{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:09:04Z","timestamp":1791274144404,"version":"4.1.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s42770-022-00876-1","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:02:54Z","timestamp":1672214574000},"page":"37-52","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Candida albicans antibiofilm molecules: analysis based on inhibition and eradication studies"],"prefix":"10.1007","volume":"54","author":[{"given":"Carolina","family":"do Ros\u00e1rio Esteves Guimar\u00e3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto Fonseca","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-433X","authenticated-orcid":false,"given":"T\u00e2nia Fraga","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"876_CR1","doi-asserted-by":"publisher","unstructured":"Prigitano A, Cavanna C, Passera M et al (2020) Evolution of fungemia in an Italian region. J Mycol Med 30(1):100906. https:\/\/doi.org\/10.1016\/j.mycmed.2019.100906","DOI":"10.1016\/j.mycmed.2019.100906"},{"key":"876_CR2","doi-asserted-by":"publisher","unstructured":"Siopi M, Tarpatzi A, Kalogeropoulou E et al (2020) Epidemiological trends of fungemia in Greece with a focus on candidemia during the recent financial crisis: a 10-year survey in a tertiary care academic hospital and review of literature. Antimicrob Agents Chemother 21;64(3):e01516\u2013e01519.\nhttps:\/\/doi.org\/10.1128\/AAC.01516-19","DOI":"10.1128\/AAC.01516-19"},{"issue":"2","key":"876_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.17843\/RPMESP.2020.372.5026","volume":"37","author":"F Villanueva","year":"2020","unstructured":"Villanueva F, Veliz J, Canasa K et al (2020) Characteristics of fungemias in a Peruvian referral center: 5-year retrospective analysis. Ver Peru Med Exp Salud Publica 37(2):276\u2013281. https:\/\/doi.org\/10.17843\/RPMESP.2020.372.5026","journal-title":"Ver Peru Med Exp Salud Publica"},{"key":"876_CR4","doi-asserted-by":"publisher","unstructured":"D\u2019Enfert C, Kaune AK, Alaban LR et al (2021) The impact of the fungus-host-microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Ver 5;45(3):fuaa060. https:\/\/doi.org\/10.1093\/femsre\/fuaa060","DOI":"10.1093\/femsre\/fuaa060"},{"key":"876_CR5","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.micron.2011.09.013","volume":"43","author":"LCF Paiva","year":"2012","unstructured":"Paiva LCF, Vidigal PG, Donatti L, Svidzinski TIE, Consolaro MEL (2012) Assessment of in vitro biofilm formation by Candida species isolates from vulvovaginal candidiasis and ultrastructural characteristics. Micron 43:497\u2013502. https:\/\/doi.org\/10.1016\/j.micron.2011.09.013","journal-title":"Micron"},{"key":"876_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrmicro2475","volume":"9","author":"JS Finkel","year":"2011","unstructured":"Finkel JS, Mitchell AP (2011) Genetic control of Candida albicans biofilm development. Nat Rev Microbiol 9:109\u2013118. https:\/\/doi.org\/10.1038\/nrmicro2475","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"876_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-micro-091014-104330","volume":"69","author":"CJ Nobile","year":"2015","unstructured":"Nobile CJ, Johnson AD (2015) Candida albicans biofilms and human disease. Annu Rev Microbiol 69(1):71\u201392. https:\/\/doi.org\/10.1146\/annurev-micro-091014-104330","journal-title":"Annu Rev Microbiol"},{"key":"876_CR8","doi-asserted-by":"publisher","unstructured":"Tsui C, Kong EF, Jabra-Rizk MA (2016) Pathogenesis of Candida albicans biofilm. Pathog Dis 74(4):ftw018. https:\/\/doi.org\/10.1093\/femspd\/ftw018","DOI":"10.1093\/femspd\/ftw018"},{"key":"876_CR9","doi-asserted-by":"publisher","unstructured":"Cavalheiro M, Teixeira MC (2018) Candida biofilms: threats, challenges, and promising strategies. Front Med 13;5:28. https:\/\/doi.org\/10.3389\/fmed.2018.00028","DOI":"10.3389\/fmed.2018.00028"},{"issue":"10","key":"876_CR10","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s10096-020-03912-w","volume":"39","author":"IE Mba","year":"2020","unstructured":"Mba IE, Nweze EI (2020) Mechanism of Candida pathogenesis: revisiting the vital drivers. Eur J Clin Microbiol Infect Dis 39(10):1797\u20131819. https:\/\/doi.org\/10.1007\/s10096-020-03912-w","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"876_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/jam.14949","volume":"131","author":"R Pereira","year":"2021","unstructured":"Pereira R, dos Santos Fontenelle RO, de Brito EHS, de Morais SM (2021) Biofilm of Candida albicans: