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The limitations of current treatment options for sporotrichosis have driven an urgent search for new antifungal drugs. Diphenyl diselenide (PhSe)\u2082, a stable organoselenium, has promising activity against\n                    <jats:italic>Sporothrix<\/jats:italic>\n                    spp. Since chemical modifications in molecules can enhance their antifungal properties, this study aimed to evaluate the anti-\n                    <jats:italic>Sporothrix<\/jats:italic>\n                    activity of two analogs of (PhSe)\u2082\u2014p-methoxyl-diphenyl diselenide (BMD) and bis-(3-trifluoromethylphenyl) diselenide (CF3)\u2014both alone and in combination with itraconazole (ITZ). A total of 25\n                    <jats:italic>Sporothrix<\/jats:italic>\n                    spp. isolates (\n                    <jats:italic>S. brasiliensis<\/jats:italic>\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920;\n                    <jats:italic>S. schenckii<\/jats:italic>\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094 and\n                    <jats:italic>S. globosa<\/jats:italic>\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) were included. The microdilution and checkerboard assays were used to assess its antifungal activity alone and in combination, respectively. BMD inhibited all isolates, with a total minimum inhibitory concentration ranging from 2 to 16\u00a0\u00b5g\/mL. In contrast, CF3 exhibited only a partial minimum inhibitory concentration activity in 92% of isolates at concentrations ranging from 2 to 16\u00a0\u00b5g\/mL. When combined with ITZ, both compounds predominantly exhibited a synergistic effect (100% for BMD and 73% for CF3). Our study presents pioneering data on two organoselenium compounds with significant\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against the main pathogenic\n                    <jats:italic>Sporothrix<\/jats:italic>\n                    species, both alone and in combination with ITZ. Further studies are needed to determine whether these\n                    <jats:italic>in vitro<\/jats:italic>\n                    findings translate into\n                    <jats:italic>in vivo<\/jats:italic>\n                    efficacy.\n                  <\/jats:p>","DOI":"10.1007\/s42770-026-01879-y","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:50:07Z","timestamp":1772959807000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemical modifications of diphenyl diselenide enhance its anti-Sporothrix spp. activity and exhibit synergism with itraconazole"],"prefix":"10.1007","volume":"57","author":[{"given":"J\u00e9ssica Estefania D\u00e1vila","family":"Hidalgo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Orzechowski","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Rodrigues","family":"Tr\u00e1paga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Campos","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diulien","family":"Canary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilson","family":"Zeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Wayne","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Almeida-Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosely Maria","family":"Zancop\u00e9-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanice Rodrigues","family":"Poester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"issue":"1","key":"1879_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3767\/003158515X687416","volume":"35","author":"H Zhang","year":"2015","unstructured":"Zhang H (2015) Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animal case reports. 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