{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:29:23Z","timestamp":1786606163839,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100014761","name":"Natural Science Foundation of Qingdao Municipality","doi-asserted-by":"publisher","award":["24-4-4-zrjj-183-jch"],"award-info":[{"award-number":["24-4-4-zrjj-183-jch"]}],"id":[{"id":"10.13039\/501100014761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s42770-026-02055-y","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:55:59Z","timestamp":1786604159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of 2-deoxyribose-5-phosphate aldolase from Bacillus altitudinis JYY-02"],"prefix":"10.1007","volume":"57","author":[{"given":"Wentao","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunqun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guicai","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-0792","authenticated-orcid":false,"given":"Ronggui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"1","key":"2055_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5334\/gh.1278","volume":"19","author":"L Laranjo","year":"2024","unstructured":"Laranjo L, Lanas F, Sun MC et al (2024) World heart federation roadmap for secondary prevention of cardiovascular disease: 2023 Update. Glob Heart 19(1):8","journal-title":"Glob Heart"},{"issue":"11","key":"2055_CR2","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1093\/cvr\/cvaf119","volume":"121","author":"T M\u00fcnzel","year":"2025","unstructured":"M\u00fcnzel T, Sorensen M, Lelieveld J et al (2025) A comprehensive review\/expert statement on environmental risk factors of cardiovascular disease. Cardiovasc Res 121(11):1653\u20131678","journal-title":"Cardiovasc Res"},{"issue":"8","key":"2055_CR3","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","volume":"143","author":"SS Virani","year":"2021","unstructured":"Virani SS, Alonso A, Aparicio HJ et al (2021) Heart disease and stroke statistics-2021 update: A report from the american heart association. Circulation 143(8):e254\u2013e743","journal-title":"Circulation"},{"key":"2055_CR4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.dcmed.2025.12.009","volume":"8","author":"D Kirubakaran","year":"2025","unstructured":"Kirubakaran D, Nagarajb D, Poongavanam SS et al (2025) Traditional Chinese medicine-based phytotherapeutics for junk food-induced obesity and metabolic dysfunction. Digit Chin Med 8:543\u2013557","journal-title":"Digit Chin Med"},{"key":"2055_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1186\/s12982-026-02126-3","volume":"23","author":"V Sethuraman","year":"2026","unstructured":"Sethuraman V, Kirubakaran D (2026) Plant derived modulators of autophagy in infectious disease, mechanisms and therapeutic potential. Discover Public Health 23:751","journal-title":"Discover Public Health"},{"issue":"7","key":"2055_CR6","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrd1112","volume":"2","author":"JA Tobert","year":"2003","unstructured":"Tobert JA (2003) Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2(7):517\u2013526","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"2055_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/1043-6618(95)80042-5","volume":"31","author":"A Corsini","year":"1995","unstructured":"Corsini A, Maggi FM, Catapano AL (1995) Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res 31(1):9\u201327","journal-title":"Pharmacol Res"},{"issue":"10","key":"2055_CR8","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1039\/D4CY00047A","volume":"14","author":"E Abdelraheem","year":"2024","unstructured":"Abdelraheem E, Kuijpers R, Hagedoorn PL et al (2024) Enzymatic cascade of DERA and ADH for lactone synthesis. Catal Sci Technol 14(10):2739\u20132751","journal-title":"Catal Sci Technol"},{"issue":"18","key":"2055_CR9","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1161\/CIRCULATIONAHA.123.064226","volume":"147","author":"SS Virani","year":"2023","unstructured":"Virani SS, Ramsey DJ, Westerman D et al (2023) Cluster randomized trial of a personalized clinical decision support intervention to improve statin prescribing in patients with atherosclerotic cardiovascular disease. Circulation 147(18):1411\u20131413","journal-title":"Circulation"},{"issue":"1","key":"2055_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10295-012-1213-y","volume":"40","author":"ZY