{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:10:32Z","timestamp":1786983032759,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2016\/08392\u00ad3"],"award-info":[{"award-number":["2016\/08392\u00ad3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s42770-021-00616-x","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T23:37:32Z","timestamp":1633909052000},"page":"2363-2371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Relationship between Papillomavirus vaccine, vaginal microbiome, and local cytokine response: an exploratory research"],"prefix":"10.1007","volume":"52","author":[{"given":"Paulo Cesar","family":"Giraldo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marcos","family":"Sanches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Gustavo","family":"Sparvolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Migliorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Damas","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Romano","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-3826","authenticated-orcid":false,"given":"Michelle Garcia","family":"Discacciati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,10]]},"reference":[{"issue":"Supplement_1","key":"616_CR1","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1073\/pnas.1002611107","volume":"108","author":"J Ravel","year":"2011","unstructured":"Ravel J, Gajer P, Abdo Z et al (2011) Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci 108(Supplement_1):4680\u20137","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"616_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/1471-0528.14390","volume":"124","author":"SS Witkin","year":"2017","unstructured":"Witkin SS, Linhares IM (2017) Why do lactobacilli dominate the human vaginal microbiota? BJOG 124(4):606\u2013611","journal-title":"BJOG"},{"issue":"11","key":"616_CR3","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1097\/GME.0000000000001236","volume":"25","author":"RM Brotman","year":"2018","unstructured":"Brotman RM, Shardell MD, Gajer P et al (2018) Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy. Menopause 25(11):1321\u20131330","journal-title":"Menopause"},{"issue":"12","key":"616_CR4","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1093\/infdis\/jiu004","volume":"209","author":"SY Doerflinger","year":"2014","unstructured":"Doerflinger SY, Throop AL, Herbst-Kralovetz MM (2014) Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner. J Infect Dis 209(12):1989\u20131999","journal-title":"J Infect Dis"},{"issue":"20","key":"616_CR5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/ijms20020266","volume":"11","author":"MG Torcia","year":"2019","unstructured":"Torcia MG (2019) Interplay among vaginal microbiome, immune response and sexually transmitted viral infections. Int J Mol Sci 11(20):266","journal-title":"Int J Mol Sci"},{"issue":"1","key":"616_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-20649-x","volume":"8","author":"G Campisciano","year":"2018","unstructured":"Campisciano G, Zanotta N, Licastro D, De Seta F, Comar M (2018) In vivo microbiome and associated immune markers: new insights into the pathogenesis of vaginal dysbiosis. Sci Rep 8(1):1\u20139","journal-title":"Sci Rep"},{"issue":"4","key":"616_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3390\/vaccines5040050","volume":"5","author":"L Vitetta","year":"2017","unstructured":"Vitetta L, Saltzman ET, Thomsen M, Nikov T, Hall S (2017) Adjuvant probiotics and the intestinal microbiome: enhancing vaccines and immunotherapy outcomes. Vaccines (Basel) 5(4):50","journal-title":"Vaccines (Basel)"},{"key":"616_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.coviro.2019.05.001","volume":"37","author":"AN Vlasova","year":"2019","unstructured":"Vlasova AN, Takanashi S, Miyazaki A, Rajashekara G, Saif LJ (2019) How the gut microbiome regulates host immune responses to viral vaccines. Curr Opin Virol 37:16\u201325","journal-title":"Curr Opin Virol"},{"issue":"2","key":"616_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.vaccine.2017.08.069","volume":"36","author":"P Zimmermann","year":"2008","unstructured":"Zimmermann P, Curtis N (2008) The influence of probiotics on vaccine responses - a systematic review. Vaccine 36(2):207\u2013213","journal-title":"Vaccine"},{"issue":"2","key":"616_CR10","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1086\/376505","volume":"188","author":"LA Pinto","year":"2003","unstructured":"Pinto LA, Edwards J, Castle PE, Harro CD, Lowy DR, Schiller JT (2003) Cellular immune responses to human papillomavirus (HPV)-16 L1 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles. J Infect Dis 188(2):327\u2013338","journal-title":"J Infect Dis"},{"issue":"Suppl 5","key":"616_CR11","doi-asserted-by":"publisher","first-page":"F83","DOI":"10.1016\/j.vaccine.2012.04.106","volume":"30","author":"M