{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:14:16Z","timestamp":1775790856092,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309948\/2018-5"],"award-info":[{"award-number":["309948\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.315426\/2019-01"],"award-info":[{"award-number":["88882.315426\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/210.889\/2019"],"award-info":[{"award-number":["E-26\/210.889\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.629\/2015"],"award-info":[{"award-number":["E-26\/211.629\/2015"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006702","name":"Universidade do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s42770-022-00710-8","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T04:30:50Z","timestamp":1644985850000},"page":"583-594","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insights of OxyR role in mechanisms of host\u2013pathogen interaction of Corynebacterium diphtheriae"],"prefix":"10.1007","volume":"53","author":[{"given":"Elisabete Alves","family":"Cappelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrezza","family":"do Esp\u00edrito Santo Cucinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane","family":"Simpson-Louredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eurydice Freire","family":"Canellas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Azevedo","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Burkovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jemima Fuentes Ribeiro","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lu\u00edza","family":"Mattos-Guaraldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra Mattos","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisy Sanches","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"710_CR1","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/S1286-4579(00)01305-8","volume":"2","author":"AL Mattos-Guaraldi","year":"2000","unstructured":"Mattos-Guaraldi AL, Duarte Formiga LC, Pereira GA (2000) Cell surface components and adhesion in corynebacterium diphtheriae. Microbes Infect 2:1507\u20131512. https:\/\/doi.org\/10.1016\/S1286-4579(00)01305-8","journal-title":"Microbes Infect"},{"key":"710_CR2","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1128\/JB.00183-12","volume":"194","author":"E Trost","year":"2012","unstructured":"Trost E, Blom J, Soares SC, Huang IH, Al-Dilaimi A et al (2012) Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia. J Bacteriol 194:3199\u20133215. https:\/\/doi.org\/10.1128\/JB.00183-12","journal-title":"J Bacteriol"},{"key":"710_CR3","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3855\/jidc.5976","volume":"9","author":"MM El-Hazmi","year":"2015","unstructured":"El-Hazmi MM (2015) Late-onset prosthetic valve endocarditis caused by nontoxigenic Corynebacterium diphtheriae. J Infect Dev Ctries 9:905\u2013909. https:\/\/doi.org\/10.3855\/jidc.5976","journal-title":"J Infect Dev Ctries"},{"key":"710_CR4","unstructured":"Zasada AA (2015) Corynebacterium diphtheriae infections currently and in the past. Przegl Epidemiol 69:439\u201344, 569\u201374. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26519837. Accessed 20 June 2021"},{"key":"710_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3934\/microbiol.2018.1.85","volume":"4","author":"L Ott","year":"2018","unstructured":"Ott L (2018) Adhesion properties of toxigenic corynebacteria. AIMS Microbiol 4:85\u2013103. https:\/\/doi.org\/10.3934\/microbiol.2018.1.85","journal-title":"AIMS Microbiol"},{"key":"710_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12866-018-1247-z","volume":"18","author":"D Weerasekera","year":"2018","unstructured":"Weerasekera D, Stengel F, Sticht H, Mattos-Guaraldi AL, Burkovski A et al (2018) The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems. BMC Microbiol 18:1\u201313. https:\/\/doi.org\/10.1186\/s12866-018-1247-z","journal-title":"BMC Microbiol"},{"key":"710_CR7","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.1128\/AEM.69.10.5907-5913.2003","volume":"69","author":"LO