You","year":"2013","unstructured":"You ZY, Liu ZQ, Zheng YG et al (2013) Characterization and application of a newly synthesized 2-deoxyribose-5-phosphate aldolase. J Ind Microbiol Biotechnol 40(1):29\u201339","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"16","key":"2055_CR11","doi-asserted-by":"publisher","first-page":"5788","DOI":"10.1073\/pnas.0307563101","volume":"101","author":"WA Greenberg","year":"2004","unstructured":"Greenberg WA, Varvak A, Hanson SR et al (2004) Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates. Proc Natl Acad Sci 101(16):5788\u20135793","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"2055_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00449-008-0205-9","volume":"31","author":"M Wolberg","year":"2008","unstructured":"Wolberg M, Filho MV, Bode S et al (2008) Chemoenzymatic synthesis of the chiral side-chain of statins: application of an alcohol dehydrogenase catalysed ketone reduction on a large scale. Bioproc Biosyst Eng 31(3):183\u2013191","journal-title":"Bioproc Biosyst Eng"},{"issue":"3","key":"2055_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3390\/catal9030260","volume":"9","author":"P Hoyos","year":"2019","unstructured":"Hoyos P, Pace V, Alc\u00e1ntara AR (2019) Biocatalyzed synthesis of statins: A sustainable strategy for the preparation of valuable drugs. Catalysts 9(3):260","journal-title":"Catalysts"},{"key":"2055_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1135\/cccc20080229","volume":"73","author":"J Stach","year":"2008","unstructured":"Stach J, Havl\u00edek J, Placek L (2008) Synthesis of some impurities and\/or degradation products of atorvastatin. Collect Czechoslov Chem Commun 73:229\u2013246","journal-title":"Collect Czechoslov Chem Commun"},{"key":"2055_CR15","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.eng.2022.04.030","volume":"24","author":"XL Tang","year":"2023","unstructured":"Tang XL, Yu JW, Geng YH et al (2023) From discovery to mass production: A perspective on bio-manufacturing exemplified by the development of statins. Engineering 24:138\u2013150","journal-title":"Engineering"},{"issue":"8","key":"2055_CR16","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1002\/(SICI)1521-3773(20000417)39:8<1352::AID-ANIE1352>3.0.CO;2-J","volume":"39","author":"TD Machajewski","year":"2000","unstructured":"Machajewski TD, Wong CH (2000) The Catalytic asymmetric aldol reaction. Angew Chem Int Ed 39(8):1352\u20131375","journal-title":"Angew Chem Int Ed"},{"issue":"5541","key":"2055_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1126\/science.1063601","volume":"294","author":"A Heine","year":"2001","unstructured":"Heine A, Desantis G, Luz JG et al (2001) Observation of covalent intermediates in an enzyme mechanism at atomic resolution. Science 294(5541):369\u2013374","journal-title":"Science"},{"issue":"12","key":"2055_CR18","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1021\/cr0684016","volume":"107","author":"S Mukherjee","year":"2007","unstructured":"Mukherjee S, Yang JW, Hoffmann S et al (2007) Asymmetric enamine catalysis. Chem Rev 107(12):5471\u20135569","journal-title":"Chem Rev"},{"issue":"22","key":"2055_CR19","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1128\/AEM.01101-07","volume":"73","author":"H Sakuraba","year":"2007","unstructured":"Sakuraba H, Yoneda K, Yoshihara K et al (2007) Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-d-ribose-5-phosphate aldolase. Appl Environ Microbiol 73(22):7427\u20137434","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"2055_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cbpa.2009.11.029","volume":"14","author":"P Clap\u00e9s","year":"2010","unstructured":"Clap\u00e9s P, Fessner WD, Sprenger GA et al (2010) Recent progress in stereoselective synthesis with aldolases. Curr Opin Chem Biol 14(2):154\u2013167","journal-title":"Curr Opin Chem Biol"},{"issue":"12","key":"2055_CR21","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1021\/ja00117a003","volume":"117","author":"C-H Wong","year":"1995","unstructured":"Wong C-H, Garcia-Junceda E, Chen L et al (1995) Recombinant 2-deoxyribose-5-phosphate aldolase in organic synthesis: use of sequential two-substrate and three-substrate aldol reactions. J Am Chem Soc 117(12):3333\u20133339","journal-title":"J