{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:32:55Z","timestamp":1786361575263,"version":"build-2736575974"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","award":["FMRG: 600-TNCPI 5\/3\/DDF (MEDIC) (006\/2021)"],"award-info":[{"award-number":["FMRG: 600-TNCPI 5\/3\/DDF (MEDIC) (006\/2021)"]}],"id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","award":["600-RMC\/GIP 5\/3 (043\/2021)"],"award-info":[{"award-number":["600-RMC\/GIP 5\/3 (043\/2021)"]}],"id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","award":["600-RMC\/GIP 5\/3 (038\/2023)"],"award-info":[{"award-number":["600-RMC\/GIP 5\/3 (038\/2023)"]}],"id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s42770-026-02047-y","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:56:20Z","timestamp":1786355780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From decay to discovery: A new antimicrobial peptide from Chrysomya megacephala (Diptera: Calliphoridae) larvae"],"prefix":"10.1007","volume":"57","author":[{"given":"Nurul","family":"Azmiera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassanain","family":"Al-Talib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krasilnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shariza","family":"Sahudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noraziah","family":"Sahlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-1023","authenticated-orcid":false,"given":"Chong Chin","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"14","key":"2047_CR1","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.2174\/1389201017666160808160513","volume":"17","author":"A Adan","year":"2016","unstructured":"Adan A, Kiraz Y, Baran Y (2016) Cell proliferation and cytotoxicity assays. Curr Pharm Biotech 17(14):1213\u20131221","journal-title":"Curr Pharm Biotech"},{"issue":"3","key":"2047_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s13205-020-2109-6","volume":"10","author":"JJ Ahire","year":"2020","unstructured":"Ahire JJ, Kashikar MS, Lakshmi SG, Madempudi R (2020) Identification and characterization of antimicrobial peptide produced by indigenously isolated Bacillus paralicheniformis UBBLi30 strain. 3 Biotech 10(3):112","journal-title":"3 Biotech"},{"key":"2047_CR3","unstructured":"Anderson RCGR, Higgins HM Jr, Pettinga CD (1961) Symposium: how a drug is born. Cincinnati J Med. 49\u201360"},{"issue":"10","key":"2047_CR4","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1086\/587654","volume":"46","author":"JG Bartlett","year":"2008","unstructured":"Bartlett JG (2008) The case for vancomycin as the preferred drug for treatment of Clostridium difficile infection. Clin Infect Dis 46(10):1489\u20131492","journal-title":"Clin Infect Dis"},{"issue":"2","key":"2047_CR5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0006-291X(78)91532-2","volume":"81","author":"F Besson","year":"1978","unstructured":"Besson F, Peypoux F, Michel G, Delcambe L (1978) Mode of action of iturin A, an antibiotic isolated from Bacillus subtilis, on Micrococcus luteus. Biochem Biophys Res Commun 81(2):297\u2013304","journal-title":"Biochem Biophys Res Commun"},{"key":"2047_CR6","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2024) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, approved standard, Pennysylvania, M07\u2013A9"},{"issue":"1","key":"2047_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.9735\/0975-3702.4.1.71-74","volume":"4","author":"T Chaiwong","year":"2012","unstructured":"Chaiwong T, Srivoramas T, Sukontason K, Sanford MR, Sukontason KL (2012) Bacterial fauna associated with the blow fly, Chrysomya megacephala (F.) in Ubon Ratchathani Province of Northeast Thailand. Int J Parasitol Res 4(1):71","journal-title":"Int J Parasitol Res"},{"issue":"13","key":"2047_CR8","doi-asserted-by":"publisher","first-page":"12316","DOI":"10.1074\/jbc.M413406200","volume":"280","author":"Y Chen","year":"2005","unstructured":"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS (2005) Rational design of \u03b1-helical