{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:50:45Z","timestamp":1772455845415,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306464\/2016-0"],"award-info":[{"award-number":["306464\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306464\/2016-0"],"award-info":[{"award-number":["306464\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s42770-022-00742-0","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T15:38:13Z","timestamp":1648827493000},"page":"1241-1247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Respiratory syncytial virus: viral load, viral decay, and disease progression in children with bronchiolitis"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-7723","authenticated-orcid":false,"given":"Ra\u00ed Andr\u00e9 Silva","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-1956","authenticated-orcid":false,"given":"Jessica Santiago","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-5507","authenticated-orcid":false,"given":"Luciano Kleber","family":"de Souza Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-946X","authenticated-orcid":false,"given":"Vit\u00f3ria Rodrigues Guimar\u00e3es","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-0831","authenticated-orcid":false,"given":"Danielle Dias","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Lyra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Sanchez","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6080-5693","authenticated-orcid":false,"given":"Nancy","family":"Bellei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"742_CR1","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00431-018-3138-6","volume":"177","author":"M Ghazaly","year":"2018","unstructured":"Ghazaly M, Nadel S (2018) Characteristics of children admitted to intensive care with acute bronchiolitis. Eur J Pediatr 177:913\u2013920. https:\/\/doi.org\/10.1007\/s00431-018-3138-6","journal-title":"Eur J Pediatr"},{"key":"742_CR2","doi-asserted-by":"publisher","first-page":"e0057","DOI":"10.1097\/MD.0000000000010057","volume":"97","author":"M Robledo-Aceves","year":"2018","unstructured":"Robledo-Aceves M, Moreno-Peregrina MJ, Velarde-Rivera F, Ascencio-Esparza E, Preciado-Figueroa FM, Caniza MA, Escobedo-Melendez G (2018) Risk factors for severe bronchiolitis caused by respiratory virus infections among Mexican children in an emergency department. Medicine (Baltimore) 97:e0057. https:\/\/doi.org\/10.1097\/MD.0000000000010057","journal-title":"Medicine (Baltimore)"},{"key":"742_CR3","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1136\/jim-2018-000708","volume":"66","author":"CE Rodriguez-Martinez","year":"2018","unstructured":"Rodriguez-Martinez CE, Sossa-Briceno MP, Nino G (2018) Predictors of prolonged length of hospital stay for infants with bronchiolitis. J Investig Med 66:986\u2013991. https:\/\/doi.org\/10.1136\/jim-2018-000708","journal-title":"J Investig Med"},{"key":"742_CR4","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","volume":"375","author":"H Nair","year":"2010","unstructured":"Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O\u2019Brien KL, Roca A, Wright PF, Bruce N, Chandran A, Theodoratou E, Sutanto A, Sedyaningsih ER, Ngama M, Munywoki PK, Kartasasmita C, Simoes EA, Rudan I, Weber MW, Campbell H (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375:1545\u20131555. https:\/\/doi.org\/10.1016\/S0140-6736(10)60206-1","journal-title":"Lancet"},{"key":"742_CR5","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1099\/jgv.0.000959","volume":"98","author":"B Rima","year":"2017","unstructured":"Rima B, Collins P, Easton A, Fouchier R, Kurath G, Lamb RA, Lee B, Maisner A, Rota P, Wang L, Ictv Report C (2017) ICTV virus taxonomy profile: pneumoviridae. J Gen Virol 98:2912\u20132913. https:\/\/doi.org\/10.1099\/jgv.0.000959","journal-title":"J Gen Virol"},{"key":"742_CR6","doi-asserted-by":"publisher","unstructured":"Vandini S, Biagi C, Lanari M (2017) Respiratory syncytial virus: the influence of serotype and genotype variability on clinical course of infection. Int J Mol Sci 18. https:\/\/doi.org\/10.3390\/ijms18081717","DOI":"10.3390\/ijms18081717"},{"key":"742_CR7","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1542\/peds.102.5.1211","volume":"102","author":"COID, CFN","year":"1998","unstructured":"COID, CFN (1998) Prevention of respiratory syncytial virus infections: indications for the use of palivizumab and update on the use of RSV-IGIV. American Academy of Pediatrics Committee on Infectious Diseases and Committee of Fetus and Newborn. Pediatrics 102:1211\u20131216. https:\/\/doi.org\/10.1542\/peds.102.5.1211","journal-title":"Pediatrics"},{"key":"742_CR8","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/infdis\/jir494","volume":"204","author":"CM El Saleeby","year":"2011","unstructured":"El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP (2011) Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 204:996\u20131002. https:\/\/doi.org\/10.1093\/infdis\/jir494","journal-title":"J Infect Dis"},{"key":"742_CR9","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/INF.0b013e3181b6de8a","volume":"29","author":"RR Jansen","year":"2010","unstructured":"Jansen RR, Schinkel J, Dek I, Koekkoek SM, Visser CE, de Jong MD, Molenkamp R, Pajkrt D (2010) Quantitation of respiratory viruses in relation to clinical course in children with acute respiratory tract infections. Pediatr Infect Dis J 29:82\u201384. https:\/\/doi.org\/10.1097\/INF.0b013e3181b6de8a","journal-title":"Pediatr Infect Dis J"},{"key":"742_CR10","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1002\/jmv.24111","volume":"87","author":"L