Moreira","year":"2003","unstructured":"Moreira LO, Andrade AFB, Vale MD, Souza SMS, Hirata-Junior R et al (2003) Effects of iron limitation on adherence and cell surface carbohydrates of Corynebacterium diphtheriae strains. Appl Environ Microbiol 69:5907\u20135913. https:\/\/doi.org\/10.1128\/AEM.69.10.5907-5913.2003","journal-title":"Appl Environ Microbiol"},{"key":"710_CR8","doi-asserted-by":"publisher","unstructured":"Santos LS, Sant\u2019Anna LO, Ramos JN, Ladeira EM, Peixoto RS, et al. Diphtheria outbreak in Maranh\u00e3o, Brazil: microbiological, clinical and epidemiological aspects. Epidemiol Infect 2015;143:791\u2013798 https:\/\/doi.org\/10.1017\/S0950268814001241","DOI":"10.1017\/S0950268814001241"},{"key":"710_CR9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3892\/ijmm.12.4.657","volume":"12","author":"SMS Souza","year":"2003","unstructured":"Souza SMS, Hirata-Junior R, Moreira LO, Gomes ML, Andrade AFB et al (2003) Influence of stannous chloride on the adhesive properties of Corynebacterium diphtheriae strains. Int J Mol Med 12:657\u2013661. https:\/\/doi.org\/10.3892\/ijmm.12.4.657","journal-title":"Int J Mol Med"},{"key":"710_CR10","doi-asserted-by":"publisher","first-page":"5495","DOI":"10.1128\/JB.00304-12","volume":"194","author":"JM Dubbs","year":"2012","unstructured":"Dubbs JM, Mongkolsuk S (2012) Peroxide-sensing transcriptional regulators in bacteria. J Bacteriol 194:5495\u20135503. https:\/\/doi.org\/10.1128\/JB.00304-12","journal-title":"J Bacteriol"},{"key":"710_CR11","doi-asserted-by":"publisher","first-page":"E6922","DOI":"10.1073\/pnas.1701587114","volume":"114","author":"M Khademian","year":"2017","unstructured":"Khademian M, Imlay JA (2017) Escherichia coli cytochrome c peroxidase is a respiratory oxidase that enables the use of hydrogen peroxide as a terminal electron acceptor. Proc Natl Acad Sci 114:E6922\u2013E6931. https:\/\/doi.org\/10.1073\/pnas.1701587114","journal-title":"Proc Natl Acad Sci"},{"key":"710_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/JB.00128-18","volume":"200","author":"ML Reniere","year":"2018","unstructured":"Reniere ML (2018) Reduce, induce, thrive: bacterial redox sensing during pathogenesis. J Bacteriol 200:1\u201312. https:\/\/doi.org\/10.1128\/JB.00128-18","journal-title":"J Bacteriol"},{"key":"710_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jss.2007.02.046","volume":"143","author":"KA Melstrom Jr","year":"2007","unstructured":"Melstrom KA Jr, Kozlowski R, Hassett DJ, Suzuki H, Bates DM et al (2007) Cytotoxicity of Pseudomonas secreted exotoxins requires OxyR expression. J Surg Res 143:50\u201357. https:\/\/doi.org\/10.1016\/j.jss.2007.02.046","journal-title":"J Surg Res"},{"key":"710_CR14","doi-asserted-by":"publisher","first-page":"7262","DOI":"10.1128\/JB.00859-07","volume":"189","author":"RMQ Shanks","year":"2007","unstructured":"Shanks RMQ, Stella NA, Kalivoda EJ, Doe MR, O\u2019Dee DM et al (2007) A Serratia marcescens OxyR homolog mediates surface attachment and biofilm formation. J Bacteriol 189:7262\u20137272. https:\/\/doi.org\/10.1128\/JB.00859-07","journal-title":"J Bacteriol"},{"key":"710_CR15","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1099\/mic.0.065052-0","volume":"159","author":"VB Srinivasan","year":"2013","unstructured":"Srinivasan VB, Mondal AM, Venkataramaiah M, Chauhan NK, Rajamohan G (2013) Role of oxyR KP, a novel LysR-family transcriptional regulator, in antimicrobial resistance and virulence in Klebsiella pneumoniae. Microbiology 159:1301\u20131314. https:\/\/doi.org\/10.1099\/mic.0.065052-0","journal-title":"Microbiology"},{"key":"710_CR16","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1128\/IAI.74.1.461-468.2006","volume":"74","author":"JR Johnson","year":"2006","unstructured":"Johnson JR, Clabots C, Rosen H (2006) Effect of inactivation of the global oxidative stress regulator oxyR on the colonization ability of Escherichia coli O1:K1:H7 in a mouse model of ascending urinary tract infection. Infect Immun 