formation, regulation and resistance. J Appl Microbiol 131(1):11\u201322. https:\/\/doi.org\/10.1111\/jam.14949","journal-title":"J Appl Microbiol"},{"issue":"4","key":"876_CR12","doi-asserted-by":"publisher","first-page":"e1002585","DOI":"10.1371\/journal.ppat.1002585","volume":"8","author":"S Fanning","year":"2012","unstructured":"Fanning S, Mitchell AP (2012) Fungal biofilms. PLoS Pathog 8(4):e1002585. https:\/\/doi.org\/10.1371\/journal.ppat.1002585","journal-title":"PLoS Pathog"},{"issue":"6","key":"876_CR13","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/mmy\/myx111","volume":"56","author":"M Chevalier","year":"2018","unstructured":"Chevalier M, Ranque S, Pr\u00eacheur I (2018) Oral fungal-bacterial biofilm models in vitro: a review. Med Mycol 56(6):653\u2013667. https:\/\/doi.org\/10.1093\/mmy\/myx111","journal-title":"Med Mycol"},{"key":"876_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.micres.2018.03.007","volume":"210","author":"SA Padder","year":"2018","unstructured":"Padder SA, Prasad R, Shah AH (2018) Quorum sensing: a less known mode of communication among fungi. Microbiol Res 210:51\u201358. https:\/\/doi.org\/10.1016\/j.micres.2018.03.007","journal-title":"Microbiol Res"},{"key":"876_CR15","doi-asserted-by":"publisher","first-page":"638609","DOI":"10.3389\/fmicb.2021.638609","volume":"12","author":"T Atriwal","year":"2021","unstructured":"Atriwal T, Azeem K, Husain FM, Hussain A, Khan MN, Alajmi MF et al (2021) Mechanistic understanding of Candida albicans biofilm formation and approaches for its inhibition. Front Microbiol 12:638609. https:\/\/doi.org\/10.3389\/fmicb.2021.638609","journal-title":"Front Microbiol"},{"issue":"1","key":"876_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/1040841X.2020.1843400","volume":"47","author":"NO Ponde","year":"2021","unstructured":"Ponde NO, Lortal L, Ramage G, Naglik JR, Richardson JP (2021) Candida albicans biofilms and polymicrobial interactions. Crit Ver Microbiol 47(1):91\u2013111. https:\/\/doi.org\/10.1080\/1040841X.2020.1843400","journal-title":"Crit Ver Microbiol"},{"issue":"4","key":"876_CR17","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1128\/EC.4.4.633-638.2005","volume":"4","author":"G Ramage","year":"2005","unstructured":"Ramage G, Saville SP, Thomas DP, L\u00f3pez-Ribot JL (2005) Candida biofilms: Na update. Eukaryot Cell 4(4):633\u2013638. https:\/\/doi.org\/10.1128\/EC.4.4.633-638.2005","journal-title":"Eukaryot Cell"},{"key":"876_CR18","doi-asserted-by":"publisher","unstructured":"De-la-Pinta I, Cobos M, Ibarretxe J et al (2019) Effect of biomaterials hydrophobicity and roughness on biofilm development. J Mater Sci Mater Med 19;30(7):77. https:\/\/doi.org\/10.1007\/s10856-019-6281-3","DOI":"10.1007\/s10856-019-6281-3"},{"issue":"21","key":"876_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41522-019-0094-5","volume":"5","author":"AD McCall","year":"2019","unstructured":"McCall AD, Pathirana RU, Prabhakar A, Cullen PJ, Edgerton M (2019) Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins. Npj Biofilms Microbiomes 5(21):1\u201312. https:\/\/doi.org\/10.1038\/s41522-019-0094-5","journal-title":"Npj Biofilms Microbiomes"},{"issue":"3","key":"876_CR20","doi-asserted-by":"publisher","first-page":"e1000828","DOI":"10.1371\/journal.ppat.1000828","volume":"6","author":"P Uppuluri","year":"2010","unstructured":"Uppuluri P, Chaturvedi AK, Srinivasan A et al (2010) Dispersion as an important step in the Candida albicans biofilm developmental cycle. PLoS Pathog 6(3):e1000828. https:\/\/doi.org\/10.1371\/journal.ppat.1000828","journal-title":"PLoS Pathog"},{"key":"876_CR21","doi-asserted-by":"publisher","unstructured":"Chandra J, Mukherjee PK (2015) Candida biofilms: development, architecture, and resistance. Microbiol Spectr 3(4). https:\/\/doi.org\/10.1128\/microbiolspec.MB-0020-2015","DOI":"10.1128\/microbiolspec.MB-0020-2015"},{"key":"876_CR22","unstructured":"Thomas JG, Litton I, Rinde H (2006) Economic impact of biofilms on treatment costs. CDC. https:\/\/www.cdc.gov\/ncidod\/hip.challenges.htm. Accessed 13 Mar\u00a02021"},{"key":"876_CR23","doi-asserted-by":"publisher","unstructured":"Dominguez EG, Andes DR (2017) \u201cCandida biofilm tolerance: Comparison of planktonic and biofilm resistance mechanisms\u201d. In Rajendra Prasad (ed) Candida albicans: Cellular and molecular biology. Springer International Publishing, Cham, pp 77\u201392. https:\/\/doi.org\/10.1007\/978-3-319-50409-4_6","DOI":"10.1007\/978-3-319-50409-4_6"},{"issue":"7","key":"876_CR24","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cmi.2017.11.005","volume":"24","author":"S