{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:10:25Z","timestamp":1786983025702,"version":"build-2736575974"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["MCTI\/CT-Sa\u00fade No 52\/2022 - A\u00e7\u00f5es em Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o para o enfrentamento da Resist\u00eancia Antimicrobiana (RAM)"],"award-info":[{"award-number":["MCTI\/CT-Sa\u00fade No 52\/2022 - A\u00e7\u00f5es em Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o para o enfrentamento da Resist\u00eancia Antimicrobiana (RAM)"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.554\/2019"],"award-info":[{"award-number":["E-26\/211.554\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s42770-024-01311-3","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T01:01:55Z","timestamp":1713142915000},"page":"1415-1425","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic determinants of antimicrobial resistance in polymyxin B resistant Pseudomonas aeruginosa isolated from airways of patients with cystic fibrosis"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-7657","authenticated-orcid":false,"given":"Felipe A.","family":"Sim\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-2215","authenticated-orcid":false,"given":"Mila M.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-0821","authenticated-orcid":false,"given":"Helo\u00edsa S.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-101X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0636-1520","authenticated-orcid":false,"given":"Robson S.","family":"Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"1311_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s11274-019-2739-1","volume":"35","author":"KA Mielko","year":"2019","unstructured":"Mielko KA, Jab\u0142o\u0144ski SJ, Milczewska J, Sands D, \u0141ukaszewicz M, M\u0142ynarz P (2019) Metabolomic studies of Pseudomonas aeruginosa. World J Microbiol Biotechnol 35:178. https:\/\/doi.org\/10.1007\/s11274-019-2739-1","journal-title":"World J Microbiol Biotechnol"},{"key":"1311_CR2","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1055\/s-0039-1697975","volume":"40","author":"CH Goss","year":"2019","unstructured":"Goss CH (2019) Acute pulmonary exacerbation in cystic fibrosis. Semin Respir Crit Care Med 40:792\u2013803. https:\/\/doi.org\/10.1055\/s-0039-1697975","journal-title":"Semin Respir Crit Care Med"},{"key":"1311_CR3","doi-asserted-by":"publisher","first-page":"e0265129","DOI":"10.1371\/journal.pone.0265129","volume":"17","author":"LJ Rojas","year":"2022","unstructured":"Rojas LJ, Yasmin M, Benjamino J et al (2022) Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: a population-level analysis beyond susceptibility testing. PLoS ONE 17:e0265129. https:\/\/doi.org\/10.1371\/journal.pone.0265129","journal-title":"PLoS ONE"},{"key":"1311_CR4","doi-asserted-by":"publisher","first-page":"1104856","DOI":"10.3389\/fphys.2023.1104856","volume":"14","author":"N Reyne","year":"2023","unstructured":"Reyne N, McCarron A, Cmielewski P, Parsons D, Donnelley M (2023) To bead or not to bead: a review of Pseudomonas aeruginosa lung infection models for cystic fibrosis. Front Physiol 14:1104856. https:\/\/doi.org\/10.3389\/fphys.2023.1104856","journal-title":"Front Physiol"},{"key":"1311_CR5","doi-asserted-by":"publisher","first-page":"212527","DOI":"10.7573\/dic.212527","volume":"7","author":"M Bassetti","year":"2018","unstructured":"Bassetti M, Vena A, Croxatto A, Righi E, Guery B (2018) How to manage Pseudomonas aeruginosa infections. Drugs Context 7:212527. https:\/\/doi.org\/10.7573\/dic.212527","journal-title":"Drugs Context"},{"key":"1311_CR6","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/cxo.12621","volume":"101","author":"D Subedi","year":"2018","unstructured":"Subedi D, Vijay AK, Wilcox M (2018) Overview of mechanisms of antibiotic resistance in Pseudomonas aeruginosa: an ocular perspective. Clin Exp Optom 101:162\u2013171. https:\/\/doi.org\/10.1111\/cxo.12621","journal-title":"Clin Exp Optom"},{"key":"1311_CR7","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1128\/JCM.03264-15","volume":"54","author":"TJ Gniadek","year":"2016","unstructured":"Gniadek TJ, Carroll KC, Simner PJ (2016) Carbapenem-resistant non-glucose-fermenting gram-negative bacilli: the missing piece to the puzzle. J Clin Microbiol 