{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:08:29Z","timestamp":1788779309760,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Braz J Microbiol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s42770-026-02079-4","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:13:17Z","timestamp":1788775997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of fermentation parameters and mutagenesis of Glarea lozoyensis ATCC 20868 towards pneumocandin B0 production"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-3184","authenticated-orcid":false,"given":"Anshu","family":"Baldia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-8277","authenticated-orcid":false,"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-603X","authenticated-orcid":false,"given":"Deepanshi","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4204-009X","authenticated-orcid":false,"given":"Kashyap Kumar","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2079_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s40643-023-00677-w","volume":"10","author":"W Zhang","year":"2023","unstructured":"Zhang W, Yi P, Zhou Y, Yuan K, Ji X, Song P (2023) Effect of fatty acids on intracellular pneumocandin B0 storage in the fermentation of Glarea lozoyensis. Bioresour Bioprocess 10:63. https:\/\/doi.org\/10.1186\/s40643-023-00677-w","journal-title":"Bioresour Bioprocess"},{"key":"2079_CR2","doi-asserted-by":"publisher","first-page":"135220","DOI":"10.1016\/j.ijbiomac.2024.135220","volume":"279","author":"Y JiangK, Jin","year":"2024","unstructured":"JiangK, Jin Y, Luo P, Wang X, Zhang Y, Shi T, Chen J, Song P, Lu L (2024) Exploration of the pneumocandin biosynthesis-related gene cluster based on efficient CRISPR\/Cas9 gene editing strategy in Glarea lozoyensis. Int J Biol Macromol 279:135220. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.135220","journal-title":"Int J Biol Macromol"},{"key":"2079_CR3","doi-asserted-by":"publisher","first-page":"9881","DOI":"10.1007\/s00253-018-9382-x","volume":"102","author":"Y Li","year":"2018","unstructured":"Li Y, Lan N, Xu L, Yue Q (2018) Biosynthesis of pneumocandin lipopeptides and perspectives for its production and related echinocandins. Appl Microbiol Biotechnol 102:9881\u20139891. https:\/\/doi.org\/10.1007\/s00253-018-9382-x","journal-title":"Appl Microbiol Biotechnol"},{"key":"2079_CR4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.synbio.2025.04.006","volume":"10","author":"X Zhang","year":"2025","unstructured":"Zhang X, Cheng S, Yang J, Lu L, Deng Z, Bian G, Liu T (2025) Engineering the cytochrome P450 to enhance parthenolide production in Saccharomyces cerevisiae. Synth Syst Biotechnol 10:381\u2013390. https:\/\/doi.org\/10.1016\/j.synbio.2025.04.006","journal-title":"Synth Syst Biotechnol"},{"key":"2079_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/BF01584104","volume":"11","author":"JS Tkacz","year":"1993","unstructured":"Tkacz JS, Giacobbe RA, Monaghan RL (1993) Improvement in the titer of echinocandin-type antibiotics: a magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0. J Ind Microbiol 11:95\u2013103. https:\/\/doi.org\/10.1007\/BF01584104","journal-title":"J Ind Microbiol"},{"key":"2079_CR6","first-page":"89","volume":"1","author":"U Luthra","year":"2014","unstructured":"Luthra U, Trivedi A, Khadpekar S (2014) Screening for significant medium components for Pneumoncandin B0 production at shake flask level through factorial design. AIJCSR 1:89\u201393","journal-title":"AIJCSR"},{"issue":"24","key":"2079_CR7","doi-asserted-by":"publisher","first-page":"10729","DOI":"10.1007\/s00253-018-9440-4","volume":"102","author":"P Song","year":"2018","unstructured":"Song P, Huang B, Zhang S, Zhang K, Yuan K, Ji X, Ren L, Wen J, Huang H (2018) Novel osmotic stress control strategy for improved pneumocandin B0 production in Glarea lozoyensis combined with a mechanistic analysis at the transcriptome level. Appl Microbiol Biotechnol 