Soldini","year":"2018","unstructured":"Soldini S, Posteraro B, Vella A et al (2018) Microbiologic and clinical characteristics of biofilm-forming Candida parapsilosis isolates associated with fungaemia and their impact on mortality. Clin Microbiol Infect 24(7):771\u2013777. https:\/\/doi.org\/10.1016\/j.cmi.2017.11.005","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"876_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1439-0507.2011.02076.x","volume":"55","author":"S Tobudic","year":"2012","unstructured":"Tobudic S, Kratzer C, Lassnigg A, Presterl E (2012) Antifungal susceptibility of Candida albicans in biofilms. Mycoses 55(3):199\u2013204. https:\/\/doi.org\/10.1111\/j.1439-0507.2011.02076.x","journal-title":"Mycoses"},{"issue":"10","key":"876_CR26","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.2217\/FMB.13.101","volume":"8","author":"HT Taff","year":"2013","unstructured":"Taff HT, Mitchell KF, Edward JA, Andes DR (2013) Mechanisms of Candida biofilm drug resistance. Future Microbiol 8(10):1325\u20131337. https:\/\/doi.org\/10.2217\/FMB.13.101","journal-title":"Future Microbiol"},{"key":"876_CR27","doi-asserted-by":"publisher","unstructured":"Silva S, Rodrigues CF, Ara\u00fajo D, Rodrigues ME, Henriques M (2017)\u00a0Candida species biofilms' antifungal resistance. J Fungi 3(1):8. https:\/\/doi.org\/10.3390\/jof3010008","DOI":"10.3390\/jof3010008"},{"key":"876_CR28","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2147\/CEOR.S91587","volume":"7","author":"SS Grau","year":"2015","unstructured":"Grau SS, Pozo JC, Rom\u00e1 E et al (2015) Cost-effectiveness of three echinocandins and fluconazole in the treatment of candidemia and\/or invasive candidiasis in nonneutropenic adult patients. Clin Econ Outcomes Res 7:527\u2013535. https:\/\/doi.org\/10.2147\/CEOR.S91587","journal-title":"Clin Econ Outcomes Res"},{"issue":"1","key":"876_CR29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1186\/s12879-017-2573-8","volume":"17","author":"HT Ou","year":"2017","unstructured":"Ou HT, Lee TY, Chen YC, Charbonneau C (2017) Pharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by Candida albicans and non-albicans Candida species. BMC Infect Dis 17(1):481. https:\/\/doi.org\/10.1186\/s12879-017-2573-8","journal-title":"BMC Infect Dis"},{"issue":"10","key":"876_CR30","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/myc.12801","volume":"61","author":"HHL Borba","year":"2018","unstructured":"Borba HHL, Steimbach LM, Riveros BS et al (2018) Cost-effectiveness of amphotericin B formulations in the treatment of systemic fungal infections. Mycoses 61(10):754\u2013763. https:\/\/doi.org\/10.1111\/myc.12801","journal-title":"Mycoses"},{"issue":"9","key":"876_CR31","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jiac.2018.04.014","volume":"24","author":"H Kato","year":"2018","unstructured":"Kato H, Hagihara M, Yamagishi Y et al (2018) The evaluation of frequency of nephrotoxicity caused by liposomal amphotericin B. J Infect Chemother 24(9):725\u2013728. https:\/\/doi.org\/10.1016\/j.jiac.2018.04.014","journal-title":"J Infect Chemother"},{"issue":"3","key":"876_CR32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s11046-020-00445-w","volume":"185","author":"PP de Barros","year":"2020","unstructured":"de Barros PP, Rossoni RD, de Souza CM, Scorzoni L, Fenley JDC, Junqueira JC (2020) Candida biofilms: an update on developmental mechanisms and therapeutic challenges. Mycopathologia 185(3):415\u2013424. https:\/\/doi.org\/10.1007\/s11046-020-00445-w","journal-title":"Mycopathologia"},{"issue":"9","key":"876_CR33","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.tim.2013.06.002","volume":"21","author":"T Bjarnsholt","year":"2013","unstructured":"Bjarnsholt T, Alhede M, Alhede M et al (2013) The in vivo biofilm. Trends Microbiol 21(9):466\u2013474. https:\/\/doi.org\/10.1016\/j.tim.2013.06.002","journal-title":"Trends Microbiol"},{"issue":"3","key":"876_CR34","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/jac\/dkr512","volume":"67","author":"MSA Khan","year":"2012","unstructured":"Khan MSA, Ahmad I (2012) Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms. J Antimicrob Chemother 67(3):618\u2013621. https:\/\/doi.org\/10.1093\/jac\/dkr512","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"876_CR35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/jam.14940","volume":"131","author":"P Gupta","year":"2021","unstructured":"Gupta P, Pruthi V, Poluri KM (2021) Mechanistic