54:1700\u20131710. https:\/\/doi.org\/10.1128\/JCM.03264-15","journal-title":"J Clin Microbiol"},{"key":"1311_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.biotechadv.2018.11.013","volume":"37","author":"Z Pang","year":"2019","unstructured":"Pang Z, Raudonis R, Glick BR, Lin T, Cheng Z (2019) Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnol Adv 37:177\u2013192. https:\/\/doi.org\/10.1016\/j.biotechadv.2018.11.013","journal-title":"Biotechnol Adv"},{"key":"1311_CR9","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3389\/fmicb.2014.00643","volume":"5","author":"AO Olaitan","year":"2014","unstructured":"Olaitan AO, Morand S, Rolain J (2014) Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol 5:643. https:\/\/doi.org\/10.3389\/fmicb.2014.00643","journal-title":"Front Microbiol"},{"key":"1311_CR10","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1136\/vr.105075","volume":"185","author":"A Scott","year":"2019","unstructured":"Scott A, Pottenger S, Timofte D et al (2019) Reservoirs of resistance: polymyxin resistance in veterinary-associated companion animal isolates of Pseudomonas aeruginosa. Vet Rec 185:206. https:\/\/doi.org\/10.1136\/vr.105075","journal-title":"Vet Rec"},{"key":"1311_CR11","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/lam.13270","volume":"70","author":"H Tahmasebi","year":"2019","unstructured":"Tahmasebi H, Dehbashi S, Arabestani MR (2019) New approach to identify colistin-resistant Pseudomonas aeruginosa by high-resolution melting curve analysis assay. Lett Appl Microbiol 70:290\u2013299. https:\/\/doi.org\/10.1111\/lam.13270","journal-title":"Lett Appl Microbiol"},{"key":"1311_CR12","doi-asserted-by":"publisher","first-page":"e000167","DOI":"10.1099\/mgen.0.000167","volume":"4","author":"D Williams","year":"2018","unstructured":"Williams D, Fothergill JL, Evans B et al (2018) Transmission and lineage displacement drive rapid population genomic flux in cystic fibrosis airway infections of a Pseudomonas aeruginosa epidemic strain. Microb Genom 4:e000167. https:\/\/doi.org\/10.1099\/mgen.0.000167","journal-title":"Microb Genom"},{"key":"1311_CR13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0140-6736(96)05169-0","volume":"348","author":"K Cheng","year":"1996","unstructured":"Cheng K, Smyth RL, Govan JR et al (1996) Spread of \u03b2-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic. Lancet 348:639\u2013642. https:\/\/doi.org\/10.1016\/S0140-6736(96)05169-0","journal-title":"Lancet"},{"key":"1311_CR14","doi-asserted-by":"publisher","first-page":"e00019","DOI":"10.1128\/CMR.00019-18","volume":"31","author":"MD Parkins","year":"2018","unstructured":"Parkins MD, Somayaji R, Waters VJ (2018) Epidemiology, biology, and impact of clonal Pseudomonas aeruginosa infections in cystic fibrosis. Clin Microbiol Rev 31:e00019\u2013e00018. https:\/\/doi.org\/10.1128\/CMR.00019-18","journal-title":"Clin Microbiol Rev"},{"key":"1311_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.12688\/wellcomeopenres.14265.2","volume":"3","author":"JA Lees","year":"2018","unstructured":"Lees JA, Kendall M, Parkhill J, Colijn C, Bentley SD, Harris SR (2018) Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study. Wellcome Open Res 3:33. https:\/\/doi.org\/10.12688\/wellcomeopenres.14265.2","journal-title":"Wellcome Open Res"},{"key":"1311_CR16","doi-asserted-by":"publisher","first-page":"000699","DOI":"10.1099\/mgen.0.000699","volume":"7","author":"B Bogaerts","year":"2021","unstructured":"Bogaerts B, Winand R, Braekel JV et al (2021) Evaluation of WGS performance for bacterial pathogen characterization with the Illumina technology optimized for time-critical situatuions. Microb Genom 7:000699. https:\/\/doi.org\/10.1099\/mgen.0.000699","journal-title":"Microb Genom"},{"key":"1311_CR17","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s00284-020-02337-0","volume":"78","author":"MM Almeida","year":"2021","unstructured":"Almeida MM, Freitas MT, Folescu TW et al (2021) Carbapenem-resistant Pseudomonas aeruginosa in chronic lung infection: current resistance profile and hypermutability in patients with cystic fibrosis. Curr Microbiol 78:696\u2013704. https:\/\/doi.org\/10.1007\/s00284-020-02337-0","journal-title":"Curr Microbiol"},{"key":"1311_CR18","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciy381","volume":"67","author":"JM Miller","year":"2018","unstructured":"Miller