102(24):10729\u201310742. https:\/\/doi.org\/10.1007\/s00253-018-9440-4","journal-title":"Appl Microbiol Biotechnol"},{"key":"2079_CR8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3389\/fmicb.2020.00190","volume":"11","author":"K Zhang","year":"2020","unstructured":"Zhang K, Huang B, Yuan K, Ji X, Song P, Ding Q (2020) Comparative Transcriptomics Analysis of the Responses of the Filamentous Fungus Glarea lozoyensis to Different Carbon Sources. Front Microbiol 11:190. https:\/\/doi.org\/10.3389\/fmicb.2020.00190","journal-title":"Front Microbiol"},{"key":"2079_CR9","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.3389\/fmicb.2018.02352","volume":"9","author":"P Song","year":"2018","unstructured":"Song P, Yuan K, Ji XJ, Ren LJ, Zhang S, Wen JP, Huang H (2018) Effects of Cotton Seed Powder as the Seed Medium Nitrogen Source on the Morphology and Pneumocandin B0 Yield of Glarea lozoyensis. Front Microbiol 9:2352. https:\/\/doi.org\/10.3389\/fmicb.2018.02352","journal-title":"Front Microbiol"},{"issue":"4","key":"2079_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/sj.jim.7000115","volume":"26","author":"LA Petersen","year":"2001","unstructured":"Petersen LA, Hughes DL, Hughes R, DiMichele L, Salmon P, Connors N (2001) Effects of amino acid and trace element supplementation on pneumocandin production by Glarea lozoyensis: impact on titre, analogue levels, and the identification of new analogues of pneumocandin B0. J Ind Microbiol Biotechnol 26(4):216\u2013221. https:\/\/doi.org\/10.1038\/sj.jim.7000115","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"3","key":"2079_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s13205-025-04236-2","volume":"15","author":"BM Karamchandani","year":"2025","unstructured":"Karamchandani BM, Maurya PA, Pawar AA, Pable A, Awale M, Dalvi SG, Banat IM, Satpute SK (2025) The role of statistical methods in optimizing and enhancing fungal chitosan commercial production. 3 Biotech 15(3):70. https:\/\/doi.org\/10.1007\/s13205-025-04236-2","journal-title":"3 Biotech"},{"key":"2079_CR12","doi-asserted-by":"publisher","first-page":"100423","DOI":"10.1016\/j.microb.2025.10042","volume":"8","author":"A Zineb","year":"2025","unstructured":"Zineb A, Ali Z, Ayoub E, Nadia Z, Assia M, Mohammed M (2025) Optimization of culture conditions for growth and secondary metabolites production by Streptomyces sp. MFB27 using response surface methodology. Microbe 8:100423. https:\/\/doi.org\/10.1016\/j.microb.2025.10042","journal-title":"Microbe"},{"issue":"2","key":"2079_CR13","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s12088-025-01467-y","volume":"65","author":"SS Dudala","year":"2025","unstructured":"Dudala SS, Venkateswarulu TC, Venkata Narayana A, John Babu D (2025) Statistical Optimization of Process Parameters and Purification of Uricase Using Isolate Pseudomonas mosselii DSS002. Indian J Microbiol 65(2):1089\u20131104. https:\/\/doi.org\/10.1007\/s12088-025-01467-y","journal-title":"Indian J Microbiol"},{"issue":"11","key":"2079_CR14","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1007\/s12010-023-04442-9","volume":"195","author":"KK Khushboo, Dubey","year":"2023","unstructured":"Khushboo, Dubey KK (2023) Enhanced production of lipstatin through NTG treatment of Streptomyces toxytricini KD18 at 5 L bioreactor level. Appl Biochem Biotechnol 195(11):6881\u20136892. https:\/\/doi.org\/10.1007\/s12010-023-04442-9","journal-title":"Appl Biochem Biotechnol"},{"issue":"5","key":"2079_CR15","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1128\/AEM.03256-14","volume":"81","author":"L Chen","year":"2015","unstructured":"Chen L, Yue Q, Li Y, Niu X, Xiang M, Wang W, Bills GF, Liu X, An Z (2015) Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate. Appl environ microbiol 81(5):1550\u20131558. https:\/\/doi.org\/10.1128\/AEM.03256-14","journal-title":"Appl environ microbiol"},{"key":"2079_CR16","doi-asserted-by":"publisher","first-page":"100438","DOI":"10.1016\/j.dwt.2024.100438","volume":"319","author":"S