insights into Candida biofilm eradication potential of eucalyptol. J Appl Microbiol 131(1):105\u2013123. https:\/\/doi.org\/10.1111\/jam.14940","journal-title":"J Appl Microbiol"},{"issue":"4","key":"876_CR36","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1111\/jam.14870","volume":"130","author":"HR Kim","year":"2021","unstructured":"Kim HR, Eom YB (2021) Antifungal and anti-biofilm effects of 6-shogaol against Candida auris. J Appl Microbiol 130(4):1142\u20131153. https:\/\/doi.org\/10.1111\/jam.14870","journal-title":"J Appl Microbiol"},{"key":"876_CR37","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3389\/fmicb.2019.01085","volume":"10","author":"Y Yan","year":"2019","unstructured":"Yan Y, Tan F, Miao H, Wang H, Cao Y (2019) Effect of Shikonin against Candida albicans biofilms. Front Microbiol 10:1085. https:\/\/doi.org\/10.3389\/fmicb.2019.01085","journal-title":"Front Microbiol"},{"key":"876_CR38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.biochi.2015.11.028","volume":"121","author":"H Yu","year":"2016","unstructured":"Yu H, Liu X, Wang C et al (2016) Assessing the potential of four cathelicidins for the management of mouse candidiasis and Candida albicans biofilms. Biochimie 121:268\u2013277. https:\/\/doi.org\/10.1016\/j.biochi.2015.11.028","journal-title":"Biochimie"},{"key":"876_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biocel.2016.09.008","volume":"80","author":"DG Yun","year":"2016","unstructured":"Yun DG, Lee DG (2016) Silibinin triggers yeast apoptosis related to mitochondrial Ca2+ influx in Candida albicans. Int J Biochem Cell Biol 80:1\u20139. https:\/\/doi.org\/10.1016\/j.biocel.2016.09.008","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"876_CR40","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1601-1546.2012.00285.x","volume":"22","author":"A Kishen","year":"2010","unstructured":"Kishen A, Haapasalo M (2010) Biofilm models and methods of biofilm assessment Introduction: changing paradigm in endodontic infection. Endod Topics 22(1):58\u201378. https:\/\/doi.org\/10.1111\/j.1601-1546.2012.00285.x","journal-title":"Endod Topics"},{"key":"876_CR41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3389\/fcimb.2018.00299","volume":"8","author":"JH Lee","year":"2018","unstructured":"Lee JH, Kim YG, Choi P, Ham J, Park JG, Lee J (2018) Antibiofilm and antivirulence activities of 6-gingerol and 6-shogaol against Candida albicans due to hyphal inhibition. Front Cel Infect Microbiol 8:299. https:\/\/doi.org\/10.3389\/fcimb.2018.00299","journal-title":"Front Cel Infect Microbiol"},{"key":"876_CR42","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bioorg.2019.03.023","volume":"87","author":"M Jovanovic","year":"2019","unstructured":"Jovanovic M, Radivojevic J, O\u2019Connor K et al (2019) Rhamnolipid inspired lipopeptides effective in preventing adhesion and biofilm formation of Candida albicans. Bioorg Chem 87:209\u2013217. https:\/\/doi.org\/10.1016\/j.bioorg.2019.03.023","journal-title":"Bioorg Chem"},{"issue":"4","key":"876_CR43","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1111\/1751-7915.13710","volume":"14","author":"JH Lee","year":"2020","unstructured":"Lee JH, Kim YG, Khadke SK, Lee J (2020) Antibiofilm and antifungal activities of medium-chain fatty acids against Candida albicans via mimicking of the quorum-sensing molecule farnesol. Microb Biotechnol 14(4):1353\u20131366. https:\/\/doi.org\/10.1111\/1751-7915.13710","journal-title":"Microb Biotechnol"},{"key":"876_CR44","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3389\/fmicb.2020.00756","volume":"11","author":"A Priya","year":"2020","unstructured":"Priya A, Pandian SK (2020) Piperine impedes biofilm formation and hyphal morphogenesis of Candida albicans. Front Microbiol 11:756. https:\/\/doi.org\/10.3389\/fmicb.2020.00756","journal-title":"Front Microbiol"},{"issue":"5","key":"876_CR45","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.micinf.2016.01.002","volume":"18","author":"M Gulati","year":"2016","unstructured":"Gulati M, Nobile CJ (2016) Candida albicans biofilms: development, regulation, and molecular mechanisms. Microbes Infect 18(5):310\u2013321. https:\/\/doi.org\/10.1016\/j.micinf.2016.01.002","journal-title":"Microbes Infect"},{"issue":"5","key":"876_CR46","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1128\/jcm.19.5.687-693.1984","volume":"19","author":"TJ Marrie","year":"1984","unstructured":"Marrie TJ, Costerton JW (1984) Scanning and transmission electron microscopy of in situ bacterial colonization of intravenous