74:461\u2013468. https:\/\/doi.org\/10.1128\/IAI.74.1.461-468.2006","journal-title":"Infect Immun"},{"key":"710_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2019.00439","volume":"10","author":"F Wan","year":"2019","unstructured":"Wan F, Yin J, Sun W, Gao H (2019) Oxidized OxyR up-regulates ahpCF expression to suppress plating defects of oxyR- and catalase-deficient strains. Front Microbiol 10:1\u20139. https:\/\/doi.org\/10.3389\/fmicb.2019.00439","journal-title":"Front Microbiol"},{"key":"710_CR18","doi-asserted-by":"publisher","first-page":"e31709","DOI":"10.1371\/journal.pone.0031709","volume":"7","author":"JS Kim","year":"2012","unstructured":"Kim JS, Holmes RK (2012) Characterization of OxyR as a negative transcriptional regulator that represses catalase production in Corynebacterium diphtheriae. PLoS ONE 7:e31709. https:\/\/doi.org\/10.1371\/journal.pone.0031709","journal-title":"PLoS ONE"},{"key":"710_CR19","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.1111\/febs.12312","volume":"280","author":"H Teramoto","year":"2013","unstructured":"Teramoto H, Inui M, Yukawa H (2013) OxyR acts as a transcriptional repressor of hydrogen peroxide-inducible antioxidant genes in Corynebacterium glutamicum R. FEBS J 280:3298\u20133312. https:\/\/doi.org\/10.1111\/febs.12312","journal-title":"FEBS J"},{"key":"710_CR20","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1574-6968.2002.tb11379.x","volume":"215","author":"R Hirata-Junior","year":"2002","unstructured":"Hirata-Junior R, Napoleao F, Monteiro-Leal LH, Andrade AFB, Nagao PE et al (2002) Intracellular viability of toxigenic Corynebacterium diphtheriae strains in HEp-2 cells. FEMS Microbiol Lett 215:115\u2013119. https:\/\/doi.org\/10.1111\/j.1574-6968.2002.tb11379.x","journal-title":"FEMS Microbiol Lett"},{"key":"710_CR21","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1099\/mic.0.000020","volume":"161","author":"CA Antunes","year":"2015","unstructured":"Antunes CA, Santos LS, Hacker E, Kohler S, Bosl K et al (2015) Characterization of DIP0733, a multi-functional virulence factor of Corynebacterium diphtheriae. Microbiology 161:639\u2013647. https:\/\/doi.org\/10.1099\/mic.0.000020","journal-title":"Microbiology"},{"key":"710_CR22","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1590\/0074-02760140479","volume":"110","author":"LS Santos","year":"2015","unstructured":"Santos LS, Antunes CA, Santos CS, Pereira JAA, Sabbadini PS et al (2015) Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans. Mem Inst Oswaldo Cruz 110:662\u2013668. https:\/\/doi.org\/10.1590\/0074-02760140479","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"710_CR23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.vetmic.2005.12.010","volume":"114","author":"FA Dorella","year":"2006","unstructured":"Dorella FA, Estevam EM, Cardoso PG, Savassi BM, Oliveira SC et al (2006) An improved protocol for electrotransformation of Corynebacterium pseudotuberculosis. Vet Microbiol 114:298\u2013303. https:\/\/doi.org\/10.1016\/j.vetmic.2005.12.010","journal-title":"Vet Microbiol"},{"key":"710_CR24","unstructured":"CLSI (2017) Performance for standards for antimicrobial susceptibility testing; twenty-third information supplement. CLSI document M100-S-23. Clinical and Laboratory Institute, Wayne, PA"},{"key":"710_CR25","doi-asserted-by":"publisher","unstructured":"Atshan SS, Shamsudin MN, Lung LTT, Ling KH, Sekawi Z, et al. (2012) Improved method for the isolation of RNA from bacteria refractory to disruption, including S. aureus producing biofilm. Gene 494:219\u2013224 https:\/\/doi.org\/10.1016\/j.gene.2011.12.010","DOI":"10.1016\/j.gene.2011.12.010"},{"key":"710_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"710_CR27","doi-asserted-by":"publisher","unstructured":"Rasmussen R. Quantification on the lightcycler. In: Meuer S, Wittwer C, Nakagawara KI (eds) Rapid Cycle Real-Time PCR. Springer, Berlin, Heidelberg, pp. 21\u201334.