antimicrobial peptides with enhanced activities and specificity\/therapeutic index. J Biol Chem 280(13):12316\u201312329","journal-title":"J Biol Chem"},{"issue":"1","key":"2047_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4103\/jgid.jgid_110_18","volume":"11","author":"A Chokshi","year":"2019","unstructured":"Chokshi A, Sifri Z, Cennimo D, Horng H (2019) Global contributors to antibiotic resistance. J Global Infect Dis 11(1):36\u201342","journal-title":"J Global Infect Dis"},{"key":"2047_CR10","doi-asserted-by":"crossref","unstructured":"Coyle JP, Abritis AJ, Mayo-Perez A, Bourgeois MM, Harbison RD (2015) Dermal and Ocular Toxicity. Hamilton & Hardy\u2019s Indust Toxicol, pp 247\u20131258","DOI":"10.1002\/9781118834015.ch113"},{"issue":"24","key":"2047_CR11","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1016\/j.febslet.2015.11.002","volume":"589","author":"KJ Cutrona","year":"2015","unstructured":"Cutrona KJ, Kaufman BA, Figueroa DM, Elmore DE (2015) Role of arginine and lysine in the antimicrobial mechanism of histone-derived antimicrobial peptides. FEBS Lett 589(24):3915\u20133920","journal-title":"FEBS Lett"},{"issue":"3","key":"2047_CR12","doi-asserted-by":"publisher","first-page":"103995","DOI":"10.1016\/j.resmic.2022.103995","volume":"174","author":"BS da Silva","year":"2023","unstructured":"da Silva BS, D\u00edaz-Roa A, Yamane ES, Hayashi MA, Junior PIS (2023) Doderlin: Isolation and characterization of a broad-spectrum antimicrobial peptide from Lactobacillus acidophilus. Res Microbiol 174(3):103995","journal-title":"Res Microbiol"},{"issue":"19","key":"2047_CR13","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1016\/j.febslet.2007.05.039","volume":"581","author":"M Daugaard","year":"2007","unstructured":"Daugaard M, Rohde M, J\u00e4\u00e4ttel\u00e4 M (2007) The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett 581(19):3702\u20133710","journal-title":"FEBS Lett"},{"issue":"2","key":"2047_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020414","volume":"23","author":"M Deptu\u0142a","year":"2018","unstructured":"Deptu\u0142a M, Wardowska A, Dzier\u017cy\u0144ska M, Rodziewicz-Motowid\u0142o S, Piku\u0142a M (2018) Antibacterial peptides in dermatology\u2013strategies for evaluation of allergic potential. Molecules 23(2):414","journal-title":"Molecules"},{"issue":"3","key":"2047_CR15","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1128\/AAC.04773-14","volume":"59","author":"RK Flamm","year":"2015","unstructured":"Flamm RK, Rhomberg PR, Simpson KM, Farrell DJ, Sader HS, Jones RN (2015) In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms. Antimicrob Agents Chemother 59(3):1751\u20131754","journal-title":"Antimicrob Agents Chemother"},{"key":"2047_CR16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ejpb.2016.04.006","volume":"108","author":"I Garcia-Orue","year":"2016","unstructured":"Garcia-Orue I, Gainza G, Girbau C, Alonso R, Aguirre JJ, Pedraz JL, Igartua M, Hernandez RM (2016) LL37 loaded nanostructured lipid carriers (NLC): a new strategy for the topical treatment of chronic wounds. Eur J Pharm Biopharm 108:310\u2013316","journal-title":"Eur J Pharm Biopharm"},{"key":"2047_CR17","doi-asserted-by":"crossref","unstructured":"Haney E, Mansour S, Hancock R (2016) Antimicrobial peptides: an introduction. In: Hansen P (ed) Antimicrobial Peptides, vol Vol. 1548. Humana Press, New York, pp 3\u201322","DOI":"10.1007\/978-1-4939-6737-7_1"},{"issue":"2","key":"2047_CR18","first-page":"53","volume":"33","author":"CC Heo","year":"2010","unstructured":"Heo CC, Ahmad NW, Kian CW, Kurahashi H, Jeffery J, Kiang HS, Omar B (2010) A study of cow dung diptera in Sentul Timur, Kuala Lumpur, Malaysia. J Trop Med Parasitol 33(2):53\u201361","journal-title":"J Trop Med Parasitol"},{"key":"2047_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2019.103476","volume":"102","author":"S Janewanthanakul","year":"2020","unstructured":"Janewanthanakul S, Supungul P, Tang S, Tassanakajon A (2020) Heat shock protein 70 from Litopenaeus