JM, Binnicker MJ, Campbell S et al (2018) A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis 67:e1\u2013e94. https:\/\/doi.org\/10.1093\/cid\/ciy381","journal-title":"Clin Infect Dis"},{"key":"1311_CR19","volume-title":"M100","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2023","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2023) Performance standards for antimicrobial susceptibility testing. M100, 33rd edn. Clinical and Laboratory Standards Institute, Wayne, PA","edition":"33"},{"key":"1311_CR20","volume-title":"Performance standards for antimicrobial susceptibility tests for bacteria that grow aerobically. M07-A10","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2018","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2018) Performance standards for antimicrobial susceptibility tests for bacteria that grow aerobically. M07-A10, 11th edn. Clinical and Laboratory Standards Institute, Wayne, PA","edition":"11"},{"key":"1311_CR21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos AP, Srinivasan A, Carey RB et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268\u2013281. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03570.x","journal-title":"Clin Microbiol Infect"},{"key":"1311_CR22","doi-asserted-by":"publisher","first-page":"e1005595","DOI":"10.1371\/journal.pcbi.1005595","volume":"13","author":"RR Wick","year":"2017","unstructured":"Wick RR, Judd LM, Gorrie CL, Holt KE (2017) Unicycler: resolving bacterial genome assemblies from short and long sequencing reads. PLoS Comput Biol 13:e1005595. https:\/\/doi.org\/10.1371\/journal.pcbi.1005595","journal-title":"PLoS Comput Biol"},{"key":"1311_CR23","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.1093\/bioinformatics\/btw493","volume":"32","author":"D Antipov","year":"2016","unstructured":"Antipov D, Hartwick N, Shen M, Raiko M, Lapidus A, Pevzner P (2016) PlasmidSPAdes: assembling plasmids from whole genome sequencing data. Bioinformatics 32:3380\u20133387. https:\/\/doi.org\/10.1093\/bioinformatics\/btw493","journal-title":"Bioinformatics"},{"key":"1311_CR24","doi-asserted-by":"publisher","first-page":"000685","DOI":"10.1099\/mgen.0.000685","volume":"7","author":"O Schwengers","year":"2021","unstructured":"Schwengers O, Jelonek L, Dieckmann MA, Beyvers S, Blom J, Goesmann A (2021) Bakta: rapid and standardized annotation of bacterial genomes via alignment-free sequence identification. Microb Genom 7:000685. https:\/\/doi.org\/10.1099\/mgen.0.000685","journal-title":"Microb Genom"},{"key":"1311_CR25","doi-asserted-by":"publisher","first-page":"W16","DOI":"10.1093\/nar\/gkw387","volume":"44","author":"D Arndt","year":"2016","unstructured":"Arndt D, Grant JR, Marcu A et al (2016) PHASTER: a better, faster version of the PHAST phage search tool. Nucleic Acids Res 44:W16\u201321. https:\/\/doi.org\/10.1093\/nar\/gkw387","journal-title":"Nucleic Acids Res"},{"key":"1311_CR26","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1101\/gr.232397.117","volume":"28","author":"Z Zhou","year":"2018","unstructured":"Zhou Z, Alikhan N, Sergeant MJ et al (2018) GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogens. Genome Res 28:1395\u20131404. https:\/\/doi.org\/10.1101\/gr.232397.117","journal-title":"Genome Res"},{"key":"1311_CR27","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/antibiotics10070827","volume":"10","author":"E Reece","year":"2021","unstructured":"Reece E, Bettio PH, Renwick J (2021) Polymicrobial interactions in the cystic fibrosis airway microbiome impact the antimicrobial susceptibility of Pseudomonas aeruginosa. Antibiot (Basel) 10:827. https:\/\/doi.org\/10.3390\/antibiotics10070827","journal-title":"Antibiot (Basel)"},{"key":"1311_CR28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-031-08491-1_5","volume":"1386","author":"P Laborda","year":"2022","unstructured":"Laborda P, Hernando-Amado S, Mart\u00ednez JL, Sanz-Garc\u00eda F (2022) Antibiotic resistance in Pseudomonas. Adv Exp Med Biol 1386:117\u2013143. https:\/\/doi.org\/10.1007\/978-3-031-08491-1_5","journal-title":"Adv Exp Med Biol"},{"key":"1311_CR29","first-page":"495","volume":"95","author":"MJ Saadh","year":"2022","unstructured":"Saadh MJ, Lohrasbi A, Ghasemian E et al (2022) The status of carbapenem resistance in cystic fibrosis: a systematic review and meta-analysis. Yale J Biol Med 95:495\u2013506","journal-title":"Yale