\u00a0https:\/\/doi.org\/10.1007\/978-3-642-59524-0_3","DOI":"10.1007\/978-3-642-59524-0_3"},{"key":"710_CR28","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00430-015-0418-x","volume":"204","author":"LG Cunha","year":"2015","unstructured":"Cunha LG, Ferreira MF, Moraes JA, Reis PA, Castro-Faria-Neto HC et al (2015) ExoU-induced redox imbalance and oxidative stress in airway epithelial cells during Pseudomonas aeruginosa pneumosepsis. Med Microbiol Immunol 204:673\u2013680. https:\/\/doi.org\/10.1007\/s00430-015-0418-x","journal-title":"Med Microbiol Immunol"},{"key":"710_CR29","doi-asserted-by":"publisher","unstructured":"Santos LS, Antunes CA, Oliveira DM, Sant\u2019Anna LO, Pereira JAA, et al. (2015) Tellurite resistance: a putative pitfall in Corynebacterium diphtheriae diagnosis? Anton Van Leeuw 108:1275\u20131279 https:\/\/doi.org\/10.1007\/s10482-015-0558-4","DOI":"10.1007\/s10482-015-0558-4"},{"key":"710_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.vetmic.2011.06.007","volume":"153","author":"AASO Dias","year":"2011","unstructured":"Dias AASO, Silva FC Jr, Santos LS, Ribeiro-Carvalho MM, Sabbadini PS et al (2011) Strain-dependent arthritogenic potential of the zoonotic pathogen Corynebacterium ulcerans. Vet Microbiol 153:323\u2013331. https:\/\/doi.org\/10.1016\/j.vetmic.2011.06.007","journal-title":"Vet Microbiol"},{"issue":"537\u2013546","key":"710_CR31","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1099\/mic.0.069948-0","volume":"160","author":"RS Peixoto","year":"2014","unstructured":"Peixoto RS, Pereira GA, Santos LS, Rocha-de-Souza CM, Gomes DLR et al (2014) Invasion of endothelial cells and arthritogenic potential of endocarditis-associated Corynebacterium diphtheriae. Microbiology 160(537\u2013546):537\u2013546. https:\/\/doi.org\/10.1099\/mic.0.069948-0","journal-title":"Microbiology"},{"key":"710_CR32","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1590\/S0074-02762003000800001","volume":"98","author":"AL Mattos-Guaraldi","year":"2003","unstructured":"Mattos-Guaraldi AL, Moreira LO, Damasco PV, Hirata-Junior R (2003) Diphtheria remains a threat to health in the developing world - an overview. Mem Inst Oswaldo Cruz 98:987\u2013993. https:\/\/doi.org\/10.1590\/S0074-02762003000800001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"710_CR33","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1099\/jmm.0.000362","volume":"65","author":"RS Peixoto","year":"2016","unstructured":"Peixoto RS, Hacker E, Antunes CA, Weerasekera D, Dias AASO et al (2016) Pathogenic properties of a Corynebacterium diphtheriae strain isolated from a case of osteomyelitis. J Med Microbiol 65:1311\u20131321. https:\/\/doi.org\/10.1099\/jmm.0.000362","journal-title":"J Med Microbiol"},{"key":"710_CR34","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1099\/mic.0.000201","volume":"162","author":"CA Antunes","year":"2016","unstructured":"Antunes CA, Clark L, Wanuske MT, Hacker E, Ott L et al (2016) Caenorhabditis elegans star formation and negative chemotaxis induced by infection with corynebacteria. Microbiology 162:84\u201393. https:\/\/doi.org\/10.1099\/mic.0.000201","journal-title":"Microbiology"},{"key":"710_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/OAB.S25500","volume":"4","author":"V D\u2019Afonseca","year":"2012","unstructured":"D\u2019Afonseca V, Soares SC, Ali A, Santos AR, Pinto AC et al (2012) Reannotation of the Corynebacterium diphtheriae NCTC13129 genome as a new approach to studying gene targets connected to virulence and pathogenicity in diphtheria. Open Access Bioinforma 4:1\u201313. https:\/\/doi.org\/10.2147\/OAB.S25500","journal-title":"Open Access Bioinforma"},{"key":"710_CR36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.micpath.2003.10.002","volume":"36","author":"R Hirata-Junior","year":"2004","unstructured":"Hirata-Junior R, Souza SMS, Rocha-De-Souza CM, Andrade AFB, Monteiro-Leal LH et al (2004) Patterns of adherence to HEp-2 cells and actin polymerisation by toxigenic Corynebacterium diphtheriae strains. Microb Pathog 36:125\u2013130. https:\/\/doi.org\/10.1016\/j.micpath.2003.10.002","journal-title":"Microb