{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:31:32Z","timestamp":1768339892111,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s42770-021-00648-3","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T17:02:27Z","timestamp":1636131747000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial effect of Casiopeinas\u00ae copper- and ruthenium-based compounds on Aggregatibacter actinomycetemcomitans and in vitro cell viability onto osteoblasts cells"],"prefix":"10.1007","volume":"53","author":[{"given":"Larios-Cervantes Alexis","family":"Alberto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch\u00e1vez-Cort\u00e9z Elda","family":"Georgina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00ednez-Hern\u00e1ndez","family":"Miryam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talavera-Contreras Luis","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Espinoza-Guillen","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrillo-\u00c1vila Bertha","family":"Arelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiz-Azuara","family":"Lena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvarez-P\u00e9rez Marco","family":"Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00ednez-Aguilar Victor","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"issue":"20","key":"648_CR1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/jcpe.12946","volume":"45","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T et al (2018) Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 45(20):162\u2013170. https:\/\/doi.org\/10.1111\/jcpe.12946","journal-title":"J Clin Periodontol"},{"issue":"20","key":"648_CR2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/jcpe.12940","volume":"45","author":"ILC Chapple","year":"2018","unstructured":"Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM et al (2018) Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 45(20):68\u201377. https:\/\/doi.org\/10.1111\/jcpe.12940","journal-title":"J Clin Periodontol"},{"key":"648_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1600-0757.1999.tb00158.x","volume":"20","author":"S Asikainen","year":"2000","unstructured":"Asikainen S (2000) Chen C (1999) Oral ecology and person-to-person transmission of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 20:65\u201381. https:\/\/doi.org\/10.1111\/j.1600-0757.1999.tb00158.x","journal-title":"Periodontol"},{"issue":"3","key":"648_CR4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/omi.12119","volume":"31","author":"BA Herbert","year":"2016","unstructured":"Herbert BA, Novince CM, Kirkwood KL (2016) Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. Mol Oral Microbiol 31(3):207\u2013227. https:\/\/doi.org\/10.1111\/omi.12119","journal-title":"Mol Oral Microbiol"},{"key":"648_CR5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/pharmaceutics13060836","volume":"24","author":"NMR Bechara Andere","year":"2018","unstructured":"Bechara Andere NMR, dos Santos NCC, Araujo CF, Mathias IF et al (2018) Evaluation of the local effect of non-surgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. Photodiagnosis Photodyn Ther 24:115\u2013120. https:\/\/doi.org\/10.3390\/pharmaceutics13060836","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"11","key":"648_CR6","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1902\/jop.2004.75.11.1553","volume":"75","author":"J Slots","year":"2004","unstructured":"Slots J (2004) Systemic antibiotics in periodontics. J Periodontol 75(11):1553\u20131565. https:\/\/doi.org\/10.1902\/jop.2004.75.11.1553","journal-title":"J Periodontol"},{"issue":"1","key":"648_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/idj.12146","volume":"65","author":"SS Oberoi","year":"2015","unstructured":"Oberoi SS, Dhingra C, Sharma G, Sardana D (2015) Antibiotics in dental practice: how justified are we. Int Dent J 65(1):4\u201310. https:\/\/doi.org\/10.1111\/idj.12146","journal-title":"Int Dent