J Biol Med"},{"key":"1311_CR30","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.ijantimicag.2018.05.008","volume":"52","author":"N Courtois","year":"2018","unstructured":"Courtois N, Caspar Y, Maurin M (2018) Phenotypic and genetic resistance traits of Pseudomonas aeruginosa strains infecting cystic fibrosis patients: a French cohort study. Int J Antimicrob Agents 52:358\u2013364. https:\/\/doi.org\/10.1016\/j.ijantimicag.2018.05.008","journal-title":"Int J Antimicrob Agents"},{"key":"1311_CR31","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.ijantimicag.2019.02.022","volume":"53","author":"R Zamudio","year":"2019","unstructured":"Zamudio R, Hijazi K, Joshi C, Aitken E, Oggioni M, Gould IM (2019) Phylogenetic analysis of resistance to ceftazidime\/avibactam, ceftolozane\/tazobactam and carbapenems in piperacillin\/tazobactam-resistant Pseudomonas aeruginosa from cystic fibrosis patients. Int J Antimicrob Agents 53:774\u2013780. https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.02.022","journal-title":"Int J Antimicrob Agents"},{"key":"1311_CR32","doi-asserted-by":"publisher","unstructured":"Sherrard LJ, Wee BA, Duplancic C et al (2022) Emergence and impact of oprD mutations in Pseudomonas aeruginosa strains in cystic fibrosis. J Cyst Fibros. 21, e-35-e43. https:\/\/doi.org\/10.1016\/j.jcf.2021.03.007","DOI":"10.1016\/j.jcf.2021.03.007"},{"key":"1311_CR33","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1128\/JCM.02638-12","volume":"51","author":"L Lutz","year":"2013","unstructured":"Lutz L, Le\u00e3o RS, Ferreira AG et al (2013) Hypermutable Pseudomonas aeruginosa in cystic fibrosis patients from two Brazilian cities. J Clin Microbiol 51:927\u2013930. https:\/\/doi.org\/10.1128\/JCM.02638-12","journal-title":"J Clin Microbiol"},{"key":"1311_CR34","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1111\/apm.12463","volume":"123","author":"AG Ferreira","year":"2015","unstructured":"Ferreira AG, Le\u00e3o RS, Carvalho-Assef AP et al (2015) Low-level resistance and clonal diversity of Pseudomonas aeruginosa among chronically colonized cystic fibrosis patients. APMIS 123:1061\u20131068. https:\/\/doi.org\/10.1111\/apm.12463","journal-title":"APMIS"},{"key":"1311_CR35","doi-asserted-by":"publisher","first-page":"5104","DOI":"10.1128\/AAC.01230-13","volume":"57","author":"O Zusman","year":"2013","unstructured":"Zusman O, Avni T, Leibovici L et al (2013) Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems. Antimicrob Agents Chemother 57:5104\u20135111. https:\/\/doi.org\/10.1128\/AAC.01230-13","journal-title":"Antimicrob Agents Chemother"},{"key":"1311_CR36","doi-asserted-by":"publisher","first-page":"e00031","DOI":"10.1128\/CMR.00031-19","volume":"32","author":"JP Horcajada","year":"2019","unstructured":"Horcajada JP, Montero M, Oliver A et al (2019) Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections. Clin Microbiol Rev 32:e00031\u2013e00019. https:\/\/doi.org\/10.1128\/CMR.00031-19","journal-title":"Clin Microbiol Rev"},{"key":"1311_CR37","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1111\/crj.12787","volume":"12","author":"F Lucca","year":"2018","unstructured":"Lucca F, Guarnieri M, Ros M, Muffato G, Rigoli R, Dalt L (2018) Antibiotic resistance evolution of Pseudomonas aeruginosa in cystic fibrosis patients (2010\u20132013). Clin Respir J 12:2189\u20132196. https:\/\/doi.org\/10.1111\/crj.12787","journal-title":"Clin Respir J"},{"key":"1311_CR38","doi-asserted-by":"publisher","unstructured":"Pedersen SS, Olesen HV, Jensen-Fangel S, N\u00f8rskov-Lauritsen N, Wang M (2018) Colistin resistance in Pseudomonas aeruginosa and Achromobacter spp. cultured from Danish cystic fibrosis patients is not related to plasmid-mediated expression of mcr-1. J Cyst Fibros 17(e22\u2013e23). https:\/\/doi.org\/10.1016\/j.jcf.2017.12.001","DOI":"10.1016\/j.jcf.2017.12.001"},{"key":"1311_CR39","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.ijantimicag.2017.01.023","volume":"49","author":"YM Wi","year":"2017","unstructured":"Wi YM, Choi J, Lee J et al (2017) Emergence of colistin resistance in Pseudomonas aeruginosa ST235 clone in South Korea. Int J Antimicrob Agents 49:767\u2013769. https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.01.023","journal-title":"Int J Antimicrob