Am Chem Soc"},{"issue":"5","key":"2055_CR22","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1021\/ja00161a064","volume":"112","author":"CF Barbas","year":"1990","unstructured":"Barbas CF, Iii, Wang YF, Wong CH (1990) Deoxyribose-5-phosphate aldolase as a synthetic catalyst. J Am Chem Soc 112(5):2013\u20132014","journal-title":"J Am Chem Soc"},{"issue":"5","key":"2055_CR23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/biot.200600020","volume":"1","author":"S Jennewein","year":"2006","unstructured":"Jennewein S, Sch\u00fcrmann M, Wolberg M et al (2006) Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase. Biotechnol J 1(5):537\u2013548","journal-title":"Biotechnol J"},{"issue":"7","key":"2055_CR24","doi-asserted-by":"publisher","first-page":"4492","DOI":"10.1039\/C5SC04574F","volume":"7","author":"M Dick","year":"2016","unstructured":"Dick M, Hartmann R, Weiergr\u00e4ber OH et al (2016) Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies. Chem Sci 7(7):4492\u20134502","journal-title":"Chem Sci"},{"issue":"2","key":"2055_CR25","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1074\/jbc.RA119.011363","volume":"295","author":"T Kim","year":"2020","unstructured":"Kim T, Stogios PJ, Khusnutdinova AN et al (2020) Rational engineering of 2-deoxyribose-5-phosphate aldolases for the biosynthesis of (R)-1,3-butanediol. J Biol Chem 295(2):597\u2013609","journal-title":"J Biol Chem"},{"issue":"6470","key":"2055_CR26","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1126\/science.aay8484","volume":"366","author":"MA Huffman","year":"2019","unstructured":"Huffman MA, Fryszkowska A, Alvizo O et al (2019) Design of an in vitro biocatalytic cascade for the manufacture of islatravir. Science 366(6470):1255\u20131259","journal-title":"Science"},{"issue":"4","key":"2055_CR27","doi-asserted-by":"publisher","first-page":"e0153522","DOI":"10.1128\/spectrum.01535-22","volume":"10","author":"J Yang","year":"2022","unstructured":"Yang J, Wang C, Guo Q et al (2022) Isolation of the thermostable \u03b2-glucosidase-secreting strain Bacillus altitudinis JYY-02 and its application in the production of gardenia blue. Microbiol Spectr 10(4):e0153522","journal-title":"Microbiol Spectr"},{"key":"2055_CR28","doi-asserted-by":"publisher","first-page":"862594","DOI":"10.3389\/fpls.2022.862594","volume":"13","author":"M Wang","year":"2022","unstructured":"Wang M, Du G, Fang J et al (2022) UGT440A1 is associated with motility, reproduction, and pathogenicity of the plant-parasitic nematode Bursaphelenchus xylophilus. Front Plant Sci 13:862594","journal-title":"Front Plant Sci"},{"key":"2055_CR29","doi-asserted-by":"publisher","first-page":"109080","DOI":"10.1016\/j.carres.2024.109080","volume":"538","author":"H Tai","year":"2024","unstructured":"Tai H, Guo Q, Zhao J et al (2024) A thermostable xylanase hydrolyzes several polysaccharides from Bacillus altitudinis JYY-02 showing promise for industrial applications. Carbohydr Res 538:109080","journal-title":"Carbohydr Res"},{"issue":"D1","key":"2055_CR30","doi-asserted-by":"publisher","first-page":"D20","DOI":"10.1093\/nar\/gkab1112","volume":"50","author":"EW Sayers","year":"2022","unstructured":"Sayers EW, Bolton EE, Brister JR et al (2022) Database resources of the national center for biotechnology information. Nucleic Acids Res 50(D1):D20\u2013D26","journal-title":"Nucleic Acids Res"},{"key":"2055_CR31","doi-asserted-by":"publisher","first-page":"1091004","DOI":"10.3389\/fimmu.2022.1091004","volume":"13","author":"P Zhou","year":"2022","unstructured":"Zhou P, Zhou Z, Huayu M et al (2022) A multi-epitope vaccine GILE against Echinococcus multilocularis infection in mice. Front Immunol 13:1091004","journal-title":"Front Immunol"},{"key":"2055_CR32","doi-asserted-by":"publisher","first-page":"125673","DOI":"10.1016\/j.biortech.2021.125673","volume":"341","author":"GB Patel","year":"2021","unstructured":"Patel GB, Rakholiya P, Shindhal T et al (2021) Lipolytic Nocardiopsis for reduction of pollution load in textile industry effluent and SWISS model for structural study of lipase. Bioresource Technol 341:125673","journal-title":"Bioresource Technol"},{"issue":"10","key":"2055_CR33","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1093\/bioinformatics\/btaa849","volume":"37","author":"G