volume":"184","author":"IM Fernandez","year":"2001","unstructured":"Fernandez IM, Silva M, Schuch R, Walker WA, Siber AM, Maurelli AT, McCormick BA (2001) Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling. J Infect Dis 184(6):743\u2013753. https:\/\/doi.org\/10.1086\/323035","journal-title":"J Infect Dis"},{"issue":"2","key":"571_CR74","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1046\/j.1462-5822.1999.00014.x","volume":"1","author":"BA McCormick","year":"1999","unstructured":"McCormick BA, Fernandez MI, Siber AM, Maurelli AT (1999) Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine. Cell Microbiol 1(2):143\u2013155. https:\/\/doi.org\/10.1046\/j.1462-5822.1999.00014.x","journal-title":"Cell Microbiol"},{"issue":"7","key":"571_CR75","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1073\/pnas.95.7.3943","volume":"95","author":"AT Maurelli","year":"1998","unstructured":"Maurelli AT, Fern\u00e1ndez RE, Bloch CA, Rode CK, Fasano A (1998) \u201cBlack holes\u201d and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc Natl Acad Sci U S A 95(7):3943\u20133948. https:\/\/doi.org\/10.1073\/pnas.95.7.3943","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"571_CR76","doi-asserted-by":"publisher","first-page":"7471","DOI":"10.1128\/IAI.69.12.7471-7480.2001","volume":"69","author":"WA Day Jr","year":"2001","unstructured":"Day WA Jr, Fern\u00e1ndez RE, Maurelli AT (2001) Pathoadaptive mutations that enhance virulence: genetic organization of the cadA regions of Shigella spp. Infect Immun 69(12):7471\u20137480. https:\/\/doi.org\/10.1128\/IAI.69.12.7471-7480.2001","journal-title":"Infect Immun"},{"key":"571_CR77","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/196090b0","volume":"196","author":"Y Kott","year":"1962","unstructured":"Kott Y (1962) Lysine decarboxylase activity as a simple test in differentiation of Enterobacteriaceae. Nature 196:90\u201391. https:\/\/doi.org\/10.1038\/196090b0","journal-title":"Nature"},{"issue":"3","key":"571_CR78","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1556\/1886.2016.00004","volume":"6","author":"I L\u00f8bersli","year":"2016","unstructured":"L\u00f8bersli I, Wester AL, Kristiansen \u00c5, Brandal LT (2016) Molecular Differentiation of Shigella Spp. from Enteroinvasive E. Coli. Eur J Microbiol Immunol 6(3):197\u2013205. https:\/\/doi.org\/10.1556\/1886.2016.00004","journal-title":"Eur J Microbiol Immunol"},{"issue":"2","key":"571_CR79","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1128\/am.14.2.212-217.1966","volume":"14","author":"JG Johnson","year":"1966","unstructured":"Johnson JG, Kunz LJ, Barron W, Ewing WH (1966) Biochemical Differentiation of the <em>Enterobacteriaceae<\/em> with the Aid of Lysine-Iron-Agar. Appl Microbiol 14(2):212\u2013217","journal-title":"Appl Microbiol"},{"issue":"3","key":"571_CR80","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1128\/IAI.3.3.500-503.1971","volume":"3","author":"P Gemski","year":"1971","unstructured":"Gemski P, Formal SB, Baron LS (1971) Identification of Two Widely Separated Loci Conferring Nicotinic Acid Dependence on Wild-Type Shigella flexneri 2a. Infect Immun 3(3):500\u2013503. https:\/\/doi.org\/10.1128\/IAI.3.3.500-503.1971","journal-title":"Infect Immun"},{"issue":"17","key":"571_CR81","doi-asserted-by":"publisher","first-page":"6482","DOI":"10.1128\/jb.00525-07","volume":"189","author":"AL Prunier","year":"2007","unstructured":"Prunier AL, Schuch R, Fern\u00e1ndez RE, Maurelli AT (2007) Genetic structure of the nadA and nadB antivirulence loci in Shigella spp. J Bacteriol 189(17):6482\u20136486. https:\/\/doi.org\/10.1128\/jb.00525-07","journal-title":"J Bacteriol"},{"issue":"7","key":"571_CR82","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1099\/mic.0.2007\/006916-0","volume":"153","author":"A-L Prunier","year":"2007","unstructured":"Prunier A-L, Schuch R, Fern\u00e1ndez RE, Mumy KL, Kohler H, McCormick BA, Maurelli AT (2007) nadA and nadB of Shigella flexneri 5a are antivirulence loci responsible for the synthesis of quinolinate, a small molecule inhibitor of Shigella pathogenicity. Microbiology 153(7):2363\u20132372. https:\/\/doi.org\/10.1099\/mic.0.2007\/006916-0","journal-title":"Microbiology"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00571-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-021-00571-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00571-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T02:08:58Z","timestamp":1636510138000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-021-00571-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,12]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["571"],"URL":"https:\/\/doi.org\/10.1007\/s42770-021-00571-7","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,12]]},"assertion":[{"value":"18 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"S.E.W. is listed as an inventor on patent US10092596B2, which describes a treatment to prevent the inflammation-associated expansion of Enterobacteriaceae. The other authors have no additional financial interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}