J"},{"issue":"1","key":"648_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/prd.12075","volume":"67","author":"M Feres","year":"2000","unstructured":"Feres M, Figueiredo LC, Soares GMS (2000) Faveri M (2015) Systemic antibiotics in the treatment of periodontitis. Periodontol 67(1):131\u2013186. https:\/\/doi.org\/10.1111\/prd.12075","journal-title":"Periodontol"},{"key":"648_CR9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jinorgbio.2017.07.025","volume":"175","author":"I Correia","year":"2017","unstructured":"Correia I, Borovic S, Cavaco I, Matos CP et al (2017) Evaluation of the binding of four anti-tumor Casiope\u00ednas\u00ae to human serum albumin. J Inorg Biochem 175:284\u2013297. https:\/\/doi.org\/10.1016\/j.jinorgbio.2017.07.025","journal-title":"J Inorg Biochem"},{"issue":"1","key":"648_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.37135\/unach.ns.001.01.02","volume":"1","author":"R Contreras","year":"2018","unstructured":"Contreras R, Urbina-Guti\u00e9rrez J et al (2018) Therapeutic potential of organometallic compounds in the cancer treatment. A short review. NOVASINERGIA 1(1):14\u201322. https:\/\/doi.org\/10.37135\/unach.ns.001.01.02","journal-title":"NOVASINERGIA"},{"issue":"1","key":"648_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10863-015-9640-x","volume":"48","author":"C Silva-Platas","year":"2016","unstructured":"Silva-Platas C, Guerrero-Beltr\u00e1n CE, Carranc\u00e1 M, Castillo EC et al (2016) Anti-neoplastic copper coordinated complexes (Casiopeinas) uncouple oxidative phosphorylation and induce mitochondrial permeability transition in cardiac mitochondria and cardiomyocytes. J Bioenerg Biomembr 48(1):43\u201354. https:\/\/doi.org\/10.1007\/s10863-015-9640-x","journal-title":"J Bioenerg Biomembr"},{"issue":"1","key":"648_CR12","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1371\/journal.pone.0054664","volume":"8","author":"AI Valencia-Cruz","year":"2013","unstructured":"Valencia-Cruz AI, Uribe-Figueroa LI, Galindo-Murillo R, Baca-L\u00f3pez K et al (2013) Whole genome gene expression analysis reveals Casiope\u00edna-induced apoptosis pathways. PLoS ONE 8(1):654\u2013664. https:\/\/doi.org\/10.1371\/journal.pone.0054664","journal-title":"PLoS ONE"},{"key":"648_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0076-6879(90)86093-B","volume":"186","author":"B Halliwell","year":"1990","unstructured":"Halliwell B, Gutteridge JMC (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1\u201385. https:\/\/doi.org\/10.1016\/0076-6879(90)86093-B","journal-title":"Methods Enzymol"},{"issue":"42","key":"648_CR14","doi-asserted-by":"publisher","first-page":"13730","DOI":"10.1002\/chem.201402775","volume":"20","author":"JC Garc\u00eda-Ramos","year":"2014","unstructured":"Garc\u00eda-Ramos JC, Galindo-Murillo R, Tovar-Tovar A, Alonso-Saenz AL et al (2014) The \u03c0-back-bonding modulation and its impact in the electronic properties of Cu (II) antineoplastic compounds: an experimental and theoretical study. Chemistry (Easton) 20(42):13730\u201313741. https:\/\/doi.org\/10.1002\/chem.201402775","journal-title":"Chemistry (Easton)"},{"issue":"5","key":"648_CR15","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00204-012-0809-3","volume":"86","author":"AM Juan","year":"2012","unstructured":"Juan AM, Sayra CG, Donato YLJ, Salud J et al (2012) Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation. Arch Toxicol 86(5):753\u2013766. https:\/\/doi.org\/10.1007\/s00204-012-0809-3","journal-title":"Arch Toxicol"},{"issue":"3","key":"648_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1021\/acs.jmedchem.6b00795","volume":"60","author":"Y Toledano-Maga\u00f1a","year":"2017","unstructured":"Toledano-Maga\u00f1a Y, Garc\u00eda-Ramos JC, Torres-Guti\u00e9rrez C, V\u00e1zquez-Gasser C et al (2017) Water-soluble ruthenium (II) chiral heteroleptic complexes with amoebicidal in vitro and in vivo activity. J Med Chem 