Liu","year":"2024","unstructured":"Liu S, Zhang Y, Zhao C, Li H, Shen X, Zhou M, Daigger GT, Zhang P, Song G (2024) Effects of nitrogen and carbon source addition on biomass and protein production by Rhodopseudomonas via the RSM-CCD approach. Desalin Water Treat 319:100438. https:\/\/doi.org\/10.1016\/j.dwt.2024.100438","journal-title":"Desalin Water Treat"},{"key":"2079_CR17","doi-asserted-by":"publisher","first-page":"102980","DOI":"10.1016\/j.bcab.2023.102980","volume":"55","author":"R Kumari","year":"2024","unstructured":"Kumari R, Kumar M, Upadhayay A, Dadheech PK, Vivekanand V, Pareek N (2024) Response surface bioprocess provenance for enhanced chitinase production by Thermomyces dupontii for translation of chitinous waste to short-chain chitooligosaccharides. Biocatal Agric Biotechnol 55:102980. https:\/\/doi.org\/10.1016\/j.bcab.2023.102980","journal-title":"Biocatal Agric Biotechnol"},{"key":"2079_CR18","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3897\/rio.7.e67379","volume":"2","author":"BB Teimoori","year":"2014","unstructured":"Teimoori BB, Pourianfar HR, Moeini MJ, Janpoor J (2014) Chemically and physically induced mutagenesis in basidiospores of oyster mushroom Pleurotus ostreatus var. florida. Int J Adv Res 2:915\u2013921. https:\/\/doi.org\/10.3897\/rio.7.e67379","journal-title":"Int J Adv Res"},{"issue":"6","key":"2079_CR19","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3390\/horticulturae9060693","volume":"9","author":"P Chutimanukul","year":"2023","unstructured":"Chutimanukul P, Sukdee S, Prajuabjinda O, Thepsilvisut O, Panthong S, Athinuwat D, Chuaboon W, Poomipan P, Vachirayagorn V (2023) The effects of soybean meal on growth, bioactive compounds, and antioxidant activity of Hericium erinaceus. Horticulturae 9(6):693. https:\/\/doi.org\/10.3390\/horticulturae9060693","journal-title":"Horticulturae"},{"key":"2079_CR20","doi-asserted-by":"publisher","unstructured":"Banaszkiewicz T (2011) Nutritional value of soybean meal. Soybean and Nutrition. InTech. Available at: https:\/\/doi.org\/10.5772\/23306","DOI":"10.5772\/23306"},{"issue":"18","key":"2079_CR21","doi-asserted-by":"publisher","first-page":"6515","DOI":"10.3390\/molecules28186515","volume":"28","author":"Y Li","year":"2023","unstructured":"Li Y, Gan S, Luo L, Yang W, Mo L, Shang C (2023) Optimization of molasses and soybean meal content to enhance tetramethylpyrazine yield by Bacillus sp. TTMP20. Molecules 28(18):6515. https:\/\/doi.org\/10.3390\/molecules28186515","journal-title":"Molecules"},{"issue":"6","key":"2079_CR22","doi-asserted-by":"publisher","first-page":"e70072","DOI":"10.1002\/mbo3.70072","volume":"14","author":"V Mani","year":"2025","unstructured":"Mani V, Jeyachandran S, Aman M (2025) The Roles of Carbon-Nitrogen Synergy and Phosphate Regulation in Producing Higher Yield of Vancomycin by Amycolatopsis orientalis. Microbiol Open 14(6):e70072. https:\/\/doi.org\/10.1002\/mbo3.70072","journal-title":"Microbiol Open"},{"issue":"1","key":"2079_CR23","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12866-024-03258-9","volume":"6","author":"Z Hu","year":"2024","unstructured":"Hu Z, Weng Q, Cai Z, Zhang H (2024) Optimization of fermentation conditions and medium components for chrysomycin a production by Streptomyces sp. 891-B6. BMC Microbiol 6(1):120. https:\/\/doi.org\/10.1186\/s12866-024-03258-9","journal-title":"BMC Microbiol"},{"issue":"1","key":"2079_CR24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41598-024-83724-6","volume":"15","author":"YT Zewide","year":"2025","unstructured":"Zewide YT, Yemata TA, Ayalew AA, Kedir HJ, Tadesse AA, Fekad AY, Shibesh AK, Getie FA, Tessema TD, Wubieneh TA, Kululo WW (2025) Application of response surface methodology (RSM) for experimental optimization in biogenic silica extraction from rice husk and straw ash. Sci Rep 15(1):132. https:\/\/doi.org\/10.1038\/s41598-024-83724-6","journal-title":"Sci Rep"},{"key":"2079_CR25","unstructured":"Shreffler J, Huecker MR (2023) Hypothesis testing, p values, confidence intervals, and significance. StatPearls. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557421\/"},{"key":"2079_CR26","doi-asserted-by":"publisher","first-page":"7206","DOI":"10.3390\/app15137206","volume":"15","author":"HY Chen","year":"2025","unstructured":"Chen HY, Chen C (2025) Importance of Using Modern Regression Analysis for Response Surface Models in Science and Technology. Appl Sci 15:7206. https:\/\/doi.org\/10.3390\/app15137206","journal-title":"Appl Sci"},{"key":"2079_CR27","unstructured":"Myers RH, Montgomery DC, Anderson-Cook CM (2009) Response surface methodology: process and product optimization using designed experiments, 4th edn. Wiley"},{"key":"2079_CR28","doi-asserted-by":"publisher","unstructured":"Rheem S, Rheem I, Oh S Response surface methodology reanalysis. Korean J Food Sci Anim Resour 37:139\u2013146. https:\/\/doi.org\/10.5851\/kosfa.2017.37.1.139","DOI":"10.5851\/kosfa.2017.37.1.139"},{"key":"2079_CR29","doi-asserted-by":"publisher","unstructured":"Bharat RA, Prathmesh SP, Sarsu F, Suprasanna P Induced mutagenesis using gamma rays: biological features and applications in crop improvement. OBM Genet 8:1\u201327. https:\/\/doi.org\/10.21926\/obm.genet.2402233","DOI":"10.21926\/obm.genet.2402233"},{"key":"2079_CR30","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/genetics\/118.4.551","volume":"118","author":"KR Tindall","year":"1988","unstructured":"Tindall KR, Stein J, Hutchinson F (1988) Changes in DNA Base Sequence Induced by Gamma-Ray Mutagenesis of Lambda Phage and Prophage. Genetics 118:551\u2013560. https:\/\/doi.org\/10.1093\/genetics\/118.4.551","journal-title":"Genetics"},{"issue":"2","key":"2079_CR31","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s11033-010-0239-3","volume":"38","author":"MS Awan","year":"2011","unstructured":"Awan MS, Tabbasam N, Ayub N, Babar ME, Rana SM, Rajoka MI (2011) Gamma radiation induced mutagenesis in Aspergillus niger to enhance its microbial fermentation activity for industrial enzyme production. Mol Biol Rep 38(2):1367\u20131374. https:\/\/doi.org\/10.1007\/s11033-010-0239-3","journal-title":"Mol Biol Rep"},{"issue":"5","key":"2079_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.4014\/jmb.1402.02040","volume":"24","author":"Y Jang","year":"2014","unstructured":"Jang Y, Lim Y, Kim K (2014) Saccharomyces cerevisiae strain improvement using selection, mutation, and adaptation for the resistance to lignocellulose-derived fermentation inhibitor for ethanol production. J Microbiol Biotechnol 24(5):667\u2013674. https:\/\/doi.org\/10.4014\/jmb.1402.02040","journal-title":"J Microbiol Biotechnol"},{"issue":"4","key":"2079_CR33","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s13205-020-2147-0","volume":"10","author":"P Khushboo","year":"2020","unstructured":"Khushboo P, Kumar P, Tripathi A, Luthra U, Dubey KK (2020) Enhanced production of lipstatin from mutant of Streptomyces toxytricini and fed-batch strategies under submerged fermentation. 3 Biotech 10(4):151. https:\/\/doi.org\/10.1007\/s13205-020-2147-0","journal-title":"3 Biotech"},{"key":"2079_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.btre.2017.04.001","volume":"14","author":"NM Elkenawy","year":"2017","unstructured":"Elkenawy NM, Yassin AS, Elhifnawy HN, Amin MA (2017) Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation. Biotechnol Rep 14:47\u201353. https:\/\/doi.org\/10.1016\/j.btre.2017.04.001","journal-title":"Biotechnol Rep"},{"key":"2079_CR35","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1134\/S0026261718040094","volume":"87","author":"EZ Gomaa","year":"2018","unstructured":"Gomaa EZ, El-Mahdy OM (2018) Improvement of Chitinase Production by Bacillus thuringiensis NM101-19 for Antifungal Biocontrol through Physical Mutation. Microbiology 87:472\u2013485. https:\/\/doi.org\/10.1134\/S0026261718040094","journal-title":"Microbiology"},{"issue":"12","key":"2079_CR36","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1093\/nar\/gki681","volume":"33","author":"C