and intraarterial catheters. J Clin Microbiol 19(5):687\u2013693. https:\/\/doi.org\/10.1128\/jcm.19.5.687-693.1984","journal-title":"J Clin Microbiol"},{"key":"876_CR47","unstructured":"PubMed (2021) National Center for Biotechnology Information (NCBI). https:\/\/www.pubmed.ncbi.nlm.nih.gov. Accessed 18 Oct\u00a02021"},{"issue":"10","key":"876_CR48","doi-asserted-by":"publisher","first-page":"17913","DOI":"10.3390\/molecules201017913","volume":"20","author":"C Ma","year":"2015","unstructured":"Ma C, Du F, Yan L et al (2015) Potent activities of roemerine against Candida albicans and the underlying mechanisms. Molecules 20(10):17913\u201317928. https:\/\/doi.org\/10.3390\/molecules201017913","journal-title":"Molecules"},{"issue":"4","key":"876_CR49","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.13005\/bbra\/2598","volume":"14","author":"RR Goswami","year":"2017","unstructured":"Goswami RR, Pohare SD, Raut JS, Karuppayil SM (2017) Cell surface hydrophobicity as a virulence factor in Candida albicans. Biosci Biotechnol Res Asia 14(4):1503\u20131511. https:\/\/doi.org\/10.13005\/bbra\/2598","journal-title":"Biosci Biotechnol Res Asia"},{"issue":"6","key":"876_CR50","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1099\/jmm.0.000747","volume":"67","author":"A Kumari","year":"2018","unstructured":"Kumari A, Mankotia S, Chaubey B, Luthra M, Singh R (2018) Role of biofilm morphology, matrix content and surface hydrophobicity in the biofilm-forming capacity of various Candida species. J Med Microbiol 67(6):889\u2013892. https:\/\/doi.org\/10.1099\/jmm.0.000747","journal-title":"J Med Microbiol"},{"issue":"1","key":"876_CR51","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/mmi.14148","volume":"111","author":"G Huang","year":"2019","unstructured":"Huang G, Huang Q, Wei Y, Wang Y, Du H (2019) Multiple roles and diverse regulation of the Ras\/cAMP\/protein kinase A pathway in Candida albicans. Mol Microbiol 111(1):6\u201316. https:\/\/doi.org\/10.1111\/mmi.14148","journal-title":"Mol Microbiol"},{"issue":"3","key":"876_CR52","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ijantimicag.2014.05.017","volume":"44","author":"M Shahzad","year":"2014","unstructured":"Shahzad M, Sherry L, Rajendran R, Edwards CA, Combet E, Ramage G (2014) Utilising polyphenols for the clinical management of Candida albicans biofilms. Int J Antimicrob Agents 44(3):269\u2013273. https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.05.017","journal-title":"Int J Antimicrob Agents"},{"issue":"22","key":"876_CR53","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.2217\/nnm-2018-0183","volume":"13","author":"V Palmieri","year":"2018","unstructured":"Palmieri V, Bugli F, Cacaci M, Perini G, Maio F, Delogu G, Torelli R, Conti C, Sanguinetti M, Spirito M, Zanoni R, Papi M (2018) Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites. Nanomedicine 13(22):2867\u20132879. https:\/\/doi.org\/10.2217\/nnm-2018-0183","journal-title":"Nanomedicine"},{"key":"876_CR54","doi-asserted-by":"publisher","unstructured":"Maa S, Moserb D, Han F, Leonharde M, Schneider-Sticklere B, Tan Y (2020) Preparation and antibiofilm studies of curcumin loaded chitosan nanoparticles against polymicrobial biofilms of Candida albicans and Staphylococcus aureus. Carbohydr Polym 241:116254. https:\/\/doi.org\/10.1016\/j.carbpol.2020.116254","DOI":"10.1016\/j.carbpol.2020.116254"},{"key":"876_CR55","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jconrel.2014.06.055","volume":"192","author":"N Nafee","year":"2014","unstructured":"Nafee N, Husari A, Maurer CK et al (2014) Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors. J Control Release 192:131\u2013140. https:\/\/doi.org\/10.1016\/j.jconrel.2014.06.055","journal-title":"J Control Release"},{"key":"876_CR56","doi-asserted-by":"publisher","unstructured":"Lobo CIV, de A. Lopes ACU, Klein MI (2021) Compounds with distinct targets present diverse antimicrobial and antibiofilm efficacy against Candida albicans and Streptococcus mutans, and combinations of compounds potentiate their effect. J Fungi 7(5):340. https:\/\/doi.org\/10.3390\/jof7050340","DOI":"10.3390\/jof7050340"},{"issue":"8","key":"876_CR57","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1046\/j.1462-5822.2002.00206.x","volume":"4","author":"P Sundstrom","year":"2002","unstructured":"Sundstrom P (2002) Adhesion in Candida spp. Cell Microbiol 4(8):461\u2013469. https:\/\/doi.org\/10.1046\/j.1462-5822.2002.00206.x","journal-title":"Cell