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The aim of the study was to evaluate the heteroresistance to vancomycin and the potential antimicrobial efficacy of teicoplanin and daptomycin against the multiresistant strains of <jats:italic>S. haemolyticus<\/jats:italic>, <jats:italic>S. hominis<\/jats:italic>, <jats:italic>S. warneri<\/jats:italic>, and <jats:italic>S. simulans<\/jats:italic>. The study covered 80 clinical coagulase-negative staphylococci. Teicoplanin, vancomycin, and daptomycin MICs for the tested strains were determined according to EUCAST recommendation. The <jats:italic>vanA<\/jats:italic> and <jats:italic>vanB<\/jats:italic> genes were searched. The brain heart infusion screen agar method detected vancomycin heteroresistance. The population analysis profile method and analysis of autolytic activity were applied for the strains growing on BHI containing 4\u00a0mg\/L vancomycin. Seven <jats:italic>S. haemolyticus<\/jats:italic>, two <jats:italic>S. hominis<\/jats:italic>, and two <jats:italic>S. warneri<\/jats:italic> strains presented a heterogeneous resistance to vancomycin. Their subpopulations were able to grow on a medium containing 4\u201312\u00a0mg\/L of vancomycin. Monitoring heteroresistance to peptide antibiotics, which are often the last resort in staphylococcal infections, is essential due to the severe crisis in antibiotic therapy and the lack of alternatives to treat infections with multiresistant strains. Our work highlights the selection of resistant strains and the need for more careful use of peptide antibiotics.<\/jats:p>","DOI":"10.1007\/s42770-022-00870-7","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T05:03:59Z","timestamp":1668402239000},"page":"159-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vancomycin heteroresistance among methicillin-resistant clinical isolates S.\u00a0haemolyticus, S.\u00a0hominis, S.\u00a0simulans, and S.\u00a0warneri"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1986-2220","authenticated-orcid":false,"given":"Magdalena","family":"Szemraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1351-433X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Lisiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-679X","authenticated-orcid":false,"given":"Paulina","family":"Glajzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7148-4063","authenticated-orcid":false,"given":"Eligia M.","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"870_CR1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3109\/23744235.2015.1122833","volume":"48","author":"AM Asaad","year":"2016","unstructured":"Asaad AM, Qureshi MA, Hasan SM (2016) Clinical significance of coagulase-negative staphylococci isolates from nosocomial bloodstream infections. 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