Agents"},{"key":"1311_CR40","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1034\/j.1399-3003.2000.16d30.x","volume":"16","author":"X Chen","year":"2020","unstructured":"Chen X, Xu J, Zhu Q, Ren Y, Zhao L (2020) Polymyxin B resistance rates in carbapenem-resistant Pseudomonas aeruginosa isolates and a comparison between Etest\u00ae and broth microdilution methods of antimicrobial susceptibility testing. Exp Ther Med 16:749\u2013767. https:\/\/doi.org\/10.1034\/j.1399-3003.2000.16d30.x","journal-title":"Exp Ther Med"},{"key":"1311_CR41","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3390\/antibiotics11060799","volume":"11","author":"C Xiao","year":"2022","unstructured":"Xiao C, Zhu Y, Yang Z et al (2022) Prevalence and molecular characteristics of polymyxin-resistant Pseudomonas aeruginosa in a Chinese tertiary teaching hospital. Antibiot (Basel) 11:799. https:\/\/doi.org\/10.3390\/antibiotics11060799","journal-title":"Antibiot (Basel)"},{"key":"1311_CR42","doi-asserted-by":"publisher","first-page":"308","DOI":"10.17843\/rpmesp.2021.382.6977","volume":"38","author":"M Zarate","year":"2021","unstructured":"Zarate M, Barrantes D, Cuicapuza D et al (2021) Frequency of colistin resistance in Pseudomonas aeruginosa: first report from Peru. Rev Peru Med Exp Salud Publica 38:308\u2013312. https:\/\/doi.org\/10.17843\/rpmesp.2021.382.6977","journal-title":"Rev Peru Med Exp Salud Publica"},{"key":"1311_CR43","doi-asserted-by":"publisher","first-page":"e00679","DOI":"10.1128\/AAC.00679-18","volume":"62","author":"E Snesrud","year":"2018","unstructured":"Snesrud E, Maybank R, Kwak YI, Jones AR, Hinkle MJ, McGann P (2018) Chromosomally encoded mcr-5 in colistin-nonsusceptible Pseudomonas aeruginosa. Antimicrob Agents Chemother 62:e00679\u2013e00618. https:\/\/doi.org\/10.1128\/AAC.00679-18","journal-title":"Antimicrob Agents Chemother"},{"key":"1311_CR44","doi-asserted-by":"publisher","first-page":"e20190237","DOI":"10.1590\/0037-8682-0237-2019","volume":"52","author":"F Hameed","year":"2019","unstructured":"Hameed F, Khan MA, Muhammad H, Sarwar T, Bilal H, Rehman TU (2019) Plasmid-mediated mcr-1 gene in Acinetobacter baumannii and Pseudomonas aeruginosa: first report from Pakistan. Rev Soc Bras Med Trop 52:e20190237. https:\/\/doi.org\/10.1590\/0037-8682-0237-2019","journal-title":"Rev Soc Bras Med Trop"},{"key":"1311_CR45","doi-asserted-by":"publisher","first-page":"105957","DOI":"10.1016\/j.ijantimicag.2020.105957","volume":"55","author":"A Lo Sciuto","year":"2020","unstructured":"Lo Sciuto A, Cervoni M, Stefanelli R, Mancone C, Imperi F (2020) Effect of lipid A aminoarabinosylation on Pseudomonas aeruginosa colistin resistance and fitness. Int J Antimicrob Agents 55:105957. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105957","journal-title":"Int J Antimicrob Agents"},{"key":"1311_CR46","doi-asserted-by":"publisher","unstructured":"Chen H, Mai H, Lopes B, Wen F, Patil S (2022) Novel Pseudomonas aeruginosa strains co-harbouring blaNDM\u20131 metallo \u03b2-lactamase and mcr-1 isolated from immunocompromised paediatric patients. Infect Drug Resist. 15, 2929\u20132936. https:\/\/doi.org\/10.2147\/IDR.S368566","DOI":"10.2147\/IDR.S368566"},{"key":"1311_CR47","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1034\/j.1399-3003.2000.16d30.x","volume":"16","author":"G D\u00f6ring","year":"2000","unstructured":"D\u00f6ring G, Conway SP, Heijerman HG et al (2000) Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus. Eur Respir J 16:749\u2013767. https:\/\/doi.org\/10.1034\/j.1399-3003.2000.16d30.x","journal-title":"Eur Respir J"},{"key":"1311_CR48","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3892\/mmr.2014.2685","volume":"11","author":"Y Li","year":"2015","unstructured":"Li Y, Zhang X, Wang C et al (2015) Characterization by phenotypic and genotypic methods of metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa isolated from patients with cystic fibrosis. Mol Med Rep 11:494\u2013498. https:\/\/doi.org\/10.3892\/mmr.2014.2685","journal-title":"Mol Med Rep"},{"key":"1311_CR49","doi-asserted-by":"publisher","first-page":"6735","DOI":"10.1128\/AAC.01046-16","volume":"60","author":"M Mustafa","year":"2016","unstructured":"Mustafa M, Chalhoub H, Denis O et al (2016) Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Northern Europe. Antimicrob Agents Chemother 60:6735\u20136741. https:\/\/doi.org\/10.1128\/AAC.01046-16","journal-title":"Antimicrob