Microbiol"},{"issue":"4","key":"876_CR58","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1128\/EC.3.4.955-965.2004","volume":"3","author":"PWJ de Groot","year":"2004","unstructured":"de Groot PWJ, de Boer AD, Cunningham J et al (2004) Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins. Eukaryot Cell 3(4):955\u2013965. https:\/\/doi.org\/10.1128\/EC.3.4.955-965.2004","journal-title":"Eukaryot Cell"},{"key":"876_CR59","doi-asserted-by":"publisher","first-page":"153033","DOI":"10.1016\/j.phymed.2019.153033","volume":"63","author":"JH Leea","year":"2019","unstructured":"Leea JH, Kima YG, Khadkea SK, Yamanob A, Woob JT, Lee J (2019) Antimicrobial and antibiofilm activities of prenylated flavanones from Macaranga tanarius. Phytomedicine 63:153033. https:\/\/doi.org\/10.1016\/j.phymed.2019.153033","journal-title":"Phytomedicine"},{"key":"876_CR60","doi-asserted-by":"publisher","first-page":"103503","DOI":"10.1016\/j.jprot.2019.103503","volume":"208","author":"KG Prasath","year":"2018","unstructured":"Prasath KG, Sethupathy S, Pandian SK (2018) Proteomic analysis uncovers the modulation of ergosterol, sphingolipid and oxidative stress pathway by myristic acid impeding biofilm and virulence in Candida albicans. J Proteomics 208:103503. https:\/\/doi.org\/10.1016\/j.jprot.2019.103503","journal-title":"J Proteomics"},{"issue":"2","key":"876_CR61","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/08927014.2020.1730333","volume":"36","author":"YG Kim","year":"2020","unstructured":"Kim YG, Lee JH, Park JG, Lee J (2020) Inhibition of Candida albicans and Staphylococcus aureus biofilms by centipede oil and linoleic acid. Biofouling 36(2):126\u2013137. https:\/\/doi.org\/10.1080\/08927014.2020.1730333","journal-title":"Biofouling"},{"key":"876_CR62","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ejmech.2019.01.012","volume":"165","author":"F Pandolfi","year":"2019","unstructured":"Pandolfi F, D\u2019Acierno F, Bortolami M et al (2019) Searching for new agents active against Candida albicans biofilm: a series of indole derivatives, design, synthesis and biological evaluation. Eur J Med Chem 165:93\u2013106. https:\/\/doi.org\/10.1016\/j.ejmech.2019.01.012","journal-title":"Eur J Med Chem"},{"issue":"3","key":"876_CR63","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/jof6030099","volume":"6","author":"R Kov\u00e1cs","year":"2020","unstructured":"Kov\u00e1cs R, Majoros L (2020) Fungal quorum-sensing molecules: a review of their antifungal effect against Candida biofilms. J Fungi 6(3):99. https:\/\/doi.org\/10.3390\/jof6030099","journal-title":"J Fungi"},{"issue":"6","key":"876_CR64","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2323\/jgam.2018.12.002","volume":"65","author":"P Singkum","year":"2020","unstructured":"Singkum P, Muangkaew W, Suwanmanee S, Pumeesat P, Wongsuk T, Luplertlop N (2020) Suppression of the pathogenicity of Candida albicans by the quorum-sensing molecules farnesol and tryptophol. J Gen Appl Microbiol 65(6):277\u2013283. https:\/\/doi.org\/10.2323\/jgam.2018.12.002","journal-title":"J Gen Appl Microbiol"},{"key":"876_CR65","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.3892\/mmr.2019.9981","volume":"19","author":"S Sebaa","year":"2019","unstructured":"Sebaa S, Boucherit-Otmani Z, Courtois P (2019) Effects of tyrosol and farnesol on Candida albicans biofilm. Mol Med Rep 19:3201\u20133209. https:\/\/doi.org\/10.3892\/mmr.2019.9981","journal-title":"Mol Med Rep"},{"issue":"10","key":"876_CR66","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1128\/EC.00194-06","volume":"5","author":"CJ Nobile","year":"2006","unstructured":"Nobile CJ, Nett JE, Andes DR, Mitchell AP (2006) Function of Candida albicans adhesin HWP1 in biofilm formation. Eukaryot Cell 5(10):1604\u20131610. https:\/\/doi.org\/10.1128\/EC.00194-06","journal-title":"Eukaryot Cell"},{"issue":"7","key":"876_CR67","doi-asserted-by":"publisher","first-page":"0636","DOI":"10.1371\/journal.ppat.0020063","volume":"2","author":"CJ Nobile","year":"2006","unstructured":"Nobile CJ, Andes DR, Nett JE et al (2006) Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog 2(7):0636\u20130649. https:\/\/doi.org\/10.1371\/journal.ppat.0020063","journal-title":"PLoS Pathog"},{"issue":"4","key":"876_CR68","first-page":"743","volume":"28","author":"CF Orsi","year":"2014","unstructured":"Orsi CF, Sabia C, Ardizzoni A et al (2014) Inhibitory effects of different lactobacilli on Candida albicans hyphal formation and biofilm development. J Biol Regul Homeost 28(4):743\u2013752","journal-title":"J Biol Regul