Zhou","year":"2015","unstructured":"Zhou L, Xiao Q, Zhao Y, Huang A, Ren L, Liu E (2015) The impact of viral dynamics on the clinical severity of infants with respiratory syncytial virus bronchiolitis. J Med Virol 87:1276\u20131284. https:\/\/doi.org\/10.1002\/jmv.24111","journal-title":"J Med Virol"},{"key":"742_CR11","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/pr.2017.173","volume":"82","author":"ME Brint","year":"2017","unstructured":"Brint ME, Hughes JM, Shah A, Miller CR, Harrison LG, Meals EA, Blanch J, Thompson CR, Cormier SA, DeVincenzo JP (2017) Prolonged viral replication and longitudinal viral dynamic differences among respiratory syncytial virus infected infants. Pediatr Res 82:872\u2013880. https:\/\/doi.org\/10.1038\/pr.2017.173","journal-title":"Pediatr Res"},{"key":"742_CR12","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/cid\/cix378","volume":"65","author":"T Benet","year":"2017","unstructured":"Benet T, Sanchez Picot V, Messaoudi M, Chou M, Eap T, Wang J, Shen K et al (2017) Microorganisms associated with pneumonia in children <5 years of age in developing and emerging countries: the GABRIEL pneumonia multicenter, prospective, case-control study. Clin Infect Dis 65:604\u2013612. https:\/\/doi.org\/10.1093\/cid\/cix378","journal-title":"Clin Infect Dis"},{"key":"742_CR13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1136\/thoraxjnl-2018-212096","volume":"74","author":"MU Bhuiyan","year":"2019","unstructured":"Bhuiyan MU, Snelling TL, West R, Lang J, Rahman T, Granland C, de Gier C, Borland ML, Thornton RB, Kirkham LS, Sikazwe C, Martin AC, Richmond PC, Smith DW, Jaffe A, Blyth CC (2019) The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: a case-control study. Thorax 74:261\u2013269. https:\/\/doi.org\/10.1136\/thoraxjnl-2018-212096","journal-title":"Thorax"},{"key":"742_CR14","doi-asserted-by":"publisher","first-page":"e32056","DOI":"10.1371\/journal.pone.0032056","volume":"7","author":"N Homaira","year":"2012","unstructured":"Homaira N, Luby SP, Petri WA, Vainionpaa R, Rahman M, Hossain K, Snider CB, Rahman M, Alamgir AS, Zesmin F, Alam M, Gurley ES, Zaman RU, Azim T, Erdman DD, Fry AM, Bresee J, Widdowson MA, Haque R, Azziz-Baumgartner E (2012) Incidence of respiratory virus-associated pneumonia in urban poor young children of Dhaka, Bangladesh, 2009\u20132011. PLoS ONE 7:e32056. https:\/\/doi.org\/10.1371\/journal.pone.0032056","journal-title":"PLoS ONE"},{"key":"742_CR15","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0140-6736(19)30721-4","volume":"394","author":"Pneumonia Etiology Research for Child Health Study G","year":"2019","unstructured":"Pneumonia Etiology Research for Child Health Study G (2019) Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study. Lancet 394:757\u2013779. https:\/\/doi.org\/10.1016\/S0140-6736(19)30721-4","journal-title":"Lancet"},{"key":"742_CR16","doi-asserted-by":"publisher","first-page":"e15098","DOI":"10.1371\/journal.pone.0015098","volume":"5","author":"AM Fry","year":"2010","unstructured":"Fry AM, Chittaganpitch M, Baggett HC, Peret TC, Dare RK, Sawatwong P, Thamthitiwat S, Areerat P, Sanasuttipun W, Fischer J, Maloney SA, Erdman DD, Olsen SJ (2010) The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand. PLoS ONE 5:e15098. https:\/\/doi.org\/10.1371\/journal.pone.0015098","journal-title":"PLoS ONE"},{"key":"742_CR17","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3201\/eid1002.030759","volume":"10","author":"SL Emery","year":"2004","unstructured":"Emery SL, Erdman DD, Bowen MD, Newton BR, Winchell JM, Meyer RF, Tong S, Cook BT, Holloway BP, McCaustland KA, Rota PA, Bankamp B, Lowe LE, Ksiazek TG, Bellini WJ, Anderson LJ (2004) Real-time reverse transcription-polymerase chain reaction assay for SARS-associated coronavirus. Emerg Infect Dis 10:311\u2013316. https:\/\/doi.org\/10.3201\/eid1002.030759","journal-title":"Emerg Infect Dis"},{"key":"742_CR18","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1002\/jmv.26185","volume":"93","author":"JS Cruz","year":"2021","unstructured":"Cruz JS, de Souza Luna LK, Alves VRG, Conte DD, Bellei NCJ (2021) Viral load of respiratory syncytial virus among children from primary care and hospital settings admitted to a university hospital in Brazil (2009\u20132013). J Med Virol 93:3397\u20133400. https:\/\/doi.org\/10.1002\/jmv.26185","journal-title":"J Med Virol"},{"key":"742_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5935\/0103-507X.20160003","volume":"28","author":"R Ferlini","year":"2016","unstructured":"Ferlini R, Pinheiro FO, Andreolio C, Carvalho PR, Piva JP (2016) Characteristics and progression of children with acute viral bronchiolitis subjected to mechanical ventilation. Rev Bras Ter Intensiva 28:55\u201361. https:\/\/doi.org\/10.5935\/0103-507X.20160003","journal-title":"Rev Bras Ter Intensiva"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-022-00742-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-022-00742-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-022-00742-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T10:04:06Z","timestamp":1661940246000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-022-00742-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["742"],"URL":"https:\/\/doi.org\/10.1007\/s42770-022-00742-0","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]},"assertion":[{"value":"24 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The following project was approved by the Ethical research committee of the Federal University of Sao Paulo, number 3.009.916, and by CEP\/UNIFESP n. 1082\/2018; nr. 98573718.0.0000.5505.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}