Agents Chemother"},{"key":"1311_CR50","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.pathol.2023.03.009","volume":"55","author":"X Kostoulias","year":"2023","unstructured":"Kostoulias X, Chang C, Wisniewski J, Abbott IJ, Zisis H, Dennison A (2023) Antimicrobial susceptibility of ceftolozane-tazobactam against multidrug-resistant Pseudomonas aeruginosa isolates from Melbourne. Australia Pathol 55:663\u2013668. https:\/\/doi.org\/10.1016\/j.pathol.2023.03.009","journal-title":"Australia Pathol"},{"key":"1311_CR51","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1099\/jmm.0.059220-0","volume":"62","author":"DM Hermes","year":"2013","unstructured":"Hermes DM, Pitt CP, Lutz L et al (2013) Evaluation of heteroresistance to polymyxin B among carbapenem-susceptible and -resistant Pseudomonas aeruginosa. J Med Microbiol 62:1184\u20131189. https:\/\/doi.org\/10.1099\/jmm.0.059220-0","journal-title":"J Med Microbiol"},{"key":"1311_CR52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s11908-018-0629-6","volume":"20","author":"L Nguyen","year":"2018","unstructured":"Nguyen L, Garcia J, Gruenberg K, MacDougall C (2018) Multidrug-resistant Pseudomonas infections: hard to treat, but hope on the horizon? Curr Infect Dis Rep 20:23. https:\/\/doi.org\/10.1007\/s11908-018-0629-6","journal-title":"Curr Infect Dis Rep"},{"key":"1311_CR53","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00103-012-1549-5","volume":"55","author":"KRINKO","year":"2012","unstructured":"KRINKO (2012) Hygiene measures for infection or colonization with multidrug-resistant gram-negative bacilli. Commission recommendation for hospital hygiene and infection prevention (KRINKO) at the Robert Koch Institute (RKI). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55:1311\u20131354. https:\/\/doi.org\/10.1007\/s00103-012-1549-5","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"1311_CR54","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s13756-019-0614-3","volume":"8","author":"A Wolfensberger","year":"2019","unstructured":"Wolfensberger A, Kuster SP, Marchesi M, Zbinden R, Hombach M (2019) The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods. Antimicrob Resist Infect Control 8:193. https:\/\/doi.org\/10.1186\/s13756-019-0614-3","journal-title":"Antimicrob Resist Infect Control"},{"key":"1311_CR55","doi-asserted-by":"publisher","first-page":"w30195","DOI":"10.4414\/smw.2022.w30195","volume":"152","author":"O Friedli","year":"2022","unstructured":"Friedli O, V\u00f6llmy I, Schrenzel J, Harbarth S, Kronenberg A (2022) Retrospective data analysis for definition of multidrug resistance in gram-negative bacteria - a consensus proposal. Swiss Med Wkly 152:w30195. https:\/\/doi.org\/10.4414\/smw.2022.w30195","journal-title":"Swiss Med Wkly"},{"key":"1311_CR56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40101-021-00269-7","volume":"40","author":"M Durda-Masny","year":"2021","unstructured":"Durda-Masny M, Go\u017adzikSpychalska J, John A et al (2021) The determinants of survival among adults with cystic fibrosis \u2013 a cohort study. J Physiol Anthropol 40:19. https:\/\/doi.org\/10.1186\/s40101-021-00269-7","journal-title":"J Physiol Anthropol"},{"key":"1311_CR57","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1590\/S1517-838220100004000028","volume":"41","author":"RS Le\u00e3o","year":"2010","unstructured":"Le\u00e3o RS, Carvalho-Assef AP, Ferreira AG et al (2010) Comparison of the worldwide transmissible Pseudomonas aeruginosa with isolates from Brazilian cystic fibrosis patients. Braz J Microbiol 41:1079\u20131081. https:\/\/doi.org\/10.1590\/S1517-838220100004000028","journal-title":"Braz J Microbiol"},{"key":"1311_CR58","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1136\/thoraxjnl-2015-208027","volume":"72","author":"MH Prickett","year":"2017","unstructured":"Prickett MH, Hauser AR, McColley SA et al (2017) Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene. Thorax 72:40\u201347. https:\/\/doi.org\/10.1136\/thoraxjnl-2015-208027","journal-title":"Thorax"},{"key":"1311_CR59","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1139\/cjm-2017-0380","volume":"63","author":"M Singh","year":"2017","unstructured":"Singh M, Yau YC, Wang S, Waters V, Kumar A (2017) MexXY efflux pump overexpression and aminoglycoside resistance in cystic fibrosis isolates