Homeost"},{"key":"876_CR69","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1099\/mic.0.033985-0","volume":"156","author":"T Oura","year":"2010","unstructured":"Oura T, Kajiwara S (2010) Candida albicans sphingolipid C9- methyltransferase is involved in hyphal elongation. Microbiology 156:1234\u20131243. https:\/\/doi.org\/10.1099\/mic.0.033985-0","journal-title":"Microbiology"},{"key":"876_CR70","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.plipres.2015.11.003","volume":"61","author":"A Rella","year":"2016","unstructured":"Rella A, Farnoud AM, Del Poeta M (2016) Plasma membrane lipids and their role in fungal virulence. Prog Lipid Res 61:63\u201372. https:\/\/doi.org\/10.1016\/j.plipres.2015.11.003","journal-title":"Prog Lipid Res"},{"key":"876_CR71","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1099\/mic.0.051086-0","volume":"157","author":"AA Lattif","year":"2011","unstructured":"Lattif AA, Mukherjee PK, Chandra J et al (2011) Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. Microbiology 157:3232\u20133242. https:\/\/doi.org\/10.1099\/mic.0.051086-0","journal-title":"Microbiology"},{"key":"876_CR72","doi-asserted-by":"publisher","unstructured":"Hara T, Sonoi A, Handa T et al (2021) Unsaturated fatty acid salts remove biofilms on dentures. Sci Rep 11(1):12524. https:\/\/doi.org\/10.1038\/s41598-021-92044-y","DOI":"10.1038\/s41598-021-92044-y"},{"key":"876_CR73","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ejmech.2016.04.020","volume":"118","author":"TVK Reddy","year":"2016","unstructured":"Reddy TVK, Jyotsna A, Devi BLAP, Prasad RBN, Poornachandra Y, Kumar CG (2016) Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. Eur J Med Chem 118:98\u2013106. https:\/\/doi.org\/10.1016\/j.ejmech.2016.04.020","journal-title":"Eur J Med Chem"},{"key":"876_CR74","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1083\/jcb.145.4.757","volume":"145","author":"F Madeo","year":"1999","unstructured":"Madeo F, Frohlich E, Ligr M et al (1999) Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145:757\u2013767. https:\/\/doi.org\/10.1083\/jcb.145.4.757","journal-title":"J Cell Biol"},{"key":"876_CR75","doi-asserted-by":"publisher","unstructured":"Zhang M, Chang W, Shi H, Li Y, Zheng S, Lou WLH (2018) Floricolin C elicits intracellular reactive oxygen species accumulation and disrupts mitochondria to exert fungicidal action. FEMS Yeast Res 18(1). https:\/\/doi.org\/10.1093\/femsyr\/foy002","DOI":"10.1093\/femsyr\/foy002"},{"key":"876_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mib.2019.04.001","volume":"52","author":"G Wall","year":"2019","unstructured":"Wall G, Montelongo-Jauregui D, Bonifacio BV, Lopez-Ribot JL, Uppuluri P (2019) Candida albicans biofilm growth and dispersal: contributions to pathogenesis. Curr Opin Microbiol 52:1\u20136. https:\/\/doi.org\/10.1016\/j.mib.2019.04.001","journal-title":"Curr Opin Microbiol"},{"key":"876_CR77","doi-asserted-by":"publisher","unstructured":"Hadanu R, Mastjeh S, Sholikhah EN, Wijayanti MA, Tahir I (2007) Quantitative structure-activity relationship analysis (QSAR) of antimalarial 1,10-phenanthroline derivatives compounds. Indo J Chem 7(1):72\u201377. https:\/\/doi.org\/10.22146\/ijc.21716","DOI":"10.22146\/ijc.21716"},{"issue":"1","key":"876_CR78","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5941\/MYCO.2017.45.1.25","volume":"45","author":"S Setiawati","year":"2017","unstructured":"Setiawati S, Nuryastuti T, Ngatidjan N et al (2017) In vitro antifungal activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide against Candida albicans and its effects on membrane integrity. Mycobiology 45(1):25\u201330. https:\/\/doi.org\/10.5941\/MYCO.2017.45.1.25","journal-title":"Mycobiology"},{"issue":"2","key":"876_CR79","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.mycmed.2017.12.010","volume":"28","author":"T Nuryastuti","year":"2018","unstructured":"Nuryastuti T, Setiawati S, Ngatidjan N et al (2018) Antibiofilm activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide against Candida albicans. J Mycol Med 28(2):367\u2013373. https:\/\/doi.org\/10.1016\/j.mycmed.2017.12.010","journal-title":"J Mycol Med"},{"issue":"12","key":"876_CR80","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1021\/acs.jnatprod.5b00744","volume":"78","author":"Q Favre-Godal","year":"2015","unstructured":"Favre-Godal Q, Dorsaz S, Queiroz EF et al (2015) Anti-Candida cassane-type diterpenoids from the root bark of Swartzia simplex. J Nat Prod 78(12):2994\u20133004. https:\/\/doi.org\/10.1021\/acs.jnatprod.5b00744","journal-title":"J Nat