Lundin","year":"2005","unstructured":"Lundin C, North M, Erixon K, Walters K, Jenssen D, Goldman AS, Helleday T (2005) Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Res 33(12):3799\u20133811. https:\/\/doi.org\/10.1093\/nar\/gki681","journal-title":"Nucleic Acids Res"},{"key":"2079_CR37","doi-asserted-by":"publisher","first-page":"e06611","DOI":"10.2903\/j.efsa.2021.6611","volume":"19","author":"EFSA Panel on Genetically Modified Organisms","year":"2021","unstructured":"EFSA Panel on Genetically Modified Organisms (2021) In vivo and in vitro random mutagenesis techniques in plants. EFSA J 19:e06611. https:\/\/doi.org\/10.2903\/j.efsa.2021.6611","journal-title":"EFSA J"},{"key":"2079_CR38","doi-asserted-by":"publisher","first-page":"e02816","DOI":"10.1128\/AEM.02816-19","volume":"86","author":"A Deshpande","year":"2020","unstructured":"Deshpande A, Vue J, Morgan J (2020) Combining Random Mutagenesis and Metabolic Engineering for Enhanced Tryptophan Production in Synechocystis sp. Strain PCC 6803. Appl Environ Microbiol 86:e02816\u2013e02819. https:\/\/doi.org\/10.1128\/AEM.02816-19","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"2079_CR39","doi-asserted-by":"publisher","first-page":"114","DOI":"10.21786\/bbrc\/12.1\/15","volume":"12","author":"M Kumar","year":"2019","unstructured":"Kumar M, Rajesh VS, Salar RK (2019) Upgradation of tannase production by Klebsiella pneumoniae KP715242 through heat, UV, NTG and MMS induced mutagenesis for enhanced tannase activity. Biosci Biotech Res Comm 12(1):114\u2013123. https:\/\/doi.org\/10.21786\/bbrc\/12.1\/15","journal-title":"Biosci Biotech Res Comm"},{"issue":"6","key":"2079_CR40","doi-asserted-by":"publisher","first-page":"831","DOI":"10.18006\/2021.9(6).831.836","volume":"9","author":"U Romruen","year":"2021","unstructured":"Romruen U, Thangsiri S, Pongsutas T, Bangyeekhun E (2021) Chemically induced mutagenesis in the king oyster mushroom pleurotus eryngii to generate high-temperature tolerant strain. J Exp Biol Agric Sci 9(6):831\u2013836. https:\/\/doi.org\/10.18006\/2021.9(6).831.836","journal-title":"J Exp Biol Agric Sci"},{"key":"2079_CR41","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1007\/s00253-018-8818-7","volume":"102","author":"L Veiter","year":"2018","unstructured":"Veiter L, Rajamanickam V, Herwig C (2018) The filamentous fungal pellet-relationship between morphology and productivity. Appl Microbiol Biotechnol 102:2997\u20133006. https:\/\/doi.org\/10.1007\/s00253-018-8818-7","journal-title":"Appl Microbiol Biotechnol"},{"key":"2079_CR42","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.biotechadv.2003.09.005","volume":"22","author":"M Papagianni","year":"2004","unstructured":"Papagianni M (2004) Fungal morphology and metabolite production in submerged mycelial culture. Biotechnol Adv 22:189\u2013259. https:\/\/doi.org\/10.1016\/j.biotechadv.2003.09.005","journal-title":"Biotechnol Adv"},{"issue":"1","key":"2079_CR43","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1080\/07388551.2025.2581878","volume":"46","author":"TM Hern\u00e1ndez-Cruz","year":"2026","unstructured":"Hern\u00e1ndez-Cruz TM, Legorreta-Casta\u00f1eda AJ, Aranda E, Guerra-S\u00e1nchez G, Carballo-S\u00e1nchez MP, Olic\u00f3n-Hern\u00e1ndez DR (2026) Fungal pellets as biotechnological tools for addressing environmental and industrial challenges: a comprehensive review. Crit Rev Biotechnol 46(1):100\u2013119. https:\/\/doi.org\/10.1080\/07388551.2025.2581878","journal-title":"Crit Rev Biotechnol"},{"issue":"2","key":"2079_CR44","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/bit.27622","volume":"118","author":"S Schmideder","year":"2021","unstructured":"Schmideder S, M\u00fcller H, Barthel L, Friedrich T, Niessen L, Meyer V, Briesen H (2021) Universal law for diffusive mass transport through mycelial networks. Biotechnol Bioeng 118(2):930\u2013943. https:\/\/doi.org\/10.1002\/bit.27622","journal-title":"Biotechnol