Stanley","year":"2012","unstructured":"Stanley M, Pinto LA, Trimble C (2012) Human papillomavirus vaccines\u2013immune responses. Vaccine 30(Suppl 5):F83-7","journal-title":"Vaccine"},{"key":"616_CR12","doi-asserted-by":"publisher","unstructured":"Bolyen E, Rideout JR, Dillon MR, et al (2018) QIIME 2: Reproducible, interactive, scalable and extensible microbiome data science. PeerJ Prepr [Internet] 852\u20137. Available from: https:\/\/doi.org\/10.7287\/peerj.preprints.27295v2","DOI":"10.7287\/peerj.preprints.27295v2"},{"issue":"4","key":"616_CR13","first-page":"265","volume":"11","author":"Chao","year":"1984","unstructured":"Chao (1984) Nonparametric estimation of the number of classes in a population. Scand J Stat 11(4):265\u2013270","journal-title":"Scand J Stat"},{"issue":"4","key":"616_CR14","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/j.1538-7305.1948.tb00917.x","volume":"27","author":"CE Shannon","year":"1948","unstructured":"Shannon CE (1948) A mathematical theory of communication. Bell Syst Tech J 27(4):623\u2013656","journal-title":"Bell Syst Tech J"},{"key":"616_CR15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.mimet.2014.08.018","volume":"107","author":"VS Pylro","year":"2014","unstructured":"Pylro VS, Roesch LFW, Morais DK, Clark IM, Hirsch PR, T\u00f3tola MR (2014) Data analysis for 16S microbial profiling from different benchtop sequencing platforms. J Microbiol Methods [Internet] 107:30\u201337","journal-title":"J Microbiol Methods [Internet]"},{"issue":"W1","key":"616_CR16","doi-asserted-by":"publisher","first-page":"W180","DOI":"10.1093\/nar\/gkx295","volume":"45","author":"A Dhariwal","year":"2017","unstructured":"Dhariwal A, Chong J, Habib S, King IL, Agellon LB, Xia J (2017) MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data. Nucleic Acids Res 45(W1):W180\u2013W188","journal-title":"Nucleic Acids Res"},{"issue":"C","key":"616_CR17","first-page":"1","volume":"14","author":"EW Beals","year":"1984","unstructured":"Beals EW (1984) Bray-curtis ordination: an effective strategy for analysis of multivariate ecological data. Adv Ecol Res 14(C):1\u201355","journal-title":"Adv Ecol Res"},{"issue":"11","key":"616_CR18","doi-asserted-by":"publisher","first-page":"e1001190","DOI":"10.1371\/journal.ppat.1001190","volume":"6","author":"RB Ferreira","year":"2010","unstructured":"Ferreira RB, Antunes LC, Finlay BB (2010) Should the human microbiome be considered when developing vaccines? PLoS Pathog 6(11):e1001190","journal-title":"PLoS Pathog"},{"key":"616_CR19","unstructured":"Human papillomavirus vaccines: WHO position paper (2017). Wkly Epidemiol Rec 92(19):241\u201368"},{"key":"616_CR20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1159\/000497617","volume":"63","author":"CM de Oliveira","year":"2019","unstructured":"de Oliveira CM, Fregnani JHTG, Villa LL (2019) HPV vaccine: updates and highlights. Acta Cytol 63:159\u2013168","journal-title":"Acta Cytol"},{"issue":"3 Suppl 1","key":"616_CR21","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.ygyno.2008.05.036","volume":"110","author":"TF Schwarz","year":"2008","unstructured":"Schwarz TF, Leo O (2008) Immune response to human papillomavirus after prophylactic vaccination with AS04-adjuvanted HPV-16\/18 vaccine: improving upon nature. Gynecol Oncol 110(3 Suppl 1):S1-10","journal-title":"Gynecol Oncol"},{"issue":"12","key":"616_CR22","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/aogs.12480","volume":"93","author":"SI Meyer","year":"2014","unstructured":"Meyer SI, Fuglsang K, Blaakaer J (2014) Cell-mediated immune response: a clinical review of the therapeutic potential of human papillomavirus vaccination. Acta Obstet Gynecol Scand 93(12):1209\u20131218","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"6","key":"616_CR23","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1089\/vim.2015.0008","volume":"28","author":"AK Gon\u00e7alves","year":"2015","unstructured":"Gon\u00e7alves AK, Giraldo PC, Machado PR et al (2015) Human papillomavirus vaccine-induced cytokine messenger RNA expression in vaccinated women. Viral Immunol 28(6):339\u2013342","journal-title":"Viral Immunol"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00616-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-021-00616-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00616-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T21:20:53Z","timestamp":1636492853000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-021-00616-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["616"],"URL":"https:\/\/doi.org\/10.1007\/s42770-021-00616-x","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,10]]},"assertion":[{"value":"10 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}