vannamei (LvHSP70) is involved in the innate immune response against white spot syndrome virus (WSSV) infection. Dev Comp Immunol 102:103476","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"2047_CR20","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/fft2.44","volume":"1","author":"S Kamiloglu","year":"2020","unstructured":"Kamiloglu S, Sari G, Ozdal T, Capanoglu E (2020) Guidelines for cell viability assays. Food Front 1(3):332\u2013349","journal-title":"Food Front"},{"issue":"4","key":"2047_CR21","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.3390\/polym3042088","volume":"3","author":"HM Kaminski","year":"2011","unstructured":"Kaminski HM, Feix JB (2011) Effects of D-lysine substitutions on the activity and selectivity of antimicrobial peptide CM15. Polymers 3(4):2088\u20132106","journal-title":"Polymers"},{"issue":"5","key":"2047_CR22","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1128\/AAC.42.5.1303","volume":"42","author":"HA Kirst","year":"1998","unstructured":"Kirst HA, Thompson DG, Nicas TI (1998) Historical yearly usage of vancomycin. Antimicrob Chemother 42(5):1303\u20131304","journal-title":"Antimicrob Chemother"},{"issue":"12","key":"2047_CR23","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","volume":"13","author":"R Laxminarayan","year":"2013","unstructured":"Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, Greko C (2013) Antibiotic resistance\u2014the need for global solutions. Lancet Infect Dis 13(12):1057\u20131098","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"2047_CR24","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","volume":"25","author":"B Lemaitre","year":"2007","unstructured":"Lemaitre B, Hoffmann J (2007) The host defense of Drosophila melanogaster. Annu Rev Immunol 25(1):697\u2013743","journal-title":"Annu Rev Immunol"},{"key":"2047_CR25","doi-asserted-by":"publisher","first-page":"105774","DOI":"10.1016\/j.pestbp.2024.105774","volume":"199","author":"P Liang","year":"2024","unstructured":"Liang P, Guo M, Wang D, Li T, Li R, Li D, Cheng S, Zhen C, Zhang L (2024) Molecular and functional characterization of heat-shock protein 70 in Aphis gossypii under thermal and xenobiotic stresses. Pest Biochem Physiol 199:105774","journal-title":"Pest Biochem Physiol"},{"issue":"1","key":"2047_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/bip.10374","volume":"71","author":"DL Lee","year":"2003","unstructured":"Lee DL, Hodges RS (2003) Structure\u2013activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S. Pept Sci 71(1):28\u201348","journal-title":"Pept Sci"},{"issue":"2","key":"2047_CR27","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.bbrc.2014.02.138","volume":"446","author":"J Lu","year":"2014","unstructured":"Lu J, Chen ZW, Wu Y, Zhang M, Ding JP, Cederlund E, J\u00f6rnvall H, Bergman T (2014) An ATPase inhibitory peptide with antibacterial and ion current effects. Biochem Biophys Res Com 446(2):519\u2013522","journal-title":"Biochem Biophys Res Com"},{"key":"2047_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.forsciint.2015.12.047","volume":"260","author":"NA Mahat","year":"2016","unstructured":"Mahat NA, Zainol-Abidin NL, Nordin NH, Abdul-Wahab R, Jayaprakash PT (2016) Patterns of oviposition and development of Chrysomya megacephala (Fabricius)(Diptera: Calliphoridae) and Chrysomya rufifacies (Macquart)(Diptera: Calliphoridae) on burned rabbit carcasses. Forensic Sci Int 260:9\u201313","journal-title":"Forensic Sci Int"},{"key":"2047_CR29","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3389\/fcimb.2016.00194","volume":"6","author":"M Mahlapuu","year":"2016","unstructured":"Mahlapuu M, H\u00e5kansson J, Ringstad L, Bj\u00f6rn C (2016) Antimicrobial peptides: an emerging category of therapeutic agents. Front Cell Infect Microbiol 6:194","journal-title":"Front Cell Infect Microbiol"},{"issue":"13","key":"2047_CR30","doi-asserted-by":"publisher","first-page":"5303","DOI":"10.1007\/s00018-021-03828-4","volume":"78","author":"AA Mart\u00ed