{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:07:06Z","timestamp":1782742026772,"version":"3.54.5"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s42770-024-01501-z","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T07:02:54Z","timestamp":1724742174000},"page":"3751-3758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary administration of Bacillus subtilis improves the health parameters and regulates the gene expression in mice receiving zearalenone-contaminated diet"],"prefix":"10.1007","volume":"55","author":[{"given":"Seyedehnegar","family":"Marashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Mostarshedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahel","family":"Ghorbanikalateh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Ghorbanikalateh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiyeh","family":"Zoshki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Taghavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-9611","authenticated-orcid":false,"given":"Ehsan","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Oskoueian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Faseleh","family":"Jahromi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Shokryazdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"1501_CR1","doi-asserted-by":"crossref","unstructured":"Luo S et al (2021) Contamination status of major mycotoxins in agricultural product and food stuff in Europe. 127:p108120","DOI":"10.1016\/j.foodcont.2021.108120"},{"key":"1501_CR2","doi-asserted-by":"crossref","unstructured":"Marin DE et al (2013) Effects of zearalenone on oxidative stress and inflammation in weanling piglets. 58:408\u2013415","DOI":"10.1016\/j.fct.2013.05.033"},{"key":"1501_CR3","doi-asserted-by":"crossref","unstructured":"Wu F et al (2021) Effects of zearalenone on genital organ development, serum immunoglobulin, antioxidant capacity, sex hormones and liver function of prepubertal gilts. 189:39\u201344","DOI":"10.1016\/j.toxicon.2020.11.005"},{"key":"1501_CR4","doi-asserted-by":"crossref","unstructured":"Virk P et al (2020) Protective effect of resveratrol against toxicity induced by the mycotoxin, zearalenone in a rat model. 146:111840","DOI":"10.1016\/j.fct.2020.111840"},{"key":"1501_CR5","doi-asserted-by":"crossref","unstructured":"Zhou J et al (2020) Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows. 6(3):372\u2013378","DOI":"10.1016\/j.aninu.2020.03.011"},{"key":"1501_CR6","doi-asserted-by":"crossref","unstructured":"Kowalska K et al (2019) Estrogen receptor \u03b2 plays a protective role in zearalenone-induced oxidative stress in normal prostate epithelial cells. 172:504\u2013513","DOI":"10.1016\/j.ecoenv.2019.01.115"},{"key":"1501_CR7","doi-asserted-by":"crossref","unstructured":"AbuZahra HM, Rajendran P, Ismail MBJA (2021) Zerumbone exhibit protective effect against zearalenone induced toxicity via ameliorating inflammation and oxidative stress induced apoptosis. 10(10):1593","DOI":"10.3390\/antiox10101593"},{"key":"1501_CR8","doi-asserted-by":"crossref","unstructured":"Bai J et al (2022) Roles of stress response-related signaling and its contribution to the toxicity of zearalenone in mammals. 21(4):3326\u20133345","DOI":"10.1111\/1541-4337.12974"},{"key":"1501_CR9","doi-asserted-by":"crossref","unstructured":"Zhu W et al (2022) Hyperoside attenuates zearalenone-induced spleen injury by suppressing oxidative stress and inhibiting apoptosis in mice. 102:108408","DOI":"10.1016\/j.intimp.2021.108408"},{"key":"1501_CR10","doi-asserted-by":"crossref","unstructured":"Rai A et al (2020) Occurrence and toxicity of a fusarium mycotoxin, zearalenone. 