of Pseudomonas aeruginosa from chronic infections. Can J Microbiol 63:929\u2013938. https:\/\/doi.org\/10.1139\/cjm-2017-0380","journal-title":"Can J Microbiol"},{"key":"1311_CR60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11274-018-2465-0","volume":"34","author":"M Suresh","year":"2018","unstructured":"Suresh M, Nithya N, Jayasree PR, Vimal KP, Kumar PR (2018) Mutational analyses of regulatory genes, mexR, nalC, nalD and mexZ of mexAB-oprM and mexXY operons, in efflux pump hyperexpressing multidrug-resistant clinical isolates of Pseudomonas aeruginosa. World J Microbiol Biotechnol 34:83. https:\/\/doi.org\/10.1007\/s11274-018-2465-0","journal-title":"World J Microbiol Biotechnol"},{"key":"1311_CR61","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.3389\/fmicb.2017.01847","volume":"8","author":"M Haenni","year":"2017","unstructured":"Haenni M, Bour M, Ch\u00e2tre P, Madec J, Pl\u00e9siat P, Jeannot K (2017) Resistance of animal strains of Pseudomonas aeruginosa to carbapenems. Front Microbiol 8:1847. https:\/\/doi.org\/10.3389\/fmicb.2017.01847","journal-title":"Front Microbiol"},{"key":"1311_CR62","doi-asserted-by":"publisher","first-page":"16463","DOI":"10.1038\/s41598-018-34694-z","volume":"8","author":"G Horna","year":"2018","unstructured":"Horna G, L\u00f3pez M, Guerra H, Sa\u00e9nz Y, Ruiz J (2018) Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa. Sci Rep 8:16463. https:\/\/doi.org\/10.1038\/s41598-018-34694-z","journal-title":"Sci Rep"},{"key":"1311_CR63","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ijantimicag.2007.12.016","volume":"31","author":"A Farra","year":"2008","unstructured":"Farra A, Islam S, Str\u00e5lfors A, S\u00f6rberg M, Wretlind B (2008) Role of outer membrane protein OprD and penicillin-binding proteins in resistance of Pseudomonas aeruginosa to imipenem and meropenem. Int J Antimicrob Agents 31:427\u2013433. https:\/\/doi.org\/10.1016\/j.ijantimicag.2007.12.016","journal-title":"Int J Antimicrob Agents"},{"key":"1311_CR64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s12275-016-5562-5","volume":"54","author":"CH Kim","year":"2016","unstructured":"Kim CH, Kang HY, Kim BR et al (2016) Mutational inactivation of OprD in carbapenem-resistant Pseudomonas aeruginosa isolates from Korean hospitals. J Microbiol 54:44\u201349. https:\/\/doi.org\/10.1007\/s12275-016-5562-5","journal-title":"J Microbiol"},{"key":"1311_CR65","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12866-016-0719-2","volume":"16","author":"C Kao","year":"2016","unstructured":"Kao C, Chen S, Hung K et al (2016) Overproduction of active efflux pump and variations of OprD dominate in imipenem-resistant Pseudomonas aeruginosa isolated from patients with bloodstream infections in Taiwan. BMC Microbiol 16:107. https:\/\/doi.org\/10.1186\/s12866-016-0719-2","journal-title":"BMC Microbiol"},{"key":"1311_CR66","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diagmicrobio.2013.11.027","volume":"78","author":"J Lee","year":"2014","unstructured":"Lee J, Ko KS (2014) Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates. Diagn Microbiol Infect Dis 78:271\u2013276. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2013.11.027","journal-title":"Diagn Microbiol Infect Dis"},{"key":"1311_CR67","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1093\/jac\/dku238","volume":"69","author":"J Lee","year":"2014","unstructured":"Lee J, Chung ES, Na IY, Kim H, Shin D, Ko KS (2014) Development of colistin resistance in pmrA-, phoP, parr- and cprr-inactivated mutants of Pseudomonas aeruginosa. J Antimicrob Chemother 69:2966\u20132971. https:\/\/doi.org\/10.1093\/jac\/dku238","journal-title":"J Antimicrob Chemother"},{"key":"1311_CR68","doi-asserted-by":"publisher","first-page":"ofw188","DOI":"10.1093\/ofid\/ofw188","volume":"3","author":"TN Domitrovic","year":"2016","unstructured":"Domitrovic TN, Hujer AM, Perez F et al (2016) Multidrug resistant Pseudomonas aeruginosa causing prosthetic valve endocarditis: a genetic-based chronicle of evolving antibiotic resistance. Open Forum Infect Dis 3:ofw188. https:\/\/doi.org\/10.1093\/ofid\/ofw188","journal-title":"Open Forum Infect Dis"},{"key":"1311_CR69","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1080\/22221751.2021.1968318","volume":"10","author":"JQ Teo","year":"2021","unstructured":"Teo JQ, Tang CY, Lim JC et al (2021) Genomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore. Emerg Microbes Infect 10:1706\u20131716. https:\/\/doi.org\/10.1080\/22221751.2021.1968318","journal-title":"Emerg Microbes Infect"},{"key":"1311_CR70","doi-asserted-by":"publisher","unstructured":"Hern\u00e1ndez-Garc\u00eda M, Garc\u00eda-Castillo M, Garc\u00eda-Fernand\u00e9z S et al (2021) Presence of chromosomal crpp-like genes is not always associated with ciprofloxacin resistance in Pseudomonas aeruginosa clinical isolates recovered in ICU patients from Portugal and Spain. Microorganisms 9(388). https:\/\/doi.org\/10.3390\/microorganisms9020388","DOI":"10.3390\/microorganisms9020388"},{"key":"1311_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1099\/jmm.0.000873","volume":"68","author":"A Rehman","year":"2019","unstructured":"Rehman A, Patrick WM, Lamont IL (2019) Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem. J Med Microbiol 68:1\u201310. https:\/\/doi.org\/10.1099\/jmm.0.000873","journal-title":"J Med Microbiol"},{"key":"1311_CR72","doi-asserted-by":"publisher","first-page":"421","DOI":"10.33073\/pjm-2021-040","volume":"70","author":"M Stasiak","year":"2021","unstructured":"Stasiak M, Ma\u0107kiw E, Kowalska J, Kucharek K, Postupolski J (2021) Silent genes: antimicrobial resistance and antibiotic production. Pol J Microbiol 70:421\u2013429. https:\/\/doi.org\/10.33073\/pjm-2021-040","journal-title":"Pol J Microbiol"},{"key":"1311_CR73","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jcf.2010.12.003","volume":"10","author":"RS Le\u00e3o","year":"2011","unstructured":"Le\u00e3o RS, Pereira RH, Folescu TW et al (2011) KPC-2 carbapenemase-producing Klebsiella pneumoniae isolates from patients with cystic fibrosis. J Cyst Fibros 10:140\u2013142. https:\/\/doi.org\/10.1016\/j.jcf.2010.12.003","journal-title":"J Cyst Fibros"},{"key":"1311_CR74","doi-asserted-by":"publisher","unstructured":"Alves DP, Carvalho-Assef AP, Concei\u00e7\u00e3o-Neto OC et al (2018) Enterobacter cloacae harbouring blaKPC\u20132 and qnrB-1 isolated from a cystic fibrosis patient: a case report. New Microbes New Infect. 25, 49\u201351. https:\/\/doi.org\/10.1016\/j.nmni.2018.06.010","DOI":"10.1016\/j.nmni.2018.06.010"},{"key":"1311_CR75","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1590\/0074-02760160130","volume":"111","author":"ER Rodrigues","year":"2016","unstructured":"Rodrigues ER, Rocha GA, Ferreira AG, Le\u00e3o RS, Albano RM, Marques EA (2016) Draft genome sequences of four Achromobacter ruhlandii strains isolated from cystic fibrosis patients. Mem Inst Oswaldo Cruz 111:777\u2013780. https:\/\/doi.org\/10.1590\/0074-02760160130","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"1311_CR76","doi-asserted-by":"publisher","first-page":"100640","DOI":"10.1016\/j.drup.2019.07.002","volume":"44","author":"J Botelho","year":"2019","unstructured":"Botelho J, Grosso F, Peixe L (2019) Antibiotic resistance in Pseudomonas aeruginosa \u2013 mechanisms, epidemiology and evolution. Drug Resist Updat 44:100640. https:\/\/doi.org\/10.1016\/j.drup.2019.07.002","journal-title":"Drug Resist Updat"},{"key":"1311_CR77","doi-asserted-by":"publisher","unstructured":"Johnson G, Banerjee S, Putonti C (2022) Diversity of Pseudomonas aeruginosa temperate phages. mSphere 7(e0101521). https:\/\/doi.org\/10.1128\/msphere.01015-21","DOI":"10.1128\/msphere.01015-21"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-024-01311-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-024-01311-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-024-01311-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T22:17:52Z","timestamp":1717625872000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-024-01311-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1311"],"URL":"https:\/\/doi.org\/10.1007\/s42770-024-01311-3","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"18 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study were in accordance with the ethical standards of the institutional research committee (CAAE: 79547616.1.0000.5259), and the approval was waived by the local Ethics Committee of Universidade do Estado do Rio de Janeiro, in view of the retrospective nature of the study and all the procedures were performed with samples stored in a bacteriological collection.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}