iL\u00edndez","year":"2021","unstructured":"Mart\u00ed iL\u00edndez AA, Reith W (2021) Arginine-dependent immune responses. Cell Mol Life Sci 78(13):5303\u20135324","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"2047_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/cosmetics4040041","volume":"4","author":"E Maur\u00edcio","year":"2017","unstructured":"Maur\u00edcio E, Rosado C, Duarte MP, Verissimo J, Bom S, Vasconcelos L (2017) Efficiency of nisin as preservative in cosmetics and topical products. Cosmetics 4(4):41","journal-title":"Cosmetics"},{"issue":"4","key":"2047_CR32","first-page":"445","volume":"95","author":"IE Mba","year":"2022","unstructured":"Mba IE, Nweze EI (2022) Antimicrobial peptides therapy: an emerging alternative for treating drug-resistant bacteria. Yale J Biol Med 95(4):445\u2013463","journal-title":"Yale J Biol Med"},{"issue":"1","key":"2047_CR33","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/jisp.jisp_326_18","volume":"23","author":"D Mitra","year":"2019","unstructured":"Mitra D, Yadav A, Prithyani S, John LE, Rodrigues S, Shah R (2019) The antiplaque efficacy of lantibiotic Nisin extract mouthrinse. J Indian Soc Periodontol 23(1):31\u201334","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"2047_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.21608\/jades.2022.247628","volume":"23","author":"NT Mohamed","year":"2022","unstructured":"Mohamed NT, Azam KS (2022) The anti-bacterial of whole body homogenates of third instar larvae of Chrysomya megacephala (Diptera: Calliphoridae) against different bacterial strains. J Egypt Acad Soc Envi Dev D Envi Stud 23(1):43\u201349","journal-title":"J Egypt Acad Soc Envi Dev D Envi Stud"},{"key":"2047_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341330","volume":"1268","author":"CCA Ng","year":"2023","unstructured":"Ng CCA, Zhou Y, Yao ZP (2023) Algorithms for de-novo sequencing of peptides by tandem mass spectrometry: a review. Anal Chim Acta 1268:341330","journal-title":"Anal Chim Acta"},{"issue":"1","key":"2047_CR36","doi-asserted-by":"publisher","first-page":"e21623","DOI":"10.1002\/arch.21623","volume":"103","author":"R Paulchamy","year":"2020","unstructured":"Paulchamy R, Sreeramulu B, Karuppiah H, Arumugam G, Sundaram J (2020) A serine protease-associated lectin in the cytolytic system of blowfly (Chrysomya megacephala) larvae: Evidence and characterization. Archiv Insect Biochem Physio 103(1):e21623","journal-title":"Archiv Insect Biochem Physio"},{"issue":"10","key":"2047_CR37","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.bbamem.2016.03.016","volume":"1858","author":"S P\u00f6yry","year":"2016","unstructured":"P\u00f6yry S, Vattulainen I (2016) Role of charged lipids in membrane structures\u2014Insight given by simulations. Biochim Biophys Acta Biomembr 1858(10):2322\u20132333","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"3","key":"2047_CR38","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s10989-019-09955-8","volume":"26","author":"SS Ranade","year":"2020","unstructured":"Ranade SS, Ramalingam R (2020) A review on bioactive porcine peptide, protegrin-1. Int J Pept Res Ther 26(3):1493\u20131501","journal-title":"Int J Pept Res Ther"},{"issue":"4","key":"2047_CR39","first-page":"295","volume":"55","author":"JL Rapp","year":"1947","unstructured":"Rapp JL (1947) Insect hemolymph: A review. J New York Entomol Soc 55(4):295\u2013308","journal-title":"J New York Entomol Soc"},{"key":"2047_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.actatropica.2015.03.021","volume":"147","author":"NA Ratcliffe","year":"2015","unstructured":"Ratcliffe NA, Vieira CS, Mendonca PM, Caetano RL, de Carvalho Queiroz MM, Garcia ES, Mello CB, Azambuja P (2015) Detection and preliminary physico-chemical properties of antimicrobial components in the native excretions\/secretions of three species of Chrysomya (Diptera, Calliphoridae) in Brazil. Acta Trop 147:6\u201311","journal-title":"Acta Trop"},{"issue":"2","key":"2047_CR41","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.molcel.2010.10.006","volume":"40","author":"K