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In view of the above, our objective was to determine the antimicrobial resistance profile of 60\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates obtained from patients with bacteremia, as well as to characterize extended-spectrum \u03b2-lactamases (ESBL) -producing isolates. The highest resistance rates were observed for ciprofloxacin (33.3%), levofloxacin (31.7%), cefuroxime (20%) and cefotaxime (20%). Furthermore, 12 isolates (20%) were ESBL producers. Genomic analysis showed that 58.3% of these ESBL-producing isolates belonged to the phylogroup B2, ST131, serotype O25:H4 and carried the following ESBL-encoding genes:\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>CTX\u2212M\u221215<\/jats:italic>\n                    <\/jats:sub>\n                    (66.7%),\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>CTX\u2212M\u22128<\/jats:italic>\n                    <\/jats:sub>\n                    (16.7%),\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>CTX\u2212M\u22122<\/jats:italic>\n                    <\/jats:sub>\n                    (8.7%) or\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>CTX\u2212M\u221227<\/jats:italic>\n                    <\/jats:sub>\n                    (8.7%). Our data highlight the high frequency of\n                    <jats:italic>E. coli<\/jats:italic>\n                    ST131 among the ESBL-producing isolates obtained from patients with bacteremia in Botucatu, Brazil.\n                  <\/jats:p>","DOI":"10.1007\/s42770-026-02018-3","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:09:17Z","timestamp":1783944557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular characterization of extended-spectrum \u03b2-lactamases-producing Escherichia coli isolated from patients with bacteremia"],"prefix":"10.1007","volume":"57","author":[{"given":"Beatrice D. V. 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