Prod"},{"key":"876_CR81","doi-asserted-by":"publisher","unstructured":"Jafri H, Ahmad I (2020) Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis. J Mycol Med 30(1):100911. https:\/\/doi.org\/10.1016\/j.mycmed.2019.100911","DOI":"10.1016\/j.mycmed.2019.100911"},{"key":"876_CR82","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.ijantimicag.2008.01.028","volume":"31","author":"S Dalleau","year":"2008","unstructured":"Dalleau S, Cateau E, Berges T, Berjeaud JM, Imbert C (2008) In vitro activity of terpenes against Candida biofilms. Int J Antimicrob Agents 31:572\u2013576. https:\/\/doi.org\/10.1016\/j.ijantimicag.2008.01.028","journal-title":"Int J Antimicrob Agents"},{"key":"876_CR83","doi-asserted-by":"publisher","unstructured":"Miranda-Cadena K, Marcos-Arias C, Mateo E, Aguirre-Urizar JM, Quindos G, Eraso E (2021) In vitro activities of carvacrol, cinnamaldehyde and thymol against Candida biofilms. Biomed Pharmacother 143:112218. https:\/\/doi.org\/10.1016\/j.biopha.2021.112218","DOI":"10.1016\/j.biopha.2021.112218"},{"key":"876_CR84","doi-asserted-by":"publisher","unstructured":"Al-Ani E, Heaselgrave W (2022) The investigation of thymol formulations containing poloxamer 407 and hydroxypropyl methylcellulose to inhibit Candida biofilm formation and demonstrate improved bio-compatibility. Pharmaceuticals 15(1):71. https:\/\/doi.org\/10.3390\/ph15010071","DOI":"10.3390\/ph15010071"},{"key":"876_CR85","doi-asserted-by":"publisher","unstructured":"Vila T, Lopez-Ribot JL (2017) Screening the pathogen box for identification of Candida albicans biofilm inhibitors. Antimicrob Agents Chemother 61(1):e02006\u201316. https:\/\/doi.org\/10.1128\/AAC.02006-16","DOI":"10.1128\/AAC.02006-16"},{"key":"876_CR86","doi-asserted-by":"publisher","unstructured":"Fathallah N, Raafat MM, Issa MY et al (2019) Bio-guided fractionation of prenylated benzaldehyde derivatives as potent antimicrobial and antibiofilm from Ammi majus l. fruits-associated Aspergillus amstelodami. Molecules 24(22):4118. https:\/\/doi.org\/10.3390\/molecules24224118","DOI":"10.3390\/molecules24224118"},{"key":"876_CR87","doi-asserted-by":"publisher","unstructured":"Wong SSW, Kao RYT, Yuen KY, Wang Y, Yang D, Samaranayake LP, Seneviratne CJ (2014) In vitro and in vivo activity of a novel antifungal small molecule against Candida infections. PLoS One 22;9(1):e85836. https:\/\/doi.org\/10.1371\/journal.pone.0085836","DOI":"10.1371\/journal.pone.0085836"},{"key":"876_CR88","doi-asserted-by":"publisher","unstructured":"Feldman M, Al-Quntar A, Polacheck I, Friedman M, Steinberg D (2014) Therapeutic potential of thiazolidinedione-8 as an antibiofilm agent against Candida albicans. PLoS One 9(5):e93225. https:\/\/doi.org\/10.1371\/journal.pone.0093225","DOI":"10.1371\/journal.pone.0093225"},{"key":"876_CR89","doi-asserted-by":"publisher","unstructured":"Navarathna DHMLP, Hornby JM, Krishnan N, Parkhurst A, Duhamel GE, Nickerson KW (n.d.) Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect Immun 75(4):1609\u20131618. https:\/\/doi.org\/10.1128\/IAI.01182-06","DOI":"10.1128\/IAI.01182-06"},{"key":"876_CR90","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fcimb.2017.00447","volume":"90 7","author":"RK Manoharan","year":"2017","unstructured":"Manoharan RK, Lee JH, Kim YG, Lee J (2017) Alizarin and chrysazin inhibit biofilm and hyphal formation by Candida albicans. Front Cell Infect Microbiol 90 7:447. https:\/\/doi.org\/10.3389\/fcimb.2017.00447","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"876_CR91","doi-asserted-by":"publisher","first-page":"18941","DOI":"10.1038\/s41598-019-55379-1","volume":"9","author":"H Mohammad","year":"2019","unstructured":"Mohammad H, Eldesouky HE, Hazbun T, Mayhoub AS, Seleem MN (2019) Identification of a phenylthiazole small molecule with dual antifungal and antibiofilm activity against Candida albicans and Candida auris. Sci Rep 9(1):18941. https:\/\/doi.org\/10.1038\/s41598-019-55379-1","journal-title":"Sci Rep"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-022-00876-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-022-00876-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-022-00876-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T21:46:30Z","timestamp":1709934390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-022-00876-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["876"],"URL":"https:\/\/doi.org\/10.1007\/s42770-022-00876-1","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,28]]},"assertion":[{"value":"22 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}