Richter","year":"2010","unstructured":"Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40(2):253\u2013266","journal-title":"Mol Cell"},{"issue":"5","key":"2047_CR42","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1128\/aac.45.5.1367-1373.2001","volume":"45","author":"DM Rothstein","year":"2001","unstructured":"Rothstein DM, Spacciapoli P, Tran LT, Xu T, Roberts FD, Dalla Serra M, Buxton DK, Oppenheim FG, Friden P (2001) Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5. Antimicrob Agents Chemother 45(5):1367\u20131373. https:\/\/doi.org\/10.1128\/aac.45.5.1367-1373.2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"2047_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17576\/jskm-2018-1602-01","volume":"4","author":"AZ Sahalan","year":"2007","unstructured":"Sahalan AZ, Omar B, Mohamed AY, Jeffery J (2007) Antibacterial activity of extracted hemolymph from larvae and pupae of local fly species, Musca domestica and Chrysomya megacephala. Jurnal Sains Kesihatan Malaysia 4(2):1\u201311","journal-title":"Jurnal Sains Kesihatan Malaysia"},{"issue":"1","key":"2047_CR44","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10989-017-9599-z","volume":"24","author":"A Sathyamoorthi","year":"2018","unstructured":"Sathyamoorthi A, Palanisamy R, Arasu MV, Al-Dhabi NA, Pasupuleti M, Arockiaraj J (2018) Fish heat shock cognate 70 derived AMPs Cs HSC70 A1 and Cs HSC70 A2. Int J Pept Res Therapy 24(1):143\u2013155","journal-title":"Int J Pept Res Therapy"},{"key":"2047_CR45","unstructured":"Schuetz AN, Bobenchik A, Campeau S (2022) Implementation of the CLSI method for direct disk diffusion testing from positive blood cultures. CLSI AST News Update, p 8"},{"issue":"11","key":"2047_CR46","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.3390\/ph3113435","volume":"3","author":"M Seil","year":"2010","unstructured":"Seil M, Nagant C, Dehaye JP, Vandenbranden M, Lensink MF (2010) Spotlight on human LL-37, an immunomodulatory peptide with promising cell-penetrating properties. Pharmaceutic 3(11):3435\u20133460","journal-title":"Pharmaceutic"},{"issue":"1","key":"2047_CR47","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1080\/21505594.2020.1731137","volume":"11","author":"G Sheehan","year":"2020","unstructured":"Sheehan G, Farrell G, Kavanagh K (2020) Immune priming: the secret weapon of the insect world. Virulence 11(1):238\u2013246","journal-title":"Virulence"},{"issue":"10","key":"2047_CR48","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1021\/ct500592m","volume":"10","author":"Y Shen","year":"2014","unstructured":"Shen Y, Maupetit J, Derreumaux P, Tuff\u00e9ry P (2014) Improved PEP-FOLD approach for peptide and miniprotein structure prediction. J Chem Theory Comput 10(10):4745\u20134758","journal-title":"J Chem Theory Comput"},{"issue":"2","key":"2047_CR49","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1165\/rcmb.2008-0091TR","volume":"39","author":"CH Serezani","year":"2008","unstructured":"Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M (2008) Cyclic AMP: master regulator of innate immune cell function. Am J Resp Cell Mol Biol 39(2):127\u2013132","journal-title":"Am J Resp Cell Mol Biol"},{"issue":"8","key":"2047_CR50","first-page":"782","volume":"49","author":"K Shimizu","year":"1996","unstructured":"Shimizu K, Orizu M, Kanno H, Kitamura S, Konishi T, Soma K, Nishitani H, Noguchi Y, Hasegawa S, Hasegawa H, Wada K (1996) Clinical studies on vancomycin in the treatment of MRSA infection. Japan J Antibiot 49(8):782\u2013799","journal-title":"Japan J Antibiot"},{"key":"2047_CR51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.peptides.2013.08.011","volume":"48","author":"M Taniguchi","year":"2013","unstructured":"Taniguchi M, Ikeda A, Nakamichi SI, Ishiyama Y, Saitoh E, Kato T, Ochiai A, Tanaka T (2013) Antimicrobial activity and mechanism of action of a novel cationic \u03b1-helical octadecapeptide derived from heat shock protein 70 of rice. Peptides 