Pathog"},{"key":"710_CR37","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1574-695X.2012.00963.x","volume":"65","author":"L Ott","year":"2012","unstructured":"Ott L, McKenzie A, Baltazar MT, Britting S, Bischof A et al (2012) Evaluation of invertebrate infection models for pathogenic corynebacteria. FEMS Immunol Med Microbiol 65:413\u2013421. https:\/\/doi.org\/10.1111\/j.1574-695X.2012.00963.x","journal-title":"FEMS Immunol Med Microbiol"},{"key":"710_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1348-0421.2009.00179.x","volume":"54","author":"CS Santos","year":"2010","unstructured":"Santos CS, Santos LS, Souza MC, Dourado FS, Dias AASO et al (2010) Non-opsonic phagocytosis of homologous non-toxigenic and toxigenic Corynebacterium diphtheriae strains by human U-937 macrophages. Microbiol Immunol 54:1\u201310. https:\/\/doi.org\/10.1111\/j.1348-0421.2009.00179.x","journal-title":"Microbiol Immunol"},{"key":"710_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.micpath.2011.12.003","volume":"52","author":"PS Sabbadini","year":"2012","unstructured":"Sabbadini PS, Assis MC, Trost E, Gomes DLR, Moreira LO et al (2012) Corynebacterium diphtheriae 67\u201372p hemagglutinin, characterized as the protein DIP0733, contributes to invasion and induction of apoptosis in HEp-2 cells. Microb Pathog 52:165\u2013176. https:\/\/doi.org\/10.1016\/j.micpath.2011.12.003","journal-title":"Microb Pathog"},{"key":"710_CR40","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1128\/IAI.70.7.3768-3776.2002","volume":"70","author":"S Benoit","year":"2002","unstructured":"Benoit S, Benachour A, Taouji S, Auffray Y, Hartke A (2002) H2O2, Which causes macrophage-related stress, triggers induction of expression of virulence-associated plasmid determinants in Rhodococcus equi. Infect Immun 70:3768\u20133776. https:\/\/doi.org\/10.1128\/IAI.70.7.3768-3776.2002","journal-title":"Infect Immun"},{"key":"710_CR41","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1128\/AEM.68.10.4835-4840.2002","volume":"68","author":"AD Frey","year":"2002","unstructured":"Frey AD, Farr\u00e9s J, Bollinger CJT, Kallio PT (2002) Bacterial hemoglobins and flavohemoglobins for alleviation of nitrosative stress in Escherichia coli. Appl Environ Microbiol 68:4835\u20134840. https:\/\/doi.org\/10.1128\/AEM.68.10.4835-4840.2002","journal-title":"Appl Environ Microbiol"},{"key":"710_CR42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1365-2958.2006.05478.x","volume":"63","author":"KL Seib","year":"2007","unstructured":"Seib KL, Wu HJ, Srikhanta YN, Edwards JL, Falsetta ML et al (2007) Characterization of the OxyR regulon of Neisseria gonorrhoeae. Mol Microbiol 63:54\u201368. https:\/\/doi.org\/10.1111\/j.1365-2958.2006.05478.x","journal-title":"Mol Microbiol"},{"key":"710_CR43","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1146\/annurev.biochem.77.061606.161055","volume":"77","author":"JA Imlay","year":"2008","unstructured":"Imlay JA (2008) Cellular defenses against superoxide and hydrogen peroxide. Annu Rev Biochem 77:755\u2013776. https:\/\/doi.org\/10.1146\/annurev.biochem.77.061606.161055","journal-title":"Annu Rev Biochem"},{"key":"710_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2017.02008","volume":"8","author":"H Jamaati","year":"2017","unstructured":"Jamaati H, Mortaz E, Pajouhi Z, Folkerts G, Movassaghi M et al (2017) Nitric oxide in the pathogenesis and treatment of tuberculosis. Front Microbiol 8:1\u201311. https:\/\/doi.org\/10.3389\/fmicb.2017.02008","journal-title":"Front Microbiol"},{"key":"710_CR45","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1590\/S0100-879X2008001100007","volume":"41","author":"R Hirata-Junior","year":"2008","unstructured":"Hirata-Junior R, Pereira GA, Filardy AA, Gomes DLR, Damasco PV et al (2008) Potential pathogenic role of aggregative- adhering Corynebacterium diphtheriae of different clonal groups in endocarditis. Braz J Med Biol Res 41:986\u2013991. https:\/\/doi.org\/10.1590\/S0100-879X2008001100007","journal-title":"Braz J Med Biol Res"},{"key":"710_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2011.00105","volume":"2","author":"MI