60(16):2710\u20132729","DOI":"10.1080\/10408398.2019.1655388"},{"key":"1501_CR11","doi-asserted-by":"crossref","unstructured":"Kraft S, Buchenauer L, T.J.I.J.o.M S, Polte (2021) Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern? 22(22): p. 12269","DOI":"10.3390\/ijms222212269"},{"key":"1501_CR12","doi-asserted-by":"crossref","unstructured":"Hennig-Pauka I et al (2018) Current challenges in the diagnosis of zearalenone toxicosis as illustrated by a field case of hyperestrogenism in suckling piglets. 4(1):1\u20139","DOI":"10.1186\/s40813-018-0095-4"},{"key":"1501_CR13","doi-asserted-by":"crossref","unstructured":"Liu J, Applegate TJT (2020) Zearalenone (ZEN) in livestock and poultry: dose, toxicokinetics, toxicity and estrogenicity. 12(6):377","DOI":"10.3390\/toxins12060377"},{"key":"1501_CR14","doi-asserted-by":"crossref","unstructured":"Possibilities for the Biological Control of Mycotoxins in Food and Feed. Toxins 2021,13, 198. 2021, s Note: MDPI stays neutral with regard to jurisdictional claims in published&#8230","DOI":"10.3390\/toxins13030198"},{"key":"1501_CR15","doi-asserted-by":"crossref","unstructured":"Fu G et al (2016) Effect of degradation of zearalenone-contaminated feed by Bacillus licheniformis CK1 on postweaning female piglets. 8(10):300","DOI":"10.3390\/toxins8100300"},{"key":"1501_CR16","doi-asserted-by":"crossref","unstructured":"Wang Y et al (2018) Isolation and characterization of the Bacillus cereus BC7 strain, which is capable of zearalenone removal and intestinal flora modulation in mice. 155:9\u201320","DOI":"10.1016\/j.toxicon.2018.09.005"},{"key":"1501_CR17","doi-asserted-by":"crossref","unstructured":"Xu J et al (2016) Isolation and characterization of Bacillus amyloliquefaciens ZDS-1: exploring the degradation of zearalenone by Bacillus spp. 68:244\u2013250","DOI":"10.1016\/j.foodcont.2016.03.030"},{"key":"1501_CR18","doi-asserted-by":"crossref","unstructured":"Wang N et al (2018) Bacillus velezensis A2 fermentation exerts a protective effect on renal injury induced by zearalenone in mice. 8(1):1\u201314","DOI":"10.1038\/s41598-018-32006-z"},{"key":"1501_CR19","doi-asserted-by":"crossref","unstructured":"Lei Y et al (2014) Degradation of zearalenone in swine feed and feed ingredients by Bacillus subtilis ANSB01G. 7(2):143\u2013151","DOI":"10.3920\/WMJ2013.1623"},{"key":"1501_CR20","doi-asserted-by":"crossref","unstructured":"Shi D et al (2018) Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts. 9(1):1\u201311","DOI":"10.1186\/s40104-018-0255-z"},{"key":"1501_CR21","unstructured":"Safaei N et al (2005) optimization of a bioassay method for evaluation of zearalenone production in fungi and its application to iranian isolates of fusarium graminearum."},{"key":"1501_CR22","doi-asserted-by":"crossref","unstructured":"Hsu T-C et al (2018) Probiotic characteristics and zearalenone-removal ability of a Bacillus licheniformis strain. 13(4):e0194866","DOI":"10.1371\/journal.pone.0194866"},{"key":"1501_CR23","doi-asserted-by":"crossref","unstructured":"M\u00f8ller COdA et al (2021) Effect of lactic acid bacteria strains on the growth and aflatoxin production potential of aspergillus parasiticus, and their ability to bind aflatoxin B1, ochratoxin A, and zearalenone in vitro. 12:655386","DOI":"10.3389\/fmicb.2021.655386"},{"key":"1501_CR24","doi-asserted-by":"crossref","unstructured":"Sanei S et al (2023) Microcapsules loaded with date seed extract and its inhibitory potential to modulate the toxic effects of mycotoxins in mice received mold-contaminated diet. 30(20):58654\u201358662","DOI":"10.1007\/s11356-023-26640-y"},{"key":"1501_CR25","doi-asserted-by":"crossref","unstructured":"Poorbagher MRM et al (2022) Hepatoprotective effect of nanoniosome loaded Myristica fragrans phenolic compounds in mice-induced hepatotoxicity. 