48:147\u2013155","journal-title":"Peptides"},{"key":"2047_CR52","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.actbio.2019.12.025","volume":"103","author":"RK Thapa","year":"2020","unstructured":"Thapa RK, Diep DB, T\u00f8nnesen HH (2020) Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects. Acta Biomater 103:52\u201367","journal-title":"Acta Biomater"},{"issue":"W1","key":"2047_CR53","doi-asserted-by":"publisher","first-page":"W288","DOI":"10.1093\/nar\/gks419","volume":"40","author":"P Th\u00e9venet","year":"2012","unstructured":"Th\u00e9venet P, Shen Y, Maupetit J, Guyon F, Derreumaux P, Tuffery P (2012) PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides. Nucleic Acids Res 40(W1):W288\u2013W293","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2047_CR54","doi-asserted-by":"publisher","first-page":"649","DOI":"10.4049\/jimmunol.1002302","volume":"186","author":"S Valanne","year":"2011","unstructured":"Valanne S, Wang JH, R\u00e4met M (2011) The Drosophila toll signaling pathway. J Immunol 186(2):649\u2013656","journal-title":"J Immunol"},{"issue":"1\u20132","key":"2047_CR55","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.drudis.2009.10.009","volume":"15","author":"P Vlieghe","year":"2010","unstructured":"Vlieghe P, Lisowski V, Martinez J, Khrestchatisky M (2010) Synthetic therapeutic peptides: science and market. Drug Discov Today 15(1\u20132):40\u201356","journal-title":"Drug Discov Today"},{"issue":"6","key":"2047_CR56","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.peptides.2008.01.015","volume":"29","author":"KR Wang","year":"2008","unstructured":"Wang KR, Zhang BZ, Zhang W, Yan JX, Li J, Wang R (2008) Antitumor effects, cell selectivity and structure\u2013activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides 29(6):963\u2013968","journal-title":"Peptides"},{"key":"2047_CR57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/jac\/14.suppl_D.7","volume":"14","author":"C Watanakunakorn","year":"1984","unstructured":"Watanakunakorn C (1984) Mode of action and in-vitro activity of vancomycin. J Antimicrob Chemother 14:7\u201318","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"2047_CR58","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1128\/CMR.00112-16","volume":"30","author":"DA Williamson","year":"2017","unstructured":"Williamson DA, Carter GP, Howden BP (2017) Current and emerging topical antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev 30(3):827\u2013860","journal-title":"Clin Microbiol Rev"},{"key":"2047_CR59","unstructured":"World Health Organization (2023) Antimicrobial resistance. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance (accessed 26 December 2024)"},{"issue":"7","key":"2047_CR60","first-page":"894","volume":"77","author":"C Xiao","year":"2021","unstructured":"Xiao C, Xiao Z, Hu C, Lu J, Cui L, Zhang Y, Dai Y, Zhang Q, Wang S, Liu W (2021) Crystal and solution structures of a novel antimicrobial peptide from Chrysomya megacephala. Biol Cryst 77(7):894\u2013903","journal-title":"Biol Cryst"},{"key":"2047_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.02.023","author":"X Zhu","year":"2015","unstructured":"Zhu X, Zhang L, Wang J, Ma Z, Xu W, Li J, Shan A (2015) Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different \u03b1-helical propensity. Acta Biomater. https:\/\/doi.org\/10.1016\/j.actbio.2015.02.023","journal-title":"Acta Biomater"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-026-02047-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-026-02047-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-026-02047-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:03:33Z","timestamp":1786359813000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-026-02047-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2047"],"URL":"https:\/\/doi.org\/10.1007\/s42770-026-02047-y","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"17 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declared no conflicting interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"233"}}