Janson","year":"2021","unstructured":"Janson G, Paiardini A (2021) PyMod 3: a complete suite for structural bioinformatics in PyMOL. Bioinformatics 37(10):1471\u20131472","journal-title":"Bioinformatics"},{"issue":"5","key":"2055_CR34","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s12223-015-0380-4","volume":"60","author":"G Liu","year":"2015","unstructured":"Liu G, Feng K, Guo D et al (2015) Overexpression and activities of 1-Cys peroxiredoxin from Pseudomonas fluorescens GcM5-1A carried by pine wood nematode. Folia Microbiol 60(5):443\u2013450","journal-title":"Folia Microbiol"},{"issue":"7","key":"2055_CR35","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3390\/f14071379","volume":"14","author":"G Dong","year":"2023","unstructured":"Dong G, Guo Q, Deng W et al (2023) Cinnamyl alcohol dehydrogenase gene regulates bursaphelenchus xylophilus reproduction and development. Forests 14(7):1379","journal-title":"Forests"},{"issue":"1","key":"2055_CR36","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1):248\u2013254","journal-title":"Anal Biochem"},{"key":"2055_CR37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.procbio.2020.03.006","volume":"92","author":"K Xuan","year":"2020","unstructured":"Xuan K, Yang G, Wu Z et al (2020) Efficient synthesis of (3R,5S)-6-chloro-2,4,6-trideoxyhexapyranose by using new 2-deoxy-d-ribose-5-phosphate aldolase from Streptococcus suis with moderate activity and aldehyde tolerance. Process Biochem 92:113\u2013119","journal-title":"Process Biochem"},{"key":"2055_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.procbio.2019.02.006","volume":"80","author":"XC Lou","year":"2019","unstructured":"Lou XC, Zheng CC, Chen WQ et al (2019) Heterologous expression and characterization of novel 2-Deoxy-d-ribose-5-phosphate aldolase (DERA) from Pyrobaculum calidifontis and Meiothermus ruber. Process Biochem 80:35\u201342","journal-title":"Process Biochem"},{"issue":"3","key":"2055_CR39","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1021\/ja01318a036","volume":"56","author":"H Lineweaver","year":"1934","unstructured":"Lineweaver H, Burk D (1934) The determination of enzyme dissociation constants. J Am Chem Soc 56(3):658\u2013666","journal-title":"J Am Chem Soc"},{"key":"2055_CR40","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.molcatb.2015.03.017","volume":"116","author":"H Fei","year":"2015","unstructured":"Fei H, Xu G, Wu JP et al (2015) Improving the acetaldehyde tolerance of DERASEP by enhancing the rigidity of its protein structure. J Mol Catal B-enzym 116:148\u2013152","journal-title":"J Mol Catal B-enzym"},{"issue":"12","key":"2055_CR41","doi-asserted-by":"publisher","first-page":"10799","DOI":"10.1074\/jbc.M212449200","volume":"278","author":"H Sakuraba","year":"2003","unstructured":"Sakuraba H, Tsuge H, Shimoya I et al (2003) The first crystal structure of archaeal aldolase. Unique tetrameric structure of 2-deoxy-d-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernix. J Biol Chem 278(12):10799\u201310806","journal-title":"J Biol Chem"},{"issue":"6","key":"2055_CR42","doi-asserted-by":"publisher","first-page":"995","DOI":"10.4014\/jmb.0912.12003","volume":"20","author":"YM Kim","year":"2010","unstructured":"Kim YM, Choi NS, Kim YO et al (2010) Expression and characterization of a novel deoxyribose 5-phosphate aldolase from Paenibacillus sp. EA001. J Microbiol Biotechnol 20(6):995\u20131000","journal-title":"J Microbiol Biotechnol"},{"key":"2055_CR43","first-page":"2898","volume":"9","author":"Q Wang","year":"2010","unstructured":"Wang Q, Chen R, Du P et al (2010) Cloning and characterization of thermostable-deoxy-D-ribose-5-phosphate aldolase from Hyperthermus butylicus. Afr J Biotechnol 9:2898\u20132905","journal-title":"Afr J Biotechnol"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-026-02055-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-026-02055-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-026-02055-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:56:00Z","timestamp":1786604160000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-026-02055-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2055"],"URL":"https:\/\/doi.org\/10.1007\/s42770-026-02055-y","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"3 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"236"}}