26(21):5517\u20135527","DOI":"10.1111\/jcmm.17581"},{"issue":"1\u20132","key":"1501_CR26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.vetmic.2009.07.001","volume":"140","author":"Y Feng","year":"2010","unstructured":"Feng Y et al (2010) Identification of changes in the composition of ileal bacterial microbiota of broiler chickens infected with Clostridium perfringens. Vet Microbiol 140(1\u20132):116\u2013121","journal-title":"Vet Microbiol"},{"key":"1501_CR27","doi-asserted-by":"crossref","unstructured":"Oskoueian E, Abdullah N, Oskoueian A (2013) Effects of flavonoids on rumen fermentation activity, methane production, and microbial population. BioMed research international, 2013","DOI":"10.1155\/2013\/349129"},{"issue":"9","key":"1501_CR28","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.3382\/ps\/pey500","volume":"98","author":"RA Whelan","year":"2019","unstructured":"Whelan RA et al (2019) The impact of Bacillus subtilis DSM 32315 on the pathology, performance, and intestinal microbiome of broiler chickens in a necrotic enteritis challenge. Poult Sci 98(9):3450\u20133463","journal-title":"Poult Sci"},{"key":"1501_CR29","doi-asserted-by":"crossref","unstructured":"Denman SE, McSweeney CS (2006) Development of a real-time PCR assay for monitoring anaerobic fungal and cellulolytic bacterial populations within the rumen. FEMS microbiology ecology. 58(3):572\u2013582","DOI":"10.1111\/j.1574-6941.2006.00190.x"},{"key":"1501_CR30","doi-asserted-by":"crossref","unstructured":"Wu N et al (2021) Recent advances in detoxification strategies for zearalenone contamination in food and feed. 30: pp. 168\u2013177","DOI":"10.1016\/j.cjche.2020.11.011"},{"key":"1501_CR31","doi-asserted-by":"crossref","unstructured":"Mahato DK et al (2021) Occurrence, impact on agriculture, human health, and management strategies of zearalenone in food and feed: A review. 13(2): p. 92","DOI":"10.3390\/toxins13020092"},{"key":"1501_CR32","doi-asserted-by":"crossref","unstructured":"Zhang J et al (2021) Effects of Bacillus subtilis ZJ-2019-1 on Zearalenone Toxicosis in female gilts. 13(11):788","DOI":"10.3390\/toxins13110788"},{"key":"1501_CR33","doi-asserted-by":"crossref","unstructured":"Shen W et al (2021) Comparison of Ameliorative effects between Probiotic and biodegradable Bacillus subtilis on Zearalenone Toxicosis in Gilts. 13(12):882","DOI":"10.3390\/toxins13120882"},{"key":"1501_CR34","doi-asserted-by":"crossref","unstructured":"Pereyra MG et al (2019) Presence of aiiA homologue genes encoding for N-Acyl homoserine lactone-degrading enzyme in aflatoxin B1-decontaminating Bacillus strains with potential use as feed additives. 124:316\u2013323","DOI":"10.1016\/j.fct.2018.12.016"},{"key":"1501_CR35","doi-asserted-by":"crossref","unstructured":"Guo Z et al (2019) Quantitative assessment of zearalenone in maize using multivariate algorithms coupled to Raman spectroscopy. 286:282\u2013288","DOI":"10.1016\/j.foodchem.2019.02.020"},{"issue":"6","key":"1501_CR36","first-page":"386","volume":"14","author":"X Han","year":"2022","unstructured":"Han X et al (2022) Res Progress Saf Zearalenone: Rev 14(6):386","journal-title":"Res Progress Saf Zearalenone: Rev"},{"key":"1501_CR37","doi-asserted-by":"crossref","unstructured":"Abb\u00e8s S et al (2006) The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice. 47(5):567\u2013574","DOI":"10.1016\/j.toxicon.2006.01.016"},{"key":"1501_CR38","doi-asserted-by":"crossref","unstructured":"\u010conkov\u00e1 E et al (2001) The effect of zearalenone on some enzymatic parameters in rabbits. 