60(3):899\u2013912. https:\/\/doi.org\/10.1021\/acs.jmedchem.6b00795","journal-title":"J Med Chem"},{"issue":"34","key":"648_CR17","doi-asserted-by":"publisher","first-page":"10164","DOI":"10.1039\/C2DT30224A","volume":"41","author":"JC Garc\u00eda-Ramos","year":"2012","unstructured":"Garc\u00eda-Ramos JC, Toledano-Maga\u00f1a Y, Talavera-Contreras L, Flores-Alamo M et al (2012) Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2 \u2019,5 \u2019-diazahexanyl)-1,1-phenanthroline (L1). Dalt Trans 41(34):10164\u201310174. https:\/\/doi.org\/10.1039\/C2DT30224A","journal-title":"Dalt Trans"},{"key":"648_CR18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ejmech.2018.03.015","volume":"150","author":"M Pal","year":"2018","unstructured":"Pal M, Nandi U, Mukherjee D (2018) Detailed account on activation mechanisms of ruthenium coordination complexes and their role as anti-neoplastic agents. Eur J Med Chem 150:419\u2013445. https:\/\/doi.org\/10.1016\/j.ejmech.2018.03.015","journal-title":"Eur J Med Chem"},{"key":"648_CR19","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.2147\/IJN.S191340","volume":"14","author":"S Liao","year":"2019","unstructured":"Liao S, Zhang Y, Pan X, Zhu F et al (2019) Antibacterial activity and mechanism of silver nanoparticles against multidrug-resistant Pseudomonas aeruginosa. Int J Nanomedicine 14:1469\u20131487. https:\/\/doi.org\/10.2147\/IJN.S191340","journal-title":"Int J Nanomedicine"},{"issue":"9","key":"648_CR20","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1139\/m93-134","volume":"39","author":"RJ McLean","year":"1993","unstructured":"McLean RJ, Hussain AA, Sayer M, Vincent PJ, Hughes DJ (1993) Antibacterial activity of multilayer silver-copper surface films on catheter material. Can J Microbiol 39(9):895\u2013899. https:\/\/doi.org\/10.1139\/m93-134","journal-title":"Can J Microbiol"},{"issue":"2","key":"648_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ijantimicag.2012.04.012","volume":"40","author":"MA Vargas-reus","year":"2012","unstructured":"Vargas-reus MA, Memarzadeh K, Huang J, Ren GG, Allaker RP (2012) Antimicrobial activity of nanoparticulate metal oxides against peri-implantitis pathogens. Int J Antimicrob Agents 40(2):135\u2013139. https:\/\/doi.org\/10.1016\/j.ijantimicag.2012.04.012","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"648_CR22","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1177\/00220345920710071501","volume":"71","author":"PD Marsh","year":"1992","unstructured":"Marsh PD (1992) Microbiological aspects of the chemical control of plaque and gingivitis. J Dent Res 71(7):1431\u20131438. https:\/\/doi.org\/10.1177\/00220345920710071501","journal-title":"J Dent Res"},{"key":"648_CR23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.compbiolchem.2018.11.021","volume":"78","author":"G de Anda-J\u00e1uregui","year":"2019","unstructured":"de Anda-J\u00e1uregui G, Espinal-Enr\u00edquez J, Hur J, Alcal\u00e1-Corona SA, Ruiz-Azuara L, Hern\u00e1ndez-Lemus E (2019) Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach. Comput Biol Chem 78:127\u2013132. https:\/\/doi.org\/10.1016\/j.compbiolchem.2018.11.021","journal-title":"Comput Biol Chem"},{"issue":"5","key":"648_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000443496","volume":"61","author":"AR Barbosa","year":"2016","unstructured":"Barbosa AR, Caleffi-Ferracioli KR, Leite CQF, Garc\u00eda-Ramos JC et al (2016) Potential of Casiope\u00ednas\u00ae copper complexes and antituberculosis drug combination against Mycobacterium tuberculosis. Chemotherapy 61(5):249\u2013255. https:\/\/doi.org\/10.1159\/000443496","journal-title":"Chemotherapy"},{"issue":"1","key":"648_CR25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.carres.2010.07.007","volume":"346","author":"JE Miranda-Calder\u00f3n","year":"2011","unstructured":"Miranda-Calder\u00f3n JE, Medina-Torres L, Tinoco-Mendez M, Moreno-Esparza R, Ruiz-Ramirez L (2011) Characterization of physical