Bioeng"},{"issue":"39","key":"2079_CR45","doi-asserted-by":"publisher","first-page":"16911","DOI":"10.1021\/acs.iecr.0c01325","volume":"59","author":"L Li","year":"2020","unstructured":"Li L, Liang T, Liu W, Liu Y, Ma F (2020) A comprehensive review of the mycelial pellet: Research status, applications, and future prospects. Ind Eng Chem Res 59(39):16911\u201316922. https:\/\/doi.org\/10.1021\/acs.iecr.0c01325","journal-title":"Ind Eng Chem Res"},{"key":"2079_CR46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11274-016-2148-7","volume":"32","author":"A Antecka","year":"2016","unstructured":"Antecka A, Bizukojc M, Ledakowicz S (2016) Modern morphological engineering techniques for improving productivity of filamentous fungi in submerged cultures. World J Microbiol Biotechnol 32:193. https:\/\/doi.org\/10.1007\/s11274-016-2148-7","journal-title":"World J Microbiol Biotechnol"},{"issue":"2","key":"2079_CR47","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/jof9020205","volume":"9","author":"Z Gong","year":"2023","unstructured":"Gong Z, Zhang S, Liu J (2023) Recent Advances in Chitin Biosynthesis Associated with the Morphology and Secondary Metabolite Synthesis of Filamentous Fungi in Submerged Fermentation. J Fungi 9(2):205. https:\/\/doi.org\/10.3390\/jof9020205","journal-title":"J Fungi"},{"issue":"12","key":"2079_CR48","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.7164\/antibiotics.45.1867","volume":"45","author":"PS Masurekar","year":"1992","unstructured":"Masurekar PS, Fountoulakis JM, Hallada TC, Sosa MS, Kaplan L (1992) Pneumocandins from Zalerion arboricola II. Modification of product spectrum by mutation and medium manipulation. J Antibiot 45(12):1867\u20131874. https:\/\/doi.org\/10.7164\/antibiotics.45.1867","journal-title":"J Antibiot"},{"key":"2079_CR49","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1017\/S095375629800687X","volume":"103","author":"GF Bills","year":"1999","unstructured":"Bills GF, Platas G, Pel\u00e1ez F, Masurekar P (1999) Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola. Mycol Res 103:179\u2013192. https:\/\/doi.org\/10.1017\/S095375629800687X","journal-title":"Mycol Res"},{"key":"2079_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s13205-017-1049-2","volume":"8","author":"P Kumar","year":"2018","unstructured":"Kumar P, Dubey KK (2018) Implication of mutagenesis and precursor supplementation towards the enhancement of lipstatin (an antiobesity agent) biosynthesis through submerged fermentation using Streptomyces toxytricini. 3 Biotech 8:29. https:\/\/doi.org\/10.1007\/s13205-017-1049-2","journal-title":"3 Biotech"},{"issue":"1","key":"2079_CR51","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/09553002.2024.2425305","volume":"101","author":"A Rana","year":"2025","unstructured":"Rana A, Rana V, Bakshi S, Sood VK (2025) Isolation and characterization of gamma rays induced mutants for improved agro-morphological performance and harder grain texture in wheat (Triticum aestivum L). Int J Radiat Biol 101(1):85\u2013100. https:\/\/doi.org\/10.1080\/09553002.2024.2425305","journal-title":"Int J Radiat Biol"}],"container-title":["Brazilian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-026-02079-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s42770-026-02079-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s42770-026-02079-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:13:19Z","timestamp":1788775999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s42770-026-02079-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2079"],"URL":"https:\/\/doi.org\/10.1007\/s42770-026-02079-4","relation":{},"ISSN":["1517-8382","1678-4405"],"issn-type":[{"value":"1517-8382","type":"print"},{"value":"1678-4405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"5 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors present consent for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no known competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"260"}}