Voskuil","year":"2011","unstructured":"Voskuil MI, Bartek IL, Visconti K, Schoolnik GK (2011) The response of Mycobacterium Tuberculosis to reactive oxygen and nitrogen species. Front Microbiol 2:1\u201312. https:\/\/doi.org\/10.3389\/fmicb.2011.00105","journal-title":"Front Microbiol"},{"key":"710_CR47","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jbspin.2007.01.027","volume":"74","author":"S Ordonez-Palau","year":"2007","unstructured":"Ordonez-Palau S, Boquet D, Gil-Garcia M, Pardina-Solano M (2007) Chronic osteomyelitis of the metatarsal sesamoid due to Corynebacterium jeikeium in a patient with rheumatoid arthritis. Jt Bone Spine 74:515\u2013516. https:\/\/doi.org\/10.1016\/j.jbspin.2007.01.027","journal-title":"Jt Bone Spine"},{"key":"710_CR48","doi-asserted-by":"publisher","first-page":"352","DOI":"10.12659\/AJCR.890855","volume":"15","author":"V Patris","year":"2014","unstructured":"Patris V, Argiriou O, Konstantinou C, Lama N, Georgiou H et al (2014) Corynebacterium diphtheriae endocarditis with multifocal septic emboli: can prompt diagnosis help avoid surgery? Am J Case Rep 15:352\u2013354. https:\/\/doi.org\/10.12659\/AJCR.890855","journal-title":"Am J Case Rep"},{"key":"710_CR49","doi-asserted-by":"publisher","first-page":"e584","DOI":"10.1016\/j.ijid.2011.04.003","volume":"15","author":"S Muttaiyah","year":"2011","unstructured":"Muttaiyah S, Best EJ, Freeman JT, Taylor SL, Morris AJ et al (2011) Corynebacterium diphtheriae endocarditis: a case series and review of the treatment approach. Int J Infect Dis 15:e584\u2013e588. https:\/\/doi.org\/10.1016\/j.ijid.2011.04.003","journal-title":"Int J Infect Dis"},{"key":"710_CR50","doi-asserted-by":"publisher","first-page":"314","DOI":"10.14740\/cr741w","volume":"9","author":"O Pachirat","year":"2018","unstructured":"Pachirat O, Kaewkes D, Pussadhamma B, Watt G (2018) Corynebacterium diphtheriae native aortic valve endocarditis in a patient with prosthetic mitral valve: a rare presentation. Cardiol Res 9:314\u2013317. https:\/\/doi.org\/10.14740\/cr741w","journal-title":"Cardiol Res"},{"key":"710_CR51","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1099\/jmm.0.46135-0","volume":"55","author":"M Puliti","year":"2006","unstructured":"Puliti M, von Hunolstein C, Marangi M, Bistoni F, Tissi L (2006) Experimental model of infection with non-toxigenic strains of Corynebacterium diphtheriae and development of septic arthritis. J Med Microbiol 55:229\u2013235. https:\/\/doi.org\/10.1099\/jmm.0.46135-0","journal-title":"J Med Microbiol"},{"key":"710_CR52","doi-asserted-by":"publisher","first-page":"e231914","DOI":"10.1136\/bcr-2019-231914","volume":"12","author":"U Sutton-Fitzpatrick","year":"2019","unstructured":"Sutton-Fitzpatrick U, Grant C, Nashev D, Fleming C (2019) Corynebacterium diphtheriae bloodstream infection: the role of antitoxin. BMJ Case Rep 12:e231914. https:\/\/doi.org\/10.1136\/bcr-2019-231914","journal-title":"BMJ Case Rep"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-022-00710-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-022-00710-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-022-00710-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T02:08:09Z","timestamp":1653962889000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-022-00710-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["710"],"URL":"https:\/\/doi.org\/10.1007\/s42770-022-00710-8","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"assertion":[{"value":"6 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments using in vivo mice model were performed by using protocols in compliance with guidelines outlined in the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for the International Organizations of Medical Sciences, and with the Brazilian government\u2019s ethical guidelines for research involving animals; IBRAG\/UERJ Ethics Committee for Animal Experiments\u2014approval number: CEUA\/029\/2015.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}