interaction between Casiopeina III-ia and chitosan. Toward a Cas III-ia drug delivery system. Carbohydr Res 346(1):121\u20136. https:\/\/doi.org\/10.1016\/j.carres.2010.07.007","journal-title":"Carbohydr Res"},{"key":"648_CR26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.micpath.2017.11.001","volume":"113","author":"P Gholizadeh","year":"2017","unstructured":"Gholizadeh P, Pormohammad A, Eslami H, Shokouhi B, Fakhrzadeh V, Kafil HS (2017) Oral pathogenesis of Aggregatibacter actinomycetemcomitans. Microb Pathog 113:303\u2013311. https:\/\/doi.org\/10.1016\/j.micpath.2017.11.001","journal-title":"Microb Pathog"},{"issue":"11","key":"648_CR27","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.1093\/nar\/gkv467","volume":"43","author":"R Galindo-Murillo","year":"2015","unstructured":"Galindo-Murillo R, Garc\u00eda-Ramos JC, Ruiz-Azuara L, Cheatham ET, Cort\u00e9s-Guzm\u00e1n F (2015) Intercalation processes of copper complexes in DNA. Nucleic Acids Res 43(11):5364\u20135376. https:\/\/doi.org\/10.1093\/nar\/gkv467","journal-title":"Nucleic Acids Res"},{"key":"648_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.biomaterials.2017.03.017","volume":"129","author":"Z Deng","year":"2017","unstructured":"Deng Z, Gao P, Yu L, Ma B et al (2017) Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells. Biomaterials 129:111\u2013126. https:\/\/doi.org\/10.1016\/j.biomaterials.2017.03.017","journal-title":"Biomaterials"},{"issue":"4","key":"648_CR29","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3390\/ph10040096","volume":"10","author":"R Dorati","year":"2017","unstructured":"Dorati R, Detrizio A, Modena T, Conti B (2017) Biodegradable scaffolds for bone regeneration combined with drug-delivery systems in osteomyelitis therapy. Pharm 10(4):96. https:\/\/doi.org\/10.3390\/ph10040096","journal-title":"Pharm"},{"key":"648_CR30","doi-asserted-by":"publisher","unstructured":"Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH (2020) The antibacterial mechanism of silver nanoparticles and its application in dentistry. Int J Nanomedicine 15:2555\u20132562. https:\/\/doi.org\/10.2147\/IJN.S246764","DOI":"10.2147\/IJN.S246764"},{"issue":"5","key":"648_CR31","doi-asserted-by":"publisher","first-page":"4869","DOI":"10.1021\/acsnano.9b02816","volume":"13","author":"DSW Benoit","year":"2019","unstructured":"Benoit DSW, Sims KR Jr, Fraser D (2019) Nanoparticles for oral biofilm treatments. ACS Nano 13(5):4869\u20134875. https:\/\/doi.org\/10.1021\/acsnano.9b02816","journal-title":"ACS Nano"},{"issue":"6","key":"648_CR32","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/aae15b","volume":"13","author":"P Chen","year":"2018","unstructured":"Chen P, Wu Z, Leung A et al (2018) Fabrication of a silver nanoparticle-coated collagen membrane with antibacterial and anti-inflammatory activities for guided bone regeneration. Biomed Mater 13(6):065014. https:\/\/doi.org\/10.1088\/1748-605X\/aae15b","journal-title":"Biomed Mater"},{"key":"648_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.actbio.2017.06.046","volume":"59","author":"JS Fernandes","year":"2017","unstructured":"Fernandes JS, Gentile P, Pires RA, Reis RL, Hatton PV (2017) Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue. Acta Biomater 59:2\u201311. https:\/\/doi.org\/10.1016\/j.actbio.2017.06.046","journal-title":"Acta Biomater"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00648-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-021-00648-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-021-00648-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T04:44:10Z","timestamp":1646023450000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-021-00648-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["648"],"URL":"https:\/\/doi.org\/10.1007\/s42770-021-00648-3","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"assertion":[{"value":"9 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}