121(3):145\u2013149","DOI":"10.1016\/S0378-4274(01)00312-5"},{"key":"1501_CR39","doi-asserted-by":"crossref","unstructured":"Van Le Thanh B et al (2016) The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs. 32(2):99\u2013116","DOI":"10.1007\/s12550-016-0245-y"},{"key":"1501_CR40","doi-asserted-by":"crossref","unstructured":"Zhong G et al (2021) Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks. 788:147780","DOI":"10.1016\/j.scitotenv.2021.147780"},{"key":"1501_CR41","doi-asserted-by":"crossref","unstructured":"Lei X et al (2015) Effect of Bacillus amyloliquefaciens-based direct-fed microbial on performance, nutrient utilization, intestinal morphology and cecal microflora in broiler chickens. 28(2):239","DOI":"10.5713\/ajas.14.0330"},{"key":"1501_CR42","doi-asserted-by":"crossref","unstructured":"Liu M et al (2014) Toxic effects of maternal zearalenone exposure on intestinal oxidative stress, barrier function, immunological and morphological changes in rats. 9(9):e106412","DOI":"10.1371\/journal.pone.0106412"},{"key":"1501_CR43","doi-asserted-by":"crossref","unstructured":"Ma L et al (2022) Quantitative proteomic analysis of Zearalenone-Induced intestinal damage in weaned piglets. 14(10):702","DOI":"10.3390\/toxins14100702"},{"key":"1501_CR44","doi-asserted-by":"crossref","unstructured":"Li P et al (2020) Detoxification Mycotoxins through Biotransform 12(2)","DOI":"10.3390\/toxins12020121"},{"key":"1501_CR45","doi-asserted-by":"crossref","unstructured":"Liu L, Xie M, Wei D (2022) Biological Detoxification of mycotoxins: current status and future advances. Int J Mol Sci, 23(3)","DOI":"10.3390\/ijms23031064"},{"key":"1501_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-015-0921-z","volume":"15","author":"E Oskoueian","year":"2015","unstructured":"Oskoueian E et al (2015) Cytoprotective effect of palm kernel cake phenolics against aflatoxin B1-induced cell damage and its underlying mechanism of action. BMC Complement Altern Med 15:1\u201312","journal-title":"BMC Complement Altern Med"},{"key":"1501_CR47","doi-asserted-by":"crossref","unstructured":"Pistol GC et al (2015) Zearalenone mycotoxin affects immune mediators, MAPK signalling molecules, nuclear receptors and genome-wide gene expression in pig spleen. 10(5):e0127503","DOI":"10.1371\/journal.pone.0127503"},{"key":"1501_CR48","doi-asserted-by":"crossref","unstructured":"Salah-Abb\u00e8s JB et al (2020) Zearalenone nephrotoxicity: DNA fragmentation, apoptotic gene expression and oxidative stress protected by Lactobacillus plantarum MON03. 175:28\u201335","DOI":"10.1016\/j.toxicon.2019.12.004"},{"key":"1501_CR49","doi-asserted-by":"crossref","unstructured":"Liew W-P-P (2018) S.J.F.i.c. Mohd-Redzwan, and i. microbiology, Mycotoxin: Its impact on gut health and microbiota. p. 60","DOI":"10.3389\/fcimb.2018.00060"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-024-01501-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-024-01501-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-024-01501-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:05:25Z","timestamp":1736348725000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-024-01501-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1501"],"URL":"https:\/\/doi.org\/10.1007\/s42770-024-01501-z","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]},"assertion":[{"value":"4 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal handling methods were accomplished as per the Islamic Azad University of Mashhad, IRAN regulations with their prior approval for using the animals. All methods are reported in accordance with ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}