{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:43:54Z","timestamp":1789670634082,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004909","name":"Universidade Federal Do Rio Grande Do Sul","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004909","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antimicrobial resistance (AMR) represents one of the major threats to global public health, particularly in hospital settings. Among the most concerning pathogens are carbapenemase-producing\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    (CPE), which compromise the effectiveness of last-line antibiotics such as meropenem. This study aimed to analyze the prevalence of carbapenemase production among\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    classified as resistant or susceptible, increased exposure to meropenem at the Hospital de Cl\u00ednicas de Porto Alegre (HCPA) between 2019 and 2024. This descriptive, retrospective study was based on laboratory data obtained through a structured query of the microbiology database, without access to clinical or identifiable patient information. Carbapenemase detection was performed using the NG-Test\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Carba 5 and high-resolution melting quantitative polymerase chain reaction (HRM-qPCR). Data were anonymized and analyzed using absolute and relative frequencies. Temporal analysis revealed a shift in the carbapenememase profile over the study period, characterized by a progressive decline in KPC-producing isolates in the post-pandemic years and a concomitant increase in NDM-producing\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    , indicating a significant epidemiological change. This study contributes to understanding the evolving epidemiology of CPE and supports improved surveillance and clinical management strategies in the context of AMR.\n                  <\/jats:p>","DOI":"10.1007\/s42770-026-01995-9","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:50:28Z","timestamp":1782924628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of carbapenemase production among Enterobacterales with reduced susceptibility to meropenem in patients at Hospital de Cl\u00ednicas de Porto Alegre (HCPA) between 2019 and 2024"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9928-3974","authenticated-orcid":false,"given":"Eduarda Lanzoni","family":"Filter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Preussler","family":"Mott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine Rigon","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Pires","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Constante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Minuto","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"1995_CR1","volume-title":"WHO bacterial priority pathogens list, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance","author":"World Health Organization","year":"2024","unstructured":"World Health Organization (2024) WHO bacterial priority pathogens list, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance. World Health Organization, Geneva. https:\/\/www.who.int\/publications\/i\/item\/9789240093461"},{"issue":"126","key":"1995_CR2","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1590\/0103-1104202012602","volume":"44","author":"RA Silva","year":"2020","unstructured":"Silva RA et al (2020) Resist\u00eancia a antimicrobianos: a formula\u00e7\u00e3o da resposta no \u00e2mbito da sa\u00fade global. Sa\u00fade Debate 44(126):607\u2013623. https:\/\/doi.org\/10.1590\/0103-1104202012602","journal-title":"Sa\u00fade Debate"},{"issue":"10325","key":"1995_CR3","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","unstructured":"Antimicrobial Resistance Collaborators (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399(10325):629\u2013655. https:\/\/doi.org\/10.1016\/S0140-6736(21)02724-0","journal-title":"Lancet"},{"issue":"4","key":"1995_CR4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1080\/21505594.2016.1222343","volume":"8","author":"D Van Duin","year":"2016","unstructured":"Van Duin D, Doi Y (2016) The global epidemiology of carbapenemase-producing Enterobacteriaceae. Virulence 8(4):460\u2013469. https:\/\/doi.org\/10.1080\/21505594.2016.1222343","journal-title":"Virulence"},{"issue":"5","key":"1995_CR5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.ijantimicag.2018.07.011","volume":"52","author":"LM Avery","year":"2018","unstructured":"Avery LM, Nicolau DP (2018) Assessing the in vitro activity of ceftazidime\/avibactam and aztreonam among carbapenemase-producing Enterobacteriaceae: defining the zone of hope. 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